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Extract from the Register of European Patents

EP About this file: EP0863917

EP0863917 - TARGETED CYTOTOXIC ANTHRACYCLINE ANALOGS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  06.08.2004
Database last updated on 06.07.2024
Most recent event   Tooltip06.08.2004No opposition filed within time limitpublished on 22.09.2004  [2004/39]
Applicant(s)For all designated states
The Administrators of the Tulane Educational Fund
1430 Tulane Avenue, SL 13
New Orleans, LA 70112 / US
[2003/12]
Former [2001/49]For all designated states
Zentaris AG
Weissmüllerstrasse 45
60314 Frankfurt/Main / DE
Former [1998/38]For all designated states
ASTA Medica Aktiengesellschaft
An der Pikardie 10
D-01277 Dresden / DE
Inventor(s)01 / SCHALLY, Andrew V., Tulane University Med. Ctr
School of Medicine, 1430 Tulane Avenue
New Orleans, LA 70112-2699 / US
02 / NAGY, Attila A., Tulane University Med. Ctr
School of Medicine, 1430 Tulane Avenue
New Orleans, LA 70112-2699 / US
03 / CAI, Ren-Zhi, Tulane University Med. Ctr
School of Medicine, 1430 Tulane Avenue
New Orleans, LA 70112-2699 / US
[1998/38]
Representative(s)Nauwald, Gunter
Zentaris AG
Patente/Marken
Meissner Strasse 35
D-01445 Radebeul / DE
[N/P]
Former [2003/12]Nauwald, Gunter
Zentaris AG Patente/Marken Meissner Strasse 35
D-01445 Radebeul / DE
Former [2001/37](deleted)
Former [1998/38]Sander, Uwe
c/o ASTA MEDICA AKTIENGESELLSCHAFT, Meissner Strasse 35
01435 Radebeul / DE
Application number, filing date96938216.714.11.1996
[1998/38]
WO1996EP05029
Priority number, dateUS1995056265227.11.1995         Original published format: US 562652
[1998/38]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9719954
Date:05.06.1997
Language:EN
[1997/24]
Type: A1 Application with search report 
No.:EP0863917
Date:16.09.1998
Language:EN
The application published by WIPO in one of the EPO official languages on 05.06.1997 takes the place of the publication of the European patent application.
[1998/38]
Type: B1 Patent specification 
No.:EP0863917
Date:01.10.2003
Language:EN
[2003/40]
Search report(s)International search report - published on:EP05.06.1997
ClassificationIPC:C07K7/23, A61K47/48
[1998/38]
CPC data not yet available
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1998/38]
TitleGerman:ZIELGERICHTETE, ZYTOTOXISCHE ANTHRACYCLIN-ANALOGE[1998/38]
English:TARGETED CYTOTOXIC ANTHRACYCLINE ANALOGS[1998/38]
French:ANALOGUES CYTOTOXIQUES CIBLES D'ANTHRACYCLINE[1998/38]
Entry into regional phase13.05.1998National basic fee paid 
13.05.1998Designation fee(s) paid 
13.05.1998Examination fee paid 
Examination procedure31.05.1997Request for preliminary examination filed
International Preliminary Examining Authority: EP
13.05.1998Examination requested  [1998/38]
13.05.2002Despatch of a communication from the examining division (Time limit: M08)
13.01.2003Reply to a communication from the examining division
19.03.2003Communication of intention to grant the patent
18.06.2003Fee for grant paid
18.06.2003Fee for publishing/printing paid
Divisional application(s)EP03010988.8  / EP1384710
Opposition(s)02.07.2004No opposition filed within time limit [2004/39]
Fees paidRenewal fee
11.11.1998Renewal fee patent year 03
10.11.1999Renewal fee patent year 04
19.01.2001Renewal fee patent year 05
27.10.2001Renewal fee patent year 06
31.10.2002Renewal fee patent year 07
Penalty fee
Additional fee for renewal fee
30.11.200005   M06   Fee paid on   19.01.2001
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[DX]US4299822  (ISRAEL MERVYN, et al) [DX] 1,32,33 * example -; claim - *;
 [X]GB2124224  (STANFORD RES INST INT) [X] 1,32,33 * example -; claim - *;
 [DX]EP0434960  (ERBA CARLO SPA [IT]) [DX] 1,32,33 * example -; claim - *;
 [DA]EP0450461  (SCHALLY ANDREW VICTOR [US], et al) [DA] 1,2,32-36 * the whole document *;
 [A]EP0624377  (BRISTOL MYERS SQUIBB CO [US]) [A] 1,32,33 * reaction schemes 12, 15, 16, 18;; examples 8,9,14,15,23 * * examples 24,28,48,49 * * examples 61,70,71; claim - *;
 [DX]  - A. CHERIF AND D. FARQUHAR, "N-(5,5-Diacetoxypent-1-yl)doxorubicin: A New Intensely Potent Doxorubicin Analogue", JOURNAL OF MEDICINAL CHEMISTRY, WASHINGTON US, (19920821), vol. 35, no. 17, pages 3208 - 3214, XP002029565 [DX] 1,32,33 * see chart I, Scheme I, scheme III; page 3210, column R, paragraph 4 - page 3212, column L, paragraph 3 *

DOI:   http://dx.doi.org/10.1021/jm00095a017
 [DX]  - MUELLER B M ET AL, "ANTIBODY CONJUGATES WITH MORPHOLINODOXORUBICIN AND ACID-CLEAVABLE LINKERS", BIOCONJUGATE CHEMISTRY, (19900901), vol. 1, no. 5, pages 325 - 330, XP000174625 [DX] 1,32,33 * see scheme I and scheme II; page 327, column L, paragraph 1 - page 329, column L, paragraph 2 *

DOI:   http://dx.doi.org/10.1021/bc00005a005
 [DX]  - F. ZUNINO ET AL., "Comparison of Antitumor Effects of Aunorubicin Covalently Linked to Poly-L-Amino Acid Carriers", EUROPEAN JOURNAL OF CANCER AND CLINICAL ONCOLOGY, (198403), vol. 20, no. 3, pages 421 - 425, XP000670366 [DX] 1,32,33 * page 421, column R, paragraph 3 - page 422, column L, paragraph 1 * * page 424, column L, paragraph 2 - page 425, column L, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/0277-5379(84)90091-9
 [DA]  - A.V. SCHALLY, "Hypothalamic Hormones: from neuroendocrinology to cancer therapy", ANTI-CANCER DRUGS, (199404), vol. 5, no. 2, pages 115 - 130, XP000670356 [DA] 1,2,32,33 * page 120, column R, paragraph 2 - page 121, column L, paragraph 1 *
 [DA]  - A. TROUET ET AL., "A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate. In vitro and in vivo studies", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, WASHINGTON US, (198201), vol. 79, pages 626 - 629, XP002029566 [DA] 1 * figure 1 *

DOI:   http://dx.doi.org/10.1073/pnas.79.2.626
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.