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EP Übersicht: EP3243821

EP3243821 - PHARMAZEUTISCHE FORMULIERUNGEN ZUR REGULIERUNG VON INTEGRIN-CD11B/CD18 [Mit Rechtsklick auf diesen Link können Sie ein Bookmark anlegen.]
StatusKein Einspruch fristgerecht eingelegt
Status aktualisiert am  01.01.2021
Datenbank zuletzt aktualisiert am 07.04.2026
FrüherePatent erteilt
Status aktualisiert am  24.01.2020
FrühereErteilung des Patents vorgesehen
Status aktualisiert am  17.01.2020
FrüherePrüfungsverfahren läuft
Status aktualisiert am  03.01.2020
FrühereErteilung des Patents vorgesehen
Status aktualisiert am  19.08.2019
FrüherePrüfungsverfahren läuft
Status aktualisiert am  07.09.2018
FrüherePrüfungsantrag gestellt
Status aktualisiert am  13.10.2017
Letztes Ereignis   Tooltip15.07.2022Erlöschen des Patents in einem Vertragsstaat
Neue Staaten: MK
veröffentlicht am 17.08.2022  [2022/33]
AnmelderFür alle benannten Staaten
GB006, Inc.
3013 Science Park Road, Suite 200
San Diego, CA 92121 / US
[2020/14]
Frühere [2019/36]Für alle benannten Staaten
GB006, Inc.
251 Little Falls Drive
Wilmington, New Castle 19808 / US
Frühere [2017/46]Für alle benannten Staaten
Adhaere Pharamaceuticals, Inc.
11950 S.W. 72nd Place
Pinecrest, FL 33156 / US
Erfinder01 / GUPTA, Vineet
Adhaere Pharmaceuticals, Inc
11950 S.W. 72nd Place
Pinecrest, FL 33156 / US
 [2017/46]
VertreterMurgitroyd & Company
165-169 Scotland Street
Glasgow G5 8PL / GB
[N/P]
Frühere [2020/09]Murgitroyd & Company
Murgitroyd House
165-169 Scotland Street
Glasgow G5 8PL / GB
Frühere [2017/46]chapman + co
18 Staple Gardens
Winchester, Hampshire SO23 8SR / GB
Anmeldenummer, Anmeldetag17177006.802.05.2011
[2017/46]
Prioritätsnummer, PrioritätstagUS20100362363P08.07.2010         Ursprünglich veröffentlichtes Format: US 362363 P
[2017/46]
AnmeldespracheEN
VerfahrensspracheEN
VeröffentlichungArt: A1 Anmeldung mit Recherchenbericht 
Nr.:EP3243821
Datum:15.11.2017
Sprache:EN
[2017/46]
Art: B1 Patentschrift 
Nr.:EP3243821
Datum:26.02.2020
Sprache:EN
[2020/09]
Art: B8 Berichtigte Titelseite der Patentschrift 
Nr.:EP3243821
Datum:15.04.2020
[2020/16]
Recherchenbericht(e)(Ergänzender) europäischer Recherchenbericht - versandt am:EP11.08.2017
KlassifikationIPC:C07D417/06, A61K31/427, A61P29/00
[2017/46]
CPC:
C07D417/06 (EP,US); A61K31/427 (CN); A61K31/5377 (CN);
A61P1/04 (EP); A61P11/06 (EP); A61P13/12 (EP);
A61P17/00 (EP); A61P17/02 (EP); A61P17/06 (EP);
A61P19/02 (EP); A61P19/04 (EP); A61P25/00 (EP);
A61P25/28 (EP); A61P29/00 (EP); A61P3/04 (EP);
A61P3/06 (EP); A61P3/10 (EP); A61P31/18 (EP);
A61P33/06 (EP); A61P35/00 (EP); A61P35/02 (EP);
A61P37/00 (EP); A61P37/02 (EP); A61P37/08 (EP);
A61P43/00 (EP); A61P7/00 (EP); A61P9/00 (EP);
