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Extract from the Register of European Patents

EP About this file: EP0610046

EP0610046 - Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispesific fusion proteins in a mammalian cell [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.10.2006
Database last updated on 29.07.2024
Most recent event   Tooltip05.09.2008Change - representativepublished on 08.10.2008  [2008/41]
Applicant(s)For all designated states
Bristol-Myers Squibb Company
Route 206 and Province Line Road
Princeton, NJ 08543 / US
[N/P]
Former [1994/32]For all designated states
Bristol-Myers Squibb Company
345 Park Avenue
New York, N.Y. 10154 / US
Inventor(s)01 / Ledbetter, Jeffrey A.
306 NW 113th Place
Seattle, WA 98177 / US
02 / Gilliland, Lisa K.
3007 NE 88th Street
Seattle, WA 98119 / US
03 / Hayden, Martha S.
9896-1 Mercy Road
San Diego, CA 92129 / US
04 / Linsley, Peter S.
2430 9th Avenue W.
Seattle, WA 98119 / US
05 / Bajorath, Jurgen
928 137th Street SW
Everett, WA 98204 / US
06 / Fell, Perry H.
741 218th Place NE
Redmond, WA 98053 / US
[1994/32]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2008/41]Carpmaels & Ransford
One Southampton Row London
WC1B 5HA / GB
Former [2003/17]Carpmaels & Ransford
43 Bloomsbury Square
London WC1A 2RA / GB
Former [1994/32]Jones, Alan John, et al
CARPMAELS & RANSFORD 43 Bloomsbury Square
London, WC1A 2RA / GB
Application number, filing date94300692.431.01.1994
[1994/32]
Priority number, dateUS1993001342001.02.1993         Original published format: US 13420
US1993012105413.09.1993         Original published format: US 121054
[1994/32]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP0610046
Date:10.08.1994
Language:EN
[1994/32]
Type: A3 Search report 
No.:EP0610046
Date:24.04.1996
[1996/17]
Type: B1 Patent specification 
No.:EP0610046
Date:21.12.2005
Language:EN
[2005/51]
Search report(s)(Supplementary) European search report - dispatched on:EP08.03.1996
ClassificationIPC:C12N15/62, C12N5/10, C12P21/00, C07K19/00, A61K39/395, G01N33/563
[2005/51]
CPC:
C07K14/005 (EP,US); C07K14/70521 (EP,US); C07K14/7155 (EP,US);
C07K16/00 (EP,US); C07K16/2809 (EP,US); C07K16/2818 (EP,US);
C07K16/2827 (EP,US); C07K16/30 (EP,US); C07K16/468 (EP,US);
C12N15/62 (EP,US); G01N33/563 (EP,US); G01N33/56972 (EP,US);
G01N33/57492 (EP,US); A61K2039/505 (EP,US); A61K38/00 (EP,US);
C07K2317/31 (EP,US); C07K2317/34 (EP,US); C07K2317/622 (EP,US);
C07K2317/732 (EP,US); C07K2317/734 (EP,US); C07K2317/74 (EP,US);
C07K2319/00 (EP,US); C07K2319/02 (EP,US); C07K2319/30 (EP,US);
C07K2319/43 (EP,US); C12N2740/16122 (EP,US); G01N2333/705 (EP,US) (-)
Former IPC [1994/32]C12N15/62, C12N15/13, C12N5/10, C12P21/08, C07K15/00, A61K39/395, G01N33/563
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1994/32]
TitleGerman:Expressionsvektoren die für bispezifische Proteine kodieren, und Verfahren zur Herstellung von biologisch-aktiven bispezifischen Fusionsproteine in Zellen von Säugertieren[1994/32]
English:Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispesific fusion proteins in a mammalian cell[1994/32]
French:Vecteurs d'expression codant pour des proteins de fusion bispécifiques et méthodes pour la production de ces protéins dans des cellules de mammifèrres[1994/32]
Biological materialThis application mentions deposited biological material, check the file for details
Examination procedure10.07.1996Examination requested  [1996/36]
06.02.2002Despatch of a communication from the examining division (Time limit: M06)
14.08.2002Reply to a communication from the examining division
06.09.2002Despatch of a communication from the examining division (Time limit: M06)
17.03.2003Reply to a communication from the examining division
09.04.2003Despatch of a communication from the examining division (Time limit: M06)
20.10.2003Reply to a communication from the examining division
21.05.2004Despatch of a communication from the examining division (Time limit: M04)
21.09.2004Reply to a communication from the examining division
19.01.2005Communication of intention to grant the patent
07.07.2005Fee for grant paid
07.07.2005Fee for publishing/printing paid
Divisional application(s)EP05077801.8  / EP1746162
Opposition(s)22.09.2006No opposition filed within time limit [2006/48]
Fees paidRenewal fee
26.01.1996Renewal fee patent year 03
08.01.1997Renewal fee patent year 04
08.01.1998Renewal fee patent year 05
11.01.1999Renewal fee patent year 06
10.01.2000Renewal fee patent year 07
11.01.2001Renewal fee patent year 08
14.01.2002Renewal fee patent year 09
14.01.2003Renewal fee patent year 10
14.01.2004Renewal fee patent year 11
12.01.2005Renewal fee patent year 12
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Documents cited:Search[X]WO8801649  (GENEX CORP [US]) [X] 1 * Claims *;
 [XY]WO8809344  (CREATIVE BIOMOLECULES INC [US]) [X] 1,2,4-6,11-13,25-30 * the whole document * [Y] 7-10,14-17;
 [Y]EP0439095  (BRISTOL MYERS SQUIBB CO [US]) [Y] 8,15 * Claims *;
 [Y]WO9200092  (BRISTOL MYERS SQUIBB CO [US]) [Y] 10,17 * claims 1,4,6,7 *;
 [X]EP0506124  (TANOX BIOSYSTEMS INC [US]) [X] 1 * the whole document *;
 [Y]WO9300431  (BRISTOL MYERS SQUIBB CO [US]) [Y] 9,16 * claims 3-26 *;
 [XY]  - HUSTON, J.S. ET AL.;, "Molecular Design and Modeling : Concepts and applications -Part B : antibodies and antigens, nucleic acids, polysaccharides and drugs.", METHODS IN ENZYMOLOGY;, vol. 203, pages 47 - 89, XP002573811 [X] 1-6,11-13,25-30 * [3] Protein engineering of single-chain Fv analogs and fusion proteins * * Paragraph "Linker chemistry" * [Y] 7-10,14-17
 [Y]  - KOSTELNY, S.A.; COLE, M.S. AND TSO, J.Y., "Formation of a bispecific antibody by the use of leucine zippers", JOURNAL OF IMMUNOLOGY, BALTIMORE US, (19920301), vol. 148, no. 5, pages 1547 - 1553 [Y] 7,14 * the whole document *
 [A]  - 1992;NOLAN, O.; O'KENNEDY, R., "Bifunctional antibodies and their potential clinical applications", INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH, vol. 22, pages 21 - 27, XP009023533 [A] 1-30 * the whole document *
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