EP1047416 - PHARMACEUTICAL COMPOSITIONS COMPRISING DISULFIRAM FOR INHIBITING ANGIOGENESIS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 29.05.2009 Database last updated on 02.09.2024 | Most recent event Tooltip | 30.09.2011 | Lapse of the patent in a contracting state New state(s): CY | published on 02.11.2011 [2011/44] | Applicant(s) | For all designated states YEDA RESEARCH AND DEVELOPMENT CO., LTD. The Weizmann Institute of Science P.O. Box 95 76100 Rehovot / IL | [2007/44] |
Former [2007/43] | For all designated states YEDA RESEARCH AND DEVELOPMEMT CO., LTD. The Weizmann Institute of Science P.O. Box 95 76100 Rehovot / IL | ||
Former [2000/44] | For all designated states YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. Weizmann Institute of Science Herzl Street at Yavne Road P.O. Box 95 Rehovot 76100 / IL | Inventor(s) | 01 /
MARIKOVSKY, Moshe Shazar Street 9 76804 Mazkeret Batya / IL | [2000/44] | Representative(s) | Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE | [N/P] |
Former [2008/35] | Vossius & Partner Siebertstrasse 3 81675 München / DE | ||
Former [2000/44] | VOSSIUS & PARTNER Siebertstrasse 4 81675 München / DE | Application number, filing date | 99900280.1 | 11.01.1999 | [2000/44] | WO1999IL00017 | Priority number, date | IL19980122892 | 11.01.1998 Original published format: IL 12289298 | [2000/44] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO9934784 | Date: | 15.07.1999 | Language: | EN | [1999/28] | Type: | A2 Application without search report | No.: | EP1047416 | Date: | 02.11.2000 | Language: | EN | The application published by WIPO in one of the EPO official languages on 15.07.1999 takes the place of the publication of the European patent application. | [2000/44] | Type: | B1 Patent specification | No.: | EP1047416 | Date: | 23.07.2008 | Language: | EN | [2008/30] | Search report(s) | International search report - published on: | EP | 08.09.2000 | Classification | IPC: | A61K31/27, A61P25/00, A61P27/02, A61P27/06, A61P35/00 | [2007/32] | CPC: |
A61K31/27 (EP,US);
A61P17/00 (EP);
A61P17/02 (EP);
A61P19/00 (EP);
A61P21/00 (EP);
A61P25/00 (EP);
A61P27/02 (EP);
A61P27/06 (EP);
A61P35/00 (EP);
A61P35/04 (EP);
A61P43/00 (EP);
A61P9/00 (EP);
A61P9/10 (EP)
(-)
|
Former IPC [2000/44] | A61K31/27 | Designated contracting states | AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2000/44] | Extension states | AL | 10.08.2000 | LT | 10.08.2000 | LV | 10.08.2000 | MK | 10.08.2000 | RO | 10.08.2000 | SI | 10.08.2000 | Title | German: | DISULFIRAM ENTHALTENDE ARZNEIMITTEL | [2008/19] | English: | PHARMACEUTICAL COMPOSITIONS COMPRISING DISULFIRAM FOR INHIBITING ANGIOGENESIS | [2000/44] | French: | COMPOSITIONS PHARMACEUTIQUES CONTENANT DU DISULFIRAME POUR INHIBER L'ANGIOGENÈSE | [2007/32] |
Former [2000/44] | DISULFIRAM ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN ZUR HEMMUNG DER ANGIOGENESE | ||
Former [2000/44] | COMPOSITIONS PHARMACEUTIQUES CONTENANT DU DISULFIRAME | Entry into regional phase | 10.08.2000 | National basic fee paid | 10.08.2000 | Designation fee(s) paid | 10.08.2000 | Examination fee paid | Examination procedure | 01.08.1999 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 10.08.2000 | Examination requested [2000/44] | 16.01.2003 | Despatch of a communication from the examining division (Time limit: M04) | 26.05.2003 | Reply to a communication from the examining division | 24.06.2004 | Despatch of a communication from the examining division (Time limit: M04) | 27.10.2004 | Reply to a communication from the examining division | 31.01.2006 | Despatch of a communication from the examining division (Time limit: M02) | 06.04.2006 | Reply to a communication from the examining division | 19.07.2007 | Cancellation of oral proceeding that was planned for 