| EP3056515 - VERFAHREN ZUR BEHANDLUNG VON DURCH CD47 VERMITTELTER PHAGOZYTOSE [Mit Rechtsklick auf diesen Link können Sie ein Bookmark anlegen.] | Status | Patent in geändertem Umfang aufrechterhalten Status aktualisiert am 18.07.2025 Datenbank zuletzt aktualisiert am 28.03.2026 | |
| Frühere | Patent erteilt Status aktualisiert am 15.03.2019 | ||
| Frühere | Erteilung des Patents vorgesehen Status aktualisiert am 03.03.2019 | ||
| Frühere | Prüfungsverfahren läuft Status aktualisiert am 05.05.2017 | Letztes Ereignis Tooltip | 18.07.2025 | Patent aufrechterhalten (B2-Veröffentlichung) | veröffentlicht am 20.08.2025 [2025/34] | Anmelder | Für alle benannten Staaten The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170, Third Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038 / US | [2019/38] |
| Frühere [2016/33] | Für alle benannten Staaten The Board of Trustees of The Leland Stanford Junior University Office of The General Counsel Building 170, 3rd Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038 / US | Erfinder | 01 /
JAISWAL, Siddhartha Department of Pathology Massachusetts General Hospital Warren 245 55 Fruit St Boston MA 02114 / US | 02 /
WEISSMAN, Irving L. 747 Santa Ynez Street Stanford, CA 97305 / US | 03 /
JAMIESON, Catriona, Helen M. Moores University of California San Diego Cancer Center, MC 0820, 3855 Healty Science Drive La Jolla, CA 92093-0820 / US | 04 /
MAJETI, Ravindra Stanford Institute for Stem Cell Bio and Regenerative Medicine 1050 Arastradero Road Building A Stanford, CA 94304 / US | [2019/16] |
| Frühere [2016/33] | 01 /
JAISWAL, Siddhartha Department of Pathology Massachusetts General Hospital Warren 245 55 Fruit St Boston MA 02114 / US | ||
| 02 /
WEISSMAN, Irving, L. 747 Santa Ynez Street Stanford, CA 97305 / US | |||
| 03 /
JAMIESON, Catriona, Helen, M. Moores University of California San Diego Cancer Center, MC 0820, 3855 Healty Science Drive La Jolla, CA 92093-0820 / US | |||
| 04 /
MAJETI, Ravindra Stanford Institute for Stem Cell Bio and Regenerative Medicine 1050 Arastradero Road Building A Stanford, CA 94304 / US | Vertreter | Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB | [2025/34] |
| Frühere [2016/33] | Chapman, Desmond Mark Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB | Anmeldenummer, Anmeldetag | 16160476.4 | 15.01.2009 | [2016/33] | Prioritätsnummer, Prioritätstag | US20080011324P | 15.01.2008 Ursprünglich veröffentlichtes Format: US 11324 P | US20080189786P | 22.08.2008 Ursprünglich veröffentlichtes Format: US 189786 P | [2016/33] | Anmeldesprache | EN | Verfahrenssprache | EN | Veröffentlichung | Art: | A1 Anmeldung mit Recherchenbericht | Nr.: | EP3056515 | Datum: | 17.08.2016 | Sprache: | EN | [2016/33] | Art: | B1 Patentschrift | Nr.: | EP3056515 | Datum: | 17.04.2019 | Sprache: | EN | [2019/16] | Art: | B2 Neue europäische Patentschrift | Nr.: | EP3056515 | Datum: | 20.08.2025 | Sprache: | EN | [2025/34] | Recherchenbericht(e) | (Ergänzender) europäischer Recherchenbericht - versandt am: | EP | 04.05.2016 | Klassifikation | IPC: | A61K39/00, C07K16/28 | [2019/11] | CPC: |
C07K16/2803 (EP,US);
A61P35/02 (EP,US);
C07K16/28 (US);
C07K16/2896 (EP,US);
C07K16/30 (US);
C12N5/0093 (EP,US);
C12N5/0694 (EP,US);
C12Q1/6886 (EP,US);
G01N33/5011 (US);
G01N33/57505 (EP,US);
A61K2039/505 (EP,US);
A61K2039/507 (US);
C07K2317/24 (US);
C07K2317/73 (US);
C07K2317/75 (EP,US);
C07K2317/76 (EP,US);
C12Q2600/112 (EP,US);
C12Q2600/136 (EP,US);
G01N2500/04 (EP,US)
(-)