A61P9/10 (EP); A61P9/12 (EP) (-)
Benannte VertragsstaatenAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/46]
Bezeichnung der ErfindungDeutsch:PHARMAZEUTISCHE FORMULIERUNGEN ZUR REGULIERUNG VON INTEGRIN-CD11B/CD18[2017/46]
Englisch:PHARMACEUTICAL FORMULATIONS FOR REGULATING INTEGRIN CD11B/CD18[2017/46]
Französisch:FORMULATIONS PHARMACEUTIQUES POUR RÉGULER L'INTÉGRINE CD11B/CD18[2017/46]
Prüfungsverfahren20.06.2017Prüfungsantrag gestellt  [2017/46]
20.06.2017Datum, an dem die Prüfungsabteilung zuständig geworden ist
11.05.2018Änderung durch den Anmelder (Ansprüche und/oder Beschreibung)
07.09.2018Absendung einer Mitteilung der Prüfungsabteilung (Frist: M04)
18.12.2018Erwiderung auf eine Mitteilung der Prüfungsabteilung
26.03.2019Absendung einer Mitteilung der Prüfungsabteilung (Frist: M04)
17.05.2019Erwiderung auf eine Mitteilung der Prüfungsabteilung
20.08.2019Ankündigung der Patenterteilung
20.12.2019Nichteinverständnis des Anmelders mit der Mitteilung über die beabsichtigte Erteilung eines Patents oder Wiederaufnahme des Prüfungsverfahrens durch das EPA
20.12.2019Erteilungsgebühr entrichtet
20.12.2019Veröffentlichungs-/Druckkostengebühr entrichtet
16.01.2020Information über die beabsichtigte Patenterteilung
16.01.2020Eingang der Übersetzungen des Patentanspruchs/der Patentansprüche
Stammanmeldung(en)   TooltipEP11803961.9  / EP2591092
Teilanmeldung(en)EP20159424.9  / EP3682947
Einspruch (Einsprüche)27.11.2020Kein Einspruch fristgerecht eingelegt [2021/05]
Entrichtete GebührenJahresgebühr
20.06.2017Jahresgebühr entrichtet Patentjahr 03
20.06.2017Jahresgebühr entrichtet Patentjahr 04
20.06.2017Jahresgebühr entrichtet Patentjahr 05
20.06.2017Jahresgebühr entrichtet Patentjahr 06
20.06.2017Jahresgebühr entrichtet Patentjahr 07
11.05.2018Jahresgebühr entrichtet Patentjahr 08
15.05.2019Jahresgebühr entrichtet Patentjahr 09
Ausschluss der ausschließlichen  Tooltip
Zuständigkeit des Einheitlichen
Patentgerichts
Zu den entsprechenden Daten siehe das Register des Einheitlichen Patentgerichts
Die Verantwortung für die Richtigkeit, Vollständigkeit oder Qualität der unter dem Link angezeigten Daten liegt allein beim Einheitlichen Patentgericht.
Erlöschen während des Einspruchsverfahrens  TooltipHU02.05.2011
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Angeführte Dokumente:Recherche[X] US2004002526  (KLEIN J PETER et al.)
 [A]   FARIDI MOHD H ET AL: "Identification of novel agonists of the integrin CD11b/CD18", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, vol. 19, no. 24, 15 December 2009 (2009-12-15), pages 6902 - 6906, XP026754144, ISSN: 0960-894X, [retrieved on 20091022], DOI: 10.1016/J.BMCL.2009.10.077

