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Extract from the Register of European Patents

EP About this file: EP1173765

EP1173765 - DIAGNOSTIC AND THERAPEUTIC USE OF ANTIBODIES AGAINST THE UROKINASE RECEPTOR [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  09.11.2007
Database last updated on 01.01.2025
Most recent event   Tooltip07.08.2009Lapse of the patent in a contracting state
New state(s): LU		published on 09.09.2009  [2009/37]
Applicant(s)For all designated states
Wilex AG
Grillparzerstrasse 10B
81675 München / DE
[2007/01]
Former [2002/04]For all designated states
Wilex AG
Grillparzer Strasse 10B
81675 München / DE
Inventor(s)01 / SCHMITT, Manfred
Hohenaschauer Strasse 10
D-81669 München / DE
02 / MAGDOLEN, Viktor
Moosachweg 3
D-85551 Kirchheim / DE
03 / LUTHER, Thomas, Institut für Pathologie
Technische Universität Dresden
D-01307 Dresden / DE
04 / ALBRECHT, Sybille, Institut für Pathologie
Technische Universität Dresden
D-01307 Dresden / DE
05 / MÜLLER, Martin, Institut für Pathologie
Technische Universität Dresden
D-01307 Dresden / DE
06 / WILHELM, Olaf
Grillparzerstrasse 10B
D-81675 München / DE
 [2007/02]
Former [2002/04]01 / SCHMITT, Manfred
Hohenaschauer Strasse 10
D-81669 München / DE
02 / NOACK, Frank
Wilex Biotechnology, Grillparzerstrasse 10B
D-81675 München / DE
03 / MAGDOLEN, Viktor
Moosachweg 3
D-85551 Kirchheim / DE
04 / GRAEFF, Henner
Josef-Schwarz-Weg 11
D-81479 München / DE
05 / LUTHER, Thomas, Institut für Pathologie
Technische Universität Dresden
D-01307 Dresden / DE
06 / ALBRECHT, Sybille, Institut für Pathologie
Technische Universität Dresden
D-01307 Dresden / DE
07 / MÜLLER, Martin, Institut für Pathologie
Technische Universität Dresden
D-01307 Dresden / DE
08 / WILHELM, Olaf
Grillparzerstrasse 10B
D-81675 München / DE
Representative(s)Weiss, Wolfgang, et al
Weickmann & Weickmann
Patent- und Rechtsanwälte PartmbB
Postfach 860 820
81635 München / DE
[N/P]
Former [2002/04]Weiss, Wolfgang, Dipl.-Chem. Dr., et al
Weickmann & Weickmann Patentanwälte Postfach 86 08 20
81635 München / DE
Application number, filing date00917083.813.04.2000
[2002/04]
WO2000EP03347
Priority number, dateEP1999010719913.04.1999         Original published format: EP 99107199
[2002/04]
Filing languageDE
Procedural languageDE
PublicationType: A1 Application with search report
No.:WO0062071
Date:19.10.2000
Language:DE
[2000/42]
Type: A1 Application with search report 
No.:EP1173765
Date:23.01.2002
Language:DE
The application published by WIPO in one of the EPO official languages on 19.10.2000 takes the place of the publication of the European patent application.
[2002/04]
Type: B1 Patent specification 
No.:EP1173765
Date:03.01.2007
Language:DE
[2007/01]
Search report(s)International search report - published on:EP19.10.2000
ClassificationIPC:G01N33/574, G01N33/577, G01N33/68, A61K39/395, A61K47/48, A61K51/10, C12N15/13, C07K16/28, C07K19/00
[2002/04]
CPC:
C07K16/28 (EP,US); A61K47/6849 (EP,US); A61K51/1027 (EP,US);
A61P35/00 (EP); C07K16/2896 (EP,US); G01N33/574 (EP,US);
G01N33/57492 (EP,US); G01N33/582 (EP,US); A61K2039/505 (EP,US);
C07K2317/565 (EP,US); C07K2317/622 (EP,US) (-)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2002/04]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
RONot yet paid
SINot yet paid
TitleGerman:DIAGNOSTISCHER UND THERAPEUTISCHER EINSATZ VON ANTIKÖRPERN GEGEN DEN UROKINASE-REZEPTOR[2002/04]
English:DIAGNOSTIC AND THERAPEUTIC USE OF ANTIBODIES AGAINST THE UROKINASE RECEPTOR[2002/04]
French:UTILISATION A DES FINS DIAGNOSTIQUES ET THERAPEUTIQUES D'ANTICORPS DIRIGES CONTRE LE RECEPTEUR DE L'UROKINASE[2002/04]
Entry into regional phase04.10.2001National basic fee paid 
04.10.2001Designation fee(s) paid 
04.10.2001Examination fee paid 
