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Extract from the Register of European Patents

EP About this file: EP0918797

EP0918797 - HUMANIZED IMMUNOGLOBULIN REACTIVE WITH ALPHA4BETA7 INTEGRIN [Right-click to bookmark this link]
Former [1999/22]HUMANIZED IMMUNOGLOBULIN REACTIVE WITH $g(a)4$g(b)7 INTEGRIN
[1999/52]
StatusPatent maintained as amended
Status updated on  21.08.2015
Database last updated on 30.10.2024
Most recent event   Tooltip21.08.2015Patent maintained (B2 publication)published on 23.09.2015  [2015/39]
Applicant(s)For all designated states
MILLENNIUM PHARMACEUTICALS, INC.
75 Sidney Street Cambridge
Massachusetts 02139 / US
[2006/13]
Former [2000/46]For all designated states
Millennium Pharmaceuticals, Inc.
75 Sidney Street
Cambridge, Massachusetts 02139 / US
Former [2000/44]For all designated states
MILLENIUM PHARMACEUTICALS, INC.
640 Memorial Drive
Cambridge, MA 02139 / US
Former [1999/22]For all designated states
Leukosite, Inc.
215 First Street
Cambridge, MA 02142 / US
Inventor(s)01 / PONATH, Paul, D.
45 Upton, No. 3
Boston, MA 02118 / US
02 / RINGLER, Douglas, J.
382 Ocean Avenue, No. 1008
Revere, MA 02151 / US
03 / JONES, S., Tarran
1 Christchurch Crescent
Radlett
Hertfordshire WD7 8AG / GB
04 / NEWMAN, Walter
3 Durham Street, No. 3
Boston, MA 02115 / US
05 / SALDANHA, José
22A Lincoln Way
Enfield
Middlesex EN1 1TE / GB
06 / BENDIG, Mary, M.
26 Gresham Avenue
London N20 0XL / GB
 [2015/39]
Former [1999/22]01 / PONATH, Paul, D.
45 Upton, No. 3
Boston, MA 02118 / US
02 / RINGLER, Douglas, J.
382 Ocean Avenue, No. 1008
Revere, MA 02151 / US
03 / JONES, S., Tarran
1 Christchurch Crescent, Radlett
Hertfordshire WD7 8AG / GB
04 / NEWMAN, Walter
3 Durham Street, No. 3
Boston, MA 02115 / US
05 / SALDANHA, José
22A Lincoln Way, Enfield
Middlesex EN1 1TE / GB
06 / BENDIG, Mary, M.
26 Gresham Avenue
London N20 0XL / GB
Representative(s)Dossmann, Gérard
Casalonga & Partners
Bayerstrasse 71-73
80335 München / DE
[2015/39]
Former [2009/30]Dossmann, Gérard
Bureau D.A. Casalonga & Josse Bayerstrasse 71/73
80335 München / DE
Former [2009/08]Dossmann, Gérard
Bureau Casalonga & Josse Bayerstrasse 71/73
80335 München / DE
Former [1999/22]Price, Vincent Andrew, et al
FRY HEATH & SPENCE The Old College 53 High Street
Horley Surrey RH6 7BN / GB
Application number, filing date97937148.106.08.1997
[1999/22]
WO1997US13884
Priority number, dateUS1996070073715.08.1996         Original published format: US 700737
[1999/22]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO9806248
Date:19.02.1998
Language:EN
[1998/07]
Type: A2 Application without search report 
No.:EP0918797
Date:02.06.1999
Language:EN
The application published by WIPO in one of the EPO official languages on 19.02.1998 takes the place of the publication of the European patent application.