DOI:   http://dx.doi.org/10.1016/j.bmcl.2009.10.077
vom Anmelder  "Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
   "Remington's Pharmaceutical Sciences", 1990
   "The United States Pharmacopeia", 1999, THE NATIONAL FORMULARY
   MARCH: "Advanced Organic Chemistry", 1992, JOHN WILEY AND SONS
   CAREY; SUNDBERG: "Advanced Organic Chemistry", vol. A, B, 1990, PLENUM PRESS, INC
   GREEN; WUTS: "Protective groups in Organic Synthesis", 1991, JOHN WILEY AND SONS
   LAROCK: "Comprehensive Organic Transformations", 1988, VCH PUBLISHERS, INC.
   YANG, W.; C.V. CARMAN; M. KIM; A. SALAS; M. SHIMAOKA; T.A. SPRINGER: "A small molecule agonist of an integrin, alpha L beta 2.", J BIOL CHEM, 2006
   CANADAS, T.N.; X. CULLERE: "Neutrophil beta2 integrins: moderators of life or death decisions.", TRENDS IMMUNOL, vol. 26, no. 7, 2005, pages 388 - 95
   LEY, K. ET AL.: "Getting to the site of inflammation: the leukocyte adhesion cascade updated.", NAT REV IMMUNOL, vol. 7, no. 9, 2007, pages 678 - 89
   SIMON, D.I. ET AL.: "Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty", J CLIN INVEST, vol. 105, no. 3, 2000, pages 293 - 300
   CAO, C. ET AL.: "A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics.", BLOOD, vol. 106, no. 9, 2005, pages 3234 - 41
   TANG, T. ET AL.: "A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis.", J EXP MED, vol. 186, no. 11, 1997, pages 1853 - 63
   PLOW, E.F ET AL.: "Ligand binding to integrins.", J BIOL CHEM, vol. 275, no. 29, 2000, pages 21785 - 8
   SORIANO, S.G. ET AL.: "Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury.", STROKE, vol. 30, no. 1, 1999, pages 134 - 9, XP055093139, DOI: doi:10.1161/01.STR.30.1.134

