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EP About this file: EP1111048

EP1111048 - NEUTRAL AMINO ACID TRANSPORTER AND GENE THEREOF [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 15.09.2006 Database last updated on 24.04.2024
Most recent event Tooltip	15.09.2006	No opposition filed within time limit	published on 18.10.2006 [2006/42]
Applicant(s)	For all designated states Japan Science and Technology Agency 4-1-8, Honcho Kawaguchi-shi Saitama / JP
	[N/P]
Former [2005/45]	For all designated states Japan Science and Technology Agency 4-1-8, Honcho Kawaguchi-shi Saitama / JP
Former [2004/21]	For all designated states Japan Science and Technology Agency 4-1-8-, Honcho Kawaguchi-shi Saitama / JP
Former [2001/26]	For all designated states Japan Science and Technology Corporation 1-8, Hon-cho 4-chome Kawaguchi-shi, Saitama 332-0012 / JP
Inventor(s)	01 / ENDOU, Hitoshi 1-23-7, Yoshinodai Sagamihara-shi, Kanagawa-ken 229-0022 / JP
	02 / KANAI, Yoshikatsu 214-102, Midori-cho, Hachioji-shi Tokyo 193-0932 / JP
	[2001/26]
Representative(s)	Cresswell, Thomas Anthony J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ / GB
	[N/P]
Former [2001/26]	Cresswell, Thomas Anthony J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5JJ / GB
Application number, filing date	99940648.1	03.09.1999
	[2001/26]
	WO1999JP04789
Priority number, date	JP19980249993	03.09.1998 Original published format: JP 24999398
	JP19990248546	02.09.1999 Original published format: JP 24854699
	[2001/26]
Filing language	JA
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO0014228
	Date:	16.03.2000
	Language:	EN
	[2000/11]
	Type:	A2 Application without search report
	No.:	EP1111048
	Date:	27.06.2001
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 16.03.2000 takes the place of the publication of the European patent application.
	[2001/26]
	Type:	B1 Patent specification
	No.:	EP1111048
	Date:	09.11.2005
	Language:	EN
	[2005/45]
Search report(s)	International search report - published on:	JP	25.05.2000
	(Supplementary) European search report - dispatched on:	EP	09.10.2001
Classification	IPC:	C12N15/12	[2001/26]
	CPC:	C07K14/705 (EP,US); A61P35/00 (EP); A01K2217/05 (EP,US); A61K38/00 (EP,US)
Designated contracting states	DE, FR, GB [2004/20]
Former [2001/26]	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE
Title	German:	NEUTRALER AMINOSÄURENTRANSPORTER UND KORRESPONDIERENDES GEN	[2001/26]
	English:	NEUTRAL AMINO ACID TRANSPORTER AND GENE THEREOF	[2001/26]
	French:	TRANSPORTEUR D'ACIDES AMINES NEUTRES ET GENE CORRESPONDANT	[2001/26]
Entry into regional phase	19.03.2001	Translation filed
	19.03.2001	National basic fee paid
	19.03.2001	Search fee paid
	19.03.2001	Designation fee(s) paid
	19.03.2001	Examination fee paid
Examination procedure	17.02.2000	Request for preliminary examination filed International Preliminary Examining Authority: JP
	19.03.2001	Examination requested [2001/26]
	07.08.2003	Despatch of a communication from the examining division (Time limit: M06)
	17.02.2004	Reply to a communication from the examining division
	13.05.2005	Communication of intention to grant the patent
	08.09.2005	Fee for grant paid
	08.09.2005	Fee for publishing/printing paid
Opposition(s)	10.08.2006	No opposition filed within time limit [2006/42]
Fees paid	Renewal fee
	12.09.2001	Renewal fee patent year 03
	12.09.2002	Renewal fee patent year 04
	12.09.2003	Renewal fee patent year 05
	14.09.2004	Renewal fee patent year 06
	14.09.2005	Renewal fee patent year 07
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X] - TORRENTS D. ET AL., "Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2 to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.", J. BIOL CHEM, (1998), vol. 273, no. 49, pages 32437 - 32445, XP002178117 [X] 1-4,16-19,29-32 * the whole document * DOI: http://dx.doi.org/10.1074/jbc.273.49.32437
		[PX] - ESTEVEZ R, CAMPS M, ROJAS AM, TESTAR X, DEVES R, HEDIGER MA, ZORZANO A, PALACIN M., "The amino acid transport system y+L/4F2hc is a heteromultimeric complex.", FASEB J, (199810), vol. 12, no. 13, pages 1319 - 1329, XP002178118 [PX] 1-4,16-19,29-32 * the whole document *
		[A] - BROER A, HAMPRECHT B, BROER S., "Discrimination of two amino acid transport activities in 4F2 heavy chain- expressing Xenopus laevis oocytes.", BIOCHEM J, (19980801), vol. 333, no. 3, pages 549 - 554, XP002178119 [A] 1-39 * the whole document *
