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Extract from the Register of European Patents

EP About this file: EP1189881

EP1189881 - PROPANOIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS [Right-click to bookmark this link]
StatusPatent maintained as amended
Status updated on  21.12.2012
Database last updated on 26.04.2025
Most recent event   Tooltip21.12.2012Patent maintained (B2 publication)published on 23.01.2013  [2013/04]
Applicant(s)For all designated states
ENCYSIVE PHARMACEUTICALS, INC.
235 East 42nd Street
New York, NY 10017 / US
[2012/41]
Former [2007/52]For all designated states
ENCYSIVE PHARMACEUTICALS, INC
4848 Loop Central Drive, Suite 700
Houston, TX 77081 / US
Former [2002/13]For all designated states
TEXAS BIOTECHNOLOGY CORPORATION
7000 Fannin Street, Suite 1920
Houston, TX 77030 / US
Inventor(s)01 / BIEDIGER, Ronald, J.
17002 E. Copper Lakes Court
Houston, TX 77095 / US
02 / HOLLAND, George, W.
10 Acorn Place
North Caldwell, NJ 07006 / US
03 / KASSIR, Jamal, M.
2121 Hepburn, Apt. 713
Houston, TX 77054 / US
04 / LI, Wen
1954 Winrock, Apt. 234
Houston, TX 77057 / US
05 / MARKET, Robert, V.
2215 St. James Place
Pearland, TX 77581 / US
06 / SCOTT, Ian, L.
25 Lea Drive
Delanson, NY 12053 / US
07 / WU, Chengde
2511 Lansing Circle
Pearland, TX 77584 / US
 [2002/13]
Representative(s)Weber, Martin
Jones Day
Prinzregentenstraße 11
80538 München / DE
[2013/04]
Former [2007/50]Weber-Quitzau, Martin
Jones Day Prinzregentenstraße 11
80538 München / DE
Former [2007/21]Weber-Quitzau, Martin
Uexküll & Stolberg Patentanwälte Thomas-Wimmer-Ring 9
80539 München / DE
Former [2006/35]Jones Day
Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11
80538 München / DE
Former [2006/32]Ricker, Mathias, et al
Jones Day, Rechtsanwälte, Attorneys-at-Law, Patentanwälte, Prinzregentenstrasse 11
80538 München / DE
Former [2005/45]Modiano, Micaela Nadia
Modiano, Josif, Pisanty & Staub Ltd., Baaderstrasse 3
80469 München / DE
Former [2002/13]Modiano, Guido, Dr.-Ing., et al
Modiano, Josif, Pisanty & Staub, Baaderstrasse 3
80469 München / DE
Application number, filing date00930450.205.05.2000
[2002/13]
WO2000US12464
Priority number, dateUS19990132967P07.05.1999         Original published format: US 132967 P
US19990170441P10.12.1999         Original published format: US 170441 P
[2002/13]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO0068188
Date:16.11.2000
Language:EN
[2000/46]
Type: A1 Application with search report 
No.:EP1189881
Date:27.03.2002
Language:EN
The application published by WIPO in one of the EPO official languages on 16.11.2000 takes the place of the publication of the European patent application.
[2002/13]
Type: B1 Patent specification 
No.:EP1189881
Date:29.09.2004
Language:EN
[2004/40]
Type: B2 New European patent specification 
No.:EP1189881
Date:23.01.2013
Language:EN
[2013/04]
Search report(s)International search report - published on:US16.11.2000
(Supplementary) European search report - dispatched on:EP14.10.2002
ClassificationIPC:C07D405/12, C07D213/64, C07D213/89, C07D409/14
[2002/38]
CPC:
C07D213/64 (EP,KR); A61P1/04 (EP); A61P11/06 (EP);
A61P17/00 (EP); A61P19/02 (EP); A61P25/00 (EP);
A61P25/28 (EP); A61P29/00 (EP); A61P3/10 (EP);
A61P31/10 (EP); A61P35/00 (EP); A61P35/02 (EP);
A61P35/04 (EP); A61P37/06 (EP); A61P37/08 (EP);
A61P43/00 (EP); A61P7/00 (EP); A61P9/10 (EP);
C07D317/60 (EP,KR); C07D405/12 (EP,KR); C07D409/14 (EP,KR) (-)
Former IPC [2002/13]C07C315/00, C07C229/00, C07C321/00, C07C205/00
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2002/13]
TitleGerman:PROPANSÄUREDERIVATE, DIE DIE BINDUNG VON INTEGRINEN AN IHRE REZEPTOREN BEHINDERN[2002/13]
English:PROPANOIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS[2002/13]
French:DERIVES DE L'ACIDE PROPANOIQUE INHIBANT LA LIAISON DES INTEGRINES A LEURS RECEPTEURS[2002/13]
Entry into regional phase29.11.2001National basic fee paid 
29.11.2001Search fee paid 
29.11.2001Designation fee(s) paid 
29.11.2001Examination fee paid 
Examination procedure28.11.2000Request for preliminary examination filed
International Preliminary Examining Authority: US
29.11.2001Amendment by applicant (claims and/or description)
29.11.2001Examination requested  [2002/13]
20.02.2003Despatch of a communication from the examining division (Time limit: M06)
30.07.2003Reply to a communication from the examining division
28.08.2003Despatch of a communication from the examining division (Time limit: M04)
08.12.2003Reply to a communication from the examining division
19.03.2004Communication of intention to grant the patent
23.06.2004Fee for grant paid
23.06.2004Fee for publishing/printing paid
Opposition(s)Opponent(s)01  28.06.2005  17.08.2005  ADMISSIBLE
Vertex Pharmaceuticals Incorporated
130 Waverly Street
Cambridge, Massachussetts 02139-4242 / US
Opponent's representative
Cornish, Kristina Victoria Joy
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
 [N/P]
Former [2011/11]
Opponent(s)01  28.06.2005  17.08.2005  ADMISSIBLE
Vertex Pharmaceuticals Incorporated
130 Waverly Street
Cambridge, Massachussetts 02139-4242 / US
Opponent's representative
Cornish, Kristina Victoria Joy
Kilburn & Strode LLP 20 Red Lion Street London
WC1R 4PJ / GB
Former [2010/24]
Opponent(s)01  28.06.2005  17.08.2005  ADMISSIBLE
Vertex Pharmaceuticals Incorporated
130 Waverly Street
Cambridge, Massachussetts 02139-4242 / US
Opponent's representative
Crooks, Elizabeth Caroline
Kilburn & Strode LLP 20 Red Lion Street
London WC1R 4PJ / GB
Former [2005/34]
Opponent(s)01  28.06.2005   
Vertex Pharmaceuticals Incorporated
130 Waverly Street
Cambridge, Massachussetts 02139-4242 / US
Opponent's representative
Minderop, Ralph H.
COHAUSZ & FLORACK Patent- und Rechtsanwälte Bleichstrasse 14
40211 Düsseldorf / DE
deletedDeletion: Legal effect of rejection of opposition [ N /P ]
24.08.2005Invitation to proprietor to file observations on the notice of opposition
28.12.2005Reply of patent proprietor to notice(s) of opposition
21.09.2007Date of oral proceedings
22.01.2008Despatch of minutes of oral proceedings
22.01.2008Date of despatch of rejection of opposition
04.05.2011Despatch of interlocutory decision in opposition
04.05.2011Legal effect of interlocutory decision in opposition
01.10.2012Despatch of communication that the patent will be maintained as amended
12.12.2012Fee for printing new specification paid
Appeal following opposition28.03.2008Appeal received No.  T0620/08
02.06.2008Statement of grounds filed
04.05.2011Result of appeal procedure: maintenance in amended form
04.05.2011Date of oral proceedings
12.05.2011Minutes of the oral proceedings despatched
Fees paidRenewal fee
14.05.2002Renewal fee patent year 03
13.05.2003Renewal fee patent year 04
13.05.2004Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT29.09.2004
BE29.09.2004
CH29.09.2004
FI29.09.2004
LI29.09.2004
NL29.09.2004
DK29.12.2004
GR29.12.2004
SE29.12.2004
PT28.02.2005
CY05.05.2005
IE05.05.2005
LU05.05.2005
MC31.05.2005
[2008/03]
Former [2007/27]AT29.09.2004
BE29.09.2004
CH29.09.2004
FI29.09.2004
LI29.09.2004
NL29.09.2004
DK29.12.2004
GR29.12.2004
SE29.12.2004
CY05.05.2005
IE05.05.2005
LU05.05.2005
MC31.05.2005
Former [2007/26]AT29.09.2004
BE29.09.2004
CH29.09.2004
FI29.09.2004
LI29.09.2004
NL29.09.2004
