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EP About this file: EP1027455

EP1027455 - METHODS AND COMPOSITIONS FOR TARGETING DNA METABOLIC PROCESSES USING AMINOGLYCOSIDE DERIVATIVES [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 25.05.2007 Database last updated on 15.06.2024
Most recent event Tooltip	25.05.2007	Application deemed to be withdrawn	published on 27.06.2007 [2007/26]
Applicant(s)	For all designated states THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION Towers Office Building Suite 1-110 1224 West Main Street Charlottesville, VA 22903 / US
	[N/P]
Former [2000/33]	For all designated states THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION Towers Office Building, Suite 1-110, 1224 West Main Street Charlottesville, VA 22903 / US
Inventor(s)	01 / HOCKENSMITH, Joel, W. 1328 Tilman Road Charlottesville, VA 22901 / US
	02 / MUTHUSWAMI, Rohini Apartment 23, 820 Dexter Street Denver, CO 80220 / US
	[2000/33]
Representative(s)	Horner, Martin Grenville, et al Marks & Clerk LLP Aurora 120 Bothwell Street Glasgow G2 7JS / GB
	[N/P]
Former [2000/33]	Horner, Martin Grenville, et al Cruikshank & Fairweather 19 Royal Exchange Square Glasgow G1 3AE Scotland / GB
Application number, filing date	98956489.3	28.10.1998
	[2000/33]
	WO1998US23341
Priority number, date	US19970063898P	31.10.1997 Original published format: US 63898 P
	US19980060470	15.04.1998 Original published format: US 60470
	US19980179558	27.10.1998 Original published format: US 179558
	[2000/33]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO9923246
	Date:	14.05.1999
	Language:	EN
	[1999/19]
	Type:	A2 Application without search report
	No.:	EP1027455
	Date:	16.08.2000
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 14.05.1999 takes the place of the publication of the European patent application.
	[2000/33]
Search report(s)	International search report - published on:	US	22.07.1999
	(Supplementary) European search report - dispatched on:	EP	23.01.2003
Classification	IPC:	C12Q1/42, C12Q1/48, A61K38/00, C12N9/14, A61K31/70, G01N33/68	[2002/46]
	CPC:	A61K31/7036 (EP,US); C12N9/14 (EP,US); C12Q1/42 (EP,US); A61K38/00 (EP,US)
	Former IPC [2000/33]	C12Q1/42, C12Q1/48, A61K38/00
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2000/33]
Title	German:	VERFAHREN UND ZUSAMMENSETZUNGEN ZUM BEEINFLUSSEN VON METABOLISCHEN PROZESSEN VON DNA UNTER VERWENDUNG VON AMINOGLYKOSIDDERIVATEN	[2000/33]
	English:	METHODS AND COMPOSITIONS FOR TARGETING DNA METABOLIC PROCESSES USING AMINOGLYCOSIDE DERIVATIVES	[2000/33]
	French:	PROCEDES ET COMPOSITIONS POUR CIBLER LES PROCESSUS METABOLIQUES DES ADN AU MOYEN DE DERIVES D'AMINOGLUCOSIDES	[2000/33]
Biological material	This application mentions deposited biological material, check the file for details
Entry into regional phase	22.05.2000	National basic fee paid
	22.05.2000	Search fee paid
	22.05.2000	Designation fee(s) paid
	22.05.2000	Examination fee paid
Examination procedure	26.05.1999	Request for preliminary examination filed International Preliminary Examining Authority: US
	22.05.2000	Examination requested [2000/33]
	21.02.2005	Despatch of a communication from the examining division (Time limit: M06)
	26.08.2005	Reply to a communication from the examining division
	27.06.2006	Despatch of a communication from the examining division (Time limit: M06)
	09.01.2007	Application deemed to be withdrawn, date of legal effect [2007/26]
	13.02.2007	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2007/26]
Fees paid	Renewal fee
	04.10.2000	Renewal fee patent year 03
	22.10.2001	Renewal fee patent year 04
	21.10.2002	Renewal fee patent year 05
	31.10.2003	Renewal fee patent year 06
	25.10.2004	Renewal fee patent year 07
	27.10.2005	Renewal fee patent year 08
	Penalty fee