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| Frühere IPC [2016/33] | C07K16/28, A61K39/395, C07K16/46, A61K47/48, C07K16/18, C07K16/30, A61K39/00 | Benannte Vertragsstaaten | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2017/12] |
| Frühere [2016/33] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR | Bezeichnung der Erfindung | Deutsch: | VERFAHREN ZUR BEHANDLUNG VON DURCH CD47 VERMITTELTER PHAGOZYTOSE | [2016/33] | Englisch: | METHODS FOR MANIPULATING PHAGOCYTOSIS MEDIATED BY CD47 | [2016/33] | Französisch: | PROCÉDÉS PERMETTANT DE MANIPULER LA PHAGOCYTOSE MÉDIÉE PAR CD47 | [2016/33] | Prüfungsverfahren | 15.03.2016 | Prüfungsantrag gestellt [2016/33] | 23.05.2016 | Absendung einer Mitteilung der Prüfungsabteilung (Frist: M04) | 03.10.2016 | Erwiderung auf eine Mitteilung der Prüfungsabteilung | 25.04.2017 | Absendung einer Mitteilung der Prüfungsabteilung (Frist: M06) | 19.09.2017 | Erwiderung auf eine Mitteilung der Prüfungsabteilung | 20.11.2017 | Einwendungen Dritter | 01.12.2017 | Absendung einer Mitteilung der Prüfungsabteilung (Frist: M04) | 11.01.2018 | Erwiderung auf eine Mitteilung der Prüfungsabteilung | 01.02.2018 | Einwendungen Dritter | 23.03.2018 | Absendung einer Mitteilung der Prüfungsabteilung (Frist: M06) | 28.09.2018 | Erwiderung auf eine Mitteilung der Prüfungsabteilung | 26.10.2018 | Absendung einer Mitteilung der Prüfungsabteilung (Frist: M04) | 12.11.2018 | Erwiderung auf eine Mitteilung der Prüfungsabteilung | 16.11.2018 | Einwendungen Dritter | 04.03.2019 | Ankündigung der Patenterteilung | 05.03.2019 | Erteilungsgebühr entrichtet | 05.03.2019 | Veröffentlichungs-/Druckkostengebühr entrichtet | 05.03.2019 | Eingang der Übersetzungen des Patentanspruchs/der Patentansprüche | Stammanmeldung(en) Tooltip | EP09701993.9 / EP2242512 | Teilanmeldung(en) | EP19168096.6 / EP3539617 | EP22191294.2 / EP4144367 | Einspruch (Einsprüche) | Einsprechende(r) | 01
16.09.2019
21.01.2020
ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Vertreter des Einsprechenden König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Düsseldorf, et al, et al Mönchenwerther Straße 11 40545 Düsseldorf / DE | 02
23.12.2019
13.10.2023
WITHDRAWN Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Vertreter des Einsprechenden Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB | 03
17.01.2020
24.01.2020
ADMISSIBLE Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V / DK Vertreter des Einsprechenden J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB | 04
17.01.2020
24.01.2020
ADMISSIBLE Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Vertreter des Einsprechenden Mathys & Squire 32 London Bridge Street The Shard London SE1 9SG / GB | [N/P] |
| Frühere [2023/47] | |||
| Einsprechende(r) | 01
16.09.2019
21.01.2020
ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Vertreter des Einsprechenden König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Düsseldorf, et al, et al Mönchenwerther Straße 11 40545 Düsseldorf / DE | ||
| 02
23.12.2019
13.10.2023
WITHDRAWN Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Vertreter des Einsprechenden Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB | |||
| 03
17.01.2020
24.01.2020
ADMISSIBLE Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V / DK Vertreter des Einsprechenden J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB | |||
| 04
17.01.2020
24.01.2020
ADMISSIBLE Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Vertreter des Einsprechenden Mathys & Squire The Shard 32 London Bridge Street London SE1 9SG / GB | |||
| Frühere [2023/42] | |||
| Einsprechende(r) | 01
16.09.2019
21.01.2020
ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Vertreter des Einsprechenden König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Düsseldorf, et al, et al Mönchenwerther Straße 11 40545 Düsseldorf / DE | ||
| 02
23.12.2019
07.01.2020
ADMISSIBLE Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Vertreter des Einsprechenden Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB | |||
| 03
17.01.2020
24.01.2020
ADMISSIBLE Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V / DK Vertreter des Einsprechenden J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB | |||
| 04
17.01.2020
24.01.2020
ADMISSIBLE Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Vertreter des Einsprechenden Mathys & Squire The Shard 32 London Bridge Street London SE1 9SG / GB | |||
| Frühere [2022/30] | |||
| Einsprechende(r) | 01
16.09.2019
21.01.2020
ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Vertreter des Einsprechenden König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Düsseldorf, et al, et al Mönchenwerter Straße 11 40545 Düsseldorf / DE | ||
| 02
23.12.2019
07.01.2020
ADMISSIBLE Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Vertreter des Einsprechenden Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB | |||
| 03
17.01.2020
24.01.2020
ADMISSIBLE Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V / DK Vertreter des Einsprechenden J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB | |||
| 04
17.01.2020
24.01.2020
ADMISSIBLE Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Vertreter des Einsprechenden Mathys & Squire The Shard 32 London Bridge Street London SE1 9SG / GB | |||
| Frühere [2020/09] | |||
| Einsprechende(r) | 01
16.09.2019
21.01.2020
ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Vertreter des Einsprechenden König, Gregor Sebastian, et al, et al König-Szynka-Tilmann-von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Straße 11 40545 Düsseldorf / DE | ||
| 02
23.12.2019
07.01.2020
ADMISSIBLE Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Vertreter des Einsprechenden Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB | |||
| 03
17.01.2020
ADMISSIBLE Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V / DK Vertreter des Einsprechenden J A Kemp LLP 14 South Square Gray's Inn London WC1R 5JJ / GB | |||
| 04
17.01.2020
ADMISSIBLE Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Vertreter des Einsprechenden Mathys & Squire The Shard 32 London Bridge Street London SE1 9SG / GB | |||
| Frühere [2020/07] | |||
| Einsprechende(r) | 01
16.09.2019
ADMISSIBLE König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Vertreter des Einsprechenden König, Gregor Sebastian, et al, et al König-Szynka-Tilmann-von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Straße 11 40545 Düsseldorf / DE | ||
| 02
23.12.2019
07.01.2020
ADMISSIBLE Arch Oncology, Inc. 2000 Sierra Point Parkway, Suite 700 Brisbane, CA 94005 / US Vertreter des Einsprechenden Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB | |||
| Frühere [2019/43] | |||
| Einsprechende(r) | 01
16.09.2019
