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Extract from the Register of European Patents

EP About this file: EP0686150

EP0686150 - Process for the preparation of C-nucleosides and C-nucleoside analogues, new C-nucleosides and C-nucleoside analogues and their use [Right-click to bookmark this link]
Former [1995/50]NUCLEOSIDES, THEIR PREPARATION AND THEIR USE AS THERAPEUTIC AGENTS AND AS BUILDING BLOCKS OF SYNTHETIC OLIGONUCLEOTIDES
[1998/21]
StatusNo opposition filed within time limit
Status updated on  26.03.1999
Database last updated on 11.09.2024
Most recent event   Tooltip28.12.2007Lapse of the patent in a contracting state
Updated state(s): FR		published on 30.01.2008  [2008/05]
Applicant(s)For all designated states
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN
Robert-Rössle-Strasse 10
13125 Berlin / DE
[N/P]
Former [1998/21]For all designated states
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN
Robert-Rössle-Strasse 10
D-13125 Berlin / DE
Former [1995/50]For all designated states
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN
Robert-Rössle-Str. 10
D-13125 Berlin / DE
Inventor(s)01 / BÄRWOLFF, Dieter
Georg-Benjamin-Strasse 37
D-13125 Berlin / DE
[1995/50]
Representative(s)Baumbach, Friedrich
Patentanwalt
Robert-Rössle-Strasse 10
13125 Berlin / DE
[N/P]
Former [1995/50]Baumbach, Friedrich
Biotez Berlin/Buch Robert-Rössle-Strasse 10
D-13125 Berlin / DE
Application number, filing date94910321.224.02.1994
[1995/50]
WO1994DE00205
Priority number, dateDE1993430685926.02.1993         Original published format: DE 4306859
DE1993432057015.06.1993         Original published format: DE 4320570
[1995/50]
Filing languageDE
Procedural languageDE
PublicationType: A1 Application with search report
No.:WO9419327
Date:01.09.1994
Language:DE
[1994/20]
Type: A1 Application with search report 
No.:EP0686150
Date:13.12.1995
Language:DE
The application published by WIPO in one of the EPO official languages on 01.09.1994 takes the place of the publication of the European patent application.
[1995/50]
Type: B1 Patent specification 
No.:EP0686150
Date:20.05.1998
Language:DE
[1998/21]
Search report(s)International search report - published on:EP01.09.1994
ClassificationIPC:C07D239/02, C07D405/04, C07H21/00, C07H19/06, C07H19/10, C07F9/6506, A61K31/70
[1995/50]
CPC:
C07H19/06 (EP); C07F9/6512 (EP); C07H19/10 (EP);
C07H21/00 (EP)
Designated contracting statesAT,   BE,   CH,   DK,   ES,   FR,   GB,   IT,   LI,   NL,   PT,   SE [1995/50]
TitleGerman:Verfahren zur Herstellung von C-Nukleosiden und C-Nukleosid-Analoga, neue C-Nukleoside und C-Nukleosid-Analoga, sowie ihre Verwendung[1998/21]
English:Process for the preparation of C-nucleosides and C-nucleoside analogues, new C-nucleosides and C-nucleoside analogues and their use[1998/21]
French:Procédé pour la préparation des C-nucléosides et des analogues, nouveaux C-nucléosides et des analogues et leur utilisation[1998/21]
Former [1995/50]NUKLEOSIDE, IHRE HERSTELLUNG UND IHRE VERWENDUNG ALS THERAPEUTIKUM UND ALS BAUSTEIN FÜR SYNTHETISCHE OLIGONUKLEOTIDE
Former [1995/50]NUCLEOSIDES, THEIR PREPARATION AND THEIR USE AS THERAPEUTIC AGENTS AND AS BUILDING BLOCKS OF SYNTHETIC OLIGONUCLEOTIDES
Former [1995/50]NUCLEOSIDES, LEUR PRODUCTION ET LEUR UTILISATION COMME AGENTS THERAPEUTIQUES ET COMME ELEMENTS CONSTITUTIFS POUR OLIGONUCLEOTIDES SYNTHETIQUES
Entry into regional phase11.09.1995National basic fee paid 
11.09.1995Designation fee(s) paid 
11.09.1995Examination fee paid 
Examination procedure22.09.1994Request for preliminary examination filed
