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EP About this file: EP1071745

EP1071745 - PROCESS FOR SYNTHESIZING COX-2 INHIBITORS [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 10.06.2005 Database last updated on 02.09.2024
Most recent event Tooltip	05.06.2009	Change - representative	published on 08.07.2009 [2009/28]
Applicant(s)	For all designated states Merck & Co., Inc. 126 East Lincoln Avenue Rahway, New Jersey 07065 / US
	[N/P]
Former [2001/05]	For all designated states MERCK & CO., INC. 126 East Lincoln Avenue Rahway, New Jersey 07065 / US
Inventor(s)	01 / CORLEY, Edward, G. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	02 / DAVIES, Ian, W. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	03 / LARSEN, Robert, D. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	04 / PYE, Philip, J. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	05 / ROSSEN, Kai 126 East Lincoln Avenue Rahway, NJ 07065 / US
	[2001/05]
Representative(s)	Horgan, James Michael Frederic Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road, Harlow Essex CM20 2QR / GB
	[N/P]
Former [2009/28]	Horgan, James Michael Frederic Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow Essex CM20 2QR / GB
Former [2001/05]	Horgan, James Michael Frederic Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR / GB
Application number, filing date	99918706.5	20.04.1999
	[2001/05]
	WO1999US08645
Priority number, date	US19980082888P	24.04.1998 Original published format: US 82888 P
	US19980085668P	15.05.1998 Original published format: US 85668 P
	[2001/05]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO9955830
	Date:	04.11.1999
	Language:	EN
	[1999/44]
	Type:	A2 Application without search report
	No.:	EP1071745
	Date:	31.01.2001
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 04.11.1999 takes the place of the publication of the European patent application.
	[2001/05]
	Type:	B1 Patent specification
	No.:	EP1071745
	Date:	04.08.2004
	Language:	EN
	[2004/32]
Search report(s)	International search report - published on:	US	29.12.1999
	(Supplementary) European search report - dispatched on:	EP	28.03.2002
Classification	IPC:	C07C251/30, C07D213/61	[2002/20]
	CPC:	C07D213/61 (EP,US); C07D401/04 (KR); A61P15/00 (EP); A61P29/00 (EP); A61P31/12 (EP); A61P31/16 (EP); (+) A61P35/00 (EP); A61P35/04 (EP); A61P43/00 (EP); C07C251/30 (EP,US) (-)
	Former IPC [2001/05]	C12N1/00
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, NL, PT, SE [2001/05]
Extension states	AL	24.11.2000
	LT	24.11.2000
	LV	24.11.2000
	MK	24.11.2000
	RO	24.11.2000
	SI	24.11.2000
Title	German:	VERFAHREN ZUR SYNTHESE VON COX-2 INHIBITOREN	[2001/05]
	English:	PROCESS FOR SYNTHESIZING COX-2 INHIBITORS	[2001/05]
	French:	PROCEDE DE SYNTHESE D'INHIBITEURS DE COX-2	[2001/05]
Entry into regional phase	24.11.2000	National basic fee paid
	24.11.2000	Search fee paid
	24.11.2000	Designation fee(s) paid
	24.11.2000	Examination fee paid
Examination procedure	22.11.1999	Request for preliminary examination filed International Preliminary Examining Authority: US
	24.11.2000	Examination requested [2001/05]
	29.07.2002	Despatch of a communication from the examining division (Time limit: M04)
	27.11.2002	Reply to a communication from the examining division
