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EP1109914
European procedure
Extract from the Register of European Patents
EP About this file: EP1109914
| EP1109914 - HEME OXYGENASE 1 FOR THE INHIBITION OF SMOOTH MUSCLE CELL MIGRATION [Right-click to bookmark this link] | |||
| Former [2001/26] | INHIBITION OF SMOOTH MUSCLE CELL MIGRATION BY HEME OXYGENASE 1 | ||
| [2005/49] | Status | No opposition filed within time limit Status updated on 30.03.2007 Database last updated on 19.10.2024 | Most recent event Tooltip | 28.11.2008 | Lapse of the patent in a contracting state New state(s): FR | published on 31.12.2008 [2009/01] | Applicant(s) | For all designated states THE REGENTS OF THE UNIVERSITY OF MICHIGAN 3003 South State Street Ann Arbor, Michigan 48109-1280 / US | [2006/20] |
| Former [2001/26] | For all designated states THE REGENTS OF THE UNIVERSITY OF MICHIGAN 3003 S. State Street Wolverine Tower, Room 2071 Ann Arbor Michigan 48109-1280 / US | Inventor(s) | 01 /
NABEL, Gary, J. 2530 30th Street N.W. Washington, DC 20008 / US | 02 /
NABEL, Elizabeth, G. 3390 Andover Ann Arbor, MI 48105 / US | [2001/26] | Representative(s) | Lock, Graham James, et al Fry Heath & Spence LLP Unit A, Faraday Court Faraday Road Crawley, West Sussex RH10 9PU / GB | [N/P] |
| Former [2001/26] | Lock, Graham James, et al Fry Heath & Spence, The Old College, 53 High Street Horley, Surrey RH6 7BN / GB | Application number, filing date | 99943865.8 | 21.08.1999 | [2001/26] | WO1999US19245 | Priority number, date | US19980097707P | 21.08.1998 Original published format: US 97707 P | [2001/26] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO0010613 | Date: | 02.03.2000 | Language: | EN | [2000/09] | Type: | A2 Application without search report | No.: | EP1109914 | Date: | 27.06.2001 | Language: | EN | The application published by WIPO in one of the EPO official languages on 02.03.2000 takes the place of the publication of the European patent application. | [2001/26] | Type: | B1 Patent specification | No.: | EP1109914 | Date: | 17.05.2006 | Language: | EN | [2006/20] | Search report(s) | International search report - published on: | EP | 06.07.2000 | Classification | IPC: | C12N15/53, A61K48/00, A61P9/00 | [2001/26] | CPC: |
A61K38/44 (EP,US);
A61P9/00 (EP);
C12Y114/99003 (EP,US);
A61K48/00 (EP,US)
| Designated contracting states | DE, FR, GB, IE, NL [2004/20] |
| Former [2001/26] | AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE | Extension states | AL | Not yet paid | LT | Not yet paid | LV | Not yet paid | MK | Not yet paid | RO | Not yet paid | SI | Not yet paid | Title | German: | HÄM-OXYGENASE 1 ZUR HEMMUNG DER GLATTEN MUSKELZELLENMIGRATION | [2005/49] | English: | HEME OXYGENASE 1 FOR THE INHIBITION OF SMOOTH MUSCLE CELL MIGRATION | [2005/49] | French: | L'HEME OXYGENASE (1) POUR L'INHIBITION DE LA MIGRATION DES CELLULES DES MUSCLES | [2005/49] |
| Former [2001/26] | HEMMUNG DER GLATTEN MUSKELZELLENMIGRATION DURCH HÄM-OXYGENASE 1 | ||
| Former [2001/26] | INHIBITION OF SMOOTH MUSCLE CELL MIGRATION BY HEME OXYGENASE 1 | ||
| Former [2001/26] | INHIBITION DE LA MIGRATION DES CELLULES DES MUSCLES LISSES AU MOYEN DE L'HEME OXYGENASE (1) | Entry into regional phase | 21.03.2001 | National basic fee paid | 21.03.2001 | Designation fee(s) paid | 21.03.2001 | Examination fee paid | Examination procedure | 20.03.2000 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 21.03.2001 | Amendment by applicant (claims and/or description) | 21.03.2001 | Examination requested [2001/26] | 28.11.2002 | Despatch of a communication from the examining division (Time limit: M04) | 31.03.2003 | Reply to a communication from the examining division | 23.02.2004 | Despatch of a communication from