EP1198254 - CARRIER-DRUG CONJUGATE [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 20.06.2008 Database last updated on 31.08.2024 | Most recent event Tooltip | 31.08.2012 | Lapse of the patent in a contracting state New state(s): FR | published on 03.10.2012 [2012/40] | Applicant(s) | For all designated states KTB Tumorforschungsgesellschaft mbH Breisacher Strasse 117 79106 Freiburg / DE | [2002/17] | Inventor(s) | 01 /
KRATZ, Felix Zum Abtsweingarten 19 79241 Ihringen / DE | [2002/17] | Representative(s) | Müller-Boré & Partner Patentanwälte PartG mbB Friedenheimer Brücke 21 80639 München / DE | [N/P] |
Former [2002/17] | Müller-Boré & Partner Patentanwälte Grafinger Strasse 2 81671 München / DE | Application number, filing date | 00943777.3 | 07.06.2000 | [2002/17] | WO2000EP05254 | Priority number, date | DE1999126475 | 10.06.1999 Original published format: DE 19926475 | [2002/17] | Filing language | DE | Procedural language | DE | Publication | Type: | A2 Application without search report | No.: | WO0076550 | Date: | 21.12.2000 | Language: | DE | [2000/51] | Type: | A2 Application without search report | No.: | EP1198254 | Date: | 24.04.2002 | Language: | DE | The application published by WIPO in one of the EPO official languages on 21.12.2000 takes the place of the publication of the European patent application. | [2002/17] | Type: | B1 Patent specification | No.: | EP1198254 | Date: | 15.08.2007 | Language: | DE | [2007/33] | Search report(s) | International search report - published on: | EP | 17.05.2001 | Classification | IPC: | A61K47/48 | [2002/17] | CPC: |
A61K47/643 (EP,US);
A61K47/65 (EP,US);
A61P29/00 (EP);
A61P31/00 (EP);
A61P31/12 (EP);
A61P35/00 (EP);
A61P37/00 (EP)
(-)
| Designated contracting states | AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2002/17] | Extension states | AL | Not yet paid | LT | Not yet paid | LV | Not yet paid | MK | Not yet paid | RO | Not yet paid | SI | Not yet paid | Title | German: | TRÄGER-PHARMAKA-KONJUGATE | [2002/17] | English: | CARRIER-DRUG CONJUGATE | [2002/17] | French: | CONJUGUE EXCIPIENT-PRODUIT PHARMACEUTIQUE | [2002/17] | Entry into regional phase | 03.01.2002 | National basic fee paid | 03.01.2002 | Designation fee(s) paid | 03.01.2002 | Examination fee paid | Examination procedure | 19.12.2000 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 03.01.2002 | Examination requested [2002/17] | 12.03.2002 | Loss of particular rights, legal effect: Claims | 29.04.2002 | Despatch of communication of loss of particular rights: Claims {1} | 16.04.2004 | Despatch of a communication from the examining division (Time limit: M06) | 15.10.2004 | Reply to a communication from the examining division | 29.04.2005 | Despatch of a communication from the examining division (Time limit: M04) | 31.08.2005 | Reply to a communication from the examining division | 05.12.2006 | Date of oral proceedings | 14.12.2006 | Minutes of oral proceedings despatched | 19.02.2007 | Communication of intention to grant the patent | 21.06.2007 | Fee for grant paid | 21.06.2007 | Fee for publishing/printing paid | Opposition(s) | 16.05.2008 | No opposition filed within time limit [2008/30] | Fees paid | Renewal fee | 26.06.2002 | Renewal fee patent year 03 | 25.06.2003 | Renewal fee patent year 04 | 29.06.2004 | Renewal fee patent year 05 | 28.06.2005 | Renewal fee patent year 06 | 28.06.2006 | Renewal fee patent year 07 | 26.06.2007 | Renewal fee patent year 08 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | CY | 15.08.2007 | DK | 15.08.2007 | FI | 15.08.2007 | NL | 15.08.2007 | SE | 15.11.2007 | GR | 16.11.2007 | ES | 26.11.2007 | PT | 15.01.2008 | FR | 11.04.2008 | [2012/40] |
