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Extract from the Register of European Patents

EP About this file: EP1150714

EP1150714 - METHODS FOR INHIBITING BRAIN TUMOR GROWTH [Right-click to bookmark this link]
StatusOpposition rejected
Status updated on  15.04.2011
Database last updated on 14.09.2024
Most recent event   Tooltip30.09.2011Lapse of the patent in a contracting state
New state(s): CY		published on 02.11.2011  [2011/44]
Applicant(s)For all designated states
CHILDRENS HOSPITAL LOS ANGELES
4650 Sunset Boulevard
Los Angeles, CA 90027 / US
[2008/21]
Former [2001/45]For all designated states
CHILDRENS HOSPITAL OF LOS ANGELES
4650 Sunset Boulevard
Los Angeles, CA 90027 / US
Inventor(s)01 / LAUG, Walter, E.
2329 Panorama Drive
La Crescenta, CA 91214 / US
 [2001/45]
Representative(s)Schnappauf, Georg, et al
ZSP Patentanwälte PartG mbB
Hansastraße 32
80686 München / DE
[N/P]
Former [2006/10]Schnappauf, Georg, et al
Dr. Volker Vossius Patent- und Rechtsanwaltskanzlei Geibelstrasse 6
81679 München / DE
Former [2001/45]Grund, Martin, Dr., et al
Dr. Volker Vossius, Patentanwaltskanzlei, Holbeinstrasse 5
81679 München / DE
Application number, filing date00905742.326.01.2000
[2001/45]
WO2000US01949
Priority number, dateUS19990118126P01.02.1999         Original published format: US 118126 P
US2000048939121.01.2000         Original published format: US 489391
[2001/45]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO0044404
Date:03.08.2000
Language:EN
[2000/31]
Type: A2 Application without search report 
No.:EP1150714
Date:07.11.2001
Language:EN
The application published by WIPO in one of the EPO official languages on 03.08.2000 takes the place of the publication of the European patent application.
[2001/45]
Type: B1 Patent specification 
No.:EP1150714
Date:21.05.2008
Language:EN
[2008/21]
Search report(s)International search report - published on:EP30.11.2000
ClassificationIPC:A61K39/395, A61K38/39
[2001/45]
CPC:
A61K38/39 (EP,US); A61K39/395 (KR); A61P35/00 (EP);
A61P43/00 (EP); C07K16/2839 (EP,US); C07K16/2848 (EP,US);
A61K2039/505 (EP,US) (-)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2008/21]
Former [2001/45]AT,  BE,  CH,  CY,  DE,  DK,  ES,  FI,  FR,  GB,  GR,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  SE 
Extension statesAL31.08.2001
LT31.08.2001
LV31.08.2001
MK31.08.2001
RO31.08.2001
SI31.08.2001
TitleGerman:VERFAHREN ZUR INHIBIERUNG VON GEHIRNTUMORWACHSTUM DURCH VERWENDUNG VON ANTAGONISTEN VON INTEGRINEN[2001/45]
English:METHODS FOR INHIBITING BRAIN TUMOR GROWTH[2001/45]
French:PROCEDES D'INHIBITION DE LA CROISSANCE DE TUMEURS CEREBRALES[2001/45]
Entry into regional phase31.08.2001National basic fee paid 
31.08.2001Designation fee(s) paid 
31.08.2001Examination fee paid 
Examination procedure15.08.2000Request for preliminary examination filed
International Preliminary Examining Authority: US
31.08.2001Examination requested  [2001/45]
10.04.2006Despatch of a communication from the examining division (Time limit: M04)
16.08.2006Reply to a communication from the examining division
31.08.2006Despatch of a communication from the examining division (Time limit: M04)
22.12.2006Reply to a communication from the examining division
17.01.2007Despatch of a communication from the examining division (Time limit: M06)
16.07.2007Reply to a communication from the examining division
07.11.2007Communication of intention to grant the patent
07.03.2008Fee for grant paid
07.03.2008Fee for publishing/printing paid
Opposition(s)Opponent(s)01  18.02.2009  23.04.2009  ADMISSIBLE
Centocor Ortho Biotech Inc.
800/850 Ridgeview Drive
Horsham, PA 19044 / US
Opponent's representative
Marshall, Cameron John
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
 [N/P]
Former [2010/07]
Opponent(s)01  18.02.2009  23.04.2009  ADMISSIBLE
Centocor Ortho Biotech Inc.