Examination procedure20.09.2000Request for preliminary examination filed
International Preliminary Examining Authority: EP
04.10.2001Examination requested  [2002/04]
29.07.2004Despatch of a communication from the examining division (Time limit: M04)
09.11.2004Reply to a communication from the examining division
26.04.2005Despatch of a communication from the examining division (Time limit: M04)
01.08.2005Reply to a communication from the examining division
15.09.2005Despatch of a communication from the examining division (Time limit: M04)
25.01.2006Reply to a communication from the examining division
11.05.2006Communication of intention to grant the patent
18.09.2006Fee for grant paid
18.09.2006Fee for publishing/printing paid
Divisional application(s)EP06021523.3  / EP1746421
Opposition(s)05.10.2007No opposition filed within time limit [2007/50]
Fees paidRenewal fee
31.01.2002Renewal fee patent year 03
28.02.2003Renewal fee patent year 04
30.01.2004Renewal fee patent year 05
31.01.2005Renewal fee patent year 06
28.02.2006Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY03.01.2007
DK03.01.2007
FI03.01.2007
IE03.01.2007
NL03.01.2007
SE03.04.2007
GR04.04.2007
LU13.04.2007
BE30.04.2007
MC30.04.2007
PT04.06.2007
[2009/37]
Former [2009/33]CY03.01.2007
DK03.01.2007
FI03.01.2007
IE03.01.2007
NL03.01.2007
SE03.04.2007
GR04.04.2007
BE30.04.2007
MC30.04.2007
PT04.06.2007
Former [2009/18]DK03.01.2007
FI03.01.2007
IE03.01.2007
NL03.01.2007
SE03.04.2007
GR04.04.2007
BE30.04.2007
MC30.04.2007
PT04.06.2007
Former [2008/19]DK03.01.2007
FI03.01.2007
IE03.01.2007
NL03.01.2007
SE03.04.2007
GR04.04.2007
BE30.04.2007
PT04.06.2007
Former [2007/48]DK03.01.2007
FI03.01.2007
IE03.01.2007
NL03.01.2007
SE03.04.2007
PT04.06.2007
Former [2007/46]DK03.01.2007
FI03.01.2007
NL03.01.2007
SE03.04.2007
PT04.06.2007
Former [2007/40]FI03.01.2007
NL03.01.2007
SE03.04.2007
PT04.06.2007
Former [2007/38]FI03.01.2007
SE03.04.2007
PT04.06.2007
Former [2007/36]FI03.01.2007
PT04.06.2007
Cited inInternational search[X]EP0317156  (BECTON DICKINSON CO [US]) [X] 1,3,4,6-13 * claims 1-10 *;
 [XY]US5234816  (TERSTAPPEN LEON W M M [US]) [X] 1-4,6-13 * the whole document * [Y] 1,5;
 [A]WO9409363  (UNIV TEXAS [US]) [A] 1 * figure 1; claims 1,2 *;
 [A]EP0608987  (BECTON DICKINSON CO [US]) [A] 1 * the whole document *;
 [A]US5519120  (DANO KELD [DK], et al) [A] 1,5,14* claim 1 *;
 [XY]  - W. XUE ET AL., "Urokinase-type plasminogen activator receptors associate with beta1 and beta3 integrins of fibrosarcoma cells: dependence on extracellular matrix components", CANCER RESEARCH, Baltimore, MD, VSA, (19970501), vol. 57, no. 9, pages 1682 - 1689, XP002117246 [X] 1-4,6-13 * abstract * [Y] 1,5
 [DX]  - T. LUTHER ET AL., "Epitope-mapped monoclonal antibodies as tools for functional and morphological analyses of the human urokinase receptor in tumor tissue", AMERICAN JOURNAL OF PATHOLOGY, Hagerstown, MD, VSA, (199704), vol. 150, no. 4, pages 1231 - 1244, XP002117251 [DX] 14-16,18,20,23-25 * the whole document *
 [DX]  - R TODD ET AL., CD87 Workshop Panel report (pages 1016-1020 in 'Leucocyte Typing VI', Eds. T Kishimoto et al.), GARLAND PUBLISHING, INC., (1997), XP002117252 [DX] 14-16,18,20,23-25 * figure . * * table - *
 [X]  - V. MAGDOLEN ET AL., "Epitope-mapped monoclonal antibodies directed to the human urokinase receptor (uPAR, CD87).", TISSUE ANTIGENS, Kopenhagen, Dänemark, (199610), vol. 48, no. 4-2, page 424, XP000929590 [X] 14-16,20,23-25 * Zusammenfassung MC-2-02 *
 [X]  - K. FISCHER ET AL., "Urokinase induces proliferation of human ovarian cancer cells: characterization of structural elements required for growth factor function.", FEBS LETTERS, Amsterdam, die Niederlande, (19981030), vol. 438, no. 1-2, pages 101 - 105, XP002143814 [X] 14,20,23-25 * abstract * * figure 3 *