[1999/22]
Type: B1 Patent specification 
No.:EP0918797
Date:29.03.2006
Language:EN
[2006/13]
Type: B2 New European patent specification 
No.:EP0918797
Date:23.09.2015
Language:EN
[2015/39]
Search report(s)International search report - published on:EP07.05.1998
ClassificationIPC:C07K16/28, C07K14/705
[1999/22]
CPC:
C07K16/2839 (EP,US); A61P1/00 (EP); A61P1/04 (EP);
A61P29/00 (EP); A61P37/00 (EP); C07K14/70503 (EP,US);
A61K38/00 (EP,US); C07K2317/24 (EP,US); C07K2319/00 (EP,US) (-)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2015/39]
Former [1999/22]AT,  BE,  CH,  DE,  DK,  ES,  FI,  FR,  GB,  GR,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  SE 
Extension statesAL08.03.1999
LT08.03.1999
LV08.03.1999
RO08.03.1999
SI08.03.1999
TitleGerman:HUMANISIERTES IMMUNGLOBULIN GEGEN DEN ALPHA4BETA7-INTEGRIN[2003/22]
English:HUMANIZED IMMUNOGLOBULIN REACTIVE WITH ALPHA4BETA7 INTEGRIN[2003/22]
French:IMMUNOGLOBINE HUMANISE REAGISSANT AVEC L'INTEGRINE ALPHA4BETA7[2003/22]
Former [1999/22]HUMANISIERTES IMMUNGLOBULIN GEGEN DEN ALPHA4BETA7-INTEGRIN
Former [1999/22]HUMANIZED IMMUNOGLOBULIN REACTIVE WITH $g(a)4$g(b)7 INTEGRIN
Former [1999/22]IMMUNOGLOBINE HUMANISE REAGISSANT AVEC L'INTEGRINE $g(a)4$g(b)7
Entry into regional phase08.03.1999National basic fee paid 
08.03.1999Designation fee(s) paid 
08.03.1999Examination fee paid 
Examination procedure27.02.1998Request for preliminary examination filed
International Preliminary Examining Authority: EP
08.03.1999Examination requested  [1999/22]
06.02.2003Amendment by applicant (claims and/or description)
24.04.2003Communication of intention to grant the patent
11.12.2003Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
13.02.2004Fee for grant paid
13.02.2004Fee for publishing/printing paid
16.03.2004Despatch of a communication from the examining division (Time limit: M04)
29.06.2004Reply to a communication from the examining division
09.09.2004Despatch of a communication from the examining division (Time limit: M02)
08.11.2004Reply to a communication from the examining division
Divisional application(s)EP06006108.2  / EP1710314
EP16168412.1
Opposition(s)Opponent(s)01  22.12.2006  02.02.2007  ADMISSIBLE
ELAN PHARMACEUTICALS INC.
800 Gateway Blvd, South San Francisco
CALIFORNIA 94080 / US
Opponents representative
Mercer, Christopher Paul
Carpmaels & Ransford LLP
One Southampton Row
London
WC1B 5HA / GB
 02  29.12.2006  02.02.2007  ADMISSIBLE
Amgen, Inc
One Amgen Center Drive
Thousand Oaks CA 91320 / US
Opponents representative
Grünecker Patent- und Rechtsanwälte PartG mbB
Leopoldstraße 4
80802 München / DE
 [2015/22]
Former [2009/51]
Opponent(s)01  22.12.2006  02.02.2007  ADMISSIBLE
ELAN PHARMACEUTICALS INC.
800 Gateway Blvd, South San Francisco
CALIFORNIA 94080 / US
Opponents representative
Mercer, Christopher Paul
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
 02  29.12.2006  02.02.2007  ADMISSIBLE
Amgen, Inc
One Amgen Center Drive
Thousand Oaks CA 91320 / US
Opponents representative
Vogelsang-Wenke, Heike
Grünecker Kinkeldey Stockmair & Schwanhäusser Anwaltssozietät Leopoldstrasse 4
80802 München / DE
Former [2007/07]
Opponent(s)01  22.12.2006   
ELAN PHARMACEUTICALS INC.
800 Gateway Blvd, South San Francisco
CALIFORNIA 94080 / US
Opponents representative
Mercer, Christopher Paul
Carpmaels & Ransford, 43-45 Bloomsbury Square
London WC1A 2RA / GB
 02  29.12.2006   
Amgen, Inc
One Amgen Center Drive
Thousand Oaks CA 91320 / US
Opponents representative
Vogelsang-Wenke, Heike
Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät Maximilianstrasse 58
80538 München / DE
Former [2007/05]
Opponent(s)01  22.12.2006   
ELAN PHARMACEUTICALS INC.
