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Extract from the Register of European Patents

EP About this file: EP1015469

EP1015469 - BI- AND TRI-CYCLIC NUCLEOSIDE, NUCLEOTIDE AND OLIGONUCLEOIDE ANALOGUES [Right-click to bookmark this link]
StatusPatent maintained as amended
Status updated on  16.10.2015
Database last updated on 29.03.2025
Most recent event   Tooltip16.10.2015Patent maintained (B2 publication)published on 18.11.2015  [2015/47]
Applicant(s)For all designated states
Exiqon A/S
Skelstedet 16
2950 Vedbæk / DK
[2015/19]
Former [2000/27]For all designated states
Exiqon A/S
Bygstubben 9
2950 Vedbaek / DK
Inventor(s)01 / WENGEL, Jesper
Rugmarken 48
DK-5260 Odense S. / DK
02 / NIELSEN, Poul
Elmevangen 6
DK-7200 Grindsted / DK
[2000/27]
Representative(s)Guardian IP Consulting I/S
Diplomvej, Building 381
2800 Kgs. Lyngby / DK
[2015/47]
Former [2011/20]Olsen, Lars Pallisgaard, et al
Guardian IP Consulting I/S Diplomvej, Bygning 381
2800 Lyngby / DK
Former [2009/42]Harding, Charles Thomas, et al
D Young & Co 120 Holborn London
EC1N 2DY / GB
Former [2003/10]Kiddle, Simon John
Mewburn Ellis, York House, 23 Kingsway
London WC2B 6HP / GB
Former [2000/27]Plougmann, Vingtoft & Partners A/S
Sankt Annae Plads 11, P.O. Box 3007
1021 Copenhagen K / DK
Application number, filing date98942516.014.09.1998
[2000/27]
WO1998DK00393
Priority number, dateDK1997000105412.09.1997         Original published format: DK 105497
DK1997000149219.12.1997         Original published format: DK 149297
DK1998000006116.01.1998         Original published format: DK 6198
DK1998000028603.03.1998         Original published format: DK 28698
DK1998000058529.04.1998         Original published format: DK 58598
US19980088309P05.06.1998         Original published format: US 88309 P
DK1998000075008.06.1998         Original published format: DK 75098
DK1998000098228.07.1998         Original published format: DK 98298
[2000/27]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO9914226
Date:25.03.1999
Language:EN
[1999/12]
Type: A2 Application without search report 
No.:EP1015469
Date:05.07.2000
Language:EN
The application published by WIPO in one of the EPO official languages on 25.03.1999 takes the place of the publication of the European patent application.
[2000/27]
Type: B1 Patent specification 
No.:EP1015469
Date:13.04.2005
Language:EN
[2005/15]
Type: B2 New European patent specification 
No.:EP1015469
Date:18.11.2015
Language:EN
[2015/47]
Search report(s)International search report - published on:EP05.08.1999
ClassificationIPC:C07H21/00
[2000/27]
CPC:
C07H19/04 (EP,KR); A61P31/12 (EP); A61P35/00 (EP);
C07H21/00 (EP)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2015/47]
Former [2000/27]AT,  BE,  CH,  CY,  DE,  DK,  ES,  FI,  FR,  GB,  GR,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  SE 
Extension statesAL12.04.2000
LT12.04.2000
LV12.04.2000
MK12.04.2000
RO12.04.2000
SI12.04.2000
TitleGerman:BI- UND TRI-ZYKLISCHE - NUKLEOSID, NUKLEOTID UND OLIGONUKLEOTID-ANALOGA[2000/27]
English:BI- AND TRI-CYCLIC NUCLEOSIDE, NUCLEOTIDE AND OLIGONUCLEOIDE ANALOGUES[2000/27]
French:ANALOGUES D'OLIGONUCLEOTIDES[2000/27]
Entry into regional phase12.04.2000National basic fee paid 
12.04.2000Designation fee(s) paid 
12.04.2000Examination fee paid 
Examination procedure06.04.1999Request for preliminary examination filed
International Preliminary Examining Authority: EP
12.04.2000Examination requested  [2000/27]
22.01.2001Request for accelerated examination filed
18.05.2001Despatch of a communication from the examining division (Time limit: M13)
18.05.2001Decision about request for accelerated examination - accepted: Yes
11.10.2002Reply to a communication from the examining division
17.02.2003Despatch of a communication from the examining division (Time limit: M06)
23.05.2003Observations by third parties
02.10.2003Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
11.12.2003Reply to a communication from the examining division
