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Extract from the Register of European Patents

EP About this file: EP1093379

EP1093379 - USE OF INHIBITORS OF PROTEIN KINASE C EPSILON TO TREAT PAIN [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  09.11.2007
Database last updated on 07.10.2024
Most recent event   Tooltip08.01.2010Lapse of the patent in a contracting state
New state(s): CY, LU		published on 10.02.2010  [2010/06]
Applicant(s)For all designated states
The Regents of the University of California
1111 Franklin Street, 12th Floor
Oakland, CA 94607 / US
[N/P]
Former [2007/01]For all designated states
The Regents of the University of California
1111 Franklin Street, 12th Floor
Oakland, CA 94607-5200 / US
Former [2003/25]For all designated states
The Regents of the University of California
12th Floor, 1111 Franklin Street
Oakland, CA 94607-5200 / US
Former [2001/17]For all designated states
Messing, Robert O.
960 Swan Street
Foster City, CA 94404 / US
For all designated states
Levine, Jon D.
791 12th Avenue
San Francisco, CA 94118 / US
Inventor(s)01 / Messing, Robert O.
960 Swan Stret
Foster City, CA 94404 / US
02 / Levine, Jon D.
791 12th Avenue
San Francisco, CA 94118 / US
 [2003/25]
Former [2001/17]01 / see applicant
...
Representative(s)Kremer, Simon Mark, et al
Mewburn Ellis LLP
Aurora Building
Counterslip
Bristol BS1 6BX / GB
[N/P]
Former [2001/17]Kremer, Simon Mark, et al
Mewburn Ellis, York House, 23 Kingsway
London WC2B 6HP / GB
Application number, filing date99932296.906.07.1999
[2001/17]
WO1999US15265
Priority number, dateUS19980091755P06.07.1998         Original published format: US 91755 P
US19980103763P09.10.1998         Original published format: US 103763 P
[2001/17]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO0001415
Date:13.01.2000
Language:EN
[2000/02]
Type: A2 Application without search report 
No.:EP1093379
Date:25.04.2001
Language:EN
The application published by WIPO in one of the EPO official languages on 13.01.2000 takes the place of the publication of the European patent application.
[2001/17]
Type: B1 Patent specification 
No.:EP1093379
Date:03.01.2007
Language:EN
[2007/01]
Search report(s)International search report - published on:EP13.04.2000
ClassificationIPC:A61K31/40, A61K38/00, A61K38/08, A61P29/00
[2006/24]
CPC:
A61K38/45 (EP); A61K45/06 (EP); A61P25/04 (EP);
A61P29/00 (EP); C12Q1/485 (EP); G01N2500/04 (EP)
C-Set:
A61K38/45, A61K2300/00 (EP)
Former IPC [2001/17]A61K38/00
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2001/17]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
RONot yet paid
SINot yet paid
TitleGerman:VERWENDUNG DER PROTEIN-KINASE-C-EPSILON-INHIBITOREN ZUR BEHANDLUNG VON SCHMERZEN[2001/17]
English:USE OF INHIBITORS OF PROTEIN KINASE C EPSILON TO TREAT PAIN[2001/17]
French:UTILISATION D'INHIBITEURS DE LA PROTEINE KINASE C EPSILON DANS LE TRAITEMENT DE LA DOULEUR[2001/17]
Entry into regional phase31.01.2001National basic fee paid 
31.01.2001Designation fee(s) paid 
31.01.2001Examination fee paid 
Examination procedure04.02.2000Request for preliminary examination filed
International Preliminary Examining Authority: US
30.01.2001Amendment by applicant (claims and/or description)
31.01.2001Examination requested  [2001/17]
19.11.2002Despatch of a communication from the examining division (Time limit: M06)
03.07.2003Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
23.07.2003Reply to a communication from the examining division
18.06.2004Despatch of a communication from the examining division (Time limit: M04)
22.10.2004Reply to a communication from the examining division
05.08.2005Despatch of a communication from the examining division (Time limit: M04)
15.12.2005Reply to a communication from the examining division
18.05.2006Communication of intention to grant the patent
20.09.2006Fee for grant paid
20.09.2006Fee for publishing/printing paid
Opposition(s)05.10.2007No opposition filed within time limit [2007/50]
Request for further processing for:23.07.2003Request for further processing filed
23.07.2003Full payment received (date of receipt of payment)
Request granted
07.08.2003Decision despatched
Fees paidRenewal fee
12.07.2001Renewal fee patent year 03
23.07.2002Renewal fee patent year 04
22.07.2003Renewal fee patent year 05
23.07.2004Renewal fee patent year 06
22.07.2005Renewal fee patent year 07
26.07.2006Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT03.01.2007
BE03.01.2007
CH03.01.2007
CY03.01.2007
DK03.01.2007
FI03.01.2007
LI03.01.2007
NL03.01.2007
GR04.04.2007
PT04.06.2007
LU06.07.2007
MC31.07.2007
[2010/06]
Former [2008/22]AT03.01.2007
BE03.01.2007
CH03.01.2007
DK03.01.2007
FI03.01.2007
LI03.01.2007
NL03.01.2007
GR04.04.2007
PT04.06.2007
MC31.07.2007
Former [2008/21]AT03.01.2007
BE03.01.2007
CH03.01.2007
DK03.01.2007
FI03.01.2007
LI03.01.2007
NL03.01.2007
GR04.04.2007
PT04.06.2007
Former [2008/18]AT03.01.2007
BE03.01.2007
CH03.01.2007
DK03.01.2007
FI03.01.2007
LI03.01.2007
NL03.01.2007
PT04.06.2007
Cited inInternational search[X]WO9715575  (PROCYON PHARM INC [US]) [X] 1,3-6,12,13 * page 19, line 7 * * page 38, lines 26-30; example 17 * * page 39; example 18 *;
 [PDA]US5783405  (MOCHLY-ROSEN DARIA [US], et al) [PDA] 1-7,10-14;
 [PX]  - CESARE P ET AL, "Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat.", NEURON, JUL 1999, 23 (3) P617-24, UNITED STATES, XP000869683 [PX] 1-7,10-14 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0896-6273(00)80813-2
 [T]  - KHASAR, S. G. ET AL, "A novel nociceptor signalling pathway revealed in Protein Kinase C epsilon mutant mice", NEURON, (199909), vol. 24, no. 1, pages 253 - 260, XP000869769 [T] 1-7,10-14 * the whole document * * especially page 257, righthand column, line 9-20 *

