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Extract from the Register of European Patents

EP About this file: EP0841932

EP0841932 - DRUG DELIVERY ENHANCEMENT VIA MODIFIED SAPONINS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  04.05.2000
Database last updated on 27.07.2024
Most recent event   Tooltip04.05.2000Application deemed to be withdrawnpublished on 21.06.2000 [2000/25]
Applicant(s)For all designated states
Aquila Biopharmaceuticals, Inc
365 Plantation Street
Worcester, MA 01605 / US
[N/P]
Former [1998/21]For all designated states
Aquila Biopharmaceuticals, Inc.
365 Plantation Street
Worcester, MA 01605 / US
Inventor(s)01 / KENSIL, Charlotte A.
15 Camp Street
Milford, MA 01757 / US
02 / SOLTYSIK, Sean
28 Devens Road
Worcester, MA 01606 / US
03 / MARCIANI, Dante J.
2013 Countryridge Circle
Birmingham, AL 35243 / US
04 / RECCHIA, Joanne
39 Hoyle Circle
Blackstone, MA 01504 / US
[1998/21]
Representative(s)Cornish, Kristina Victoria Joy, et al
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
[N/P]
Former [1998/21]Cornish, Kristina Victoria Joy, et al
Kilburn & Strode, 20 Red Lion Street
London WC1R 4PJ / GB
Application number, filing date96918033.003.06.1996
[1998/21]
WO1996US08711
Priority number, dateUS1995045950202.06.1995         Original published format: US 459502
[1998/21]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9638161
Date:05.12.1996
Language:EN
[1996/53]
Type: A1 Application with search report 
No.:EP0841932
Date:20.05.1998
Language:EN
The application published by WIPO in one of the EPO official languages on 05.12.1996 takes the place of the publication of the European patent application.
[1998/21]
Search report(s)International search report - published on:US05.12.1996
(Supplementary) European search report - dispatched on:EP16.11.1998
ClassificationIPC:A61K35/78, A61K38/28, A61K31/70, A61K31/705, A61K31/60, A61K31/56, C07J15/00
[1998/21]
CPC:
A61K31/704 (EP,US); A61K38/28 (EP,US); A61K39/39 (EP,US);
A61K47/46 (EP,US); A61K9/0014 (EP,US); C07J63/008 (EP,US);
A61K2039/55577 (EP,US) (-)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1998/21]
TitleGerman:VERBESSERTE DROGENVERABREICHUNG DURCH MODIFIZIERTE SAPONINE[1998/21]
English:DRUG DELIVERY ENHANCEMENT VIA MODIFIED SAPONINS[1998/21]
French:AMELIORATION DE L'ADMINISTRATION DE MEDICAMENTS PAR SAPONINES MODIFIEES[1998/21]
Entry into regional phase31.12.1997National basic fee paid 
31.12.1997Search fee paid 
31.12.1997Designation fee(s) paid 
31.12.1997Examination fee paid 
Examination procedure02.01.1997Request for preliminary examination filed
International Preliminary Examining Authority: US
02.01.1998Examination requested  [1998/21]
03.06.1999Despatch of a communication from the examining division (Time limit: M04)
14.10.1999Application deemed to be withdrawn, date of legal effect  [2000/25]
30.11.1999Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2000/25]
Fees paidRenewal fee
10.08.1998Renewal fee patent year 03
14.06.1999Renewal fee patent year 04
Penalty fee
Additional fee for renewal fee
30.06.199803   M06   Fee paid on   10.08.1998
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:SearchJPS5920298  [ ] (SUNTORY LTD);
 [X]WO9305789  (CAMBRIDGE BIOTECH CORP [US]) [X] 1,4-6,9,12,13 * page 49, line 27 - line 29; examples 8,21,22 * * page 60; figure 10; table 7 *;
 [X]WO9401118  (CAMBRIDGE BIOTECH CORP [US]) [X] 1-16 * page 15, line 9 - line 15; figure 1; examples 1-3 * * page 7, line 10 - line 30 * * page 11, line 1 - line 11 * * page 12, line 1 - line 7 * * page 18, line 12 - page 19, line 3 *;
 [X]  - YASUKAWA K ET AL, "STEROL AND TRITERPENE DERIVATIVES FORM PLANTS INHIBIT THE EFFECTS OF A TUMOR PROMOTER, AND SITOSTEROL AND BETULINIC ACID INHIBIT TUMOR FORMATION IN MOUSE SKIN TWO-STAGE CARCINOGENESIS", ONCOLOGY, (19910101), vol. 48, no. 1, pages 72 - 76, XP000567825 [X] 1,5,12,13 * compound - Chrysanthelline B *; page 73; table 2 *
 [X]  - MASAYO IWAMOTO ET AL, "Studies on the Constituents of Momordica cochinchinesis SPRENG. I. Isolation and Characterisation of the Seed Saponins, Momoridica Saponins I and II", CHEMICAL AND PHARMACEUTICAL BULLETIN., TOKYO JP, (198502), vol. 33, no. 2, pages 464 - 478, XP002079359 [X] 1,5,12,13 * page 466, compounds XIX and XXII *
 [X]  - JUNEI KINJO ET AL, "Two New Triterpenoid Glycosides from Medicago polymorpha L.", CHEMICAL AND PHARMACEUTICAL BULLETIN., TOKYO JP, (199406), vol. 42, no. 6, pages 1339 - 1341, XP002079360 [X] 1 * page 1339, compounds 1 and 2 *
 [X]  - M. M. ANISIMOV ET AL, "Mechanism of cytotoxic action of some triterpene glycosides", CHEMICAL ABSTRACTS, (19780731), vol. 89, no. 5, Database accession no. 37600, page 134, column 2, XP002079362 [X] 1,5,12,13 * abstract *
    [ ] - TOXICON, (1978), vol. 16, no. 3, pages 207 - 218
 [X]  - SUNTRY LTD, "Sodium 3-(alpha-L-arabinopyranosyl)-16,23-dihydroxyolean-12-en-28-oate", CHEMICAL ABSTRACTS, (19840806), vol. 101, no. 6, Database accession no. 43572, page 322, column 2, XP002079363 [X] 1,5,12,13 * abstract *
 [PX]  - PILLION D J ET AL, "STRUCTURE-FUNCTION RELATIONSHIP AMONG QUILLAJA SAPONINS SERVING AS EXCIPIENTS FOR NASAL AND OCULAR DELIVERY OF INSULIN", JOURNAL OF PHARMACEUTICAL SCIENCES, (19960501), vol. 85, no. 5, pages 518 - 524, XP000583530 [PX] 1,5-7,10-16 * page 519, compound DS-1(R) *; page 521; figure 3 * * page 523, column 2, paragraph 3 *

