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Extract from the Register of European Patents

EP About this file: EP1165578

EP1165578 - METHODS AND COMPOSITIONS FOR THE MANUFACTURE OF C-3' AND C-4' ANTHRACYCLINE ANTIBIOTICS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  28.12.2012
Database last updated on 12.07.2024
Most recent event   Tooltip30.05.2014Lapse of the patent in a contracting state
New state(s): LU		published on 02.07.2014  [2014/27]
Applicant(s)For all designated states
Priebe, Waldemar
4239 Emory Avenue
Houston, TX 77005 / US
For all designated states
Fokt, Izabela
1908 Nursery Road
The Woodlands, TX 77380 / US
For all designated states
Przewloka, Teresa
Apartment No. 1406
1200 Sawmill Road
The Woodlands, TX 77380 / US
For all designated states
Krawczyk, Marta
4210 S. Ravinia Dr.
Apt. No. 114
Greenfield, WI 53221 / US
For all designated states
Skibicki, Piotr
Apartment 24
Waszyngton Street 39
04-015 Warsaw / PL
For all designated states
Grynkiewicz, Grzegorz
u. Zielona 16 B/2
05-092 Lominaki / PL
For all designated states
Perez-Soler, Roman
564 1st Ave.
No. 20T
New York, NY 10016 / US
[2012/08]
Former [2002/01]For all designated states
Priebe, Waldemar
4239 Emory Avenue
Houston, TX 77005 / US
For all designated states
Fokt, Izabela
1908 Nursery Road
The Woodlands, TX 77380 / US
For all designated states
Przewloka, Teresa
Apartment No. 1406, 1200 Sawmill Road
Teh Woodlands, TX 77380 / US
For all designated states
Krawczyk, Marta
Apt. 2308, 175 N. Locust Hill Drive
Lexington, KY 40503 / US
For all designated states
Skibicki, Piotr
Apt. 24, Waszyngton Street 39
04-015 Warsaw / PL
For all designated states
Grynkiewicz, Gegorz
u. Zielona 16 B/2
05-092 Lominaki / PL
For all designated states
Perez-Soler, Roman
564 First Avenue, Apt. 20T
New York City, New York 10016 / US
Inventor(s)01 / see applicant
...
 [2002/01]
Representative(s)Catherine, Alain, et al
Cabinet HARLE et PHELIP
14-16, Rue Ballu
75009 Paris / FR
[N/P]
Former [2002/01]Catherine, Alain, et al
Cabinet Harlé & Phélip 7, rue de Madrid
75008 Paris / FR
Application number, filing date00935417.615.03.2000
[2002/01]
WO2000IB00527
Priority number, dateUS19990125505P19.03.1999         Original published format: US 125505 P
[2002/01]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO0056267
Date:28.09.2000
Language:EN
[2000/39]
Type: A2 Application without search report 
No.:EP1165578
Date:02.01.2002
Language:EN
The application published by WIPO in one of the EPO official languages on 28.09.2000 takes the place of the publication of the European patent application.
[2002/01]
Type: B1 Patent specification 
No.:EP1165578
Date:22.02.2012
Language:EN
[2012/08]
Search report(s)International search report - published on:US22.02.2001
(Supplementary) European search report - dispatched on:EP12.07.2002
ClassificationIPC:C07H1/00, C07H15/24
[2002/01]
CPC:
C07H15/252 (EP,US); A61K31/704 (EP,US)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2002/01]
TitleGerman:VERFAHREN UND ZUSAMMENSETZUNGEN ZUR HERSTELLUNG VON C-3' und C-4' -ANTHRACYCLIN ANTIBIOTIKA[2002/01]
English:METHODS AND COMPOSITIONS FOR THE MANUFACTURE OF C-3' AND C-4' ANTHRACYCLINE ANTIBIOTICS[2002/01]
French:PROCEDES ET COMPOSITIONS DESTINES A LA FABRICATION D'ANTIBIOTIQUES DU TYPE ANTHRACYCLINES A SUBSTITUTION EN C-3' ET C-4'[2002/01]
Entry into regional phase19.10.2001National basic fee paid 
19.10.2001Search fee paid 
19.10.2001Designation fee(s) paid 
19.10.2001Examination fee paid 
Examination procedure19.10.2000Request for preliminary examination filed
International Preliminary Examining Authority: US
19.10.2001Examination requested  [2002/01]
06.12.2001Amendment by applicant (claims and/or description)
16.12.2008Despatch of a communication from the examining division (Time limit: M06)