International Preliminary Examining Authority: EP
11.09.1995Examination requested  [1995/50]
19.09.1996Despatch of a communication from the examining division (Time limit: M04)
15.11.1996Reply to a communication from the examining division
10.04.1997Despatch of communication of intention to grant (Approval: No)
05.08.1997Despatch of communication of intention to grant (Approval: later approval)
27.08.1997Communication of intention to grant the patent
19.11.1997Fee for grant paid
19.11.1997Fee for publishing/printing paid
Opposition(s)23.02.1999No opposition filed within time limit [1999/19]
Fees paidRenewal fee
19.02.1996Renewal fee patent year 03
24.02.1997Renewal fee patent year 04
24.02.1998Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipES20.05.1998
FR20.05.1998
GB20.05.1998
IT20.05.1998
NL20.05.1998
DK20.08.1998
PT20.08.1998
SE20.08.1998
[2006/14]
Former [2003/45]ES20.05.1998
GB20.05.1998
IT20.05.1998
NL20.05.1998
DK20.08.1998
PT20.08.1998
SE20.08.1998
FR16.10.1998
Former [2003/08]ES20.05.1998
GB20.05.1998
IT20.05.1998
NL20.05.1998
PT20.08.1998
SE20.08.1998
FR16.10.1998
Former [2002/26]ES20.05.1998
GB20.05.1998
IT20.05.1998
PT20.08.1998
SE20.08.1998
FR16.10.1998
Former [1999/42]GB20.05.1998
IT20.05.1998
PT20.08.1998
SE20.08.1998
FR16.10.1998
Former [1999/32]GB20.05.1998
PT20.08.1998
SE20.08.1998
FR16.10.1998
Former [1999/25]GB20.05.1998
SE20.08.1998
FR16.10.1998
Former [1999/22]SE20.08.1998
FR16.10.1998
Former [1998/47]SE20.08.1998
Cited inInternational search[X]EP0103464  (WARNER LAMBERT CO [US]) [X] 1 * page 12; figure II * * page 35, line 19 ** page 62; figure IV; claim 6 *;
 [A]EP0398231  (BRISTOL MYERS SQUIBB CO [US]) [A] 1,13-15 * the whole document *
 [X]  - J.A.SECRIST III, "Homo-C-nucleosides. The Synthesis of Certain 6-Substituted 4-Pyrimidinones", JOURNAL OF ORGANIC CHEMISTRY., EASTON US, (19780707), vol. 43, no. 14, pages 2925 - 2927 [X] 1 * page 2925, column 2; examples 4a-4e *
 [X]  - T.L.CUPPS ET AL., "Use of Allyltrimethylsilane in the Formation of Potential C-Nucleoside Precursors.", JOURNAL OF ORGANIC CHEMISTRY., EASTON US, (19821217), vol. 47, no. 26, pages 5115 - 5120 [X] 1 * page 5116, column 2; example 10 *
 [X]  - T.L.CUPPS ET AL., "A Novel Three-Step Synthesis of a Pyrrolo(3,2-d)pyrimidine C-Nucleoside.", JOURNAL OF ORGANIC CHEMISTRY., EASTON US, (19860404), vol. 51, no. 7, pages 1058 - 1064 [X] 1 * page 1061; examples 16,22,23 *
 [X]  - G.RENZ ET AL., "Synthesen von 2,4-substituierten Homo-C-pyrimidin-nucleosiden.", LIEBIGS ANNALEN DER CHEMIE, WEINHEIM DE, (19860612), no. 6, pages 957 - 966 [X] 1 * page 958; example 3 * * page 959; examples 10,12 *
 [X]  - N.KATAGIRI ET AL., "Synthesis of Homo-C-Nucleosides using Pyrimidinylmethylenephosphoranes.", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, LETCHWORTH GB, (1983), pages 201 - 209 [X] 1 * page 205, column 1; examples 22-32 *
 [A]  - W.O.FOYE ET AL., "Pyridinium- and Quinolinium-2-dithioecetic Acid Zwitterions: Antiradiation an Anticancer Activities.", JOURNAL OF PHARMACEUTICAL SCIENCES, (1978), vol. 67, no. 7, pages 962 - 964 [A] 1 * the whole document *
 [X]  - J.HUNG ET AL., "Fluoride- Assisted Nucleophilic Substitution of 6-Alkyl-5-bromouracils with Nitrogen-containing Heterocycles.", SYNTHESIS., STUTTGART DE, (198501), no. 1, pages 80 - 81 [X] 1
Examination   - JOURNAL OF ORGANIC CHEMISTRY. Bd. 43, Nr. 14 , 7. Juli 1978 EASTON US Seiten 2925 - 2927 J.A.SECRIST III 'Homo-C-nucleosides. The Synthesis of Certain 6-
    - Substituted 4-Pyrimidinones'
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.