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EP About this file: EP0973534

EP0973534 - PLANT EXTRACTS HAVING APPETITE SUPPRESSANT ACTIVITY [Right-click to bookmark this link]
Former [2000/04]	PHARMACEUTICAL COMPOSITIONS HAVING APPETITE SUPPRESSANT ACTIVITY
	[2006/17]
Status	No opposition filed within time limit Status updated on 14.09.2007 Database last updated on 14.05.2024
Most recent event Tooltip	01.01.2010	Lapse of the patent in a contracting state New state(s): CY, LU	published on 03.02.2010 [2010/05]
Applicant(s)	For all designated states CSIR Corporate Building, Scientia Pretoria 0001 / ZA
	[2006/44]
Former [2000/04]	For all designated states CSIR Corporate Building, Scientia Pretoria 0002 / ZA
Inventor(s)	01 / VAN HEERDEN, Fanie, Retief 19 Parkgate, 247 Kessel Street, Fairland Johannesburg 2195 / ZA
	02 / VLEGGAAR, Robert 317 Arizona Crescent, Faerie Glen Pretoria 0043 / ZA
	03 / HORAK, Roelof, Marthinus 41 Peffer Street, ElardusPark X1 Pretoria 0181 / ZA
	04 / LEARMONTH, Robin, Alec 571 Grafiet Street, Elardus Park Pretoria 0181 / ZA
	05 / MAHARAJ, Vinesh 16 Ironwood Street, Heuweloord Pretoria 0149 / ZA
	06 / WHITTAL, Rory, Desmond 28 Springbark Avenue Heuwelloord, Centurion Pretoria 0149 / ZA
	[2000/04]
Representative(s)	Brown, David Leslie, et al Haseltine Lake Kempner LLP Redcliff Quay 120 Redcliff Street Bristol BS1 6HU / GB
	[N/P]
Former [2004/11]	Brown, David Leslie, et al Haseltine Lake, Imperial House, 15-19 Kingsway London WC2B 6UD / GB
Former [2003/48]	Benedum, Ulrich Max, Dr., et al Haseltine Lake Partners Motorama Haus 502 Rosenheimer Strasse 30 81669 München / DE
Former [2002/08]	Eddowes, Simon, et al Urquhart-Dykes & Lord, 30 Welbeck Street London W1G 8ER / GB
Former [2000/04]	Simpson, Alison Elizabeth Fraser, et al Urquhart-Dykes & Lord, 91 Wimpole Street London W1M 8AH / GB
Application number, filing date	98917372.9	15.04.1998
	[2000/04]
	WO1998GB01100
Priority number, date	ZA19970003201	15.04.1997 Original published format: ZA 9703201
	[2000/04]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO9846243
	Date:	22.10.1998
	Language:	EN
	[1998/42]
	Type:	A1 Application with search report
	No.:	EP0973534
	Date:	26.01.2000
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 22.10.1998 takes the place of the publication of the European patent application.
	[2000/04]
	Type:	B1 Patent specification
	No.:	EP0973534
	Date:	02.11.2006
	Language:	EN
	[2006/44]
Search report(s)	International search report - published on:	EP	22.10.1998
Classification	IPC:	A61K36/27	[2006/17]
	CPC:	A61K31/57 (EP,US); A61K36/33 (KR); A23L33/105 (EP,US); A61K31/58 (EP,US); A61K31/704 (EP,US); A61K31/78 (EP,US); (+) A61K36/27 (EP,US); A61P1/00 (EP); A61P3/00 (EP); A61P3/04 (EP); C07H13/08 (EP,US); C07H3/04 (EP,US); C07H3/06 (EP,US); C07H5/10 (EP,US); C07J15/00 (EP,US); C07J17/00 (EP,US); C07J17/005 (EP,US); C07J41/00 (EP,US); C07J7/002 (EP,US); C07J7/0025 (EP,US); C07J7/0035 (EP,US); C07J7/007 (EP,US); Y02P20/582 (EP,US) (-)
	C-Set:	A61K36/27, A61K2300/00 (EP,US)
	Former IPC [2000/04]	A61K35/78
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2000/04]
Extension states	AL	23.08.1999
	LT	23.08.1999
	LV	23.08.1999
	RO	23.08.1999
	SI	23.08.1999
Title	German:	PFLANZENEXTRAKTE MIT APPETITUNTERDRÜCKENDER AKTIVITÄT	[2006/17]