König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Strasse 11 40545 Düsseldorf / DE Vertreter des Einsprechenden König, Gregor Sebastian, et al, et al König-Szynka-Tilmann-von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Straße 11 40545 Düsseldorf / DE | 03.02.2020 | Aufforderung des Patentinhabers, eine Stellungnahme zum Einspruch einzureichen | 13.08.2020 | Erwiderung des Patentinhabers auf den Einspruch (die Einsprüche) | 16.08.2023 | Absage der mündlichen Verhandlung die für den 19.10.2023 geplant war | 19.10.2023 | Termin der mündlichen Verhandlung | 17.10.2024 | Rechtswirksamkeit der Zwischenentscheidung im Einspruchsverfahren | 18.10.2024 | Absage der mündlichen Verhandlung die für den 21.10.2024 geplant war | 21.10.2024 | Termin der mündlichen Verhandlung | 23.12.2024 | Absendung der Zwischenentscheidung im Einspruchsverfahren | 23.12.2024 | Niederschrift über die mündliche Verhandlung abgesandt | 19.05.2025 | Absendung der Mitteilung über die Aufrechterhaltung des Patents in geändertem Umfang | Entrichtete Gebühren | Jahresgebühr | 15.03.2016 | Jahresgebühr entrichtet Patentjahr 03 | 15.03.2016 | Jahresgebühr entrichtet Patentjahr 04 | 15.03.2016 | Jahresgebühr entrichtet Patentjahr 05 | 15.03.2016 | Jahresgebühr entrichtet Patentjahr 06 | 15.03.2016 | Jahresgebühr entrichtet Patentjahr 07 | 15.03.2016 | Jahresgebühr entrichtet Patentjahr 08 | 11.01.2017 | Jahresgebühr entrichtet Patentjahr 09 | 15.01.2018 | Jahresgebühr entrichtet Patentjahr 10 | 15.01.2019 | Jahresgebühr entrichtet Patentjahr 11 |
| Ausschluss der ausschließlichen Tooltip Zuständigkeit des Einheitlichen Patentgerichts | Zu den entsprechenden Daten siehe das Register des Einheitlichen Patentgerichts | ||
| Die Verantwortung für die Richtigkeit, Vollständigkeit oder Qualität der unter dem Link angezeigten Daten liegt allein beim Einheitlichen Patentgericht. | Erlöschen während des Einspruchsverfahrens Tooltip | HU | 15.01.2009 | CY | 17.04.2019 | CZ | 17.04.2019 | EE | 17.04.2019 | HR | 17.04.2019 | LT | 17.04.2019 | LV | 17.04.2019 | MK | 17.04.2019 | MT | 17.04.2019 | PL | 17.04.2019 | RO | 17.04.2019 | SI | 17.04.2019 | SK | 17.04.2019 | TR | 17.04.2019 | BG | 17.07.2019 | GR | 18.07.2019 | [2022/32] |
| Frühere [2022/28] | HU | 15.01.2009 | |
| CY | 17.04.2019 | ||
| CZ | 17.04.2019 | ||
| EE | 17.04.2019 | ||
| HR | 17.04.2019 | ||
| LT | 17.04.2019 | ||
| LV | 17.04.2019 | ||
| MT | 17.04.2019 | ||
| PL | 17.04.2019 | ||
| RO | 17.04.2019 | ||
| SI | 17.04.2019 | ||
| SK | 17.04.2019 | ||
| TR | 17.04.2019 | ||
| BG | 17.07.2019 | ||
| GR | 18.07.2019 | ||
| Frühere [2020/26] | CZ | 17.04.2019 | |
| EE | 17.04.2019 | ||
| HR | 17.04.2019 | ||
| LT | 17.04.2019 | ||
| LV | 17.04.2019 | ||
| PL | 17.04.2019 | ||
| RO | 17.04.2019 | ||
| SI | 17.04.2019 | ||
| SK | 17.04.2019 | ||
| TR | 17.04.2019 | ||
| BG | 17.07.2019 | ||
| GR | 18.07.2019 | ||
| Frühere [2020/17] | CZ | 17.04.2019 | |
| EE | 17.04.2019 | ||
| HR | 17.04.2019 | ||
| LT | 17.04.2019 | ||
| LV | 17.04.2019 | ||
| PL | 17.04.2019 | ||
| RO | 17.04.2019 | ||
| SK | 17.04.2019 | ||
| TR | 17.04.2019 | ||
| BG | 17.07.2019 | ||
| GR | 18.07.2019 | ||
| Frühere [2020/11] | CZ | 17.04.2019 | |
| EE | 17.04.2019 | ||
| HR | 17.04.2019 | ||
| LT | 17.04.2019 | ||
| LV | 17.04.2019 | ||
| PL | 17.04.2019 | ||
| RO | 17.04.2019 | ||
| SK | 17.04.2019 | ||
| BG | 17.07.2019 | ||
| GR | 18.07.2019 | ||
| Frühere [2020/10] | CZ | 17.04.2019 | |
| HR | 17.04.2019 | ||
| LT | 17.04.2019 | ||
| LV | 17.04.2019 | ||
| PL | 17.04.2019 | ||
| RO | 17.04.2019 | ||
| BG | 17.07.2019 | ||
| GR | 18.07.2019 | ||
| Frühere [2020/09] | CZ | 17.04.2019 | |
| HR | 17.04.2019 | ||
| LT | 17.04.2019 | ||
| LV | 17.04.2019 | ||
| PL | 17.04.2019 | ||
| BG | 17.07.2019 | ||
| GR | 18.07.2019 | ||
| Frühere [2019/52] | HR | 17.04.2019 | |
| LT | 17.04.2019 | ||
| LV | 17.04.2019 | ||
| PL | 17.04.2019 | ||
| BG | 17.07.2019 | ||
| GR | 18.07.2019 | ||
| Frühere [2019/51] | HR | 17.04.2019 | |
| LT | 17.04.2019 | ||
| LV | 17.04.2019 | ||
| BG | 17.07.2019 | ||
| GR | 18.07.2019 | ||