800/850 Ridgeview Drive
Horsham, PA 19044 / US
Opponent's representative
Marshall, Cameron John
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Former [2009/51]
Opponent(s)01  18.02.2009  23.04.2009  ADMISSIBLE
Centocor
200 Great Valley Parkway
Malvern, PA 19355 / US
Opponent's representative
Marshall, Cameron John
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Former [2009/14]
Opponent(s)01  18.02.2009   
Centocor
200 Great Valley Parkway
Malvern, PA 19355 / US
Opponent's representative
Marshall, Cameron John
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
06.05.2009Invitation to proprietor to file observations on the notice of opposition
06.11.2009Reply of patent proprietor to notice(s) of opposition
30.11.2010Cancellation of oral proceeding that was planned for 06.12.2010
06.12.2010Date of oral proceedings
17.12.2010Date of despatch of rejection of opposition
27.12.2010Legal effect of rejection of opposition [2011/20]
Fees paidRenewal fee
14.01.2002Renewal fee patent year 03
14.01.2003Renewal fee patent year 04
14.01.2004Renewal fee patent year 05
12.01.2005Renewal fee patent year 06
12.01.2006Renewal fee patent year 07
12.01.2007Renewal fee patent year 08
14.01.2008Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY21.05.2008
MC31.01.2009
[2011/44]
Former [2009/37]MC31.01.2009
Cited inInternational search[X]  - D R FRIEDLANDER ET AL., "Migration of brain tumor cells on extracellular matrix proteins in vitro correlates with tumor type and grade and involves alphaV and beta1 integrins", CANCER RESEARCH, MD US, (19960415), vol. 56, pages 1939 - 1947, XP002141914 [X] 1-3,7,11-15,17-19,22-26 * the whole document *
 [X]  - File Medline, abstract no. 95105899, 1995, XP002141917 [X] 1-3,7,11-15,17-19,22-26
    [ ] - A PA AMAR ET AL., "Development of an in vitro extracellular matrix assay for studies of brain tumor cell invasion", JOURNAL OF NEURO-ONCOLOGY, (1994), vol. 20, no. 1, pages 1 - 15 [ ] * abstract *
 [X]  - File Medline, abstract 94157639, 1994, XP002141918 [X] 1-3,7,11-15,17-19,22-26
    [ ] - W PAULUS & J C TONN, "Basement membrane invasion of glioma cells mediated by integrin receptors", JOURNAL OF NEUROSURGERY, (199403), vol. 80, no. 3, pages 515 - 519 [ ] * abstract *
 [X]  - File Medline, abstract 97093660, 1997, XP002141919 [X] 1-3,7,11-15,17-19,22-26
    [ ] - C L GLADSON, "Expression of integrin alphaV beta3 in small blood vessels of glioblastoma tumors", JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, (199611), vol. 55, no. 11, pages 1143 - 1149 [ ] * abstract *
 [X]  - File Medline, abstract 1998369538, 1998, XP002141920 [X] 1-3,7,11-15,17-19,22-26
    [ ] - J C TONN ET AL., "Invasive behaviour of human gliomas is mediated by interindividually different integrin patterns", ANTICANCER RESEARCH, (199807), vol. 8, no. 4A, pages 2599 - 2605 [ ] * abstract *
 [X]  - File Medline, abstract 1998396970, 1998, XP002141921 [X] 1-3,7,11-15,17-19,22-26
    [ ] - S TREASURYWALA & M E BERENS, "Mgration arrest in glioma cells is dependent on the alphaV integrin subunit", GLIA, (199810), vol. 24, no. 2, pages 236 - 243 [ ] * abstract *
 [X]  - T J MACDONALD ET AL., "Migration of human brain tumor cells and human brain endothelial cells on tenascin requires the integrin alphaVbeta3; a unifying model for brain tumor invasion and angiogenesis", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, (199803), vol. 39, page 497, XP002141915 [X] 1-3,7,11-15,17-19,22-26 * see abstract no. 3382 *
 [PX]  - T J MACDONALD ET AL., "Antagonist to alphaV-integrin inhibits frowth of orthotopically but not heterotopically transplanted brain tumors", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, (199903), vol. 40, page 621, XP002141916 [PX] 1-28 * see abstract no. 4096 *
ExaminationEP0770622
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