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Extract from the Register of European Patents

EP About this file: EP0778835

EP0778835 - 7-AZABICYCLO 2.2.1 -HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS [Right-click to bookmark this link]
Former [1997/25]	7-AZABICYCLO 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS
	[2007/46]
Status	The application is deemed to be withdrawn Status updated on 31.05.2002 Database last updated on 20.05.2024
Most recent event Tooltip	12.10.2007	Change - English title	published on 14.11.2007 [2007/46]
Applicant(s)	For all designated states UNIVERSITY OF VIRGINIA P.O. Box 9025 Charlottesville, VA 22906 / US
	[1997/25]
Inventor(s)	01 / SHEN, T., Y. 303 Ednam Drive Charlottesville, VA 22903 / US
	02 / HARMAN, W., Dean 4530 Mill Run Lane Earlysville, VA 22936 / US
	03 / HUANG, Dao, Fei 212 Raymond Avenue Charlottesville, VA 22903 / US
	04 / GONZALEZ, Javier 320 Reflections Circle 205 Casselberry, FL 32707 / US
	[1997/25]
Representative(s)	McNeeney, Stephen Phillip Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
	[N/P]
Former [2001/34]	McNeeney, Stephen Phillip Eric Potter Clarkson, Park View House, 58 The Ropewalk Nottingham NG1 5DD / GB
Former [1998/22]	Bassett, Richard Simon Eric Potter Clarkson, Park View House, 58 The Ropewalk Nottingham NG1 5DD / GB
Former [1997/25]	Bassett, Richard ERIC POTTER & CLARKSON St. Mary's Court St. Mary's Gate Nottingham NG1 1LE / GB
Application number, filing date	95932333.8	25.08.1995
	[1997/25]
	WO1995US10884
Priority number, date	USA 296463	25.08.1994
	USA 2551	21.08.1995
	[1997/43]
Former [1997/43]	US19940296463	25.08.1994
	[1997/25]	02.05.1997
Former [1997/25]	USA 296463	25.08.1994
	USA	21.08.1995
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO9606093
	Date:	29.02.1996
	Language:	EN
	[1996/10]
	Type:	A1 Application with search report
	No.:	EP0778835
	Date:	18.06.1997
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 29.02.1996 takes the place of the publication of the European patent application.
	[1997/25]
Search report(s)	International search report - published on:	US	29.02.1996
	(Supplementary) European search report - dispatched on:	EP	21.12.1998
Classification	IPC:	C07D487/08, A61K31/40, // (C07D487/08, 209:00, 209:00)	[1999/04]
	CPC data not yet available
	Former IPC [1997/25]	C07D401/04, C07D403/04, C07D407/04, C07D409/04, C07D413/04, C07D417/04, C07D419/04, A61K31/40, A61K31/415, A61K31/42, A61K31/425
Designated contracting states	AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [1997/25]
Title	German:	7-AZABICYCLO (2.2.1)-HEPTAN- UND -HEPTEN- DERIVATE ALS LIGANDEN DER CHOLIENERGISCHEN REZEPTOREN	[1997/25]
	English:	7-AZABICYCLO 2.2.1 -HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS	[2007/46]
	French:	DERIVES DE 7-AZABICYCLO 2.2.1 -HEPTANE ET -HEPTENE UTILISES COMME LIGANDS DES RECEPTEURS CHOLINERGIQUES	[2007/46]
	Former [1997/25]	7-AZABICYCLO 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS
	Former [1997/25]	DERIVES DE 7-AZABICYCLO 2.2.1]-HEPTANE ET -HEPTENE UTILISES COMME LIGANDS DES RECEPTEURS CHOLINERGIQUES
Entry into regional phase	24.03.1997	National basic fee paid
	24.03.1997	Search fee paid
	24.03.1997	Designation fee(s) paid
	24.03.1997	Examination fee paid
Examination procedure	20.03.1996	Request for preliminary examination filed International Preliminary Examining Authority: US
	24.03.1997	Examination requested [1997/35]
	07.07.1999	Amendment by applicant (claims and/or description)