	Additional fee for renewal fee
	31.10.2006	09 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[Y] - BIAMONTI G. ET AL., "Total purification of a DNA-dependent ATPase and of a DNA-bindiing protein from human cells.", EMBO J., (1983), vol. 2, no. 2, pages 161 - 165, XP001105079 [Y] 1-12,58,59 * the whole document *
		[Y] - PAZI M.J. AND KADONAGA J.T., "SWI2/SNF2 and related proteins:ATP-driven motors that disrupt protein-DNA interactions?", CELL, (19970321), vol. 88, pages 737 - 740, XP002213671 [Y] 1-12,58,59 * the whole document * DOI: http://dx.doi.org/10.1016/S0092-8674(00)81918-2
		[Y] - MESNER L.D. ET AL., "DNA-dependent Adenosinetriphosphatase A: immunoaffinity purification and characterization of immunological reagents.", BIOCHEMISTRY, (19930803), vol. 32, pages 7772 - 7778, XP001095833 [Y] 1-12,58,59 * the whole document * DOI: http://dx.doi.org/10.1021/bi00081a024
		[Y] - MESNER L.D. ET AL., "DNA-dependent Adenosinetriphosphatase A is the eukaryotic analogue of the bacteriophage T4 gene 44 protein: immunological identity of DNA replication-associated ATPases.", BIOCHEMISTRY, (19911210), vol. 30, pages 11490 - 11494, XP001095986 [Y] 1-12,58,59 * the whole document * DOI: http://dx.doi.org/10.1021/bi00113a002
		[Y] - OKABE I. ET AL., "Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae.", NUCLEIC ACID RES., (19920911), vol. 20, no. 17, pages 4649 - 4655, XP001095981 [Y] 1-12,58,59 * the whole document *
	International search	[A] - ABDEL-MONEM M, DUERWALD H, HOFFMANN-BERLING H, "ENZYMIC UNWINDING OF DNA 2. CHAIN SEPARATION BY AN ATP-DEPENDENT DNA UNWINDING ENZYME", European Journal of Biochemistry, Wiley-Blackwell Publishing Ltd., GB, GB, (19760101), vol. 65, no. 02, doi:10.1111/j.1432-1033.1976.tb10359.x, ISSN 0014-2956, pages 441 - 449, XP002916689 DOI: http://dx.doi.org/10.1111/j.1432-1033.1976.tb10359.x
		[X] - MORITA M., TASAKA M., FUJISAWA H., "DNA PACKAGING ATPASE OF BACTERIOPHAGE T3.", Virology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (19930101), vol. 193., doi:10.1006/viro.1993.1183, ISSN 0042-6822, pages 748 - 752., XP002916690 DOI: http://dx.doi.org/10.1006/viro.1993.1183
		[XP] - SIMONEAU B, ET AL., "HELICASE-PRIMASE INHIBITORS AS NOVEL ANTI-HSV AGENTS", NATIONAL MEETING OF THE AMERICAN CHEMICAL SOCIETY, XX, XX, XX, (19980823), page COMPLETE, XP002916691
		[X] - ROY R., ET AL., "THE DNA-DEPENDENT ATPASE ACTIVITY ASSOCIATED WITH THE CLASS II BASIC TRANSCRIPTION FACTOR BTF2/TFIIH.", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (19940101), vol. 269., ISSN 0021-9258, pages 9826 - 9832., XP002916692
		[X] - SERIZAWA H., CONAWAY R. C., CONAWAY J. W., "MULTIFUNCTIONAL RNA POLYMERASE II INITIATION FACTOR & FROM RAT LIVER. RELATIONSHIP BETWEEN CARBOXYL-TERMINAL DOMAIN KINASE, ATPASEAND DNA HELICASE ACTIVITIES.", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (19930815), vol. 268., no. 23., ISSN 0021-9258, pages 17300 - 17308., XP002916693
		[X] - GEORGE J. W., ET AL., "INHIBITION OF DNA HELICASE II UNWINDING AND ATPASE ACTIVITIES BY DNA-INTERACTING LIGANDS.", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (19920525), vol. 267., no. 15., ISSN 0021-9258, pages 10683 - 10689., XP002916744
		[X] - THOMAS D. C., REIN D. C., MEYER R. R., "PURIFICATION AND ENZYMOLOGICAL CHARACTERIZATION OF DNA-DEPENDENT ATPASE IV FROM THE NOVIKOFF HEPATOMA.", Nucleic Acids Research, Information Retrieval Ltd., GB, GB, (19880101), vol. 16., no. 14., ISSN 0305-1048, pages 6447 - 6464., XP002916694
		[X] - BISWAS E. E., BISWAS B., BISHOP J. E., "DNABETA PROTEIN OF ESCHERICHIA COLI: MECHANISM OF NUCLEOTIDE BINDING, HYDROLYSIS, AND MODULATION BY DNAC PROTEIN.", Biochemistry, American Chemical Society, US, US, (19860101), vol. 25., no. 23., doi:10.1021/bi00371a019, ISSN 0006-2960, pages 7368 - 7374., XP002916695 DOI: http://dx.doi.org/10.1021/bi00371a019
