blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

Italy joins the Federated Register

Click here for more information on the Federated Register.

2025-06-12

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register User Manual
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP0640687

EP0640687 - Methods of using, storing and transporting metal protease enzyme in a stabilized form [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.02.2003
Database last updated on 28.03.2026
Most recent event   Tooltip28.12.2007Lapse of the patent in a contracting state
New state(s): IT		published on 30.01.2008  [2008/05]
Applicant(s)For all designated states
HOLLAND SWEETENER COMPANY V.O.F.
Koestraat 1
6167 RA Geleen / NL
[N/P]
Former [2001/46]For all designated states
Holland Sweetener Company V.o.F.
Koestraat 1
6167 RA Geleen / NL
Former [1995/09]For all designated states
HOLLAND SWEETENER COMPANY V.O.F.
Blekerij 52
NL-6212 XW Maastricht / NL
Inventor(s)01 / Harada, Tsuneo
Hajima 2 chome 10-18
Shinanyo-city, Yamaguchi-pref. / JP
02 / Kunisawa, Yukio
Fukugawa 3-chome 4-22
Shinanyo-city, Yamaguchi-pref. / JP
03 / Oyama, Kiyotaka
Minamiyukigaya 4-24-2
Ohta-ku, Tokyo-pref. / JP
04 / Smeets, Johanna Christina Maria
Thorbeckestraat 100
6163 DD Sittard / NL
05 / Takasuga, Shuya
Nishimasu-cho 4-2-304
Shinanyo-city, Yamaguchi-pref. / JP
06 / van den Tweel, Wilhelmus Johannes Joseph
Klooesterberg 6A
6241 ED Meerssen / NL
 [2002/13]
Former [1995/09]01 / Harada, Tsuneo
Hajima 2 chome 10-18
Shinanyo-city, Yamaguchi-pref. / JP
02 / Kunisawa, Yukio
Fukugawa 3-chome 4-22
Shinanyo-city, Yamaguchi-pref. / JP
03 / Oyama, Kiyotaka
Minamiyukigaya 4-24-2
Ohta-ku, Tokyo-pref. / JP
04 / Smeets, Johanna Christina Maria
Thorbeckestraat 100
6163 DD Sittard / NL
05 / Takasuga, Shuya
Nishimasu-cho 4-2-304
Shinanyo-city, Yamaguchi-pref. / JP
06 / van den Tweel, Wilhelmus Johannes Joseph
Klosterberg 6 A
6241 ED Meerssen / NL
Application number, filing date94202399.522.08.1994
[1995/09]
Priority number, dateEP1993020251727.08.1993         Original published format: EP 93202517
[1995/09]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP0640687
Date:01.03.1995
Language:EN
[1995/09]
Type: B1 Patent specification 
No.:EP0640687
Date:03.04.2002
Language:EN
[2002/14]
Search report(s)(Supplementary) European search report - dispatched on:EP07.12.1994
ClassificationIPC:C12N9/96, C12N9/50
[1995/09]
CPC:
C12N9/54 (EP,KR,US); C12N9/96 (EP,US); C12Y304/24027 (KR)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   IT,   LI,   NL,   SE [1995/09]
TitleGerman:Verfahren zur Anwendung, Lagern und Transport des Proteaseenzymes im stabilisierter Form[1995/09]
English:Methods of using, storing and transporting metal protease enzyme in a stabilized form[1995/09]
French:Méthode d'utilisation, d'approvisionement et de transport de l'enzyme protease sous une forme stabilisee[1995/09]
Examination procedure14.06.1995Examination requested  [1995/32]
18.06.1999Despatch of a communication from the examining division (Time limit: M06)
20.12.1999Reply to a communication from the examining division
01.09.2000Despatch of a communication from the examining division (Time limit: M04)