12.06.2009Reply to a communication from the examining division
08.03.2010Despatch of a communication from the examining division (Time limit: M06)
26.10.2010Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
22.12.2010Reply to a communication from the examining division
25.02.2011Despatch of a communication from the examining division (Time limit: M04)
08.06.2011Reply to a communication from the examining division
27.07.2011Communication of intention to grant the patent
24.11.2011Fee for grant paid
24.11.2011Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  16.12.2008
Opposition(s)23.11.2012No opposition filed within time limit [2013/05]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
22.12.2010Request for further processing filed
22.12.2010Full payment received (date of receipt of payment)
Request granted
10.01.2011Decision despatched
Fees paidRenewal fee
30.01.2002Renewal fee patent year 03
31.03.2003Renewal fee patent year 04
15.03.2004Renewal fee patent year 05
30.03.2005Renewal fee patent year 06
09.03.2006Renewal fee patent year 07
14.03.2007Renewal fee patent year 08
14.03.2008Renewal fee patent year 09
13.03.2009Renewal fee patent year 10
15.03.2010Renewal fee patent year 11
15.03.2011Renewal fee patent year 12
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT22.02.2012
BE22.02.2012
CY22.02.2012
DK22.02.2012
FI22.02.2012
IT22.02.2012
NL22.02.2012
SE22.02.2012
IE15.03.2012
LU15.03.2012
MC31.03.2012
GR23.05.2012
ES02.06.2012
PT22.06.2012
[2014/27]
Former [2013/22]AT22.02.2012
BE22.02.2012
CY22.02.2012
DK22.02.2012
FI22.02.2012
IT22.02.2012
NL22.02.2012
SE22.02.2012
IE15.03.2012
MC31.03.2012
GR23.05.2012
ES02.06.2012
PT22.06.2012
Former [2013/08]AT22.02.2012
BE22.02.2012
CY22.02.2012
DK22.02.2012
FI22.02.2012
IT22.02.2012
NL22.02.2012
SE22.02.2012
IE15.03.2012
MC31.03.2012
GR23.05.2012
PT22.06.2012
Former [2013/07]AT22.02.2012
BE22.02.2012
CY22.02.2012
DK22.02.2012
FI22.02.2012
IT22.02.2012
NL22.02.2012
SE22.02.2012
MC31.03.2012
GR23.05.2012
PT22.06.2012
Former [2012/50]BE22.02.2012
CY22.02.2012
DK22.02.2012
FI22.02.2012
IT22.02.2012
NL22.02.2012
SE22.02.2012
MC31.03.2012
GR23.05.2012
PT22.06.2012
Former [2012/49]BE22.02.2012
CY22.02.2012
DK22.02.2012
FI22.02.2012
NL22.02.2012
SE22.02.2012
MC31.03.2012
GR23.05.2012
PT22.06.2012
Former [2012/48]BE22.02.2012
CY22.02.2012
FI22.02.2012
NL22.02.2012
SE22.02.2012
MC31.03.2012
GR23.05.2012
PT22.06.2012
Former [2012/47]BE22.02.2012
CY22.02.2012
FI22.02.2012
NL22.02.2012
MC31.03.2012
GR23.05.2012
PT22.06.2012
Former [2012/41]BE22.02.2012
CY22.02.2012
FI22.02.2012
NL22.02.2012
GR23.05.2012
PT22.06.2012
Former [2012/37]BE22.02.2012
FI22.02.2012
NL22.02.2012
GR23.05.2012
PT22.06.2012
Former [2012/36]NL22.02.2012
GR23.05.2012
Former [2012/35]NL22.02.2012
Documents cited:Search[X]US4351937  (STEFANSKA BARBARA J, et al) [X] 1-16 * claim 1 *;
 [X]EP0402259  (HOECHST SA LAB [FR]) [X] 32 * page 7 *;
 [X]WO9420114  (UNIV TEXAS [US]) [X] 1-16 * page 9, line 21 - page 15, line 5 * * in particular page 12, lines 1-8 *;
 [X]  - KLAFFKE W ET AL, "ARTIFICIAL DEOXY GLYCOSIDES OF ANTHRACYCLINES", LIEBIGS ANNALEN DER CHEMIE, VERLAG CHEMIE GMBH. WEINHEIM, DE, (1991), no. 6, ISSN 0170-2041, pages 509 - 512, XP001080146 [X] 1-16 * compound 12 *
 [X]  - HASSON H ET AL, "HPLC Analysis of adriamycine as N-2,4-dinitrophenyladriamycine", JOURNAL OF LIQUID CHROMATOGRAPHY, (1990), vol. 13, no. 8, pages 1637 - 1649, XP002203737 [X] 1-16 * Scheme 1, compound III *
 [X]  - GEORGE L. TONG ET AL., "Adriamycin Analogues. 3. Synthesis of N-Alkylated Anthracyclines with Enhanced Efficacy and Reduced Cardiotoxicity", JOURNAL OF MEDICINAL CHEMISTRY, (1979), vol. 22, no. 8, pages 912 - 918, XP002203738 [X] 1-16 * the whole document * * compounds 3h and 4h *