800 Gateway Blvd, South San Francisco
CALIFORNIA 94080 / US
Opponents representative
Mercer, Christopher Paul
Carpmaels & Ransford, 43-45 Bloomsbury Square
London WC1A 2RA / GB
09.02.2007Invitation to proprietor to file observations on the notice of opposition
08.08.2007Reply of patent proprietor to notice(s) of opposition
15.12.2009Date of oral proceedings
26.04.2010Despatch of interlocutory decision in opposition
26.04.2010Despatch of minutes of oral proceedings
02.04.2015Legal effect of interlocutory decision in opposition
11.05.2015Despatch of communication that the patent will be maintained as amended
13.08.2015Fee for printing new specification paid
Appeal following opposition06.07.2010Appeal received No.  T1521/10
23.08.2010Statement of grounds filed
02.04.2015Result of appeal procedure: appeal of the proprietor withdrawn
Request for further processing for:13.02.2004Request for further processing filed
13.02.2004Full payment received (date of receipt of payment)
Request granted
03.03.2004Decision despatched
Fees paidRenewal fee
28.07.1999Renewal fee patent year 03
21.07.2000Renewal fee patent year 04
31.07.2001Renewal fee patent year 05
14.08.2002Renewal fee patent year 06
13.08.2003Renewal fee patent year 07
12.08.2004Renewal fee patent year 08
19.08.2005Renewal fee patent year 09
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Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  Tooltipdeleted
[2012/23]
Former [2010/05]IT06.08.2008
Cited inInternational search[A]JPH06303990  ;
 [A]WO9417828  (BIOGEN INC [US], et al) [A] 1-51 * page 15, line 4 - page 17, line 25 * * examples 1-4 * * claim - *;
 [A]WO9519790  (ATHENA NEUROSCIENCES INC [US], et al) [A] 1-51 * the whole document *;
 [PA]WO9718838  (ATHENA NEUROSCIENCES INC [US], et al) [PA] 1-51* the whole document *;
 [DA]  - A. LAZAROVITS ET AL., "Differential expression in rheumatoid synovium and synovial fluid of alpha4beta7 integrin.", THE JOURNAL OF IMMUNOLOGY, BALTIMORE, MD, USA, (19931201), vol. 151, no. 11, pages 6482 - 6489, XP002048548 [DA] 1-40 * the whole document *
 [DA]  - C. KETTLEBOROUGH ET AL., "Humanization of a mouse monoclonal antibody by CDR-grafting: the importance of framework residues on loop conformation.", PROTEIN ENGINEERING, OXFORD, GB, (199110), vol. 4, no. 7, pages 773 - 783, XP002048549 [DA] 1-40 * the whole document *
 [DA]  - T. SCHWEIGHOFFER ET AL., "Selective expression of integrin alpha4beta7 on a subset of human CD4+ memory T cells with hallmarks of gut-trophism.", THE JOURNAL OF IMMUNOLOGY, BALTIMORE, MD, USA, (19930715), vol. 151, no. 2, pages 717 - 729, XP002048550 [DA] 1-40 * the whole document *
 [A]  - M. BRISKIN ET AL., "Structural requirements for mucosal vascular addressin binding to its lymphocyte receptor alpha4beta7.", THE JOURNAL OF IMMUNOLOGY, BALTIMORE, MD, USA, (19960115), vol. 156, no. 2, pages 719 - 726, XP002048551 [A] 1-51 * abstract *
 [A]  - DATABASE WPI, 1, Derwent World Patents Index, vol. 95, no. 03, Database accession no. 95-018280, XP002048552 & JPH06303990 A 19941101 (KANEBO LTD.) [A] 1-40 * abstract *
OppositionUS5530101
    - A. I. LAZAROVITS ET AL., "Lymphocyte activation antigens", THE JOURNAL OF IMMUNOLOGY, (19841004), vol. 133, no. 4, pages 1857 - 1862
    - D. G. WOODSIDE ET AL., "Specific Inhibition of T Lymphocyte Coactivation by Triggering Integrin ß¹ Reveals Convergence of ß¹, ß², and ß7 Signaling Pathways¹", THE JOURNAL OF IMMUNOLOGY, (1996), vol. 157, no. 2, pages 700 - 706
    - R. VAN DER VOORT ET AL., "Paracrine Regulation of Germinal Center B Cell Adhesion through the c-Met-Hepatocyte Growth Factor/Scatter Factor Pathway", J. EXP. MED., (19970616), vol. 185, no. 12, pages 2121 - 2131
    - L. S. ROTT ET AL., "Expression of Mucosal Homing Receptor x4ß7 by Circualting CD4+ Cells with Memoryfor Intestinal Rotavirus", THE JOURNAL OF CLINICAL INVESTIGATION, (19970905), vol. 100, no. 5, pages 1204 - 1208
    - T. KENT ET AL., "Integrin x4ß7 Co-Stimulation of Human Peripheral Blood T Cell Proliferation", CELL ADHESION AND COMMUNICATION, (1994), vol. 2, pages 539 - 547
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.