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Extract from the Register of European Patents

EP About this file: EP1075488

EP1075488 - PROTEIN PURIFICATION BY ION EXCHANGE CHROMATOGRAPHY [Right-click to bookmark this link]
StatusPatent maintained as amended
Status updated on  05.07.2013
Database last updated on 29.03.2025
Most recent event   Tooltip05.07.2013Patent maintained (B2 publication)published on 07.08.2013  [2013/32]
Applicant(s)For all designated states
Genentech, Inc.
1 DNA Way
South San Francisco, CA 94080-4990 / US
[N/P]
Former [2013/32]For all designated states
Genentech, Inc.
1 DNA Way
South San Francisco CA 94080-4990 / US
Former [2001/07]For all designated states
Genentech, Inc.
1 DNA Way
South San Francisco, CA 94080-4990 / US
Inventor(s)01 / BASEY, Carol, D.
319 Hillview Lane
Winters, CA 95694 / US
02 / BLANK, Greg, S.
1320 Hobart Street
Menlo Park, CA 94025 / US
 [2001/07]
Representative(s)Kremer, Simon Mark
Mewburn Ellis LLP
Aurora Building
Counterslip
Bristol BS1 6BX / GB
[N/P]
Former [2013/32]Kremer, Simon Mark
Mewburn Ellis LLP
33 Gutter Lane
London
EC2V 8AS / GB
Former [2001/07]Kremer, Simon Mark
Mewburn Ellis, York House, 23 Kingsway
London WC2B 6HP / GB
Application number, filing date99921610.403.05.1999
[2001/07]
WO1999US09637
Priority number, dateUS19980084459P06.05.1998         Original published format: US 84459 P
[2001/07]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9957134
Date:11.11.1999
Language:EN
[1999/45]
Type: A1 Application with search report 
No.:EP1075488
Date:14.02.2001
Language:EN
The application published by WIPO in one of the EPO official languages on 11.11.1999 takes the place of the publication of the European patent application.
[2001/07]
Type: B1 Patent specification 
No.:EP1075488
Date:02.05.2003
Language:EN
[2003/18]
Type: B2 New European patent specification 
No.:EP1075488
Date:07.08.2013
Language:EN
[2013/32]
Search report(s)International search report - published on:EP11.11.1999
ClassificationIPC:C07K1/18, C07K16/32
[2001/07]
CPC:
C07K16/32 (EP,US); C07K1/18 (EP,KR,US); A61P35/00 (EP);
A61P43/00 (EP); C07K16/065 (EP,US); C07K16/2863 (US);
A61K2039/505 (US); A61K38/00 (EP,US); C07K2317/21 (US);
C07K2317/24 (EP,US); C07K2317/51 (US); C07K2317/515 (US);
C07K2317/56 (EP,US) (-)
Designated contracting statesBE,   CH,   DE,   DK,   ES,   FR,   GB,   IE,   IT,   LI,   NL [2003/18]
Former [2001/07]AT,  BE,  CH,  CY,  DE,  DK,  ES,  FI,  FR,  GB,  GR,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  SE 
TitleGerman:REINIGUNG VON PROTEINEN DURCH IONENAUSTAUSCHCHROMATOGRAPHIE[2001/07]
English:PROTEIN PURIFICATION BY ION EXCHANGE CHROMATOGRAPHY[2001/07]
French:PURIFICATION DE PROTEINES PAR CHROMATOGRAPHIE PAR ECHANGE D'IONS[2001/07]
Entry into regional phase27.11.2000National basic fee paid 
27.11.2000Designation fee(s) paid 
27.11.2000Examination fee paid 
Examination procedure08.10.1999Request for preliminary examination filed
International Preliminary Examining Authority: EP
27.11.2000Examination requested  [2001/07]
13.11.2001Despatch of a communication from the examining division (Time limit: M06)
22.05.2002Reply to a communication from the examining division
30.08.2002Communication of intention to grant the patent
08.01.2003Fee for grant paid
08.01.2003Fee for publishing/printing paid
Divisional application(s)EP02029008.6  / EP1308455
EP02029009.4  / EP1308456
EP07006011.6   Application deemed to be withdrawn  : 24.04.2007
Opposition(s)Opponent(s)01  02.02.2004  12.02.2004  ADMISSIBLE
Novo Nordisk A/S
Novo Alle
2880 Bagsvaerd / DK
Opponent's representative
Woods, Geoffrey Corlett
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
 [N/P]
Former [2004/14]
Opponent(s)01  02.02.2004  12.02.2004  ADMISSIBLE
NOVO NORDISK A/S
Novo Alle
2880 Bagsvaerd / DK
Opponent's representative
Woods, Geoffrey Corlett
J.A. KEMP & CO. Gray's Inn 14 South Square
London WC1R 5JJ / GB
08.03.2004Invitation to proprietor to file observations on the notice of opposition
16.11.2004Reply of patent proprietor to notice(s) of opposition
15.11.2006Date of oral proceedings
10.01.2007Despatch of minutes of oral proceedings
23.04.2010Despatch of a communication from the opposition division (Time limit: M06)
15.10.2010Reply to a communication from the opposition division
05.04.2011Despatch of a communication from the opposition division (Time limit: M02)
16.08.2011Despatch of interlocutory decision in opposition
26.08.2011Legal effect of interlocutory decision in opposition
29.04.2013Despatch of communication that the patent will be maintained as amended
18.06.2013Fee for printing new specification paid
Appeal following opposition21.03.2007Appeal received No.  T0458/07
17.05.2007Statement of grounds filed
23.09.2009Result of appeal procedure: maintenance in amended form
12.03.2007Appeal received
23.09.2009Date of oral proceedings
Fees paidRenewal fee
14.05.2001Renewal fee patent year 03
14.05.2002Renewal fee patent year 04
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Cited inInternational search[A]WO8905157  (INVITRON CORP [US]) [A] * page 12 *;
 [A]EP0333574  (FIDIA SPA [IT]) [A] * column 6, paragraph STEP.4 *;
 [A]EP0460426  (MILES INC [US]) [A] * page 3, column 1, paragraph 1; example 1; claim - *;
 [A]EP0556083  (SNOW BRAND MILK PROD CO LTD [JP]) [A] * abstract *;
 [X]WO9633208  (GENENTECH INC [US]) [X] 28-30 * page 17, line 25 * * page 12 *;
 [X]  - H. GRAF ET AL., "Ion exchange resins for the purification of monoclonal antibodies from animal cell culture", BIOSEPARATION, (199402), vol. 4, no. 1, pages 7 - 20, XP002112750 [X] 22,24-26 * abstract * * page 12 * * pages 16-17 *
 [A]  - E.A. NEIDHARDT ET AL, "Rapid, two-step purification process for the preparation of pyrogen-free murine immunoglobulin G1 monoclonal antibodies", J. CHROMATOGR., (1992), vol. 590, pages 255 - 261, XP002112751 [A] * abstract *