DOI:   http://dx.doi.org/10.1161/01.STR.30.1.134
   KUBOTA, Y ET AL.: "M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis.", J EXP MED, vol. 206, no. 5, 2009, pages 1089 - 102
   HYNES, R.O.: "Integrins: bidirectional, allosteric signaling machines", CELL, vol. 110, no. 6, 2002, pages 673 - 87
   ARNAOUT, M.A: "Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response", IMMUNOL REV, vol. 114, 1990, pages 145 - 80
   PHILLIPSON, M ET AL.: "Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade", J EXP MED, vol. 203, no. 12, 2006, pages 2569 - 75
   AHN, G.O. ET AL.: "Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment.", PROC NATL ACAD SCI USA., vol. 107, no. 18, pages 8363 - 8
   OPHASCHAROENSUK, V. ET AL.: "Role of intrinsic renal cells versus infiltrating cells in glomerular crescent formation", KIDNEY INT, vol. 54, no. 2, 1998, pages 416 - 25
   LE HIR, M. ET AL.: "Podocyte bridges between the tuft and Bowman's capsule: an early event in experimental crescentic glomerulonephritis", J AM SOC NEPHROL, vol. 12, no. 10, 2001, pages 2060 - 71
   TANG, T. ET AL.: "A role for Mac-I (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor- dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis", J EXP MED, vol. 186, no. 11, 1997, pages 1853 - 63
   FAN, S.T.; T.S. EDGINGTON: "Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response", J CLIN INVEST, vol. 87, no. 1, 1991, pages 50 - 7
   WHITLOCK, B.B. ET AL.: "Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms", J CELL BIOL, vol. 151, no. 6, 2000, pages 1305 - 20
   REZZONICO. R. ET AL.: "Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-lbeta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB", BLOOD, vol. 97, no. 10, 2001, pages 2932 - 40
   GUHA, M.; N. MACKMAN: "The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells", J BIOL CHEM, vol. 277, no. 35, 2002, pages 32124 - 32
   RUBEL, C ET AL.: "Fibrinogen-CD11b/GD18 interaction activates the NF-kappa B pathway and delays apoptosis in human neutrophils", EUR J IMMUNOL, vol. 33, no. 5, 2003, pages 1429 - 38
   KETTRITZ, R. ET AL.: "Integrins and cytokines activate nuclear transcription factor-kappaB in human neutrophils", J BIOL CHEM, vol. 279, no. 4, 2004, pages 2657 - 65
   GIANCOTTI, F.G.; E, RUOSLAHTI: "Integrin signaling", SCIENCE, vol. 285, no. 5430, 1999, pages 1028 - 32
   SHEIKH, S.; G.B, NASH: "Continuous activation and deactivation of integrin CD11b/CD18 during de novo expression enables rolling neutrophils to immobilize on platelets", BLOOD, vol. 87, no. 12, 1996, pages 5040 - 50
   JAESCHKE, H. ET AL.: "Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver", HEPATOLOGY, vol. 17, no. 5, 1993, pages 915 - 23
   ROGERS, C.; E.R. EDELMAN; D.I. SIMON: "A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits", PROC NATL ACAD SCI U S A, vol. 95, no. 17, 1998, pages 10134 - 9
   WILSON, I. ET AL.: "Inhibition of neutrophil adherence improves postischemic ventricular performance of the neonatal heart", CIRCULATION, vol. 88, 1993, pages II372 - 9
   PLOW, E.F.; L. ZHANG: "A MAC-1 attack: integrin functions directly challenged in knockout mice", J CLIN INVEST, vol. 99, no. 6, 1997, pages 1145 - 6
   YONEKAWA, K.; J.M. HARLAN: "Targeting leukocyte integrins in human diseases", J LEUKOC BIOL, vol. 77, no. 2, 2005, pages 129 - 40
   DOVE, A.: "CD18 trials disappoint again", NAT BIOTECHNOL, vol. 18, no. 8, 2000, pages 817 - 8
   SHIMIZU, K. ET AL.: "Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection", CIRCULATION, vol. 117, no. 15, 2008, pages 1997 - 2008
   RAMAMOORTHY, C. ET AL.: "CD18 adhesion blockade decreases bacterial clearance and neutrophil recruitment after intrapulmonary E. coli, but not after S. aureus", J LEUKOC BIOL, vol. 61, no. 2, 1997, pages 167 - 72
   LUM, A.F. ET AL.: "Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow", J BIOL CHEM, vol. 277, no. 23, 2002, pages 20660 - 70
   ALLISON, M.: "PML problems loom for Rituxan", NAT BIOTECHNOL, vol. 28, no. 2, 2010, pages 105 - 6
   BANSAL, V.S. ET AL.: "Small molecule antagonists of complement receptor type 3 block adhesion and adhesion-dependent oxidative burst in human polymorphonuclear leukocytes", J PHARMACOL EXP THER, vol. 304, no. 3, 2003, pages 1016 - 24, XP055170322, DOI: doi:10.1124/jpet.102.045286

