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Extract from the Register of European Patents

EP About this file: EP0625157

EP0625157 - PLATELET GPIIIa P1A1 AND P1A2 EPITOPES, THEIR PREPARATION AND USE [Right-click to bookmark this link]
Former [1994/47]PLATELET GPIIIa P1?A1 AND P1?A2 EPITOPES, THEIR PREPARATION AND USE
[2001/46]
StatusNo opposition filed within time limit
Status updated on  09.01.2004
Database last updated on 02.09.2024
Most recent event   Tooltip09.01.2004No opposition filed within time limitpublished on 25.02.2004  [2004/09]
Applicant(s)For all designated states
THE SCRIPPS RESEARCH INSTITUTE
10666 North Torrey Pines Road
La Jolla, CA 92037 / US
[1994/47]
Inventor(s)01 / BOWDITCH, Ronald, D.
810 3rd. Street
Encinitas, CA 92024 / US
02 / McMILLAN, Robert
203 12th Street
Del Mar, CA 92014 / US
03 / GINSBERG, Mark, H.
2944 Renault Place
San Diego, CA 92122 / US
[1994/47]
Representative(s)Fisher, Adrian John, et al
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [1994/47]Fisher, Adrian John, et al
CARPMAELS & RANSFORD 43 Bloomsbury Square
London WC1A 2RA / GB
Application number, filing date93900656.524.11.1992
[1994/47]
WO1992US10178
Priority number, dateUS1991080845709.12.1991         Original published format: US 808457
[1994/47]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9312127
Date:24.06.1993
Language:EN
[1993/15]
Type: A1 Application with search report 
No.:EP0625157
Date:23.11.1994
Language:EN
The application published by WIPO in one of the EPO official languages on 24.06.1993 takes the place of the publication of the European patent application.
[1994/47]
Type: B1 Patent specification 
No.:EP0625157
Date:05.03.2003
Language:EN
[2003/10]
Search report(s)International search report - published on:US24.06.1993
(Supplementary) European search report - dispatched on:EP10.05.1995
ClassificationIPC:C12N15/12, C12N15/62, C12N15/70, C07K14/705, G01N33/68, G01N33/543, G01N33/577, G01N33/80, G01N33/532, // C07K16/28, C07K17/00, G01N33/541
[2001/46]
CPC:
C07K14/70557 (EP,US); C07K16/2848 (EP,US); C07K2317/34 (EP,US);
C07K2319/24 (EP,US); C07K2319/50 (EP,US); C07K2319/61 (EP,US)
Former IPC [1995/26]C12N15/12, C12N15/62, C12N15/70, C07K13/00, G01N33/68, G01N33/543, G01N33/577, G01N33/80, G01N33/532, // C07K15/28, C07K17/00, G01N33/541
Former IPC [1994/47]C07H15/12, C07K3/00, C07K15/00, C12N15/00, C12P21/06, C12Q1/68
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1994/47]
TitleGerman:BLUTPLAETTCHEN-GPIIIa P1A1 und -P1A2-EPITOPE, IHRE HERSTELLUNG UND VERWENDUNG[1994/47]
English:PLATELET GPIIIa P1A1 AND P1A2 EPITOPES, THEIR PREPARATION AND USE[2001/46]
French:EPITOPES P1A1 ET P1A2 DE LA GPIIIa PLAQUETTAIRE, LEUR PREPARATION ET UTILISATION[2001/46]
Former [1994/47]PLATELET GPIIIa P1?A1 AND P1?A2 EPITOPES, THEIR PREPARATION AND USE
Former [1994/47]EPITOPES P1?A1 ET P1?A2 DE LA GPIIIa PLAQUETTAIRE, LEUR PREPARATION ET UTILISATION
Entry into regional phase17.06.1994National basic fee paid 
17.06.1994Search fee paid 
17.06.1994Designation fee(s) paid 
17.06.1994Examination fee paid 
Examination procedure28.06.1993Request for preliminary examination filed
International Preliminary Examining Authority: DE
17.06.1994Examination requested  [1994/47]
27.01.1999Despatch of a communication from the examining division (Time limit: M06)
15.06.1999Reply to a communication from the examining division
11.08.1999Despatch of a communication from the examining division (Time limit: M06)
10.02.2000Reply to a communication from the examining division
16.08.2000Despatch of a communication from the examining division (Time limit: M04)
11.09.2000Reply to a communication from the examining division
14.11.2001Despatch of communication of intention to grant (Approval: No)
06.06.2002Despatch of a communication from the examining division (Time limit: M04)
01.08.2002Despatch of communication of intention to grant (Approval: later approval)
01.08.2002Reply to a communication from the examining division
12.08.2002Communication of intention to grant the patent
22.10.2002Fee for grant paid
22.10.2002Fee for publishing/printing paid
Opposition(s)08.12.2003No opposition filed within time limit [2004/09]
Fees paidRenewal fee
17.06.1994Renewal fee patent year 03
09.11.1995Renewal fee patent year 04
11.11.1996Renewal fee patent year 05
10.11.1997Renewal fee patent year 06
10.11.1998Renewal fee patent year 07
12.11.1999Renewal fee patent year 08
13.11.2000Renewal fee patent year 09
14.11.2001Renewal fee patent year 10
13.11.2002Renewal fee patent year 11
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Documents cited:Search[XY]WO9012593  (BLOOD CENTER OF SOUTHEASTERN W [US]) [X] 1,3,14,25-30 * the whole document * [Y] 2,4-11,15,19,23,32;
 [PY]  - KOUNS ET AL., "Further characterization of the loop structure of Platelet Glycoprotein IIa : Partial mapping of functionally significant glycoprotein IIIa epitopes", BLOOD, (19911215), vol. 78, no. 12, pages 3215 - 3223, XP000672885 [PY] 1-35 * the whole document *
 [Y]  - BENNETT ET AL., "Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody", PROC. NATL ACAD. SCI., (198305), vol. 80, doi:doi:10.1073/pnas.80.9.2417, pages 2417 - 2421, XP008052286 [Y] 14,15,19,23,25,26,28-30 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.80.9.2417
 [YD]  - NEWMAN ET AL., "Studies on the nature of the human platelet alloantigen, PlA1 : localization to a 17,000-Dalton polypeptide", MOL. IMMUNOL, (1985), vol. 22, no. 6, doi:doi:10.1016/0161-5890(85)90103-8, pages 719 - 729, XP023852714 [YD] 1-35 * the whole document *

