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Extract from the Register of European Patents

EP About this file: EP0993437

EP0993437 - 2-(4-BROMO OR 4-IODO PHENYLAMINO) BENZOIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.09.2007
Database last updated on 26.07.2024
Most recent event   Tooltip01.01.2010Lapse of the patent in a contracting state
New state(s): CY, LU		published on 03.02.2010  [2010/05]
Applicant(s)For all designated states
Warner-Lambert Company LLC
235 East 42nd Street
New York, NY 10017 / US
[2007/08]
Former [2006/45]For all designated states
Warner-Lambert Company LLC
201 Tabor Road Morris Plains
NJ 07950 / US
Former [2005/22]For all designated states
WARNER-LAMBERT COMPANY LLC
201 Tabor Road
Morris Plains, NJ 07950 / US
Former [2000/16]For all designated states
WARNER-LAMBERT COMPANY
201 Tabor Road
Morris Plains New Jersey 07950 / US
Inventor(s)01 / BARRETT, Stephen, Douglas
14220 Sunbury
Livonia, MI 48154 / US
02 / BRIDGES, Alexander, James
3301 Textile Road
Saline, MI 48176 / US
03 / CODY, Donna, Reynolds
1314 Maplewood Drive
Saline, MI 48176 / US
04 / DOHERTY, Annette, Marian
33, rue Poussin
F-75016 Paris / FR
05 / DUDLEY, David, Thomas
3201 Hays Court
Ann Arbor, MI 48108 / US
06 / SALTIEL, Alan, Robert
2002 Valley View Drive
Ann Arbor, MI 48105 / US
07 / SCHROEDER, Mel, Conrad
7858 Ridgeway Court
Dexter, MI 48130 / US
08 / TECLE, Haile
3048 Turnberry
Ann Arbor, MI 48108 / US
[2000/16]
Representative(s)Dekker, Henrike Cornelie Christine, et al
Pfizer
European Pharma Patent Department
23-25, avenue du Docteur Lannelongue
75668 Paris Cedex 14 / FR
[N/P]
Former [2006/33]Dekker, Henrike Cornelie Christine, et al
Pfizer European Pharma Patent Department 23-25, avenue du Docteur Lannelongue
75668 Paris Cedex 14 / FR
Former [2006/28]Peter, Beate, et al
Pfizer Limited European Patent Department Ramsgate Road
Sandwich, Kent CT13 9NJ / GB
Former [2000/16]Mansmann, Ivo, et al
Warner-Lambert Company, Legal Division, Legal Department, c/o Gödecke AG
79090 Freiburg / DE
Application number, filing date98932829.924.06.1998
[2000/16]
WO1998US13105
Priority number, dateUS19970051433P01.07.1997         Original published format: US 51433 P
[2000/16]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9901421
Date:14.01.1999
Language:EN
[1999/02]
Type: A1 Application with search report 
No.:EP0993437
Date:19.04.2000
Language:EN
The application published by WIPO in one of the EPO official languages on 14.01.1999 takes the place of the publication of the European patent application.
[2000/16]
Type: B1 Patent specification 
No.:EP0993437
Date:08.11.2006
Language:EN
[2006/45]
Search report(s)International search report - published on:EP14.01.1999
ClassificationIPC:C07C229/58, C07C237/30, C07C215/68, C07C243/38, C07D257/04, C07D295/12, A61K31/195
[2000/16]
CPC:
C07D213/40 (EP); C07C229/58 (EP,KR); A61P17/06 (EP);
A61P25/28 (EP); A61P29/00 (EP); A61P3/10 (EP);
A61P35/00 (EP); A61P37/02 (EP); A61P43/00 (EP);
A61P9/00 (EP); A61P9/04 (EP); A61P9/10 (EP);
C07C215/68 (EP); C07C237/30 (EP); C07C237/32 (EP);
C07C237/36 (EP); C07C243/38 (EP); C07C311/44 (EP);
C07D257/04 (EP); C07D295/155 (EP); C07D295/32 (EP);
C07D333/20 (EP) (-)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2000/16]
Extension statesAL01.02.2000
LT01.02.2000
LV01.02.2000
MK01.02.2000
RO01.02.2000