the examining division (Time limit: M06) | 07.07.2004 | Reply to a communication from the examining division | 06.05.2005 | Despatch of a communication from the examining division (Time limit: M04) | 01.09.2005 | Reply to a communication from the examining division | 21.11.2005 | Communication of intention to grant the patent | 19.01.2006 | Fee for grant paid | 19.01.2006 | Fee for publishing/printing paid | Opposition(s) | 20.02.2007 | No opposition filed within time limit [2007/18] | Fees paid | Renewal fee | 06.08.2001 | Renewal fee patent year 03 | 21.08.2002 | Renewal fee patent year 04 | 25.08.2003 | Renewal fee patent year 05 | 23.08.2004 | Renewal fee patent year 06 | 19.08.2005 | Renewal fee patent year 07 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | FR | 17.05.2006 | GB | 21.08.2006 | [2009/01] |
| Former [2008/18] | GB | 21.08.2006 | Cited in | International search | [XY] - ABRAHAM N G ET AL, "Adenovirus-mediated heme oxygebase-1 gene transfer into rabbit ocular tissues", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,US,ASSOCIATION FOR RESEARCH IN VISION AND, (19951001), vol. 36, no. 11, ISSN 0146-0404, pages 2202 - 2210, XP002086227 [X] 15,18,22 * page 2202 * * abstract * * page 2203, paragraph 6 - page 2204, paragraph 1 * * page 2204, paragraph 4 - paragraph 5 * * page 2208, paragraph 3 - page 2209, last paragraph * [Y] 1-14,16,17,19-21 | [Y] - MORITA T ET AL, "Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells", JOURNAL OF BIOLOGICAL CHEMISTRY, (26 DEC 1997) VOL. 272, NO. 52, PP. 32804-32809. PUBLISHER: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814. ISSN: 0021-9258., CHILDRENS HOSP, JOINT PROGRAM NEONATOL, 300 LONGWOOD AVE, ENDERS 9, BOSTON, MA 02115 (Reprint);HARVARD UNIV, SCH MED, DEPT PEDIAT, JOINT PROGRAM NEONATOL, BOSTON, MA 02115; BOSTON UNIV, MED CTR, DEPT MED, BOSTON, MA 02118, XP002133627 [Y] 1-14,16,17,19-21 * page 32804, summary, first sentence; page 32804, paragraph 1 - page 32805, paragraph 1 * * page 32805, results, paragraph 2 * * page 32805, 'cell culture'; page 32809, paragraph 4 - paragraph 5 * DOI: http://dx.doi.org/10.1074/jbc.272.52.32804 | [DA] - NABEL ET AL, "SITE-SPECIFIC GENE EXPRESSION IN VIVO BY DIRECT GENE TRANSFER INTO THE ARTERIAL WALL", SCIENCE, (1990), vol. 249, pages 1285 - 1288, XP002133628 [DA] 6,7,9,10,12,16,17,19 * page 1285, paragraph 3 - page 1286, paragraph 2 * * page 1287, paragraph 4 - paragraph 5 * DOI: http://dx.doi.org/10.1126/science.2119055 | [A] - NABEL ET AL, "RECOMBINANT GENE EXPRESSION IN VIVO WITHIN ENDOTHELIAL CELLS OF THE ARTERIAL WALL", SCIENCE, (1989), vol. 244, pages 1342 - 1344, XP002133629 [A] 9,10,12-14,16,17,19-21 * page 1342, abstract; page 1343; figure 1 * DOI: http://dx.doi.org/10.1126/science.2499928 | [A] - MORITA T ET AL, "Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.", JOURNAL OF CLINICAL INVESTIGATION, (1995 DEC) 96 (6) 2676-82., XP000876619 [A] * page 2676, paragraph 6 - page 2677, paragraph 1 * * pages 2680-2682, 'Discussion' * * page 2681, para. 3, last sentence * DOI: http://dx.doi.org/10.1172/JCI118334 | [A] - ABRAHAM ET AL, "Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, (199507), vol. 92, no. 92, ISSN 0027-8424, pages 6798 - 6802-6802, XP002100374 [A] * page 6798 * * abstract * DOI: http://dx.doi.org/10.1073/pnas.92.15.6798 | [PX] - DUCKERS, HENRICUS J. (1) ET AL, "Protective properties of recombinant heme oxygenase 1 in vitro and in vivo in the balloon injured porcine artery.", CIRCULATION, (OCT. 27, 1998) VOL. 98, NO. 17 SUPPL., PP. I739-I740. MEETING INFO.: 71ST SCIENTIFIC SESSIONS OF THE AMERICAN HEART ASSOCIATION DALLAS, TEXAS, USA NOVEMBER 8-11, 1998 THE AMERICAN HEART ASSOCIATION., XP000876603 [PX] 1-22 * abstract 3877 * |