11.03.2004Communication of intention to grant the patent
22.04.2004Observations by third parties
06.09.2004Fee for grant paid
06.09.2004Fee for publishing/printing paid
Divisional application(s)EP04020014.9  / EP1557424
EP10161457.6  / EP2253639
EP10185895.9  / EP2341057
EP10185908.0  / EP2341058
Opposition(s)Opponent(s)01  13.01.2006  02.02.2006  ADMISSIBLE
Isis Pharmaceuticals, Inc.
1896 Rutherford Road
Carlsbad CA 92008 / US
Opponent's representative
Hallybone, Huw George
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
 [N/P]
Former [2009/51]
Opponent(s)01  13.01.2006  02.02.2006  ADMISSIBLE
Isis Pharmaceuticals, Inc.
1896 Rutherford Road
Carlsbad CA 92008 / US
Opponent's representative
Hallybone, Huw George
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Former [2006/10]
Opponent(s)01  13.01.2006   
Isis Pharmaceuticals, Inc.
1896 Rutherford Road
Carlsbad CA 92008 / US
Opponent's representative
Hallybone, Huw George
Carpmaels and Ransford, 43-45 Bloomsbury Square
London WC1A 2RA / GB
21.02.2006Invitation to proprietor to file observations on the notice of opposition
03.11.2006Reply of patent proprietor to notice(s) of opposition
08.04.2008Date of oral proceedings
07.08.2008Despatch of minutes of oral proceedings
07.08.2008Despatch of communication that the patent will be revoked
03.09.2013Despatch of a communication from the opposition division (Time limit: M04)
29.11.2013Reply to a communication from the opposition division
21.03.2014Despatch of a communication from the opposition division (Time limit: M04)
27.05.2014Reply to a communication from the opposition division
06.06.2014Despatch of a communication from the opposition division (Time limit: M02)
15.08.2014Reply to a communication from the opposition division
08.09.2014Despatch of interlocutory decision in opposition
18.09.2014Legal effect of interlocutory decision in opposition
09.01.2015Despatch of communication that the patent will be maintained as amended
26.03.2015Fee for printing new specification paid
Appeal following opposition14.10.2008Appeal received No.  T2165/08
17.12.2008Statement of grounds filed
06.03.2013Result of appeal procedure: maintenance in amended form
06.03.2013Date of oral proceedings
11.03.2013Minutes of the oral proceedings despatched
Request for further processing for:11.12.2003Request for further processing filed
11.12.2003Full payment received (date of receipt of payment)
Request granted
26.01.2004Decision despatched
11.10.2002Request for further processing filed
11.10.2002Full payment received (date of receipt of payment)
Request granted
24.10.2002Decision despatched
Fees paidRenewal fee
28.09.2000Renewal fee patent year 03
20.09.2001Renewal fee patent year 04
20.09.2002Renewal fee patent year 05
23.09.2003Renewal fee patent year 06
22.09.2004Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT13.04.2005
FI13.04.2005
NL13.04.2005
DK13.07.2005
GR13.07.2005
SE13.07.2005
PT13.09.2005
CY14.09.2005
IE14.09.2005
LU30.09.2005
MC30.09.2005
[2007/21]
Former [2007/18]AT13.04.2005
FI13.04.2005
NL13.04.2005
DK13.07.2005
GR13.07.2005
SE13.07.2005
PT13.09.2005
IE14.09.2005
LU30.09.2005
MC30.09.2005
Former [2006/40]AT13.04.2005
FI13.04.2005
NL13.04.2005
DK13.07.2005
GR13.07.2005
SE13.07.2005
PT13.09.2005
IE14.09.2005
MC30.09.2005
Former [2006/30]AT13.04.2005
FI13.04.2005
NL13.04.2005
DK13.07.2005
GR13.07.2005
SE13.07.2005
PT13.09.2005
MC30.09.2005
Former [2006/14]AT13.04.2005
FI13.04.2005
NL13.04.2005
DK13.07.2005
GR13.07.2005
SE13.07.2005
PT13.09.2005
Former [2006/13]AT13.04.2005
FI13.04.2005
DK13.07.2005
SE13.07.2005
Former [2005/52]FI13.04.2005
SE13.07.2005
Former [2005/50]SE13.07.2005
Cited inInternational search[DY]  - P.NIELSEN ET AL., "A Novel Class of COnformationally Restricted Oligonucleotide Analogues : Synthesis of 2',3'-Bridged Monomers and RNA-Selective Hybridisation.", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS., LETCHWORTH GB, (19970507), no. 9, pages 825 - 826, XP002046993 [DY] 1-75,80-140 * see page 825, compounds 5 and x *

