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Extract from the Register of European Patents

EP About this file: EP1003373

EP1003373 - COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  17.12.2004
Database last updated on 02.09.2024
Most recent event   Tooltip11.01.2008Lapse of the patent in a contracting state
New state(s): IT, PT		published on 13.02.2008  [2008/07]
Applicant(s)For all designated states
Ardent Pharmaceuticals, Inc.
104 Sierra Drive
Chapel Hill, North Carolina 27514 / US
[2001/38]
Former [2000/22]For all designated states
DELTA PHARMACEUTICALS, INC.
104 Sierra Drive
Chapel Hill, North Carolina 27514 / US
Inventor(s)01 / CHANG, Kwen-Jen
2476 Foxwood Drive
Chapel Hill, NC 27514 / US
02 / MCNUTT, Robert, W., Jr.
Apartment B-9 700 Morreene Road
Durham, NC 17705 / US
03 / PETTIT, Hugh, O.
106 Wyatts Pond Lane
Cary, NC 27513 / US
04 / BISHOP, Michael, J.
235 Lochridge Drive
Durham, NC 27713 / US
[2000/22]
Representative(s)Schüssler, Andrea, et al
Kanzlei Huber & Schüssler
Truderinger Strasse 246
81825 München / DE
[N/P]
Former [2004/05]Schüssler, Andrea, Dr., et al
Kanzlei Huber & Schüssler Truderinger Strasse 246
81825 München / DE
Former [2002/31]Wright, Robert Gordon McRae, Dr., et al
Elkington & Fife, Beacon House, 113 Kingsway
London WC2B 6PN / GB
Former [2000/22]Marchant, James Ian, et al
Elkington and Fife, Prospect House, 8 Pembroke Road
Sevenoaks, Kent TN13 1XR / GB
Application number, filing date97910777.801.10.1997
[2000/22]
WO1997US17852
Priority number, dateUS1997088731203.07.1997         Original published format: US 887312
[2000/22]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9901033
Date:14.01.1999
Language:EN
[1999/02]
Type: A1 Application with search report 
No.:EP1003373
Date:31.05.2000
Language:EN
The application published by WIPO in one of the EPO official languages on 14.01.1999 takes the place of the publication of the European patent application.
[2000/22]
Type: B1 Patent specification 
No.:EP1003373
Date:11.02.2004
Language:EN
[2004/07]
Search report(s)International search report - published on:US14.01.1999
(Supplementary) European search report - dispatched on:EP04.08.2000
ClassificationIPC:A61K31/13, A61K31/445, A61K31/495, A61K38/08, A61P25/00
[2003/37]
CPC:
A61K31/495 (EP,KR,US); A61K31/00 (EP,US); A61K31/40 (EP,US);
A61K31/445 (EP,US); A61K31/485 (EP,US); A61K31/496 (EP,US);
A61K31/55 (EP,US); A61K45/06 (EP,US); A61P11/00 (EP);
A61P11/16 (EP); A61P25/00 (EP); A61P43/00 (EP);
C07D295/096 (EP,US); C07D295/155 (EP,US) (-)
C-Set:
A61K31/485, A61K2300/00 (EP,US);
A61K31/495, A61K2300/00 (US,EP)
Former IPC [2000/38]A61K31/13, A61K31/445, A61K31/495, A61K38/08
Former IPC [2000/22]A01N43/36, A01N43/40, A01N43/46, A61K31/40, A61K31/445, A61K31/55
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2000/22]
Extension statesAL22.12.1999
LT22.12.1999
LV22.12.1999
RO22.12.1999
SI22.12.1999
TitleGerman:ZUSAMMMENSETZUNGEN UND VERFAHREN ZUR VERMINDERUNG DER ATMUNGSDEPRESSIONEN UND BEGLEITENDER NEBENMWIRKUNGEN VON MU-OPIOID-VERBINDUNGEN[2000/22]
English:COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS[2000/22]
French:COMPOSITIONS ET METHODES PERMETTANT D'ATTENUER LA DEPRESSION RESPIRATOIRE ET LES EFFETS SECONDAIRES DES COMPOSES OPIOIDES MU[2000/22]
Entry into regional phase22.12.1999National basic fee paid 
22.12.1999Search fee paid 
22.12.1999Designation fee(s) paid 
22.12.1999Examination fee paid 
Examination procedure02.02.1999Request for preliminary examination filed
International Preliminary Examining Authority: US
22.12.1999Examination requested  [2000/22]
04.05.2000Request for accelerated examination filed
11.12.2000Despatch of a communication from the examining division (Time limit: M04)
11.12.2000Decision about request for accelerated examination - accepted: Yes
20.04.2001Reply to a communication from the examining division
24.07.2001Despatch of a communication from the examining division (Time limit: M04)
03.12.2001Reply to a communication from the examining division
22.05.2002Despatch of a communication from the examining division (Time limit: M02)
25.05.2002Reply to a communication from the examining division
12.12.2002Despatch of a communication from the examining division (Time limit: M04)
19.04.2003Reply to a communication from the examining division
