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Extract from the Register of European Patents

EP About this file: EP1066050

EP1066050 - APPLICATION OF HSP70 PROTEINS [Right-click to bookmark this link]
StatusPatent maintained as amended
Status updated on  30.04.2010
Database last updated on 11.04.2026
Most recent event   Tooltip10.09.2010Petition for review: decisionpublished on 13.10.2010  [2010/41]
Applicant(s)For all designated states
Multhoff, Gabriele, Prof. Dr.
Kirchenstrasse 17c
81675 München / DE
[2005/24]
Former [2001/02]For all designated states
Multhoff, Gabriele
Kirchenstrasse 17c
81675 München / DE
Inventor(s)01 / see applicant
...
 [2001/02]
Representative(s)Steinecke, Peter, et al
Müller Fottner Steinecke
Rechtsanwalts- und Patentanwaltspartnerschaft mbB
Römerstrasse 16 b
52428 Jülich / DE
[N/P]
Former [2010/09]Steinecke, Peter, et al
Müller Fottner Steinecke Rechtsanwälte - Patentanwälte Technologiezentrum Jülich Karl-Heinz-Beckurts-Strasse 13
52428 Jülich / DE
Former [2004/06]Knauthe Eggers
Rechtsanwälte Patentanwälte Postfach 31 01 40
80102 München / DE
Former [2001/02]VOSSIUS & PARTNER
Siebertstrasse 4
81675 München / DE
Application number, filing date99913314.329.03.1999
[2001/02]
WO1999EP02165
Priority number, dateDE1998101376027.03.1998         Original published format: DE 19813760
WO1999EP0205626.03.1999         Original published format: PCT/EP99/02056
[2002/01]
Former [2001/02]DE1998101376027.03.1998
WO2020EP0569926.03.1999
Filing languageDE
Procedural languageDE
PublicationType: A2 Application without search report
No.:WO9949881
Date:07.10.1999
Language:DE
[1999/40]
Type: A2 Application without search report 
No.:EP1066050
Date:10.01.2001
Language:DE
The application published by WIPO in one of the EPO official languages on 07.10.1999 takes the place of the publication of the European patent application.
[2001/02]
Type: B1 Patent specification 
No.:EP1066050
Date:15.06.2005
Language:DE
[2005/24]
Type: B2 New European patent specification 
No.:EP1066050
Date:02.06.2010
Language:DE
[2010/22]
Search report(s)International search report - published on:EP23.12.1999
ClassificationIPC:A61K38/17, A61K35/26, A61P35/00, A61P37/04
[2004/29]
CPC:
C12N5/0646 (EP,US); A61K38/1709 (EP,US); A61K38/2013 (EP,US);
A61K38/208 (EP,US); A61K38/2086 (EP,US); A61K40/15 (EP,US);
A61K40/4262 (EP,US); A61P31/00 (EP); A61P35/00 (EP);
A61P37/04 (EP); A61P43/00 (EP); A61K2239/31 (EP,US);
A61K2239/50 (EP,US); C12N2501/07 (EP,US) (-)
C-Set:
A61K38/1709, A61K2300/00 (US,EP);
A61K38/2013, A61K2300/00 (EP,US);
A61K38/2086, A61K2300/00 (US,EP);
A61K38/208, A61K2300/00 (US,EP)
Former IPC [2001/02]A61K38/17, A61K35/26
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2001/02]
TitleGerman:VERWENDUNG VON HSP70 PROTEIN[2001/02]
English:APPLICATION OF HSP70 PROTEINS[2001/02]
French:UTILISATION DE PROTEINES HSP70[2001/02]
Entry into regional phase23.10.2000National basic fee paid 
23.10.2000Designation fee(s) paid 
23.10.2000Examination fee paid 
Examination procedure20.09.1999Request for preliminary examination filed
International Preliminary Examining Authority: EP
23.10.2000Examination requested  [2001/02]
29.03.2001Despatch of a communication from the examining division (Time limit: M06)
08.10.2001Reply to a communication from the examining division
11.10.2002Despatch of a communication from the examining division (Time limit: M04)
21.02.2003Reply to a communication from the examining division
07.06.2004Communication of intention to grant the patent
21.01.2005Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
31.03.2005Fee for grant paid
31.03.2005Fee for publishing/printing paid
Opposition(s)Opponent(s)01  14.03.2006  22.03.2006  ADMISSIBLE
Dr. Kübler GmbH
Siebertstrasse 6
D-81675 München / DE
Opponent's representative
Egger, Matthes
RAe Dr. Beckstein und Kollegen Thumenberger Weg 12
90491 Nürnberg / DE
 [2009/41]
Former [2006/18]
Opponent(s)01  14.03.2006   
Dr. Kübler GmbH
Siebertstrasse 6
D-81675 München / DE
Opponent's representative
Nätebusch, Roderich
Ottostrasse 24a
85521 Ottobrunn / DE
24.04.2006Invitation to proprietor to file observations on the notice of opposition
05.07.2006Reply of patent proprietor to notice(s) of opposition
13.07.2006Communication of observations of patent proprietor (Time limit: M02)
12.09.2006Reply of parties involved to observations of patent proprietor
30.09.2008Date of oral proceedings
17.10.2008Despatch of interlocutory decision in opposition
17.10.2008Despatch of minutes of oral proceedings
08.09.2009Legal effect of interlocutory decision in opposition
11.03.2010Despatch of communication that the patent will be maintained as amended
13.04.2010Fee for printing new specification paid
Appeal following opposition17.12.2008Appeal received No.  T2351/08
20.02.2009Statement of grounds filed
08.09.2009Result of appeal procedure: appeal of the opponent was rejected
08.09.2009Date of oral proceedings
23.09.2009Minutes of the oral proceedings despatched
Petition(s) for review:09.04.2010Petition for review received
 Number:  R0020/09
 for appeal No.  T2351/08-3304
 Petitioner:  OP01
07.09.2010Decision:  Petition for review obviously unsubstantiated only.
Request for further processing for:31.03.2005Request for further processing filed
31.03.2005Full payment received (date of receipt of payment)
Request granted
14.04.2005Decision despatched
Fees paidRenewal fee
30.03.2001Renewal fee patent year 03
28.03.2002Renewal fee patent year 04
31.03.2003Renewal fee patent year 05
20.02.2004Renewal fee patent year 06
21.03.2005Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY15.06.2005
FI15.06.2005
IE15.06.2005
NL15.06.2005
DK15.09.2005
GR15.09.2005
SE15.09.2005
PT24.11.2005
LU31.03.2006
MC31.03.2006
[2009/02]
Former [2007/22]FI15.06.2005
IE15.06.2005
NL15.06.2005
DK15.09.2005
GR15.09.2005
SE15.09.2005
PT24.11.2005
LU31.03.2006
MC31.03.2006
Former [2006/46]FI15.06.2005
IE15.06.2005
NL15.06.2005
DK15.09.2005
GR15.09.2005
SE15.09.2005
PT24.11.2005
MC31.03.2006
Former [2006/26]FI15.06.2005
IE15.06.2005
NL15.06.2005
DK15.09.2005
GR15.09.2005
SE15.09.2005
PT24.11.2005
Former [2006/25]FI15.06.2005
IE15.06.2005
NL15.06.2005
GR15.09.2005
SE15.09.2005
PT24.11.2005
Former [2006/22]FI15.06.2005
NL15.06.2005
GR15.09.2005
SE15.09.2005
PT24.11.2005
Former [2006/14]FI15.06.2005
GR15.09.2005
SE15.09.2005
PT24.11.2005
Former [2005/52]FI15.06.2005
SE15.09.2005
Former [2005/50]SE15.09.2005
Cited inInternational search[A]   S. SUZUKI ET AL.: "IL-12 induced enhancement of MHC class I antigen expression on cancer cells.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 37, March 1996 (1996-03-01), USA, pages 445, XP002118456 [A] 15-17 * Zusammenfassung 3036 *
 [DA]   Y. TAMURA ET AL.: "Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations.", SCIENCE, vol. 278, no. 5335, 3 October 1997 (1997-10-03), Washington, DC, USA, pages 117 - 120, XP002118457 [DA] 1-30 * page 118, column R, line 11 - line 32 *