SI01.02.2000
TitleGerman:2-(4-BROM OR 4-IOD PHENYLAMINO)BENZOESÄUREDERIVATE UND IHRE ANWENDUNG ALS MEK-INHIBITOREN[2000/16]
English:2-(4-BROMO OR 4-IODO PHENYLAMINO) BENZOIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS[2000/16]
French:DERIVES D'ACIDE BENZOIQUE 2-(4-BROMO OU 4-IODO PHENYLAMINO) ET UTILISATION DE CES DERNIERS EN TANT QU'INHIBITEURS DE MEK[2000/16]
Entry into regional phase01.02.2000National basic fee paid 
01.02.2000Designation fee(s) paid 
01.02.2000Examination fee paid 
Examination procedure14.01.1999Request for preliminary examination filed
International Preliminary Examining Authority: EP
11.12.1999Amendment by applicant (claims and/or description)
01.02.2000Examination requested  [2000/16]
06.06.2003Despatch of a communication from the examining division (Time limit: M06)
05.12.2003Reply to a communication from the examining division
14.09.2004Despatch of a communication from the examining division (Time limit: M06)
23.03.2005Reply to a communication from the examining division
21.09.2005Despatch of a communication from the examining division (Time limit: M06)
09.03.2006Reply to a communication from the examining division
10.04.2006Communication of intention to grant the patent
21.08.2006Fee for grant paid
21.08.2006Fee for publishing/printing paid
Opposition(s)09.08.2007No opposition filed within time limit [2007/42]
Fees paidRenewal fee
30.06.2000Renewal fee patent year 03
02.07.2001Renewal fee patent year 04
01.07.2002Renewal fee patent year 05
30.06.2003Renewal fee patent year 06
30.06.2004Renewal fee patent year 07
30.06.2005Renewal fee patent year 08
30.06.2006Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT08.11.2006
BE08.11.2006
CH08.11.2006
CY08.11.2006
FI08.11.2006
LI08.11.2006
NL08.11.2006
DK08.02.2007
SE08.02.2007
GR09.02.2007
PT09.04.2007
GB24.06.2007
LU24.06.2007
MC30.06.2007
[2010/05]
Former [2008/26]AT08.11.2006
BE08.11.2006
CH08.11.2006
FI08.11.2006
LI08.11.2006
NL08.11.2006
DK08.02.2007
SE08.02.2007
GR09.02.2007
PT09.04.2007
GB24.06.2007
MC30.06.2007
Former [2008/21]AT08.11.2006
BE08.11.2006
CH08.11.2006
FI08.11.2006
LI08.11.2006
NL08.11.2006
DK08.02.2007
SE08.02.2007
GR09.02.2007
PT09.04.2007
MC30.06.2007
Former [2008/16]AT08.11.2006
BE08.11.2006
CH08.11.2006
FI08.11.2006
LI08.11.2006
NL08.11.2006
DK08.02.2007
SE08.02.2007
PT09.04.2007
MC30.06.2007
Former [2007/30]AT08.11.2006
BE08.11.2006
CH08.11.2006
FI08.11.2006
LI08.11.2006
NL08.11.2006
SE08.02.2007
Former [2007/29]AT08.11.2006
FI08.11.2006
NL08.11.2006
SE08.02.2007
Cited inInternational search[X]US2077249  (FRITZ MIETZSCH, et al) [X] 1 * page 2, column 2, line 21 - line 26 *;
 [A]US5525625  (BRIDGES ALEXANDER J [US], et al) [A] 1-34* column W *;
 [E]WO9837881  (WARNER LAMBERT CO [US], et al) [E] 1-34 * page 3, line 16 - page 14, line 31 * * page 23, line 25 - page 53, line 4 * * page 72, line 1 - page 79, line 30; claims 6,7 *;
 [X]  - BEKEMEIER H ET AL, "STRUCTURE-ACTIVITY RELATIONSHIP IN NONSTEROIDAL ANTIINFLAMMATORY AGENTS, INCLUDING OSAR IN FENAMATE DERIVATIVES", AGENTS AND ACTIONS SUPPLEMENTS, (19820701), pages 17 - 34, XP002063635 [X] 1,19,20 * see page 25, table I, compound 15; page 24, lines 16 to 28 *