	15.09.2000	Despatch of a communication from the examining division (Time limit: M04)
	20.10.2000	Reply to a communication from the examining division
	12.12.2000	Despatch of a communication from the examining division (Time limit: M06)
	18.06.2001	Reply to a communication from the examining division
	20.08.2001	Despatch of a communication from the examining division (Time limit: M04)
	01.01.2002	Application deemed to be withdrawn, date of legal effect [2002/29]
	11.02.2002	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2002/29]
Fees paid	Renewal fee
	08.08.1997	Renewal fee patent year 03
	26.08.1998	Renewal fee patent year 04
	04.08.1999	Renewal fee patent year 05
	07.08.2000	Renewal fee patent year 06
	Penalty fee
	Additional fee for renewal fee
	31.08.2001	07 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X]EP0382687 (ISTITUTO DE ANGELI) [X] 1,9,11 * page 3, line 25 - line 32; example 6; claims 1,16 *;
		[PX]JPH0761940 ;
		[PX]WO9422868 (UNIVERSITY OF VIRGINIA) [PX] 1,9,11 * claims 1,7,14,43 *;
		[PX]EP0657455 (EGIS) [PX] 1,9,11 * claims 1,15,16 *;
		[A]DE3445377 (SANDOZ) [A] 1,9,11 * claims 1,8 *
		[X] - S. F. NELSEN ET AL, "The nitrogen inversion barrier of 7-methyl-7-azabicyclo(2.2.1)heptane and the "bicyclic effect"", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, DC US, (1989), vol. 111, pages 1776 - 1781, XP002086467 [X] 1-3 * page 1777; examples 8,9,11 * DOI: http://dx.doi.org/10.1021/ja00187a034
		[X] - A. P. KRAPCHO ET AL, "The synthesis of a cocaine intermediate via a sodium-liquid ammonia carbon-carbon sigma-bond cleavage of an azabicyclic succinate-type ester", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, LETCHWORTH GB, (1985), pages 233 - 234, XP002086468 [X] 1-3 * page 233; example 3 * DOI: http://dx.doi.org/10.1039/c39850000233
		[DX] - S. R. FLETCHER ET AL, "Total synthesis and determination of the absolute configuration of epibatidine", JOURNAL OF ORGANIC CHEMISTRY, EASTON US, (1994), vol. 59, no. 7, pages 1771 - 1778, XP002086469 [DX] 1,3 * page 1772; example 14 * DOI: http://dx.doi.org/10.1021/jo00086a030
		[PX] - "Novel aza-bicycloheptane deriv(s). - useful for treating Alzheimer's disease, Parkinson's disease, hypertension, tobacco dependence etc.", DATABASE WPI, 1, Derwent World Patents Index, vol. 95, no. 18, Database accession no. 95-136801, XP002086471 & JPH0761940 A 19950307 (EISAI) [PX] 1,9,11 * abstract *
		[PX] - A. HASSNER ET AL, "A simple method of preparation of 7-alkyl-7-azabicyclo(2.2.1)heptanes", TETRAHEDRON LETTERS, OXFORD GB, (1995), vol. 36, no. 10, pages 1709 - 1712, XP002086470 [PX] 1-3 * page 1710; examples 2A-D * DOI: http://dx.doi.org/10.1016/0040-4039(95)00051-D
	International search	[X]US5314899 (DALY JOHN W [US], et al)
		[X] - TETRAHEDRON LETTERS, Vol. 34, No. 46, issued 12 November 1993, CLAYTON et al., "A Total Synthesis of (+)-Epibatidine", pages 7493-7496.
		[X] - THE JOURNAL OF ORGANIC CHEMISTRY, Volume 58, Number 21, issued 08 October 1993, COREY et al., "Stereocontrolled Total Synthesis of (+)- and (-) Epibatidine", pages 5600-5602.
		[X] - TETRAHEDRON LETTERS, Vol. 34, No. 28, issued 09 July 1993, HUANG et al., "A Versatile Total Synthesis of Epibatidine and Analogs", pages 4477-4480.
		[X] - CHEMICAL ABSTRACTS, Vol. 120, No. 25, issued 20 June 1994, BADIO et al., "Epibatidine, a Potent Analgetic and Nicotinic Agonist", page 21, Abstract No. 120:315194s.

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