DOI:   http://dx.doi.org/10.1016/S0896-6273(00)80837-5
 [T]  - KHASAR, S.G. ET AL, "Epinephrine produces a beta-adrenergic receptor mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors", JOURNAL OF NEUROPHYSIOLOGY, (199903), vol. 81, no. 3, pages 1104 - 11112, XP000869664 [T] 1-7,10-14 * the whole document *
 [DY]  - HUNDLE, B. ET AL, "An inhibitory fragment derived from Protein Kinase C epsilon prevents enhancement of Nerve Growth Factor responses by ethanol and phorbol esters", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (1997), vol. 272, no. 23, pages 15028 - 15035, XP002119149 [DY] 1-7,12-14 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.272.23.15028
 [Y]  - HUNDLE, B. ET AL, "Overexpression of epsilon-Protein kinase C enhances Nerve Growth Factor-induced phosphorylation of mitogen-activated protein kinases and neurite outgrowth", THE JOURNAL OF BIOOGICAL CHEMISTRY, (1995), vol. 270, no. 50, pages 30134 - 30140, XP000867400 [Y] 1-7,12-14 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.270.50.30134
 [Y]  - LEWIN, G.R. ET AL, "Nerve growth factor and nociception", TRENDS IN NEUROSCIENCE, (1993), vol. 16, no. 9, pages 353 - 359, XP000870184 [Y] 1-7,12-14 * page 355, column L, line 65 - page 358, column R, line 17 *