	English:	PLANT EXTRACTS HAVING APPETITE SUPPRESSANT ACTIVITY	[2006/17]
	French:	EXTRAITS DE PLANTES DOTÉS D'UNE ACTIVITÉ COUPE-FAIM	[2006/17]
	Former [2000/04]	PHARMAZEUTISCHE ZUSAMMENSETZUNGEN MIT APPETITUNTERDRÜCKENDER AKTIVITÄT
	Former [2000/04]	PHARMACEUTICAL COMPOSITIONS HAVING APPETITE SUPPRESSANT ACTIVITY
	Former [2000/04]	COMPOSITIONS PHARMACEUTIQUES DOTEES D'UNE ACTIVITE COUPE-FAIM
Entry into regional phase	23.08.1999	National basic fee paid
	23.08.1999	Designation fee(s) paid
	23.08.1999	Examination fee paid
Examination procedure	09.11.1998	Request for preliminary examination filed International Preliminary Examining Authority: EP
	23.08.1999	Examination requested [2000/04]
	14.06.2000	Despatch of a communication from the examining division (Time limit: M06)
	23.01.2001	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	21.03.2001	Reply to a communication from the examining division
	25.06.2001	Despatch of a communication from the examining division (Time limit: M08)
	11.02.2002	Reply to a communication from the examining division
	17.10.2002	Despatch of a communication from the examining division (Time limit: M02)
	16.12.2002	Reply to a communication from the examining division
	28.10.2003	Date of oral proceedings
	03.12.2003	Despatch of communication that the application is refused, reason: substantive examination {1}
	03.12.2003	Minutes of oral proceedings despatched
	22.04.2005	Despatch of a communication from the examining division (Time limit: M04)
	08.07.2005	Reply to a communication from the examining division
	23.03.2006	Communication of intention to grant the patent
	02.08.2006	Fee for grant paid
	02.08.2006	Fee for publishing/printing paid
Appeal following examination	15.12.2003	Appeal received No. T0543/04
	13.04.2004	Statement of grounds filed
	27.01.2005	Result of appeal procedure: remittal for grant
	27.01.2005	Date of oral proceedings
	01.02.2005	Minutes of oral proceedings despatched
Divisional application(s)	EP02004100.0 / EP1222927
	EP02004101.8 / EP1213020
	EP04002070.3 / EP1438965
	EP05017768.2 / EP1598054
Opposition(s)	03.08.2007	No opposition filed within time limit [2007/42]
Request for further processing for:	21.03.2001	Request for further processing filed
	21.03.2001	Full payment received (date of receipt of payment) Request granted
	05.04.2001	Decision despatched
Fees paid	Renewal fee
	20.04.2000	Renewal fee patent year 03
	23.04.2001	Renewal fee patent year 04
	08.02.2002	Renewal fee patent year 05
	08.03.2003	Renewal fee patent year 06
	29.04.2004	Renewal fee patent year 07
	27.04.2005	Renewal fee patent year 08
	26.04.2006	Renewal fee patent year 09
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Licence(s)	ID:	01 00/exclusive
	For:	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Licencee:	PHYTOPHARM PLC Corpus Christi House, 9 West Street Godmanchester Cambridgeshire PE18 8HG / GB
	Date:	12.03.2004
	[2006/44]
Former [2004/26]	ID:	01 00/exclusive
	For:	all designated states
	Licencee:	PHYTOPHARM PLC Corpus Christi House, 9 West Street Godmanchester Cambridgeshire PE18 8HG / GB
	Date:	12.03.2004
	[2006/44]
Lapses during opposition Tooltip	CY	02.11.2006
	LU	15.04.2007
	MC	30.04.2007
	[2010/05]
Former [2009/18]	MC	30.04.2007
Cited in	International search	[X]EP0101383 (NATIVELLE SA ETS [FR]) [X] 35,41,43 * example 9 *;
