EP0841932 - DRUG DELIVERY ENHANCEMENT VIA MODIFIED SAPONINS [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 04.05.2000 Database last updated on 27.07.2024 | Most recent event Tooltip | 04.05.2000 | Application deemed to be withdrawn | published on 21.06.2000 [2000/25] | Applicant(s) | For all designated states Aquila Biopharmaceuticals, Inc 365 Plantation Street Worcester, MA 01605 / US | [N/P] |
Former [1998/21] | For all designated states Aquila Biopharmaceuticals, Inc. 365 Plantation Street Worcester, MA 01605 / US | Inventor(s) | 01 /
KENSIL, Charlotte A. 15 Camp Street Milford, MA 01757 / US | 02 /
SOLTYSIK, Sean 28 Devens Road Worcester, MA 01606 / US | 03 /
MARCIANI, Dante J. 2013 Countryridge Circle Birmingham, AL 35243 / US | 04 /
RECCHIA, Joanne 39 Hoyle Circle Blackstone, MA 01504 / US | [1998/21] | Representative(s) | Cornish, Kristina Victoria Joy, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | [N/P] |
Former [1998/21] | Cornish, Kristina Victoria Joy, et al Kilburn & Strode, 20 Red Lion Street London WC1R 4PJ / GB | Application number, filing date | 96918033.0 | 03.06.1996 | [1998/21] | WO1996US08711 | Priority number, date | US19950459502 | 02.06.1995 Original published format: US 459502 | [1998/21] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO9638161 | Date: | 05.12.1996 | Language: | EN | [1996/53] | Type: | A1 Application with search report | No.: | EP0841932 | Date: | 20.05.1998 | Language: | EN | The application published by WIPO in one of the EPO official languages on 05.12.1996 takes the place of the publication of the European patent application. | [1998/21] | Search report(s) | International search report - published on: | US | 05.12.1996 | (Supplementary) European search report - dispatched on: | EP | 16.11.1998 | Classification | IPC: | A61K35/78, A61K38/28, A61K31/70, A61K31/705, A61K31/60, A61K31/56, C07J15/00 | [1998/21] | CPC: |
A61K31/704 (EP,US);
A61K38/28 (EP,US);
A61K39/39 (EP,US);
A61K47/46 (EP,US);
A61K9/0014 (EP,US);
C07J63/008 (EP,US);
A61K2039/55577 (EP,US)
(-)
| Designated contracting states | AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [1998/21] | Title | German: | VERBESSERTE DROGENVERABREICHUNG DURCH MODIFIZIERTE SAPONINE | [1998/21] | English: | DRUG DELIVERY ENHANCEMENT VIA MODIFIED SAPONINS | [1998/21] | French: | AMELIORATION DE L'ADMINISTRATION DE MEDICAMENTS PAR SAPONINES MODIFIEES | [1998/21] | Entry into regional phase | 31.12.1997 | National basic fee paid | 31.12.1997 | Search fee paid | 31.12.1997 | Designation fee(s) paid | 31.12.1997 | Examination fee paid | Examination procedure | 02.01.1997 | Request for preliminary examination filed International Preliminary Examining Authority: US | 02.01.1998 | Examination requested [1998/21] | 03.06.1999 | Despatch of a communication from the examining division (Time limit: M04) | 14.10.1999 | Application deemed to be withdrawn, date of legal effect [2000/25] | 30.11.1999 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2000/25] | Fees paid | Renewal fee | 10.08.1998 | Renewal fee patent year 03 | 14.06.1999 | Renewal fee patent year 04 | Penalty fee | Additional fee for renewal fee | 30.06.1998 | 03   M06   Fee paid on   10.08.1998 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | JPS5920298 [ ] (SUNTORY LTD); | [X]WO9305789 (CAMBRIDGE BIOTECH CORP [US]) [X] 1,4-6,9,12,13 * page 49, line 