DOI:   http://dx.doi.org/10.1016/0161-5890(85)90103-8
International search[XY]WO9006953  (GENENTECH INC [US]);
 [YE]US5177188  (GINSBERG MARK H [US], et al)
 [XY]  - Blood, Volume 78, No. 3, issued 01 August 1991, A. GOLDBERGER et al., "Effect of Single Amino Acid Substitutions on the Formation of the PlA and Bak Alloantigenic Epitopes", pp. 681-687, see entire document.
 [XY]  - The Journal of Biological Chemistry, Volume 264, No. 32, issued 15 November 1989, S.C. BODARY et al., "Expression of Recombinant Platelet Glycoprotein IIbIIIa Results in a Functional Fibrinogen-binding Complex", pp. 18859-18862, see entire document.
 [XY]  - The Journal of Biological Chemistry, Volume 262, No. 9, issued 25 March 1987, L.A. FITZGERALD et al., "Protein Sequence of Endothelial Glycoprotein IIIa Derived from a cDNA Clone", pp. 3936-3939, see entire document.
 [XY]  - Journal of Clinical Investigation, Volume 81, issued May 1988, A.B. ZIMRIN et al., "Structure of Platelet Glycoprotein IIIa", pp. 1470-1475, see entire document.
 [XY]  - The Journal of Biological Chemistry, Volume 265, No. 15, issued 25 May 1990, A.B. ZIMRIN et al., "The Genomic Organization of Platelet Glycoprotein IIIa", pp. 8590-8595, see entire document.
 [XY]  - Blood, Volume 74, No. 1, issued July 1989, T.E. O'TOOLE et al., "Efficient Surface Expression of Platelet GPIIb-IIIa Requires Both Subunits", pp. 14-18, see entire document.
 [Y]  - Thrombosis and Heomostasis, Volume 66, No. 1, issued 1991, P.J. NEWMAN, "Platelet GPIIb-IIIa: Molecular Variations and Alloantigens", pp. 111-118, see entire document.
 [XY]  - Blood, Volume 63, No. 2, issued February 1984, V.L. WOODS et al., "Autoantibodies Against the Platelet Glycoprotein IIb/IIIa Complex in Patients with Chronic ITP", pp. 368-375, see entire document.
 [Y]  - Proceedings of the National Academy of Sciences USA, Volume 80, issued March 1983, R.A. YOUNG et al., "Efficient Isolation of Genes by Using Antibody Probes", pp. 1194-1198, see entire document.
 [XPY]  - Blood, Volume 79, No. 3, issued 01 February 1992, R.D. BOWDITCH et al., "Localization of a PlA1 Epitope to the Amino Terminal 66 Residues of Platelet Glycoprotein IIIa", pp. 559-562, see entire document.
Examination   - FLUG ET AL., "A 13-mer peptide straddling the leucine33/proline33 ...", BLOOD, (19910105), vol. 77, no. 9, pages 1964 - 1969
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.