Former [2009/33] | CY | 15.08.2007 | |
DK | 15.08.2007 | ||
FI | 15.08.2007 | ||
NL | 15.08.2007 | ||
SE | 15.11.2007 | ||
GR | 16.11.2007 | ||
ES | 26.11.2007 | ||
PT | 15.01.2008 | ||
Former [2008/28] | DK | 15.08.2007 | |
FI | 15.08.2007 | ||
NL | 15.08.2007 | ||
SE | 15.11.2007 | ||
GR | 16.11.2007 | ||
ES | 26.11.2007 | ||
PT | 15.01.2008 | ||
Former [2008/26] | DK | 15.08.2007 | |
FI | 15.08.2007 | ||
NL | 15.08.2007 | ||
GR | 16.11.2007 | ||
ES | 26.11.2007 | ||
PT | 15.01.2008 | ||
Former [2008/23] | DK | 15.08.2007 | |
FI | 15.08.2007 | ||
NL | 15.08.2007 | ||
GR | 16.11.2007 | ||
ES | 26.11.2007 | ||
Former [2008/19] | FI | 15.08.2007 | |
NL | 15.08.2007 | ||
GR | 16.11.2007 | ||
ES | 26.11.2007 | ||
Former [2008/10] | FI | 15.08.2007 | |
NL | 15.08.2007 | ||
ES | 26.11.2007 | ||
Former [2008/09] | NL | 15.08.2007 | |
ES | 26.11.2007 | ||
Former [2008/08] | ES | 26.11.2007 | Cited in | International search | [DY]DE19636889 (KRATZ FELIX DR [DE]) [DY] 1-18 * page 3, line 18 - line 28; claim - *; | [E]WO0076551 (KTB TUMORFORSCHUNGS GMBH [DE], et al) [E] 1 * page 17, line 18 - line 26; claim - *; | [Y] - KRATZ F ET AL, "PREPARATION, CHARACTERIZATION AND IN VITRO EFFICACY OF ALBUMIN CONJUGATES OF DOXORUBICIN", BIOLOGICAL & PHARMACEUTICAL BULLETIN (OF JAPAN),JP,PHARMACEUTICAL SOCIETY OF JAPAN, (1998), vol. 21, no. 1, ISSN 0918-6158, pages 56 - 61, XP000738275 [Y] 1-18 * figure 1 * | [XY] - A. TROUET ET AL., "A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropc drug-carrier conjugate; In vitro and in vivo studies.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, WASHINGTON US, (198201), vol. 79, pages 626 - 629, XP002162367 [X] 1 * figure 1; table 1 * [Y] 1-18 DOI: http://dx.doi.org/10.1073/pnas.79.2.626 | [DY] - S. NETZEL-ARNETT, "Comparitive sequence specificities of human 72- and 92-kDa gelatinases (type iv Collagenases) and PUMP (Matrilysin)", BIOCHEMISTRY, EASTON, PA US, (1993), vol. 32, no. 25, pages 6427 - 6432, XP002162368 [DY] 1-18 * table 1 * DOI: http://dx.doi.org/10.1021/bi00076a016 | [A] - M. NICHIFOR ET AL., "Macromolecular prodrugs of 5-fluorouracil. 2: Enzymatic degradation.", JOURNAL OF CONTROLLED RELEASE, AMSTERDAM NL, (1996), vol. 39, pages 79 - 92, XP002162369 [A] 1 * abstract * DOI: http://dx.doi.org/10.1016/0168-3659(95)00141-7 | [A] - G. M. DUBOWCHIK ET AL., "Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin.", BIOORG MED CHEM LETT., (199812), vol. 8, no. 23, pages 3341 - 3346, XP002162370 [A] 1-18 * page 3342; table 1 * DOI: http://dx.doi.org/10.1016/S0960-894X(98)00609-X | Examination | WO9308842 | - Derossi et al. (1998) Trends Cell Biol. 8, 84-87. | - Narazaki et al. (1997) BBA 1338, 275-281. | - Kratz et al (1999) Crit. Rev. Ther. Drug. Carrier Syst. 16, 245-288. | - Firestone et al. (1996) J. Controll. Rel. 39, 251-259. | - Willner et al. (1993) Bioconjugate Chem. 4, 521-527. | - Derossi et al: (1998) Trends Cell Biol. 8, 84-87. | - Narazaki et al: (1997) BBA 1338, 275-281. | - Kratz et al: (1999) Crit. Rev. Ther. Drug. Carrier Syst. 16, 245-288. | - Firestone et al: (1996) J. Controll. Rel. 39, 251-259. | - Willner et al: (1993) Bioconjugate Chem. 4, 521-527. | - Yasuzawa & Tomer (1997) Bioconjugate Chem. 8, 391-399. | - Burton et al. (1989) Eur. J. Biochem. 179, 379-387. | - Kratz et al. (2002) J. Med. Chem. 45, 5523-5533 + Supporting info. | - Kratz et al. (2001) Bioorg. Med. Chem. Lett. 11, 2001-2006. | - Stehle et al. (1997) Anti-Cancer Drugs 8, 677-685. |