		[A]US5605698 (UENO GAKU [JP]) [A] 1-48,60-95,118-121 * column W *;
		[PX]WO9747316 (MILLENNIUM PHARM INC [US]) [PX] 81,84-86,89,92,93 * page 6, line 16 - line 24 * * page 19, line 8 - line 12 * * page 17, line 11 - page 22, line 23 *;
		[PX]WO9810068 (UNIV OREGON HEALTH SCIENCES [US], et al) [PX] 81,84-86,89,92,93 * page 7, line 28 - line 31; example 4 *;
		[E]WO9827113 (RUDOLF MAGNUS INST FOR NEUROSC [NL], et al) [E] 81,84-86,89,92,93 * page 4, line 7 - line 14 * * page 8; table 1 *;
		[X] - P. BRUYNS, "A Revision of Hoodia and Lavrania (Asclepiadaceae - Stapelieae)", BOTANISCHE JAHRBÜCHER FÜR SYSTEMATIK PFLANZENGESCHICHTE UND PFLANZENGEOGRAPHIE, (1993), vol. 115, no. 2, pages 145 - 270, XP002072474 [X] 1-24,81,82,84-87,89,90,92-94,118 * page 175, paragraph L - page 176, paragraph 1 *
		[X] - HUSZAR D ET AL, "TARGETED DISRUPTION OF THE MELANOCORTIN-4 RECEPTOR RESULTS IN OBESITY IN MICE", CELL, (19970110), vol. 88, no. 1, pages 131 - 141, XP002058786 [X] 81,84-86,89,92,93 * page 135, column 1, paragraph L - column 2, paragraph 1 * DOI: http://dx.doi.org/10.1016/S0092-8674(00)81865-6
		[X] - W. FAN ET AL, "Role Melanocortinergic Neurons in Feeding and The Agouti Obesity Syndrome", NATURE., LONDON GB, (19970109), vol. 385, pages 165 - 168, XP002072475 [X] 81,84-86,89,92,93 * see the whole document, in particular page 166, column 1, figure 1 * DOI: http://dx.doi.org/10.1038/385165a0
		[A] - PROF. DR. OTTO WARBURG, DIE PFLANZENWELT, DRITTER BAND, LEIPZIG, BIBLIOGRAPHISCHES INSTITUT, (1922), XP002084114 [A] 1-48,60-95,118-121 * page 146, paragraph 7 *
		[X] - HABERMEHL G G ET AL, "Rearrangement of 14.beta.-hydroxy-12.beta.-sulfoxy steroids to 13,17-seco-12,17-cyclosteroids;a 2D-NMR analysis", ZEITSCHRIFT FUR NATURFORSCHUNG, TEIL B: ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE., TUBINGEN DE, (198505), vol. 40B, no. 5, pages 656 - 660, XP002084092 [X] 35,41 * page 659, column 1, paragraph 1 *
		[X] - OKI M ET AL, "Intramolecular interaction between hydroxyl group and carbonyl moiety in keto-alcohols", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, TOKYO JP, (196801), vol. 41, no. 1, pages 176 - 182, XP002084093 [X] 35,41 * page 178; table I *
		[X] - MITSUHASHI H ET AL, "Constituents of Asclepiadaceae plants. XXV. Components of Cynanchum boerhavifolium", CHEMICAL ABSTRACTS, (19700216), vol. 072, no. 7, Database accession no. 028873, page 53, column 2, XP002084115 [X] 35,41,53 * abstract *
		[ ] - YAKUGAKU ZASSHI (YKKZAJ);69; VOL.89 (10); PP.1352-7, HOKKAIDO UNIV.;FAC. PHARM. SCI.; SAPPORO; JAPAN
		[X] - H. MITSUHASHI ET AL, "Constituents of Asclepiadaceae plants. XVI. Components of Metaplexis japonica", CHEMICAL ABSTRACTS, (19661107), vol. 65, no. 10, Database accession no. 15447d, column 15447, XP002084116 [X] 35,41,42,53 * abstract *
		[ ] - CHEMICAL AND PHARMACEUTICAL BULLETIN, TOKYO JP, (1965), vol. 13, no. 11, pages 1332 - 1340
		[X] - R. TSCHESCHE ET AL, "Über Digitanolglykoside - IX (1) Zur Konstitution des Digipurpurogenin", TETRAHEDRON LETTERS., OXFORD GB, (1964), no. 9, pages 473 - 480, XP002084094 [X] 35,41,42,53 * see page 477, compounds IV and V; page 473, paragraph 1 *
		[X] - R. TSCHESCHE ET AL, "Über pflanzliche Herzgifte, XXX. Mitteil. : Neue Glykoside aus den Blättern von Digitalis purpurea und Digitalis lanata", CHEMISCHE BERICHTE, WEINHEIM DE, (1955), vol. 88, no. 10, pages 1569 - 1576, XP002084095 [X] 35,41,42,53 * see the summary on page 1569 *