		[A] - WELLS RG ET AL., "The 4F2 antigen heavy chain induces uptake of neutral and dibasic amino acids in Xenopus oocytes", J. BIOL CHEM, (19920805), vol. 267, no. 22, pages 15285 - 15288, XP002178120 [A] 1-39 * the whole document *
		[A] - GOTTESDIENER ET AL., "Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation", MOLECULAR AND CELLULAR BIOLOGY, (198809), vol. 8, no. 9, pages 3809 - 3819, XP001025922 [A] 1-39 * the whole document *
		[A] - SPINDLER ET AL., "Characterization of early aldosterone-induced RNAs identified in A6 kidney epithelia", PFLUGERS ARCH, (1997), vol. 434, pages 323 - 333, XP001025924 [A] 1-39 * the whole document * DOI: http://dx.doi.org/10.1007/s004240050403
		[T] - BRÖER ET AL., "Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains", BIOCHEM. J., (20010501), vol. 355, no. 3, pages 725 - 731, XP001025945 [T] 1-39 * the whole document *
	International search	[XP] - PRASAD D.P. ET AL., "Human LAT1, a Subunit of System L Amino Acid Transporter: Molecular Cloning and Transport Function", BIOCHEM. BIOPHYS. RES. COMMUN., (199902), vol. 255, no. 2, pages 283 - 288, XP002925587 DOI: http://dx.doi.org/10.1006/bbrc.1999.0206
		[XP] - TSURUDOME M. ET AL., "Cutting Edge: Primary Structure of the Light Chain of Fusion Regulatory Protein-1/CD98/4F2 Predicts a Protein with Multiple Transmembrane Domains that is Almost Identical to the Amino Acid Transporter E16", J. IMMUNOL., (199903), vol. 162, no. 5, pages 2462 - 2466, XP002925588
		[XP] - MASTROBERARDINO L. ET AL., "Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family", NATURE, (19980917), vol. 395, no. 6699, pages 288 - 291, XP002925589 DOI: http://dx.doi.org/10.1038/26246
		[XP] - KANAI Y. ET AL., "Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)", J. BIOL. CHEM.., (19980911), vol. 273, no. 37, pages 23629 - 23632, XP002925590 DOI: http://dx.doi.org/10.1074/jbc.273.37.23629
		[XP] - NAKAMURA E. ET AL., "4F2(CD98) Heavy Chain is Associated Covalently with an Amino Acid Transporter and Controls Intracellular Trafficking and Membrane Topology of 4F2 Heterodimer", J. BIOL. CHEM., (199902), vol. 274, no. 5, pages 3009 - 3016, XP002925591 DOI: http://dx.doi.org/10.1074/jbc.274.5.3009
		[X] - HAYNES F.B. ET AL., "Characterization of a Monoclonal Antibody(4F2) that Binds to Human Monocytes and to a Subset of Activated Lymphocytes", J. IMMUNOL., (1981), vol. 128, no. 4, pages 1409 - 1414, XP002925592
		[X] - HEMLER M. E. ET AL., "Characterization of the Antigen Recognized by the Monoclonal Antibody(4F2): Different Molecular Forms on Human T and B Lymphoblastoid Cell Lines", J. IMMUNOL., (1982), vol. 129, no. 2, pages 623 - 628, XP002925593
		[A] - TEIXEIRA S. ET AL., "Primary Structure of the Human 4F2 Antigen Heavy Chain Predicts a Transmembrane Protein with a Cytoplasmic NH2 Terminus", J. BIOL. CHEM., (1987), vol. 262, no. 20, pages 9574 - 9580, XP002925594
		[A] - LUMADUE J.A. ET AL., "Cloning, sequence analysis and expression of the large subunit of the human lymphocyte activation antigen 4F2", PROC. NATL. ACAD. SCI. USA, (1987), vol. 84, no. 24, pages 9204 - 9208, XP002925595 DOI: http://dx.doi.org/10.1073/pnas.84.24.9204
		[A] - QUACKENBUSH E. ET AL., "Molecular Cloning of Complementary DNAs Encoding the Heavy Chain of the Human 4F2 Cell-Surface Antigen: A Type II Membrane Glycoprotein Involved in Normal and Neoplastic Cell Growth", PROC. NATL. ACAD. SCI. USA, (1987), vol. 84, no. 18, pages 6526 - 6530, XP002925596 DOI: http://dx.doi.org/10.1073/pnas.84.18.6526
		[A] - BROER S. ET AL., "The 4F2hc surface antigen is necessary for expression of system L-like neutral amino acid-transport activity in C6-BU-1 rat glioma cells: evidence from expression studies in Xenopus laevis oocytes", BIOCHEM. J., (1995), vol. 312, no. 3, pages 863 - 870, XP002925597
		[A] - YAO S.Y.M. ET AL., "Cloning and Functional Expression of a cDNA from Rat Jejunal Epithelium Encoding a Protein(4F2hc) with System y+L Amino Acid Transport Activity", BIOCHEM. J., (199803), vol. 330, no. 2, pages 745 - 752, XP002925598
		[A] - GAUGITSCH H.W. ET AL., "A Novel Transiently Expressed, Integral Membrane Protein Linked to Cell Activation", J. BIOL. CHEM., (1992), vol. 267, no. 16, pages 11267 - 11273, XP002925599

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