08.08.2003Communication of intention to grant the patent
03.12.2003Fee for grant paid
03.12.2003Fee for publishing/printing paid
Opposition(s)12.11.2004No opposition filed within time limit [2005/05]
Fees paidRenewal fee
22.12.1999Renewal fee patent year 03
11.10.2000Renewal fee patent year 04
11.10.2001Renewal fee patent year 05
15.10.2002Renewal fee patent year 06
14.10.2003Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT11.02.2004
BE11.02.2004
CH11.02.2004
FI11.02.2004
FR11.02.2004
IT11.02.2004
LI11.02.2004
NL11.02.2004
DK11.05.2004
GR11.05.2004
SE11.05.2004
DE12.05.2004
ES22.05.2004
PT11.07.2004
IE01.10.2004
LU01.10.2004
MC31.10.2004
[2008/07]
Former [2007/17]AT11.02.2004
BE11.02.2004
CH11.02.2004
FI11.02.2004
FR11.02.2004
LI11.02.2004
NL11.02.2004
DK11.05.2004
GR11.05.2004
SE11.05.2004
DE12.05.2004
ES22.05.2004
IE01.10.2004
LU01.10.2004
MC31.10.2004
Former [2006/14]AT11.02.2004
BE11.02.2004
CH11.02.2004
FI11.02.2004
FR11.02.2004
LI11.02.2004
NL11.02.2004
DK11.05.2004
GR11.05.2004
SE11.05.2004
DE12.05.2004
ES22.05.2004
IE01.10.2004
MC31.10.2004
Former [2006/12]AT11.02.2004
BE11.02.2004
CH11.02.2004
FI11.02.2004
LI11.02.2004
NL11.02.2004
DK11.05.2004
GR11.05.2004
SE11.05.2004
DE12.05.2004
ES22.05.2004
IE01.10.2004
MC31.10.2004
Former [2005/46]AT11.02.2004
BE11.02.2004
CH11.02.2004
FI11.02.2004
LI11.02.2004
DK11.05.2004
GR11.05.2004
SE11.05.2004
DE12.05.2004
ES22.05.2004
IE01.10.2004
MC31.10.2004
Former [2005/45]AT11.02.2004
BE11.02.2004
CH11.02.2004
FI11.02.2004
LI11.02.2004
DK11.05.2004
GR11.05.2004
SE11.05.2004
DE12.05.2004
ES22.05.2004
MC31.10.2004
Former [2005/12]AT11.02.2004
BE11.02.2004
CH11.02.2004
FI11.02.2004
LI11.02.2004
DK11.05.2004
GR11.05.2004
SE11.05.2004
DE12.05.2004
ES22.05.2004
Former [2005/02]AT11.02.2004
BE11.02.2004
CH11.02.2004
FI11.02.2004
LI11.02.2004
DK11.05.2004
GR11.05.2004
SE11.05.2004
ES22.05.2004
Former [2005/01]AT11.02.2004
BE11.02.2004
CH11.02.2004
FI11.02.2004
LI11.02.2004
GR11.05.2004
SE11.05.2004
ES22.05.2004
Former [2004/46]AT11.02.2004
CH11.02.2004
FI11.02.2004
LI11.02.2004
GR11.05.2004
SE11.05.2004
ES22.05.2004
Former [2004/44]AT11.02.2004
CH11.02.2004
FI11.02.2004
LI11.02.2004
GR11.05.2004
SE11.05.2004
Former [2004/43]AT11.02.2004
FI11.02.2004
GR11.05.2004
SE11.05.2004
Former [2004/41]FI11.02.2004
GR11.05.2004
SE11.05.2004
Former [2004/40]FI11.02.2004
SE11.05.2004
Documents cited:Search[X]EP0415693  (ARIZONA TECH DEV [US]) [X] 7-9,16 * column 5, line 4 - line 12 * * figure - * * column 10, line 57 - column 11, line 36 * * claims 1,8,9 *;
 [Y]WO9315062  (WELLCOME FOUND [GB]) [Y] 1-3,6-24 * abstract * * formula (I) * * page 12 - page 24 * * page 24, line 21 - line 28 * * page 27, line 9 - line 19 * * page 29, line 30 - page 30, line 4 *;
 [Y]WO9504051  (WELLCOME FOUND [GB], et al) [Y] 1-3,6-24 * abstract * * page 1, line 6 - line 10 * * formulae (I) and (II) * * page 14, line 21 - line 24 * * page 16, line 10 - line 18 *;
 [X]WO9602545  (SMITHKLINE BEECHAM FARMA [IT], et al) [X] 1,3 * page 1, line 26 - line 34 * * page 8, line 11 - line 20 *;
 [X]US5574159  (CHANG KWEN-JEN [US], et al) [X] 1-3,6-24 * abstract * * formula (I) * * column 13, line 50 - line 58 * * table A *;
 [DX]WO9636620  (SMITHKLINE BEECHAM SPA [IT], et al) [DX] 1-4,7-10,13-16 * formula (I) * * page 7, line 14 - line 22 * * claim - *;
 [DX]WO9710230  (SMITHKLINE BEECHAM SPA [IT], et al) [DX] 1-3,5,7-9,13-16 * formula (I) * * page 1, line 20 - line 27 *;
 [E]WO9746240  (DELTA PHARMACEUTICALS INC [US]) [E] 1-3,6-24 * abstract * * page 1, line 30 - page 2, line 21 * * formula (I) * * page 12, line 19 - page 14, line 14 * * page 15, line 1 - page 16, line 17 * * example - *;
 [A]  - ERSPAMER V ET AL, "DELTORPHINS: A FAMILY OF NATURALLY OCCURRING PEPTIDES WITH HIGH AFFINITY AND SELECTIVITY FOR OPIOID BINDING SITES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, (19890701), vol. 86, no. 13, ISSN 0027-8424, pages 5188 - 5192, XP000033899 [A] 1-24 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.86.13.5188
International search[X]  - DATABASE CAPLUS ON STN, DEP. PHARMACOLOGY, UNIVERSITY MICHIGAN, (Ann Arbor, MI), Document No. 121:271967, NEGUS S. et al., "Behavioral Effects of the Systemically Active Delta Opioid Agonist BW373U86 in Rhesus Monkeys"; & J. PHARMACOL. EXP. THER., 270(3), 1994, 1025-1034.
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.