DOI:   http://dx.doi.org/10.1039/a608231i
 [Y]  - V.E.MARQUEZ ET AL., "Nucleosides with a Twist. Can Fixed Forms of Sugar Ring Pucker Influence Biological Activity in Nucleosides and Oligonucleotides ?", JOURNAL OF MEDICINAL CHEMISTRY., WASHINGTON US, (19960913), vol. 39, no. 19, pages 3739 - 3747, XP002094300 [Y] 1-75,80-140 * the whole document *

DOI:   http://dx.doi.org/10.1021/jm960306+
 [Y]  - M.BOLLI ET AL., "Bicyclo-DNA : A Hoogsteen-Selective Pairing System.", CHEMISTRY AND BIOLOGY, (199603), no. 3, pages 197 - 206, XP002094301 [Y] 1-75,80-140 * the whole document *

DOI:   http://dx.doi.org/10.1016/S1074-5521(96)90263-X
 [DA]  - C.G.YANNOPOULOS ET AL., "2',3'-Cyclopropanated Nucleoside Dimers.", SYNLETT., STUTTGART DE, (1997), no. 4, pages 378 - 380, XP002046994 [DA] 1 * the whole document *

DOI:   http://dx.doi.org/10.1055/s-1997-802
 [A]  - G.ZIGEUNER ET AL., "Heterocycles. XVI. 1,4-Dimethyl-3-acetoxy-7-acetamido-2-oxabicyclo(2.2.1)heptane.", CHEMICAL ABSTRACTS, (19690106), vol. 70, no. 1, Database accession no. 3737b, page 343, column 1, XP002046995 [A] 1 * abstract *
    [ ] - MONATSCH. CHEM., (1968), vol. 99, no. 5, pages 2111 - 2120
 [PX]  - R.KUMAR ET AL., "The first Analogues of LNA (Locked Nucleic Acids) : Phosphorothioate-LNA and 2'-Thio-LNA.", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, (1998), no. 8, pages 2219 - 2222, XP002094302 [PX] 1-75,80-140 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0960-894X(98)00366-7
 [PX]  - S.K.SINGH ET AL., "LNA (Locked Nucleic Acids) : Synthesis and High-Affinity Nucleic Acid Recognition.", CHEMICAL COMMUNICATIONS., CIETY OF CHEMISTRY GB, (19980221), no. 4, pages 455 - 456, XP002094303 [PX] 1-75,80-140 * the whole document *

DOI:   http://dx.doi.org/10.1039/a708608c
 [PX]  - A.A.KOSHKIN ET AL., "LNA (Locked Nucleic Acids) : Synthesis of the Adenine, Cytosine, Guanine, 5-Methylcytosine, Thymine and Uracil Bicyclonucleoside Monomers, Oligomerisation, and the Unprecedented Nucleic Acid Recognition.", TETRAHEDRON, (1998), vol. 54, pages 3607 - 3630, XP002094304 [PX] 1-75,80-140 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0040-4020(98)00094-5
 [T]  - P.HERDEWIJN, "Targeting RNA with Conformationally Restricted Oligonucleotides.", LIEBIGS ANNALEN: ORGANIC AND BIOORGANIC CHEMISTRY., ISHERS US, (199609), no. 9, pages 1337 - 1348, XP002094305 [T] 1 * the whole document *
other   - "Poster POI-101", THE SIXTEENTH INTERNATIONAL CONGRESS OF HETEROCYCLIC CHEMISTRY, MONTANA STATE UNIVERSITY, (19970810), page 11, XP002959762
    - IMANISHI T., "SYNTHESIS AND PROPERTY OF NOVEL CONFORMATIONALLY CONSTRAINED NUCLEOSIDE AND OLIGONUCLEOTIDE ANALOGES", THE SIXTEENTH INTERNATIONAL CONGRESS OF HETEROCYCLIC CHEMISTRY, MONTANA STATE UNIVERSITY, (19970810), page POI-101, XP002959763
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.