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Extract from the Register of European Patents

EP About this file: EP1165800

EP1165800 - MITOMYCIN BIOSYNTHETIC GENE CLUSTER [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  13.05.2005
Database last updated on 01.01.2025
Most recent event   Tooltip13.05.2005Application deemed to be withdrawnpublished on 29.06.2005  [2005/26]
Applicant(s)For all designated states
REGENTS OF THE UNIVERSITY OF MINNESOTA
University Gateway, Suite 600
200 Oak Street SE
Minneapolis, MN 55455 / US
For all designated states
Sherman, David H.
2248 Drew Avenue South
St. Louis Park, MN 55416 / US
For all designated states
Mao, Yingqing
1393 North Cleveland Avenue
St. Paul, MN 55108 / US
For all designated states
Varoglu, Mustafa
2120 Como Avenue 3
St. Paul, MN 55108 / US
For all designated states
He, Min
2004 Knapp Avenue
St. Paul, MN 55108 / US
For all designated states
Sheldon, Paul C.
2959 King James Way
Fitchburg, Wi 53719-1674 / US
[N/P]
Former [2002/01]For all designated states
REGENTS OF THE UNIVERSITY OF MINNESOTA
600 University Gateway, 200 Oak Street SE
Minneapolis, MN 55455-2070 / US
For all designated states
Sherman, David H.
2248 Drew Avenue South
St. Louis Park, MN 55416 / US
For all designated states
Mao, Yingqing
1393 North Cleveland Avenue
St. Paul, MN 55108 / US
For all designated states
Varoglu, Mustafa
2120 Como Avenue 3
St. Paul, MN 55108 / US
For all designated states
He, Min
2004 Knapp Avenue
St. Paul, MN 55108 / US
For all designated states
Sheldon, Paul C.
2959 King James Way
Fitchburg, Wi 53719-1674 / US
Inventor(s)01 / SHERMAN, David, H.
2248 Drew Avenue South
St. Louis Park, MN 55416 / US
02 / MAO, Yingqing
1393 North Cleveland Avenue
St. Paul, MN 55108 / US
03 / VAROGLU, Mustafa
2120 Como Avenue 3
St. Paul, MN 55108 / US
04 / HE, Min
2004 Knapp Avenue
St. Paul, MN 55108 / US
05 / SHELDON, Paul, C.
2959 King James Way
Fitchburg, WI 53719-1674 / US
 [2002/01]
Representative(s)Schüssler, Andrea
Kanzlei Huber & Schüssler
Truderinger Strasse 246
81825 München / DE
[N/P]
Former [2002/01]Schüssler, Andrea, Dr.
Kanzlei Huber & Schüssler Truderinger Strasse 246
81825 München / DE
Application number, filing date00917855.910.03.2000
[2002/01]
WO2000US06394
Priority number, dateUS1999026696512.03.1999         Original published format: US 266965
[2002/01]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO0053737
Date:14.09.2000
Language:EN
[2000/37]
Type: A2 Application without search report 
No.:EP1165800
Date:02.01.2002
Language:EN
The application published by WIPO in one of the EPO official languages on 14.09.2000 takes the place of the publication of the European patent application.
[2002/01]
Search report(s)International search report - published on:EP21.12.2000
ClassificationIPC:C12N15/52, C12N9/00, C12N9/02, C12N9/10, C12N9/12, C12N9/14, C12N9/88, C12N1/21, C07D487/14, C07D519/00, C12P17/18
[2002/01]
CPC:
C12N9/93 (EP,US); C07K14/36 (EP,US); C12N15/52 (EP,US);
C12N9/0004 (EP,US); C12N9/10 (EP,US); C12N9/1007 (EP,US);
C12N9/12 (EP,US); C12N9/14 (EP,US); C12N9/88 (EP,US);
C12P17/182 (EP,US); C12Q1/6827 (EP,US) (-)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2002/01]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
RONot yet paid
SINot yet paid
TitleGerman:MITOMYCIN-BIOSYNTHESE GENGRUPPE[2002/01]
English:MITOMYCIN BIOSYNTHETIC GENE CLUSTER[2002/01]
French:GROUPE DE GENES BIOSYNTHETIQUES DESTINES A LA MITOMYCINE[2002/01]
Entry into regional phase12.10.2001National basic fee paid 
12.10.2001Designation fee(s) paid 
12.10.2001Examination fee paid 
Examination procedure12.10.2000Request for preliminary examination filed
International Preliminary Examining Authority: EP
12.10.2001Amendment by applicant (claims and/or description)
12.10.2001Examination requested  [2002/01]
19.07.2004Despatch of a communication from the examining division (Time limit: M04)
30.11.2004Application deemed to be withdrawn, date of legal effect  [2005/26]
05.01.2005Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2005/26]
Fees paidRenewal fee
22.03.2002Renewal fee patent year 03
24.03.2003Renewal fee patent year 04
22.03.2004Renewal fee patent year 05
Penalty fee
Additional fee for renewal fee
31.03.200506   M06   Not yet paid
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Cited inInternational search[X]WO9509926  (UNIV MINNESOTA [US], et al) [X] 1,4,5,11,34-37,39,41 * page 4 - page 6; figure 14; examples 1,3,6,9; claims 3-5 * * page 10 - page 15 * * page 19 - page 21 *;
 [X]US4395558  (KASAI MASAJI [US], et al) [X] 17-19 * column 1 - column 5 *;
 [X]WO9807868  (CIBA GEIGY AG [CH], et al) [X] 29-31 * abstract * * page 5 - page 18 *;
 [XD]  - KIM C-G ET AL., "3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics", JOURNAL OF BIOLOGICAL CHEMISTRY, (19980313), vol. 273, no. 11, pages 6030 - 6040, XP002145258 [XD] 1,2,4-6,11,22,23,29,31,34,35,37-39 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.273.11.6030
 [X]  - XUE Y ET AL, "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, (19981013), vol. 95, no. 21, ISSN 0027-8424, pages 12111 - 12116, XP002117399 [X] 21,25,27 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.95.21.12111
 [X]  - M BIERMAN ET AL, "Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, (19920701), vol. 116, no. 1, ISSN 0378-1119, pages 43 - 49, XP002116076 [X] 32,33 * the whole document *

DOI:   http://dx.doi.org/10.1016/0378-1119(92)90627-2
 [X]  - AUGUST P R ET AL, "Inducible synthesis of the Mitomycin C resistance gene product (MCRA) from Streptomyces lavendulae", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES,GB,ELSEVIER SCIENCE PUBLISHERS, BARKING, (19961010), vol. 175, no. 1, ISSN 0378-1119, pages 261 - 267, XP004043324 [X] 40,41 * abstract * * page 266, paragraph 2 *

DOI:   http://dx.doi.org/10.1016/0378-1119(96)00172-2
 [A]  - RUAN X ET AL., "A second type-I PKS cluster isolated from Streptomyces hygroscopicus ATCC 29253, a rapamycin-producing strain", GENE, (1997), vol. 203, pages 1 - 9, XP002145259 [A] 24 * abstract * * page 6 - page 7 *

DOI:   http://dx.doi.org/10.1016/S0378-1119(97)00450-2
 [PXD]  - MAO Y ET AL., "Molecular characterization and analysisof the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces levendulae NRRL 2564", CHEMISTRY AND BIOLOGY, (19990323), vol. 6, pages 251 - 263, XP000924816 [PXD] 1-19,21-44 * the whole document * * see especially page 263, bottom of right hand column *

DOI:   http://dx.doi.org/10.1016/S1074-5521(99)80040-4
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.