02.01.2001Reply to a communication from the examining division
18.07.2001Despatch of communication of intention to grant (Approval: Yes)
02.10.2001Communication of intention to grant the patent
20.12.2001Fee for grant paid
20.12.2001Fee for publishing/printing paid
Opposition(s)06.01.2003No opposition filed within time limit [2003/13]
Fees paidRenewal fee
10.08.1996Renewal fee patent year 03
18.07.1997Renewal fee patent year 04
13.07.1998Renewal fee patent year 05
02.07.1999Renewal fee patent year 06
03.08.2000Renewal fee patent year 07
21.08.2001Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT03.04.2002
BE03.04.2002
CH03.04.2002
FR03.04.2002
IT03.04.2002
LI03.04.2002
NL03.04.2002
SE03.07.2002
DE04.07.2002
ES30.10.2002
[2008/05]
Former [2006/14]AT03.04.2002
BE03.04.2002
CH03.04.2002
FR03.04.2002
LI03.04.2002
NL03.04.2002
SE03.07.2002
DE04.07.2002
ES30.10.2002
Former [2004/04]AT03.04.2002
BE03.04.2002
CH03.04.2002
LI03.04.2002
NL03.04.2002
SE03.07.2002
DE04.07.2002
ES30.10.2002
FR03.01.2003
Former [2003/48]AT03.04.2002
BE03.04.2002
CH03.04.2002
LI03.04.2002
NL03.04.2002
SE03.07.2002
DE04.07.2002
FR03.01.2003
Former [2003/47]AT03.04.2002
CH03.04.2002
LI03.04.2002
NL03.04.2002
SE03.07.2002
DE04.07.2002
FR03.01.2003
Former [2003/30]AT03.04.2002
CH03.04.2002
LI03.04.2002
NL03.04.2002
SE03.07.2002
DE04.07.2002
Former [2003/16]AT03.04.2002
CH03.04.2002
LI03.04.2002
NL03.04.2002
SE03.07.2002
Former [2003/10]AT03.04.2002
NL03.04.2002
SE03.07.2002
Former [2003/08]NL03.04.2002
SE03.07.2002
Former [2002/42]SE03.07.2002
Documents cited:Search[YD] JPS62269689  
 [Y] JPS6112298  
 [Y]   CHEMICAL ABSTRACTS, vol. 107, no. 19, 1987, Columbus, Ohio, US; abstract no. 174422g, "Manufacture of N - protected L-aspartyl-L- phenylalanine lower alkyl ester" [Y] 1-9 * abstract * * & JP-A-62029996 (Oshima et al.) *
 [YD]   PATENT ABSTRACTS OF JAPAN vol. 012, no. 155 (C - 494) 12 May 1988 (1988-05-12) [YD] 1-9 * abstract *
 [Y]   DATABASE WPI Week 8609, Derwent World Patents Index; AN 86-059600 [Y] 1-9 * abstract *
 [A]   CHEMICAL ABSTRACTS, vol. 117, no. 3, 1991, Columbus, Ohio, US; abstract no. 27071v, CHEN, SHUI TEIN; CHEN, SHIAH YUN; HSIAO, SHU CHYONG; WANG, KUNG TSUNG: "Kinetic resolution of N - protected amino acid esters in organic solvents catalyzed by a stable industrial alkaline protease" [A] 1-9 * abstract * * & Biotechnol. Lett., 13(11), 773-8 1991 *
 [A]   BIOTECHNOL. LETT., 13(11), 773-8, 1991
 [A]   CHEMICAL ABSTRACTS, vol. 103, no. 3, 22 July 1985, Columbus, Ohio, US; abstract no. 21136, NAKANISHI, K. ET AL: "Continuous synthesis of N-( benzyloxycarbonyl )-L-aspartyl-L-phenylalanine methyl ester with immobilized thermolysin in an organic solvent" [A] 1-9 * abstract *
 [A]   BIO/TECHNOLOGY (1985), 3(5), 459-64 CODEN: BTCHDA;ISSN: 0733-222X
 [A]   YANG, CHIN PIN ET AL: "Synthesis of aspartame precursor:.alpha.-L-aspartyl-L- phenylalanine methyl ester in ethyl acetate using thermolysin entrapped in polyurethane", BIOTECHNOLOGY AND BIOENGINEERING, vol. 32, no. 5, 1988, NY US [A] 1-9
Examination  JOURNAL OF THE CHEMICAL SOCIETY Perkin Transactions II Vol. 2, 1981, pp 356-360 [Y] 1-9 * abstract * * & JP-A-62029996 (Oshima et al.) *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.