DOI:   http://dx.doi.org/10.1021/jm00194a005
 [X]  - JOHN H. PETERS ET AL., "Redox activities of antitumor anthracyclines determines by microsomal oxygen consumption and assays for superoxide anion and hydroxyl radical generation", BIOCHEMICAL PHARMACOLOGY, (1986), vol. 35, no. 8, pages 1309 - 1323, XP001079579 [X] 1-16 * the whole document * * Table 2; compounds wherein R2 represents a heteroatomic six-member ring *

DOI:   http://dx.doi.org/10.1016/0006-2952(86)90276-5
 [X]  - CZERWINSKI A. ET AL., "Synthesis of new N-alkyl daunorubicin derivatives via Michael addition to substituted maleimides", THE JOURNAL OF ANTIBIOTICS; COMMUNICATION TO THE EDITOR, (1987), vol. XL, no. 7, pages 1067 - 1070, XP002203739 [X] 1-16 * compounds 1-5 * * page 1069, column R *
 [X]  - ALIGIANNIS N ET AL, "Synthesis and biological activity of 4'-azido- and 4'-trifluoracetamido-3'-chloro-3'-deamino-4'-deoxydaunorubicin", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, (19961022), vol. 6, no. 20, ISSN 0960-894X, pages 2473 - 2476, XP004135861 [X] 32 * scheme 1: conversion of compound 6a into compound 1 *

DOI:   http://dx.doi.org/10.1016/0960-894X(96)00457-X
 [X]  - KLAFFKE W. ET AL., "Approaches to the C-B-A trisaccharide of dihydroaclacinomycin by extending the chain from either side", CARBOHYDRATE RESEARCH, (1991), vol. 216, pages 475 - 481, XP002203740 [X] 40 * compound 5 *

DOI:   http://dx.doi.org/10.1016/0008-6215(92)84182-R
 [X]  - DALEY L. ET AL., "A short and high yield access to glycosyl donors of amino-deoxy-sugars of biological relevance", SYNTHETIC COMMUNICATIONS, (1998), vol. 28, no. 1, pages 61 - 73, XP002203741 [X] 41 * compound 8 *

DOI:   http://dx.doi.org/10.1080/00397919808005074
International search[A]US4355026  (UMEZAWA HAMAO, et al)
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.