DOI:   http://dx.doi.org/10.1124/jpet.102.045286
   BJORKLUND, M. ET AL.: "Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment", BIOCHEMISTRY, vol. 45, no. 9, 2006, pages 2862 - 71, XP055046653, DOI: doi:10.1021/bi052238b

DOI:   http://dx.doi.org/10.1021/bi052238b
   FARIDI, M.H.: "Identification of novel agonists of the integrin CD11b/CD18", BIOORG MED CHEM LETT, 2009
   ARNAOUT, M.A. ET AL.: "Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol)", J CLIN INVEST, vol. 72, no. 1, 1983, pages 171 - 9
   WRIGHT, S.D. ET AL.: "Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies", PROC NATL ACAD SCI USA, vol. 80, no. 18, 1983, pages 5699 - 703, XP000654996, DOI: doi:10.1073/pnas.80.18.5699

DOI:   http://dx.doi.org/10.1073/pnas.80.18.5699
   HOGG, N. ET AL.: "A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-f", J CLIN INVEST, vol. 103, no. 1, 1999, pages 97 - 106
   DRANSFIELD, I.; N, HOGG: "Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits", EMBO J, vol. 8, no. 12, 1989, pages 3759 - 65
   COXON, A. ET AL.: "A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation", IMMUNITY, vol. 5, no. 6, 1996, pages 653 - 66
   PARK, J.Y.; M.A. ARNAOUT; V. GUPTA: "A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18", J BIOMOL SCREEN, vol. 12, no. 3, 2007, pages 406 - 17
   GUPTA, V. ET AL.: "The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18.", BLOOD, vol. 109, no. 8, 2007, pages 3513 - 20
   ALONSO, J.L. ET AL.: "Does the integrin alphaA domain act as a ligand for its betaA domain?", CURR BIOL, vol. 12, no. 10, 2002, pages R340 - 2
   GUPTA, V.: "HTS identification of compounds that enhance the binding of CD11b/CD18 to fibrinogen via a luminescence assay", PUBCHEM ASSAY ID, 2009, pages 1499
   CHEN, L.Y ET AL.: "Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter", HUM MOL GENET, vol. 12, no. 19, 2003, pages 2547 - 58
   BERGMEIER, W. ET AL.: "Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III", J CLIN INVEST, vol. 117, no. 6, 2007, pages 1699 - 707
   SZCZUR, K. ET AL.: "Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils", BLOOD, vol. 108, no. 13, 2006, pages 4205 - 13
   ZIGMOND, S.H.: "Orientation chamber in chemotaxis", METHODS ENZYMOL, vol. 162, 1988, pages 65 - 72
   PLUSKOTA, E. ET AL.: "Neutrophil apoptosis: selective regulation by different ligands of integrin alphaMbeta2", J IMMUNOL, vol. 181, no. 5, 2008, pages 3609 - 19
   LI, R.; M.A. ARNAOUT: "Functional analysis of the beta 2 integrins", METHODS MOL BIOL, vol. 129, 1999, pages 105 - 24
   XIONG, J.P. ET AL.: "An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain", J BIOL CHEM, vol. 275, no. 49, 2000, pages 38762 - 7, XP002905767, DOI: doi:10.1074/jbc.C000563200

DOI:   http://dx.doi.org/10.1074/jbc.C000563200
   LU, C. ET AL.: "Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation.", J IMMUNOL, vol. 166, no. 9, 2001, pages 5629 - 37
   XIONG, J.P. ET AL.: "New insights into the structural basis of integrin activation", BLOOD, vol. 102, no. 4, 2003, pages 1155 - 9, XP055224905, DOI: doi:10.1182/blood-2003-01-0334

DOI:   http://dx.doi.org/10.1182/blood-2003-01-0334
   SEMMRICH, M. ET AL.: "Importance of integrin LFA-1 deactivation for the generation of immune responses", J EXP MED, vol. 201, no. 12, 2005, pages 1987 - 98
   GABELER, E.E. ET AL.: "A comparison of balloon injury models of endovascular lesions in rat arteries", BMC CARDIOVASC DISORD, vol. 2, 2002, pages 16, XP021015219, DOI: doi:10.1186/1471-2261-2-16

DOI:   http://dx.doi.org/10.1186/1471-2261-2-16
   RENSHAW, S.A. ET AL.: "A transgenic zebrafish model of neutrophilic inflammation", BLOOD, vol. 108, no. 13, 2006, pages 3976 - 8, XP002447426, DOI: doi:10.1182/blood-2006-05-024075

DOI:   http://dx.doi.org/10.1182/blood-2006-05-024075
   NUSSLEIN-VOLHARD, C.: "Practical Approach Series", 2002, OXFORD UNIVERSITY PRESS, article "Zebrafish - A Practical Approach"
   LEE, J.O. ET AL.: "Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18).", CELL, vol. 80, no. 4, 1995, pages 631 - 8, XP002920554, DOI: doi:10.1016/0092-8674(95)90517-0

DOI:   http://dx.doi.org/10.1016/0092-8674(95)90517-0
   WEITZ-SCHMIDT, G. ET AL.: "Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site", NAT MED, vol. 7, no. 6, 2001, pages 687 - 92
   LEE, J.O. ET AL.: "Two conformations of the integrin A-domain (1-domain): a pathway for activation?", STRUCTURE, vol. 3, no. 12, 1995, pages 1333 - 40, XP004587940, DOI: doi:10.1016/S0969-2126(01)00271-4