DOI:   http://dx.doi.org/10.1016/0166-2236(93)90092-Z
 [Y]  - LEWIN, G.R. ET AL, "Nerve growth factor-induced hyperalgesia in the neonatal and adult rat", THE JOURNAL OF NEUROSCIENCE, (1993), vol. 13, no. 5, pages 2136 - 2148, XP000870190 [Y] 1-7,12-14 * the whole document *
 [DA]  - JOHNSON, J. A. ET AL, "A Protein Kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (1996), vol. 271, no. 40, pages 24962 - 66, XP000867211 [DA] 3,13 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.271.40.24962
 [X]  - HATTORI, KIYOSHI, "Role of spinal N-type Ca channels and protein kinase C activities in modulating hyperalgesia. Determination of spinal amino acid release and pain related response", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, XP002129369 [X] 1,2,5,6,12 * abstract *
    [ ] - KYUSHU SHIKA GAKKAI ZASSHI, (1996), vol. 50, no. 5, pages 789 - 806
 [X]  - MAO, JIANREN, "Excitatory central mechanisms of post-injury neuropathic pain", DISSERTATION ABSTRACTS, UMI, XP002129370 [X] 1,2,5,6,12 * abstract *
    [ ] - DISSERTATION ABSTRACTS INTERNATIONAL, (1992), vol. 53, no. 04-B, page 1726
 [X]  - SLUKA K.A. ET AL, "Capsaicin-induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor", BRAIN RESEARCH, (1997), vol. 772, no. 1-2, pages 82 - 86, XP000869915 [X] 1,2,5,6,12 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0006-8993(97)00876-7
 [DX]  - AHLGREN, S.C. ET AL, "Protein Kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the Streptozotocin-diabetic rat", THE JOURNAL OF NEUROPHYSIOLOGY, (1994), vol. 72, no. 2, pages 684 - 692, XP000869507 [DX] 1,2,5,6,12 * the whole document *
 [A]  - SLUKA KA ET AL, "The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin.", PAIN, (1997), vol. 71, no. 2, pages 165 - 178, XP000869590 [A] 1,2,5,6,12 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0304-3959(97)03371-X
 [X]  - CODERRE TJ ET AL, "Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.", EUROPEAN JOURNAL OF NEUROSCIENCE, AUG 1 1994, 6 (8) P1328-34, (1994), vol. 6, no. 8, pages 1328 - 34, XP000869767 [X] 1,2,5,6,12 * the whole document *
 [X]  - MUNRO F.E. ET AL, "Evidence for a role of protein kinase C in the sustained activation of rat dorsal horn neurons evoked by cutaneous mustard oil application", NEUROSCIENCE LETTERS, (1994), vol. 170, no. 2, pages 199 - 202, XP000869681 [X] 1,2,5,6,12 * the whole document *

DOI:   http://dx.doi.org/10.1016/0304-3940(94)90318-2
 [X]  - OHSAWA, MASAHIRO ET AL, "Modulation of the formalin-induced nociceptive response by diabetes: possible involvement of protein kinase C", BRAIN RESEARCH, (1998), vol. 803, no. 1,2, pages 198 - 203, XP000869976 [X] 1,2,5,6,12 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0006-8993(98)00615-5
 [X]  - CODERRE TJ, "Contribution of protein kinase C to central sensitization and persistent pain following tissue injury.", NEUROSCIENCE LETTERS, (1992), vol. 140, no. 2, pages 181 - 184, XP000869761 [X] 1,2,5,6,12 * the whole document *

DOI:   http://dx.doi.org/10.1016/0304-3940(92)90097-Q
 [X]  - YASHPAL K ET AL, "Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C.", THE JOURNAL OF NEUROSCIENCE, (1995), vol. 15, no. 5 part 1, pages 3263 - 3272, XP000869657 [X] 1,2,5,6,12 * the whole document *
 [X]  - LIN Q ET AL, "Inhibition of primate spinothalamic tract neurons by spinal glycine and GABA is reduced during central sensitization.", THE JOURNAL OF NEUROPHYSIOLOGY, AUG 1996, 76 (2) P1005-14, (1996), vol. 76, no. 2, pages 1005 - 1014, XP000869667 [X] 1,2,5,6,12 * the whole document *
 [DX]  - MCGUIRK, S.M. ET AL, "G-protein mediation in nociceptive signal transduction: an investigation into the excitatory action of bradykinin in a subpopulation of cultured rat sensory neurons", NEUROSCIENCE, (1992), vol. 49, no. 1, pages 117 - 128, XP000869517 [DX] 1,2,5,6,12 * the whole document * * especially page 125, lefthand column, line 36-41 *

DOI:   http://dx.doi.org/10.1016/0306-4522(92)90079-H
 [A]  - MAO J. ET AL, "Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy", NEUROSCIENCE LETTERS, (1995), vol. 198, no. 2, pages 75 - 78, XP000869679 [A] 1-7,10-14 * the whole document *

DOI:   http://dx.doi.org/10.1016/0304-3940(95)11975-3
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.