DOI:   http://dx.doi.org/10.1016/0021-9673(92)85389-B
 [A]  - MHATRE R ET AL, "Purification of antibody Fab fragments by cation-exchange chromatography and pH gradient elution", JOURNAL OF CHROMATOGRAPHY A, (19950721), vol. 707, no. 2, ISSN 0021-9673, page 225-231, XP004038812 [A] * abstract *

DOI:   http://dx.doi.org/10.1016/0021-9673(95)00319-I
 [A]  - TISHCHENKO G A ET AL, "Effect of salt concentration gradient on separation of different types of specific immunoglobulins by ion-exchange chromatography on DEAE cellulose", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, (19980227), vol. 706, no. 1, ISSN 0378-4347, page 157-166, XP004110842 [A] * page 159, column 2, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/S0378-4347(97)00453-2
otherWO9635718
OppositionEP0289129
 US5279823
 WO9422905
 WO9640883
 US5677171
    - E.L.V. HARRIS ET AL, Protein purification applications, OXFORD, IRL PRESS, (1995), pages 151 - 156
    - Slides presented at the Waterside Monoclonal Conference, pp.1-7(April 22-25 1997)
    - R. LOVE ET AL., "Protein Purification: Micro to Micro, MADISON, RICHARD BURGESS, (1987), pages 491 - 500
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.