		[X] - H. MITSUHASHI ET AL, "Studies on the Constituents of Asclepiadaceae plants. XIII. Epimerization at C-17 and Optical Rotatory Dispersion Study of C/D Cis Pregnane-2-one Derivatives", STEROIDS., SAN FRANCISCO US, (1964), vol. 4, no. 4, pages 483 - 493, XP002084096 [X] 35,41,42,53,46 * see page 484, compounds III, IIIa and IIIb; page 483, paragraph 2 * * page 485; example VIIIB * * page 486, paragraph 2 * * page 489, paragraph L - page 490, paragraph 1 * DOI: http://dx.doi.org/10.1016/0039-128X(64)90095-9
		[A] - GLENDINNING J I, "Effectiveness of cardenolides as feeding deterrents to Peromyscus mice", CHEMICAL ABSTRACTS, (19921221), vol. 117, no. 25, Database accession no. 249115, page 463, column 1, XP002084117 [A] 1-50,53,56-95,110,111,115,118-121 * abstract *
		[A] - DE RICK A ET AL, "Digoxin-quinidine interaction in the dog", J. VET. PHARMACOL. THER., (1981), vol. 4, no. 3, pages 215 - 218, XP002084097 [A] 1-50,53,56-95,110,111,115,118-121 * page 217, column 2, paragraph 2 *
		[A] - M. HELLER ET AL, "Electrophilic Addition to the delta-14 Double Bond of a Steroid", STEROIDS., SAN FRANCISCO US, (196402), vol. 3, no. 2, pages 193 - 201, XP002084098 [A] 49,50,96,99,100 * page 196, paragraph 3 - page 198, paragraph 2 * DOI: http://dx.doi.org/10.1016/0039-128X(64)90076-5
		[A] - YOSHII E ET AL, "Pregn-14-en-20-ones. Facile preparation and 14.beta.-hydroxylation", CHEMICAL ABSTRACTS, (19721023), vol. 077, no. 17, Database accession no. 114653, page 477, column 1, XP002084118 [A] 49,50,96,99,100 * abstract *
		[ ] - CHEM. PHARM. BULL. (CPBTAL);72; VOL.20 (8); PP.1827-9, UNIV. TOYAMA;FAC. PHARM. SCI.; TOYAMA; JAPAN
		[A] - J. F. TEMPLETON ET AL, "Progesterone Derivatives That Bind to the Digitalis Receptor: Synthesis of 14.beta.-Hydroxyprogesterone. A Novel Steroid with Positive Inotropic Activity", JOURNAL OF MEDICINAL CHEMISTRY., WASHINGTON US, (198708), vol. 30, no. 8, pages 1502 - 1505, XP002084099 [A] 49,50,96,99,100 * see page 1503, scheme 1 * DOI: http://dx.doi.org/10.1021/jm00391a038
		[X] - TANAKA T ET AL, "Studies on the constituents of Asclepiadaceae plants. Part 71. Pregnane glycosides from Boucerosia aucheriana", PHYTOCHEMISTRY, (1990), vol. 29, no. 1, pages 229 - 237, XP002084100 [X] 43 * see page 230, compounds 1-4; page 235, column 1, paragraph L * * page 235, column 2, paragraph 3 * DOI: http://dx.doi.org/10.1016/0031-9422(90)89040-G
		[X] - HAYASHI K ET AL, "Four pregnane glycosides, boucerosides AI, AII, BI and BII, from Boucerosia aucheriana", PHYTOCHEMISTRY, (1988), vol. 27, no. 12, pages 3919 - 3924, XP002084101 [X] 43 * see page 3920, compounds 5-8 * DOI: http://dx.doi.org/10.1016/0031-9422(88)83045-0
		[X] - DEEPAK D ET AL, "A new pregnane glycoside from Periploca calophylla", INDIAN JOURNAL OF CHEMISTRY, SECTION B, (198601), vol. 25b, no. 1, pages 44 - 45, XP002084102 [X] 43 * see page 44, compounds 1 and 2 *
		[X] - BANDO H ET AL, "Constituents of Asclepiadaceae plants. XXXI. Component of Stapelia grandiflora", CHEMICAL AND PHARMACEUTICAL BULLETIN, TOKYO JP, (1974), vol. 22, no. 5, pages 1209 - 1211, XP002084103 [X] 43 * see page 1210, compounds I and II *