DOI:   http://dx.doi.org/10.1021/js9504651
 [PX]  - SOLTYSIK S ET AL, "Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function", VACCINE, (199510), vol. 13, no. 15, page 1403-1410, XP004057449 [PX] 1,4,5,8,9,12,13 * page 1404, column 2, paragraph L - page 1405, column 1, paragraph 1 * * page 1408, column 2, paragraph 2 *

DOI:   http://dx.doi.org/10.1016/0264-410X(95)00077-E
 [PX]  - J. RECCHIA ET AL, "A semisynthetic Quillaja saponin as a drug delivery agent for aminoglycoside antibiotics", CHEMICAL ABSTRACTS, (19960219), vol. 124, no. 8, Database accession no. 97470, page 751, column 1, XP002079364 [PX] 5,6,10-16 * abstract *
    [ ] - PHARMACEUTICAL RESEARCH, (199512), vol. 12, no. 12, pages 1917 - 1923
 [PX]  - M. YOSHIKAWA ET AL, "Medicinal Foodstuffs. I. The Hypoglycemic Constituents from a Garnish Foodstuff "Taranome," the Young Shoot of Aralia elata SEEM.: Elatosides G, H, I, J and K", CHEMICAL AND PHARMACEUTICAL BULLETIN., TOKYO JP, (199511), vol. 43, no. 11, pages 1878 - 1882, XP002079361 [PX] 1,5,12,13 * page 1880, compound 5; page 1881; table 2 *
International search[XP]  - JOURNAL OF PHARMACEUTICAL SCIENCES, November 1995, Vol. 84, No. 11, PILLION et al., "DS-1, a Modified Quillaja Saponin, Enhances Ocular and Nasal Absorption of Insulin", pages 1276-1279.
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.