 [X]  - BERNER N H ET AL, "SUBSTITUTED N-PHENYLANTHRANILIC ACID HYDRAZIDES AS POTENTIAL ANTIMALARIAL AND ANTIMICROBIAL AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, (1970), vol. 13, no. 3, pages 552 - 554, XP002063637 [X] 1,19,20 * see page 553, table I, compound 5; page 553, column 2 - 254, column 1 *

DOI:   http://dx.doi.org/10.1021/jm00297a052
 [X]  - R. M. ACHESON ET AL., "The Condensation of Acridone with Tertiary Aromatic Amines and the Ultraviolet Absorption Spectra of the Products", JOURNAL OF THE CHEMICAL SOCIETY., LETCHWORTH GB, (1956), pages 484 - 489, XP002081068 [X] 1,2 * see page 488, last two lines - page 489, middle *

DOI:   http://dx.doi.org/10.1039/jr9560000484
 [X]  - RAMANUJAM P ET AL, "ANTIFUNGAL ACTIVITY OF SOME N-SUBSTITUTED ANTHRANILIC ACID DERIVATIVES", PLANTA MEDICA, (1974), vol. 25, no. 1, pages 43 - 46, XP002063636 [X] 1 * see page 44, table I, compound 6 *
 [X]  - M. KHALIFA ET AL., "Synthesis and Biological Activity of Certain Derivatives of 2,4-Dioxo-1,2,3,4-tetrahydroquinazoline", CHEMICAL ABSTRACTS, (19831107), vol. 99, no. 19, Database accession no. 158369f, page 613, column 2, XP002081073 [X] 1,2 * abstract *
    [ ] - EGYPT. J. CHEM., (1983), vol. 25, no. 3, pages 285 - 291
 [X]  - I. S. SHUL'GA ET AL., "Synthesis of 6-Nitrodiphenylamine-2-carboxylic acid Derivatives, their Physiochemical and Antimicrobial Properties", CHEMICAL ABSTRACTS, (19721106), vol. 77, no. 19, Database accession no. 122522g, page 65, column 1, XP002081074 [X] 1 * abstract *
    [ ] - FARM. ZH., kiev, (1972), vol. 27, no. 3, pages 84 - 85
 [X]  - A. N. GAIDUKEVICH ET AL., "Reactivity of Derivatives of Phenylanthranilic Acid. VII. Acid-base Properties of Derivatives of Phenylanthranilic Acid in Binary Solvent Dioxane-Water", CHEMICAL ABSTRACTS, (19910513), vol. 114, no. 19, Database accession no. 184706m, page 714, column 1, XP002081075 [X] 1 * abstract *
    [ ] - CHEMICAL ABSTRACTS 12TH COLLECTIVE INDEX., COLUMBUS US, (1987), vol. 106-115, page 14641cs, XP002081069 [ ] * column 2, line 44 - line 47 *
    [ ] - ORG. REACT. TARTU), (1990), vol. 27, no. 1-2, pages 87 - 96
 [X]  - I. S. SHUL'GA ET AL., "Synthesie and Phisiochemical and Biological Properties on Diphenylamine-2-carboxylic Acid Derivatives", CHEMICAL ABSTRACTS, (19881024), vol. 109, no. 17, Database accession no. 149000b, page 682, column 1, XP002081076 [X] 1 * abstract *
    [ ] - CHEMICAL ABSTRACTS 12TH COLLECTIVE INDEX., COLUMBUS US, (1987), vol. 106-115, page 15109cs, XP002081070 [ ] * column 2, line 38 - line 41 *
    [ ] - FARM. ZH. (KIEV), (1988), no. 1, pages 42 - 45
 [X]  - V. I. MAKURINA ET AL., "A Study of Acid-base Equilibria in Aqueous Dioxane Solutions of Phenanthranyl Acid Derivatives", CHEMICAL ABSTRACTS, (19840716), vol. 101, no. 3, Database accession no. 22893z, page 549, column 2, XP002081077 [X] 1 * abstract *
    [ ] - CHEMICAL ABSTRACTS 11TH COLLECTIVE INDEX., COLUMBUS US, (1982), vol. 96-105, page 10688cs, XP002081071 [ ] * column 2, lines 12-14 * * column 2, line 23 - line 25 * * column 2, line 34 - line 39 *
    [ ] - ORG. REACT (TARTU), (1983), vol. 20, no. 3, pages 311 - 315
 [X]  - JACEK ROMANOWSKI ET AL., "Use of 2,6-Dichlorobenzonitrile (Dichlobenil) as a Starting Substance for Synthesizing Herbicides Derived from Benzoic Acid", CHEMICAL ABSTRACTS, (19750721), vol. 83, no. 3, Database accession no. 27831x, page 473, column 1, XP002081078 [X] 1 * abstract *
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.