DOI:   http://dx.doi.org/10.1016/S0969-2126(01)00271-4
   SHIMAOKA, M. ET AL.: "Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds", PROC NATL ACAD SCI U S A, vol. 99, no. 26, 2002, pages 16737 - 41
   MCCLEVERTY, C.J.; R.C. LIDDINGTON: "Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies", BIOCHEM J, vol. 372, 2003, pages 121 - 7
   SHERMAN, W. ET AL.: "Novel procedure for modeling ligand/receptor induced fit effects", J MED CHEM, vol. 49, no. 2, 2006, pages 534 - 53, XP055186996, DOI: doi:10.1021/jm050540c

DOI:   http://dx.doi.org/10.1021/jm050540c
   KEVIN, J.B. ET AL.: "Scalable Algorithms for Molecular Dynamics Simulations on Commodity Clusters", PROCEEDINGS OF THE ACM/IEEE CONFERENCE ON SUPERCOMPUTING (SC06), TAMPA, FLORIDA, 11 November 2006 (2006-11-11)
   BARNARD, J.W. ET AL.: "Neutrophil inhibitory factor prevents neutrophil-dependent lung injury", J IMMUNOL, vol. 155, no. 10, 1995, pages 4876 - 81
   ZERRIA, K. ET AL.: "Recombinant integrin CD11b A-domain blocks polymorphonuclear cells recruitment and protects against skeletal muscle inflammatory injury in the rat", IMMUNOLOGY, vol. 119, no. 4, 2006, pages 431 - 40
   FENG, Y. ET AL.: "Peptides derived from the complementarity-determining regions of anti-Mac-1 antibodies block intercellular adhesion molecule-1 interaction with Mac-1", J BIOL CHEM, vol. 273, no. 10, 1998, pages 5625 - 30
   LI, R. ET AL.: "Two functional states of the CD11b A-domain: correlations with key features of two Mn2+-complexed crystal structures.", J CELL BIOL, vol. 143, no. 6, 1998, pages 1523 - 34, XP002209418, DOI: doi:10.1083/jcb.143.6.1523

DOI:   http://dx.doi.org/10.1083/jcb.143.6.1523
   ABAD-ZAPAFERO, C.; J.T. METZ: "Ligand efficiency indices as guideposts for drug discovery", DRUG DISCOV TODAY, vol. 10, no. 7, 2005, pages 464 - 9, XP004871769, DOI: doi:10.1016/S1359-6446(05)03386-6

DOI:   http://dx.doi.org/10.1016/S1359-6446(05)03386-6
   FRIESNER, R.A. ET AL.: "Glide: a new approach for rapid. accurate docking and scoring. 1. Method and assessment of docking accuracy.", J MED CHEM, vol. 47, no. 7, 2004, pages 1739 - 49, XP002592019, DOI: doi:10.1021/JM0306430