DOI:   http://dx.doi.org/10.1016/S0014-5793(98)01279-4
 [DY]  - H. ALLGAYER ET AL., "Immunocytochemical phenotyping of disseminated tumor cells in bone marrow by uPA receptor and CK18: investigation of sensitivity and specificity of an immunogold/alkaline phosphatase double staining protocol", JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY, Baltimore, MD, VSA, (199702), vol. 45, no. 2, pages 203 - 212, XP002117247 [DY] 1,5 * abstract *
 [DY]  - M. HEISS ET AL., "Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: a reference to early systemic disease in solid cancer", NATURE MEDICINE, New York, NY, VSA, (199510), vol. 1, no. 10, pages 1035 - 1039, XP002117248 [DY] 1,5 * page 1039, column 1, line 18, paragraph 2 - line 39 *

DOI:   http://dx.doi.org/10.1038/nm1095-1035
 [DA]  - I. FUNKE ET AL., "Comparative analyses of bone marrow micrometastases in breast and gastric cancer", INTERNATIONAL JOURNAL OF CANCER, New York, NY, VSA, (19960315), vol. 65, no. 6, pages 755 - 761, XP002117249 [DA] 1 * abstract *

DOI:   http://dx.doi.org/10.1002/(SICI)1097-0215(19960315)65:6<755::AID-IJC8>3.0.CO;2-Y
 [DA]  - R. CICCOCIOPPO ET AL., "Detection of the receptor for the human urokinase-type plasminogen activator using fluoresceinated uPA", JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY, Baltimore, MD, VSA, (199709), vol. 45, no. 9, pages 1307 - 1313, XP002117250 [DA] 1,5 * figures 1,2 *
Examination   - BIRD R.E. ET AL, "Single chain antibody variable regions", TRENDS IN BIOTECHNOLOGY, (1991), vol. 9, no. 4, pages 132 - 137, XP000207923

DOI:   http://dx.doi.org/10.1016/0167-7799(91)90044-I
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.