		[YP] - HU G.-F., "NEOMYCIN INHIBITS ANGIOGENIN-INDUCED ANGIOGENESIS.", Proceedings of the National Academy of Sciences, National Academy of Sciences, US, US, (19980801), vol. 95., doi:10.1073/pnas.95.17.9791, ISSN 0027-8424, pages 9791 - 9795., XP002916696 DOI: http://dx.doi.org/10.1073/pnas.95.17.9791
		[X] - HU G-F, RIORDAN J F, "ACCUMULATION AND DISSOCIATION OF HUMAN ANGIOGENIN IN THE NUCLEUS OFHUMAN ENDOTHELIAL CELLS", The FASEB Journal, Federation of American Societies for Experimental Biology, US, US, (19970101), vol. 11, ISSN 0892-6638, XP002916701
		[A] - OCHEM A. E., ET AL., "FUNCTIONAL PROPERTIES OF THE SEPARATE SUBUNITS OF HUMAN DNA HELICASE 22/KU AUTOANTIGEN.", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (19971121), vol. 272., no. 47., doi:10.1074/jbc.272.47.29919, ISSN 0021-9258, pages 29919 - 29926., XP002916697 DOI: http://dx.doi.org/10.1074/jbc.272.47.29919
		[A] - VISHWANATHA J. K., TAUER T. J., RHODE II, S. L., "CHARACTERIZATION OF THE HELA CELL SINGLE-STRANDED DNA-DEPENDENT ATPASE/DNA HELICASE II.", MOLECULAR AND CELLULAR BIOCHEMISTRY, NORWELL, MA, US, US, (19950101), vol. 146., doi:10.1007/BF00944604, ISSN 0300-8177, pages 121 - 126., XP002916698 DOI: http://dx.doi.org/10.1007/BF00944604
		[A] - CAO Q. P., ET AL., "DNA-DEPENDENT ATPASE FROM HELA CELLS IS RELATED TO HUMAN KU AUTOANTIGEN.", Biochemistry, American Chemical Society, US, US, (19940101), vol. 33., no. 28., doi:10.1021/bi00194a021, ISSN 0006-2960, pages 8548 - 8557., XP002916699 DOI: http://dx.doi.org/10.1021/bi00194a021
		[A] - TUTEJA N., ET AL., "HUMAN DNA HELICASE II: A NOVEL DNA UNWINDING ENZYME IDENTIFIED AS THE KU AUTOANTIGEN.", EMBO JOURNAL., OXFORD UNIVERSITY PRESS, SURREY., GB, GB, (19940101), vol. 13., no. 20., ISSN 0261-4189, pages 4991 - 5001., XP002916700
		[XP] - LUN ET AL., "Helicase blockade by CI-958, a drug for prostate cancer", PROC. AM. ASSOC. CANCER RES., (199703), vol. 38, page 306, ABSTRACT 2068, XP002932089
		[XP] - NARENDRA TUTEJA ET AL., "Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents", BIOCHEM. BIOPHYS. RES. COMM., (1997), vol. 236, no. 3, pages 636 - 640, XP002932090 DOI: http://dx.doi.org/10.1006/bbrc.1997.7021
		[X] - LUN ET AL., "DNA helicase blockade by anthracycline antibiotics", PROC. AM. ASSOC. CANCER RES., (1995), vol. 36, page 351, ABSTRACT 2091, XP002932091
		[Y] - VILLANI GIUSEPPE ET AL., "Effect of the major DNA adduct of the antitumor drug cis-diamminedichloroplatinum(II) on the activity of a helicase essential for DNA relication, the herpes simplex virus type-I origin-binding protein", J. BIOL. CHEM., (19940826), vol. 269, no. 34, pages 21676 - 21681, XP002932092
		[A] - EBISUZAKI ET AL., "Postinfection control in T4 bacteriophage infection: inhibition of the rep function", J. VIROL., (198103), vol. 37, no. 3, pages 893 - 898, XP002932093
		[A] - SUSUMU MITSUHASHI ET AL, MICROBIAL DRUG RESTISTANCE, BALTIMORE UNIV. PRESS., (1975), XP002932094 [A] * The relationship of aminoglycoside permeability to streptomycin and gentamicin susceptibility of Pseudomonas aeruginosa; page 475 - page 490 *
		[A] - NEU, H.C. ET AL, "Overview of mechanisms of bacterial resistance", DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, (1989), vol. 12, pages 109S - 116S, XP002932095
		[XP] - HU, GUO-FU, "Neomycin inhibitits angiogenin-induced angiogenesis", PROC. NATL. ACAD. SCI. USA., (199808), vol. 95, pages 9791 - 9795, XP002932096 DOI: http://dx.doi.org/10.1073/pnas.95.17.9791
		[X] - MAURIN ET AL., "Bartonella (Rochalimaea) quintana infections", CLINICAL MICROBIOLOGY REVIEWS, (199607), vol. 9, no. 3, pages 273 - 292, XP002932097

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