DOI:   http://dx.doi.org/10.1126/science.278.5335.117
 [A]   G. MULTHOFF ET AL.: "CD3- large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcoma cells.", BLOOD, vol. 86, no. 4, 15 August 1995 (1995-08-15), New York, NY, USA, pages 1374 - 1382, XP002090860 [A] 1-30 * the whole document *
 [A]   C. SAVARY ET AL.: "Role of heat shock proteins (Hsp) in immunity to breast cancer.", BREAST CANCER RESEARCH AND TREATMENT, vol. 46, no. 1, October 1997 (1997-10-01), Den Haag, Niederlande, pages 69, XP002118458 [A] 1-30 * the whole document *
 [A]   G. MULTHOFF ET AL.: "Heat shock proteins and the immune response.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 851, 1998, New York, NY, USA, pages 86 - 93, XP002118459 [A] 1-30 * page 89, line 3 - line 30 *

DOI:   http://dx.doi.org/10.1111/j.1749-6632.1998.tb08980.x
 [A]   H. UDONO ET AL.: "Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.", THE JOURNAL OF IMMUNOLOGY, vol. 152, no. 11, 1 June 1994 (1994-06-01), Baltimore, MD, USA, pages 5398 - 5403, XP002118460 [A] 1-30 * abstract * * page 5402, column L, line 10 - line 35 *
 [DA]   C. BOTZLER ET AL.: "Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response.", CELL STRESS AND CHAPERONES, vol. 3, no. 1, March 1998 (1998-03-01), pages 6 - 11, XP002118461 [DA] 1-30 * abstract *

DOI:   http://dx.doi.org/10.1379/1466-1268(1998)003<0006:DOELEO>2.3.CO;2
 [DA]   G. MULTHOFF ET AL.: "The role of heat shock proteins in the stimulation of an immune response.", BIOLOGICAL CHEMISTRY, vol. 379, no. 3, March 1998 (1998-03-01), pages 295 - 300, XP002118462 [DA] 1-30 * page 296, column R, line 21 - page 297, column L, line 2 * * page 297, column R, line 54 - page 298, column L, line 25 *
OppositionWO9115219
 US5348945
 WO9321529
 WO9503418
 EP0584715
   IMMUNOLOGICAL INVESTIGATIONS, vol. 29, no. 2, 2000, pages 131 - 137
   Internet homepage www.multiimmune.de
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.