27 - line 29; examples 8,21,22 * * page 60; figure 10; table 7 *; | [X]WO9401118 (CAMBRIDGE BIOTECH CORP [US]) [X] 1-16 * page 15, line 9 - line 15; figure 1; examples 1-3 * * page 7, line 10 - line 30 * * page 11, line 1 - line 11 * * page 12, line 1 - line 7 * * page 18, line 12 - page 19, line 3 *; | [X] - YASUKAWA K ET AL, "STEROL AND TRITERPENE DERIVATIVES FORM PLANTS INHIBIT THE EFFECTS OF A TUMOR PROMOTER, AND SITOSTEROL AND BETULINIC ACID INHIBIT TUMOR FORMATION IN MOUSE SKIN TWO-STAGE CARCINOGENESIS", ONCOLOGY, (19910101), vol. 48, no. 1, pages 72 - 76, XP000567825 [X] 1,5,12,13 * compound - Chrysanthelline B *; page 73; table 2 * | [X] - MASAYO IWAMOTO ET AL, "Studies on the Constituents of Momordica cochinchinesis SPRENG. I. Isolation and Characterisation of the Seed Saponins, Momoridica Saponins I and II", CHEMICAL AND PHARMACEUTICAL BULLETIN., TOKYO JP, (198502), vol. 33, no. 2, pages 464 - 478, XP002079359 [X] 1,5,12,13 * page 466, compounds XIX and XXII * | [X] - JUNEI KINJO ET AL, "Two New Triterpenoid Glycosides from Medicago polymorpha L.", CHEMICAL AND PHARMACEUTICAL BULLETIN., TOKYO JP, (199406), vol. 42, no. 6, pages 1339 - 1341, XP002079360 [X] 1 * page 1339, compounds 1 and 2 * | [X] - M. M. ANISIMOV ET AL, "Mechanism of cytotoxic action of some triterpene glycosides", CHEMICAL ABSTRACTS, (19780731), vol. 89, no. 5, Database accession no. 37600, page 134, column 2, XP002079362 [X] 1,5,12,13 * abstract * | [ ] - TOXICON, (1978), vol. 16, no. 3, pages 207 - 218 | [X] - SUNTRY LTD, "Sodium 3-(alpha-L-arabinopyranosyl)-16,23-dihydroxyolean-12-en-28-oate", CHEMICAL ABSTRACTS, (19840806), vol. 101, no. 6, Database accession no. 43572, page 322, column 2, XP002079363 [X] 1,5,12,13 * abstract * | [PX] - PILLION D J ET AL, "STRUCTURE-FUNCTION RELATIONSHIP AMONG QUILLAJA SAPONINS SERVING AS EXCIPIENTS FOR NASAL AND OCULAR DELIVERY OF INSULIN", JOURNAL OF PHARMACEUTICAL SCIENCES, (19960501), vol. 85, no. 5, pages 518 - 524, XP000583530 [PX] 1,5-7,10-16 * page 519, compound DS-1(R) *; page 521; figure 3 * * page 523, column 2, paragraph 3 * DOI: http://dx.doi.org/10.1021/js9504651 | [PX] - SOLTYSIK S ET AL, "Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function", VACCINE, (199510), vol. 13, no. 15, page 1403-1410, XP004057449 [PX] 1,4,5,8,9,12,13 * page 1404, column 2, paragraph L - page 1405, column 1, paragraph 1 * * page 1408, column 2, paragraph 2 * DOI: http://dx.doi.org/10.1016/0264-410X(95)00077-E | [PX] - J. RECCHIA ET AL, "A semisynthetic Quillaja saponin as a drug delivery agent for aminoglycoside antibiotics", CHEMICAL ABSTRACTS, (19960219), vol. 124, no. 8, Database accession no. 97470, page 751, column 1, XP002079364 [PX] 5,6,10-16 * abstract * | [ ] - PHARMACEUTICAL RESEARCH, (199512), vol. 12, no. 12, pages 1917 - 1923 | [PX] - M. YOSHIKAWA ET AL, "Medicinal Foodstuffs. I. The Hypoglycemic Constituents from a Garnish Foodstuff "Taranome," the Young Shoot of Aralia elata SEEM.: Elatosides G, H, I, J and K", CHEMICAL AND PHARMACEUTICAL BULLETIN., TOKYO JP, (199511), vol. 43, no. 11, pages 1878 - 1882, XP002079361 [PX] 1,5,12,13 * page 1880, compound 5; page 1881; table 2 * | International search | [XP] - JOURNAL OF PHARMACEUTICAL SCIENCES, November 1995, Vol. 84, No. 11, PILLION et al., "DS-1, a Modified Quillaja Saponin, Enhances Ocular and Nasal Absorption of Insulin", pages 1276-1279. |