| Frühere [2019/50] | HR | 17.04.2019 | |
| LT | 17.04.2019 | ||
| LV | 17.04.2019 | ||
| GR | 18.07.2019 | ||
| Frühere [2019/47] | LT | 17.04.2019 | Angeführte Dokumente: | Recherche | [XI] EP1693385 (CHUGAI PHARMACEUTICAL CO LTD et al.) | [I] US2007111238 (JAMIESON CATRIONA H M et al.) | [X] PARTHA MANNA ET AL: "CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A.", CANCER RESEARCH, vol. 64, no. 3, 1 February 2004 (2004-02-01), pages 1026 - 1036, XP055030076, ISSN: 0008-5472 DOI: http://dx.doi.org/10.1158/0008-5472.CAN-03-1708 | [A] Y. LIU ET AL: "Signal Regulatory Protein (SIRPalpha ), a Cellular Ligand for CD47, Regulates Neutrophil Transmigration", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 12, 15 March 2002 (2002-03-15), pages 10028 - 10036, XP055030073, ISSN: 0021-9258, DOI: 10.1074/jbc.M109720200 DOI: http://dx.doi.org/10.1074/jbc.M109720200 | RAVINDRA MAJETI1 ET AL: "CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells", DEVELOPMENTAL CELL, CELL PRESS, CAMBRIDGE, MA, US, vol. 138, no. 2, 23 July 2009 (2009-07-23), pages 286 - 299, XP002632714, ISSN: 1097-4172, [retrieved on 20090723], DOI: 10.1016/J.CELL.2009.05.045 DOI: http://dx.doi.org/10.1016/J.CELL.2009.05.045 | S. B. WILLINGHAM ET AL: "The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 109, no. 17, 26 March 2012 (2012-03-26), pages 6662 - 6667, XP055029983, ISSN: 0027-8424, DOI: 10.1073/pnas.1121623109 DOI: http://dx.doi.org/10.1073/pnas.1121623109 | [PI] MAJETI RAVINDRA ET AL: "CD47 Is An Independent Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 112, no. 11, 1 November 2008 (2008-11-01), pages 284, XP009160228, ISSN: 0006-4971 | [A] PETTERSEN R F ET AL: "CD47 SIGNALS T CELL DEATH", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 162, 1 January 1999 (1999-01-01), pages 7031 - 7040, XP002940659, ISSN: 0022-1767 | X. W. ZHAO ET AL: "Is targeting of CD47-SIRP enough for treating hematopoietic malignancy?", BLOOD, vol. 119, no. 18, 3 May 2012 (2012-05-03), pages 4333 - 4334, XP055116565, ISSN: 0006-4971, DOI: 10.1182/blood-2011-11-391367 DOI: http://dx.doi.org/10.1182/blood-2011-11-391367 | [X] P. P. MANNA ET AL: "The Mechanism of CD47-Dependent Killing of T Cells: Heterotrimeric Gi-Dependent Inhibition of Protein Kinase A", THE JOURNAL OF IMMUNOLOGY, vol. 170, no. 7, 1 April 2003 (2003-04-01), pages 3544 - 3553, XP055116597, ISSN: 0022-1767, DOI: 10.4049/jimmunol.170.7.3544 DOI: http://dx.doi.org/10.4049/jimmunol.170.7.3544 | M. P. CHAO ET AL: "Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia", CANCER RESEARCH, vol. 71, no. 4, 15 February 2011 (2011-02-15), pages 1374 - 1384, XP055029988, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-10-2238 DOI: http://dx.doi.org/10.1158/0008-5472.CAN-10-2238 | JAISWAL S ET AL: "Macrophages as mediators of tumor immunosurveillance", TRENDS IN IMMUNOLOGY, ELSEVIER LTD. * TRENDS JOURNALS, GB, vol. 31, no. 6, 1 June 2010 (2010-06-01), pages 212 - 219, XP027079216, ISSN: 1471-4906, [retrieved on 20100601], DOI: 10.1016/J.IT.2010.04.001 DOI: http://dx.doi.org/10.1016/j.it.2010.04.001 | X. W. ZHAO ET AL: "CD47-signal regulatory protein- (SIRP ) interactions form a barrier for antibody-mediated tumor cell destruction", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. 45, 8 November 2011 (2011-11-08), pages 18342 - 18347, XP055055636, ISSN: 0027-8424, DOI: 10.1073/pnas.1106550108 DOI: http://dx.doi.org/10.1073/pnas.1106550108 | vom Anmelder | US6465247 | US95627901 | WO9910478 | US5985660 | MOTEGI S. 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