	20.12.2002	Despatch of a communication from the examining division (Time limit: M04)
	03.03.2003	Reply to a communication from the examining division
	10.04.2003	Communication of intention to grant the patent
	20.10.2003	Fee for grant paid
	20.10.2003	Fee for publishing/printing paid
	20.10.2003	Despatch of a communication from the examining division (Time limit: M06)
	26.04.2004	Reply to a communication from the examining division
Opposition(s)	06.05.2005	No opposition filed within time limit [2005/30]
Fees paid	Renewal fee
	02.05.2001	Renewal fee patent year 03
	02.05.2002	Renewal fee patent year 04
	07.04.2003	Renewal fee patent year 05
	06.04.2004	Renewal fee patent year 06
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[A]GB1397869 (MERCK SHARP & DOHME) [A] 1-22* page 3, line 17 - line 20 *;
		[X]WO9006913 (HOECHST AG [DE]) [X] 23,24,27 * claim 1 *;
		[A]WO9803484 (MERCK FROSST CANADA INC [CA], et al) [A] 1-22 * claim 1 *;
		[X] - PETRICH, S A ET AL, "The Reaction of a benzotriazole substituted vinamidinium salt with Grignard Reagents", HETEROCYCLES, (1994), vol. 39, no. 2, pages 623 - 637, XP000994905 [X] 23,24,27 * examples 2,7 *
		[X] - BACHER E ET AL, "1-Acceptorsubstituierte Vinamidiniumsalze : Stabilität und Reaktivität", ZEITSCHRIFT FÜT NATURFORSCHUNG. SECTION B. A JOURNAL OF CHEMICAL SCIENCES, (1989), vol. 44, no. 7, pages 839 - 849, XP000994904 [X] 23-26 * examples 14A,14D,14F,14G,14K *
		[X] - LIEPA A J, "A Synthesis of Hydroxylated Isoflavylium Salts and their Reduction Products.", AUSTRALIAN JOURNAL OF CHEMISTRY, (1981), vol. 34, no. 12, pages 2647 - 2655, XP000994913 [X] 23,24 * examples 5A-5D *
		[X] - REICHARDT C ET AL, "SYNTHESEN MIT SUBSTITUIERTEN MALONDIALDEHYDEN, XIX DARSTELLUNG FLUORSUBSTITUIERTER CARBO- UND HETEROCYCLEN", JUSTUS LIEBIGS ANNALEN DER CHEMIE,VERLAG CHEMIE GMBH. WEINHEIM,DE, (1975), no. 3, ISSN 0075-4617, pages 470 - 483, XP000994953 [X] 23-25 * example 2 * DOI: http://dx.doi.org/10.1002/jlac.197519750311
	International search	[AP]US5861419 (DUBE DANIEL [CA], et al);
		[A] - CHAN K. S., TSE A. K.-S., "SYNTHESIS OF BIS(TRIFLUOROMETHYL)-2,2'-BIPYRIDINES BY NICKEL CATALYSED HOMOCOUPLING REACTIONS.", Synthetic Communications, Taylor & Francis Inc., PHILADELPHIA, PA; US, PHILADELPHIA, PA; US, (19930101), vol. 23., no. 14., doi:10.1080/00397919308009849, ISSN 0039-7911, pages 1929 - 1934., XP002923054 DOI: http://dx.doi.org/10.1080/00397919308009849
		[A] - Uchida, Y. Kajita, R. Kawasaki, Y. Oae, S., "Unusual formation of 5-halo-2,2@?-bipyridyls by treatment of tris(2-pyridyl)phosphine derivatives with halogens", Tetrahedron Letters, Pergamon, GB, GB, (19950605), vol. 36, no. 23, doi:10.1016/0040-4039(95)00719-S, ISSN 0040-4039, pages 4077 - 4080, XP004027920 DOI: http://dx.doi.org/10.1016/0040-4039(95)00719-S
		[A] - IWAMOTO K.-I., ET AL., "RING TRANSFORMATION OF FUSED PYRIDAZINES. IV. REACTION OF HALO-SUBSTITUTED FUSED PYRIDAZINES WITH YNAMINES.", Heterocycles: International Journal for Reviews and Communications in Heterocyclic Chemistry, Japan Institute of Heterocyclic Chemistry, JP, JP, (19960101), vol. 43., no. 01., ISSN 0385-5414, pages 199 - 204., XP002923055

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