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Extract from the Register of European Patents

EP About this file: EP0657456

EP0657456 - Process for preparing epibatidine [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  09.04.1998
Database last updated on 15.07.2024
Most recent event   Tooltip04.01.2003Lapse of the patent in a contracting state
New state(s): NL
published on 19.02.2003  [2003/08]
Applicant(s)For all designated states
EGIS GYÓGYSZERGYÁR RT.
Keresztúri út 30-38
1106 Budapest / HU
[N/P]
Former [1995/24]For all designated states
EGIS GYOGYSZERGYAR RT.
Kereszturi ut 30-38
H-1106 Budapest / HU
Inventor(s)01 / Csaba Szantay Dr., chemical engineer
8 Zsombolyai u.
H-1113 Budapest / HU
02 / Zsuzsanna Balogh née Kardos, Dr., chemist
7/b Galgoczy köz
H-1125 Budapest / HU
03 / Istvan Moldvai, Dr., chemistry teacher
107 Kossuth L.u.
H-1212 Budapest / HU
04 / Eszter Temesvari née Major, Dr., chemical engineer
52 Ratz L.u.
H-1116 Budapest / HU
05 / Csaba Szantay jr., Dr., chemical engineer
8 Zsombolyai u.
H-1113 Budapest / HU
06 / Attila Mandi, Dr., chemical engineer
12 Riado u.
H-1026 Budapest / HU
07 / Gabor Blasko, Dr., chemical engineer
12 Molnar E. u.
H-1113 Budapest / HU
08 / Gyula Simig, Dr., chemical engineer
25 Hollosy S. u.
H-1126 Budapest / HU
09 / * * *
10 / Sandor Drabant, Dr., physician
27 Körömvirag u.
H-1171 Budapest / HU
11 / Tamas Szallasi, Dr., physician
44 Margit krt.
H-1027 Budapest / HU
12 / Marton Fekete, Dr., physician
49 Fo u.
H-1027 Budapest / HU
13 / Gabor Gigler, biologist
41 Terez krt.
H-1067 Budapest / HU
[1995/24]
Representative(s)Beszédes, Stephan G.
Patentanwalt
Münchener Strasse 80a
85221 Dachau / DE
[N/P]
Former [1995/24]Beszédes, Stephan G., Dr.
Patentanwalt, Münchener Strasse 80a
D-85221 Dachau / DE
Application number, filing date94119544.809.12.1994
[1995/24]
Priority number, dateHU1935000059309.12.1993         Original published format: HU 3500593
HU1935000059306.10.1994         Original published format: HU 3500593
[1995/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP0657456
Date:14.06.1995
Language:EN
[1995/24]
Type: B1 Patent specification 
No.:EP0657456
Date:04.06.1997
Language:EN
[1997/23]
Search report(s)(Supplementary) European search report - dispatched on:EP23.02.1995
ClassificationIPC:C07D487/08, A61K31/44
[1995/24]
CPC:
C07D487/08 (EP,KR,US); A61P25/04 (EP)
Designated contracting statesAT,   CH,   DE,   DK,   GB,   LI,   NL,   SE [1995/24]
TitleGerman:Verfahren zur Herstellung von Epibatidin[1995/24]
English:Process for preparing epibatidine[1995/24]
French:Procédé pour la préparation d'épibatidine[1995/24]
MiscellaneousEPB 1996/33: Teilanmeldung 96107729.4 eingereicht am 15/05/96
EPB 1996/33: Divisional application 96107729.4 filed on 15/05/96
EPB 1996/33: Demande divisionnaire 96107729.4 déposée le 15/05/96
Examination procedure23.08.1995Examination requested  [1995/42]
23.01.1996Despatch of a communication from the examining division (Time limit: M04)
15.05.1996Reply to a communication from the examining division
05.07.1996Despatch of communication of intention to grant (Approval: Yes)
26.11.1996Communication of intention to grant the patent
27.02.1997Fee for grant paid
27.02.1997Fee for publishing/printing paid
Divisional application(s)EP96107729.4  / EP0736534
Opposition(s)05.03.1998No opposition filed within time limit [1998/22]
Fees paidRenewal fee
19.12.1996Renewal fee patent year 03
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT04.06.1997
CH04.06.1997
DK04.06.1997
LI04.06.1997
NL04.06.1997
DE29.07.1997
SE04.09.1997
[2003/08]
Former [1998/15]AT04.06.1997
CH04.06.1997
DK04.06.1997
LI04.06.1997
DE29.07.1997
SE04.09.1997
Former [1998/12]AT04.06.1997
CH04.06.1997
LI04.06.1997
DE29.07.1997
SE04.09.1997
Former [1998/04]AT04.06.1997
CH04.06.1997
LI04.06.1997
DE29.07.1997
Former [1998/03]AT04.06.1997
DE29.07.1997
Former [1998/02]AT04.06.1997
Documents cited:Search[AD]WO9318037  (US HEALTH [US]) [AD] 1 *scheme 1*;
 [XD]  - S.R. FLETCHER ET AL., "The synthesis of (+)- and (-)-epibatidine", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, LETCHWORTH GB, (19930807), no. 15, pages 1216 - 1218 [XD] 1 *epimerisation of 16 to 15 on page 1217*
 [XP]  - S.Y. KO ET AL., "The total synthesis of epibatidine", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, LETCHWORTH GB, (19940817), no. 15 [XP] 1 *conversion of 10 to 1 on page 1775*
 [XP]  - C. SZANTAY ET AL., "A practical route to epibatidine", TETRAHEDRON LETTERS., OXFORD GB, (19940509), vol. 35, no. 19, doi:doi:10.1016/S0040-4039(00)76859-6, pages 3171 - 3174, XP000575831 [XP] 1-23 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)76859-6
 [AD]  - D.F. HUANG ET AL., "A versatile total synthesis of epibatidine and analogs", TETRAHEDRON LETTERS., OXFORD GB, (1993), vol. 34, no. 28, doi:doi:10.1016/0040-4039(93)88063-O, pages 4477 - 4480, XP000575830 [AD] 1-23

DOI:   http://dx.doi.org/10.1016/0040-4039(93)88063-O
 [AD]  - E.J. COREY ET AL., "Stereocontrolled total synthesis of (+)- and (-)-epibatidine", JOURNAL OF ORGANIC CHEMISTRY., EASTON US, (1993), vol. 58, no. 21, doi:doi:10.1021/jo00073a013, pages 5600 - 5602, XP002001261 [AD] 1-23

DOI:   http://dx.doi.org/10.1021/jo00073a013
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