14.09.2007 | 19.07.2007 | Minutes of oral proceedings despatched | 13.08.2007 | Communication of intention to grant the patent | 14.09.2007 | Date of oral proceedings (cancelled) | 20.12.2007 | Fee for grant paid | 20.12.2007 | Fee for publishing/printing paid | Opposition(s) | 24.04.2009 | No opposition filed within time limit [2009/27] | Fees paid | Renewal fee | 11.01.2001 | Renewal fee patent year 03 | 14.01.2002 | Renewal fee patent year 04 | 14.01.2003 | Renewal fee patent year 05 | 14.01.2004 | Renewal fee patent year 06 | 12.01.2005 | Renewal fee patent year 07 | 12.01.2006 | Renewal fee patent year 08 | 12.01.2007 | Renewal fee patent year 09 | 14.01.2008 | Renewal fee patent year 10 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | AT | 23.07.2008 | BE | 23.07.2008 | CY | 23.07.2008 | FI | 23.07.2008 | IT | 23.07.2008 | GR | 24.10.2008 | ES | 03.11.2008 | PT | 23.12.2008 | LU | 11.01.2009 | MC | 31.01.2009 | [2011/44] |
Former [2011/25] | AT | 23.07.2008 | |
BE | 23.07.2008 | ||
FI | 23.07.2008 | ||
IT | 23.07.2008 | ||
GR | 24.10.2008 | ||
ES | 03.11.2008 | ||
PT | 23.12.2008 | ||
LU | 11.01.2009 | ||
MC | 31.01.2009 | ||
Former [2010/06] | AT | 23.07.2008 | |
BE | 23.07.2008 | ||
FI | 23.07.2008 | ||
IT | 23.07.2008 | ||
ES | 03.11.2008 | ||
PT | 23.12.2008 | ||
MC | 31.01.2009 | ||
Former [2009/19] | AT | 23.07.2008 | |
BE | 23.07.2008 | ||
FI | 23.07.2008 | ||
ES | 03.11.2008 | ||
PT | 23.12.2008 | ||
Former [2009/15] | AT | 23.07.2008 | |
FI | 23.07.2008 | ||
ES | 03.11.2008 | ||
PT | 23.12.2008 | ||
Former [2009/12] | FI | 23.07.2008 | |
ES | 03.11.2008 | ||
PT | 23.12.2008 | ||
Former [2009/09] | ES | 03.11.2008 | |
PT | 23.12.2008 | Cited in | International search | [A]EP0284879 (MERRELL DOW PHARMA [US]) [A] 1-39 * claim - *; | [D]US4870101 (KU GEORGE [US], et al); | [X]WO9530415 (UNIV EMORY [US]) [X] 1-13,22-24,32-34 * page 7, lines 17-32 * * page 35, lines 1-8 * * page 62, lines 11-22; claims 17-50 * * page 39, lines 36,37 * * page 40 *; | [X] - M. TAKAHASHI, "Inhibition of spontaneous leukemia in F-344 rats by tetramethylthiuram disulfide", GANN, (1983), vol. 74, no. 6, pages 810 - 813, XP002108882 [X] 1-13,20,22-24,31 * the whole document * | [X] - G. WEBER, "Neue systemische Therapie der Psoriasis", HAUTARZT, (1985), vol. 36, no. 1, pages 20 - 24, XP002108883 [X] 1-13,22-24 * the whole document * | [X] - B.S. WARREN, "Mechanisms of inhibition of tumor progression", BASIC LIFE SCI., (1993), vol. 61, pages 279 - 289, XP002108884 [X] 1-13,20-24,31 * page 285; figure 3; table 2 * | [X] - G.Y. LIU, "Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through cordinative modulation of NFkB, c-fos/c-jun, and p53 proteins", MOL. CARCINOGEN., (1988), vol. 22, no. 4, pages 235 - 246, XP002108885 [X] 1-13,20-24,31 * the whole document * DOI: http://dx.doi.org/10.1002/(SICI)1098-2744(199808)22:4<235::AID-MC5>3.0.CO;2-I | [X] - D.J. STEWART, "Phase I study of the combination of disulfiram with cisplatin", AM. J. CLIN. ONCOL., (1987), vol. 10, no. 6, pages 517 - 519, XP002108886 [X] 1-13,20-24,31 * the whole document * | [X] - H.K.A. SCHIRMER, "Disulfiram and tumor inhibition", TRANSACTIONS OF THE AMERICAN ASSOCIATION OF GENITO-URINARY SURGEONS, (1966), vol. 58, pages 63 - 66, XP002108887 [X] 1-13,20-24,31 * the whole document * | [A] - G.N. HANNAN, "Regulation of polypeptide synthesis in endothelial cells and hybridoma cells by the copper ionophore disulfiram", CELL. BIOL. INT. REP., (1982), vol. 6, no. 5, pages 423 - 432, XP002108888 [A] 1-39 * the whole document * DOI: http://dx.doi.org/10.1016/0309-1651(82)90114-X | Examination | - BOLONTRADE M.F. ET AL, "Angiogenesis is an early event in the development of chemically induced skin tumors", CARCINOGENESIS, OXFORD, (1998), vol. 19, no. 12, pages 2107 - 2113 |