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Extract from the Register of European Patents

EP About this file: EP0583579

EP0583579 - New 17-hydroxyiminomethyl-5beta, 14beta-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  09.10.1998
Database last updated on 15.06.2024
Most recent event   Tooltip09.10.1998No opposition filed within time limitpublished on 25.11.1998 [1998/48]
Applicant(s)For all designated states
SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.
Viale Shakespeare, 47
00144 Roma / IT
[N/P]
Former [1997/49]For all designated states
Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
Viale Shakespeare, 47
00144 Roma / IT
Former [1994/08]For all designated states
Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
Viale Shakespeare, 47
I-00144 Roma / IT
Inventor(s)01 / Cerri, Alberto
7, Monte San Michele
I-20060 Gessate (Milan) / IT
02 / Bernardi, Luigi
30, Via Pinerolo
I-20151 Milan / IT
03 / Bianchi, Giuseppe
5, Via Vigoni
I-20124 Milan / IT
04 / Florio, Monica
32 Via Don Sturzo
I-20091 Bresso / IT
05 / Folpini, Elena
6, Via della Rondine
I-20147 Milan / IT
06 / Melloni, Piero
1, Via Centurelli
I-20091 Bresso (Milan) / IT
[1994/19]
Former [1994/08]01 / Cerri, Alberto
7, Monte San Michele
I-20060 Gessate (Milan) / IT
02 / Bernardi, Luigi
30, Via Pinerolo
I-20151 Milan / IT
03 / Bianchi, Giuseppe
5, Via Vigoni
I-20124 Milan / IT
04 / Florio, Monica
32 Via Don Sturza
I-20091 Bresso / IT
05 / Folpini, Elena
6, Via della Rondine
I-20147 Milan / IT
06 / Melloni, Piero
1, Via Centurelli
I-20091 Bresso (Milan) / IT
Representative(s)Fassi, Aldo, et al
Hoffmann-Eitle & Partner, Patent-und Rechtsanwälte, Postfach 81 04 20
81904 München / DE
[N/P]
Former [1994/08]Fassi, Aldo, et al
Hoffmann-Eitle & Partner, Patent-und Rechtsanwälte, Postfach 81 04 20
D-81904 München / DE
Application number, filing date93110189.325.06.1993
[1994/08]
Priority number, dateDE1992422760520.08.1992         Original published format: DE 4227605
[1994/08]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP0583579
Date:23.02.1994
Language:EN
[1994/08]
Type: A3 Search report 
No.:EP0583579
Date:22.03.1995
Language:EN
[1995/12]
Type: B1 Patent specification 
No.:EP0583579
Date:03.12.1997
Language:EN
[1997/49]
Search report(s)(Supplementary) European search report - dispatched on:EP06.02.1995
ClassificationIPC:C07J41/00, C07J43/00, A61K31/56, A61K31/57, A61K31/58
[1994/08]
CPC:
C07J41/0016 (EP,US); C07J41/0044 (KR); A61P9/00 (EP);
A61P9/04 (EP); A61P9/12 (EP); C07J41/0005 (EP,US);
C07J41/0038 (EP,KR,US); C07J41/0088 (EP,US); C07J43/003 (EP,US) (-)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1994/08]
TitleGerman:Neue 17-Hydroxyiminomethyl-5beta, 14beta-Androstan-Derivate, kardioaktives Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon[1994/08]
English:New 17-hydroxyiminomethyl-5beta, 14beta-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same[1994/08]
French:Nouveaux 17-hydroxyiminométhyl-5béta, 14béta-androstanes cardioactifs, procédé pour leur production et les compositions pharmaceutiques les renfermant[1994/08]
Examination procedure23.05.1995Examination requested  [1995/29]
06.10.1995Despatch of a communication from the examining division (Time limit: M04)
23.01.1996Reply to a communication from the examining division
08.05.1996Despatch of a communication from the examining division (Time limit: M02)
17.06.1996Reply to a communication from the examining division
14.03.1997Despatch of communication of intention to grant (Approval: No)
04.06.1997Despatch of communication of intention to grant (Approval: later approval)
09.06.1997Communication of intention to grant the patent
02.09.1997Fee for grant paid
02.09.1997Fee for publishing/printing paid
Opposition(s)04.09.1998No opposition filed within time limit [1998/48]
Fees paidRenewal fee
27.06.1995Renewal fee patent year 03
28.06.1996Renewal fee patent year 04
27.06.1997Renewal fee patent year 05
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Documents cited:Search[DX]  - B. TESTA, ADVANCES IN DRUG RESEARCH, VOLUME 19, LONDON, GB, ACADEMIC PRESS, (1990) [DX] 1-3 * pages 535-545, particularly pages 538-540, compound CCXXX *
 [PX]  - Templeton J F et al, "Synthesis of 20.alpha.- and 20.beta.-acetamido, amino, nitro, and hydroxy derivatives of 14-hydroxy-5.beta.,14.beta.-pregnane 3.beta.-glycosides: pregnanes that bind to the digitalis receptor", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, LETCHWORTH GB, (19921007), no. 19, pages 2503 - 2517 [PX] 1-4 * page 2504; examples 2b,c *
 [PA]  - Templeton J F et al, "Synthesis of 20-hydroxy-, 20-amino-, and 20-nitro-14-hydroxy-21-nor -5.beta.,14.beta.-pregnane C-3 glycosides and related derivatives: structure-activity relationships of pregnanes that bind to the digitalis receptor", JOURNAL OF MEDICINAL CHEMISTRY, WASHINGTON US, (19930108), vol. 36, no. 1, doi:doi:10.1021/jm00053a006, pages 42 - 45, XP002001546 [PA] 1-4 * page 43; examples 7a,b *

DOI:   http://dx.doi.org/10.1021/jm00053a006
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