DOI:   http://dx.doi.org/10.1021/JM0306430
   GUIMARAES, C.R.; M. CARDOZO: "MM-GB/SA rescoring of docking poses in structure-based lead optimization", J CHEM INF MODEL, vol. 48, no. 5, 2008, pages 958 - 70
   LIU, L. ET AL.: "Requirement for RhoA kinase activation in leukocyte de-adhesion", J IMMUNOL, vol. 169, no. 5, 2002, pages 2330 - 6
   HUTTENLOCHER, A.; M.H. GINSBERG; A.F. HORWITZ: "Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity.", J CELL BIOL, vol. 134, no. 6, 1996, pages 1551 - 62
   PALECEK, S.P. ET AL.: "Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness", NATURE, vol. 385, no. 6616, 1997, pages 537 - 40
   PARK. E.J. ET AL.: "Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut", J CLIN INVEST, vol. 117, no. 9, 2007, pages 2526 - 38
   DE BRUYN, K.M. ET AL.: "The small GTPase Rapt is required for Mn(2+)-and antibody-induced LFA-1- and VLA-4-mediated cell adhesion", J BIOL CHEM, vol. 277, no. 33, 2002, pages 29468 - 76
   LEFORT, C.T. ET AL.: "Outside-in signal transmission by conformational changes in integrin Mac-1", J IMMUNOL, vol. 183, no. 10, 2009, pages 6460 - 8
   WANG, Y. ET AL.: "Leukocyte engagement of platelet glycoprotein lbalpha via the integrin Mac-1 is critical for the biological response to vascular injury", CIRCULATION, vol. 112, no. 19, 2005, pages 2993 - 3000
   KUIJPERS, T.W. ET AL.: "Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration", J EXP MED, vol. 178, no. 1, 1993, pages 279 - 84
   PARK, E.J. ET AL.: "Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes.", BLOOD, vol. 115, no. 8, 2010, pages 1572 - 81
   HAN C. JIN J; XU S; LIU H; LI N; CAO X.: "Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b", NAT IMMUNOL., vol. 11, no. 8, pages 734 - 42
   CAO C; GAO Y; LI Y; ANTALIS TM; CASTELLINO FJ; ZHANG L.: "The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD1 1 b.", J CLIN INVEST., vol. 120, no. 6, pages 1971 - 80
   MEANS TK; LUSTER AD.: "Integrins limit the Toll", NAT IMMUNOL, vol. 11, no. 8, pages 691 - 3
   DRIESSENS MH; VAN HULTEN P; ZUURBIER A; LA RIVIERE G; ROOS E.: "Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and - 3 are distinct.", J LEUKOC BIOL, vol. 60, no. 6, 1996, pages 758 - 65
   REICHERT F; SLOBODOV U; MAKRANZ C; ROTSHENKER S.: "Modulation (inhibition and augmentation) of complement receptor-3-mediated myelin phagocytosis.", NEUROBIOL DIS., vol. 8, no. 3, 2001, pages 504 - 12
   PAVLOVIC MD; COLIC M; PEJNOVIC N; TAMATANI T; MIYASAKA M; DUJIC A.: "A novel anti-rat CD18 monoclonal antibody triggers lymphocyte homotypic aggregation and granulocyte adhesion to plastic: different intracellular signaling pathways in resting versus activated thymocytes.", EUR J IMMUNOL., vol. 24, no. 7, 1994, pages 1640 - 8
   STOCK! J; MAJDIC O; PICKL WF; ROSENKRANZ A; PRAGER E; GSCHWANTLER E ET AL.: "Granulocyte activation via a binding site near the C-terminal region of complement receptor type 3 alpha-chain (CD11b) potentially involved in intramembrane complex formation with glycosylphosphatidylinositol-anchored Fc gamma RIIIB (CD16) molecules", J IMMUNOL., vol. 154, no. 10, 1995, pages 5452 - 63
   PETRUZZELLI L; MADUZIA L; SPRINGER TA: "Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18", J IMMUNOL, vol. 155, no. 2, 1995, pages 854 - 66, XP002209615
   KEIZER GD; VISSER W; VLIEM M; FIGDOR CG.: "A monoclonal antibody (NKI-L16) directed against a unique epitope on the alpha-chain of human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions", J IMMUNOL., vol. 140, no. 5, 1988, pages 1393 - 400
   ANDREW D; SHOCK A; BALL E; ORTLEPP S; BELL J; ROBINSON M.: "KIM185, a monoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA-1- and CR3-dependent adhesion", EUR J IMMUNOL., vol. 23, no. 9, 1993, pages 2217 - 22
   ROBINSON MK; ANDREW D; ROSEN H; BROWN D; ORTLEPP S; STEPHENS P ET AL.: "Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-- 1- and CR3-dependent adhesion events", J IMMUNOL., vol. 148, no. 4, 1992, pages 1080 - 5
   DRANSFIELD I; HOGG N.: "Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits", EMBO J., vol. 8, no. 12, 1989, pages 3759 - 65
   BAZIL V; STEFANOVA I; HILGERT I; KRISTOFOVA H; VANEK S; HOREJSI V.: "Monoclonal antibodies against human leucocyte antigens, IV. Antibodies against subunits of the LFA-1 (CD11a/CD18) leucocyte-adhesion glycoprotein.", FOLIA BIOL (PRAHA, vol. 36, no. 1, 1990, pages 41 - 50
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