DK29.12.2004
GR29.12.2004
SE29.12.2004
CY05.05.2005
IE05.05.2005
LU05.05.2005
Former [2007/20]AT29.09.2004
BE29.09.2004
CH29.09.2004
FI29.09.2004
LI29.09.2004
NL29.09.2004
DK29.12.2004
GR29.12.2004
SE29.12.2004
CY05.05.2005
IE05.05.2005
LU31.05.2005
Former [2007/08]AT29.09.2004
BE29.09.2004
CH29.09.2004
FI29.09.2004
LI29.09.2004
NL29.09.2004
DK29.12.2004
GR29.12.2004
SE29.12.2004
IE05.05.2005
LU31.05.2005
Former [2006/25]AT29.09.2004
BE29.09.2004
CH29.09.2004
FI29.09.2004
LI29.09.2004
NL29.09.2004
DK29.12.2004
GR29.12.2004
SE29.12.2004
IE05.05.2005
Former [2006/14]AT29.09.2004
BE29.09.2004
CH29.09.2004
FI29.09.2004
LI29.09.2004
NL29.09.2004
DK29.12.2004
GR29.12.2004
SE29.12.2004
Former [2005/46]AT29.09.2004
BE29.09.2004
CH29.09.2004
FI29.09.2004
LI29.09.2004
DK29.12.2004
GR29.12.2004
SE29.12.2004
Former [2005/28]AT29.09.2004
BE29.09.2004
CH29.09.2004
FI29.09.2004
LI29.09.2004
GR29.12.2004
SE29.12.2004
Former [2005/25]AT29.09.2004
CH29.09.2004
FI29.09.2004
LI29.09.2004
GR29.12.2004
SE29.12.2004
Former [2005/18]AT29.09.2004
FI29.09.2004
GR29.12.2004
SE29.12.2004
Former [2005/13]AT29.09.2004
FI29.09.2004
SE29.12.2004
Former [2005/11]FI29.09.2004
SE29.12.2004
Former [2005/10]SE29.12.2004
Documents cited:Search[X]EP0512831  (MERCK & CO INC [US]) [X] 4 * page 44 * * page 66; claim 1 *;
 [X]EP0761680  (ONO PHARMACEUTICAL CO [JP]) [X] 4 * examples 25,26; claim 1 *;
 [X]WO9804247  (BIOGEN INC [US], et al) [X] 1-12 * page 164 *;
 [X]WO9808840  (MERCK & CO INC [US], et al) [X] 4 * page 180 - page 183 * * claim 3 *;
 [X]WO9816502  (WARNER LAMBERT CO [US], et al) [X] 4 * page 98; examples 5Z,5AA * * claims 1,35 *;
 [Y]EP0842943  (HOECHST AG [DE]) [Y] 4* example 54 *;
 [X]WO9850420  (AKZO NOBEL NV [NL], et al) [X] 4 * examples 30-32,45; claim 1 *;
 [X]US5847135  (BEMIS GUY W [US], et al) [X] 4 * column 14 * * column 46 * * column 49 - column 55 * * column 96 * * column 136 - column 139 * * column 154 - column 155 * * column 169 * * column 171 *;
 [X]US5874424  (BATCHELOR MARK JAMES [GB], et al) [X] 4 * column 203 - column 204; claim 1 *;
 [Y]EP0903353  (HOECHST MARION ROUSSEL DE GMBH [DE]) [Y] 4 * page 49 - page 51 *;
 [PX]WO0021920  (HOFFMANN LA ROCHE [CH]) [PX] 4 * page 165; example 266 *;
 [E]WO0061631  (ASTRAZENECA AB [SE], et al) [E] 4 * examples 12-15,17,18; claim 1 *;
 [X]  - GOLEC J M C ET AL, "Structure-based design of non-peptidic pyridone aldehydes as inhibitors of interleukin-1beta converting enzyme", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, (19970909), vol. 7, no. 17, ISSN 0960-894X, pages 2181 - 2186, XP004136410 [X] 4 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0960-894X(97)00394-6
 [X]  - SEMPLE G ET AL, "Peptidomimetic aminomethylene ketone inhibitors of interleukin-1beta-converting enzyme (ICE)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, (19980421), vol. 8, no. 8, ISSN 0960-894X, pages 959 - 964, XP004136999 [X] 4 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0960-894X(98)00136-X
 [X]  - SEMPLE G ET AL, "PYRIDONE-BASED PEPTIDOMIMETIC INHIBITORS OF INTERLEUKIN-1beta-CONVER TING ENZYME (ICE)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, (19970520), vol. 7, no. 10, ISSN 0960-894X, pages 1337 - 1342, XP004136329 [X] 4 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0960-894X(97)00220-5
International searchWO9822494  [ ] (ATHENA NEUROSCIENCES INC [US], et al)
 [X]  - AUDIA J. ET AL., "Preparation of N-(phenylacetyl)di and tripeptide derivatives for inhibiting amyloid peptide release", CHEMICAL ABSTRACTS, (19980528), vol. 129, Database accession no. 41414
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.