		[X] - H. NIKAIDO ET AL, "Components of Boucerosia aucheriana DECNE", CHEMICAL AND PHARMACEUTICAL BULLETIN., TOKYO JP, (1967), vol. 15, no. 5, pages 725 - 726, XP002084104 [X] 43 * see page 726, compounds I and II *
		[A] - CHEN S W ET AL, "The hyperphagic effect of 3.alpha.-hydroxylated pregnane steroids in male rats", PHARMACOLOGY, BIOCHEMISTRY AND BEHAVIOR, (1996), vol. 53, no. 4, pages 777 - 782, XP002084105 [A] 45-47,60,62-64,66,68,69,87,90,94 * the whole document * DOI: http://dx.doi.org/10.1016/0091-3057(95)02142-6
		[X] - R. TSCHESCHE ET AL, "Über Digitanolglykoside, 15. Synthese von 12.alpha.20R-Epoxy-5.alpha.,14.beta.,17.beta-H-Pregnanen", CHEMISCHE BERICHTE, WEINHEIM DE, (1967), vol. 100, no. 2, pages 464 - 479, XP002084106 [X] 46 * see page 465, compounds 6b and 6c; page 473, paragraph 7 - paragraph 8 *
		[XA] - YOSHIKAWA K ET AL, "Steroidal glycosides from the fresh stem of Stephanotis lutchuensis var. japonica (Asclepiadaceae). Chemical structures of stephanosides K-Q", CHEMICAL AND PHARMACEUTICAL BULLETIN., TOKYO JP, (199612), vol. 44, no. 12, pages 2243 - 2248, XP002084107 [X] 48 * see page 2244, compounds 3 and 4 * [A] 116,117
		[XA] - YOSHIKAWA K ET AL, "Steroidal glycosides from the fresh stem of Stephanotis lutchuensis var. japonica (Asclepiadaceae). Chemical structures of stephanosides A-J", CHEMICAL AND PHARMACEUTICAL BULLETIN., TOKYO JP, (199610), vol. 44, no. 10, pages 1790 - 1796, XP002084108 [X] 48 * see page 1791, compounds 5 and 8 * [A] 116,117
		[XA] - CHEN J ET AL, "A novel C21 steroidal glycoside from Marsdenia incisa", CHEMICAL ABSTRACTS, (19911223), vol. 115, no. 25, Database accession no. 275751, page 591, column 2, XP002084119 [X] 48 * abstract * [A] 116,117
		[X] - MIWA H ET AL, "Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, (199504), vol. 273, no. 1, pages 367 - 372, XP002084109 [X] 81,84-86,89,92,93 * page 368; figure 1 * * page 370; table 1 *
		[PX] - HASKELL-LUEVANO C ET AL, "Discovery of Prototype Peptidomimetic Agonists at the Human Melanocortin Receptors MC1R and MC4R", JOURNAL OF MEDICINAL CHEMISTRY., WASHINGTON US, (19970704), vol. 40, no. 14, pages 2133 - 2139, XP002084110 [PX] 81,84-86,89,92,93 * see pag 2135, table 3, peptides 6 and 7; page 2138, column 1, paragraph 2 * DOI: http://dx.doi.org/10.1021/jm960840h
		[A] - DOLLE R E ET AL, "Total synthesis of elfamycins: aurodox and efrotomycin. 1. Strategy and construction of key intermediates", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., (19850320), vol. 107, no. 6, pages 1691 - 1694, XP002084111 [A] 51,52,54,55,103-109,112-114 * see page 1692, scheme II * DOI: http://dx.doi.org/10.1021/ja00292a038
		[A] - DOLLE R E ET AL, "Total synthesis of elfamycins: aurodox and efrotomycin. 2. Coupling of key intermediates and completion of the synthesis", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., DC US, (19850320), vol. 107, no. 6, pages 1695 - 1698, XP002084112 [A] 51,52,54,55,103-109,112-114 * see page 1695, column 2, scheme I * DOI: http://dx.doi.org/10.1021/ja00292a039
		[A] - R. TRIVEDI ET AL, "A pregnane ester oligoglycoside from Oxystelma esculentum", PHYTOCHEMISTRY, (1989), vol. 28, no. 4, pages 1211 - 1213, XP002084113 [A] 112-114 * the whole document * DOI: http://dx.doi.org/10.1016/0031-9422(89)80211-0

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