EP1227084 - DRUG DISCHARGE PUMP INHIBITORS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 20.10.2006 Database last updated on 15.07.2024 | Most recent event Tooltip | 05.12.2008 | Lapse of the patent in a contracting state New state(s): CY | published on 07.01.2009 [2009/02] | Applicant(s) | For all designated states Trine Pharmaceuticals, Inc. 78 Fourth Avenue Waltham, MA 02451 / US | For all designated states DAIICHI PHARMACEUTICAL CO., LTD. 14-10, Nihonbashi 3-chome Chuo-ku Tokyo 103-8234 / JP | [N/P] |
Former [2005/50] | For all designated states Trine Pharmaceuticals, Inc. 78 Fourth Avenue Waltham, MA 02451 / US | ||
For all designated states DAIICHI PHARMACEUTICAL CO., LTD. 14-10, Nihonbashi 3-chome Chuo-ku Tokyo 103-8234 / JP | |||
Former [2005/42] | For all designated states Trine Pharmaceuticals Inc. 78 Fourth Avenue Waltham, MA 02451 / US | ||
For all designated states DAIICHI PHARMACEUTICAL CO., LTD. 14-10, Nihonbashi 3-chome Chuo-ku, Tokyo 103-8234 / JP | |||
Former [2002/35] | For all designated states Essential Therapeutics, Inc. 1365 Main Street Waltham, MA 02451 / US | ||
For all designated states DAIICHI PHARMACEUTICAL CO., LTD. 14-10, Nihonbashi 3-chome Chuo-ku, Tokyo 103-8234 / JP | |||
Former [2002/31] | For all designated states Microcide Pharmaceuticals, Inc. 850 Maude Avenue Mountainview, CA 94043 / US | ||
For all designated states DAIICHI PHARMACEUTICAL CO., LTD. 14-10, Nihonbashi 3-chome Chuo-ku, Tokyo 103-8234 / JP | Inventor(s) | 01 /
LEGER, Roger 202, Upper Edison Saint-Lambert, Quebec J4R 2V8 / CA | 02 /
WATKINS, William, John 626, Oneida Drive Sunnyvale, CA 94087 / US | 03 /
ZHANG, Jason, Zhijia 770, Crane Avenue Foster City, CA 94404 / US | 04 /
RENAU, Thomas, Eric 900, Pepper Tree Lane 224 Santa Clara, CA 95051 / US | 05 /
LEE, Ving, Jack 1335, Carvo Court Los Altos, CA 94024 / US | 06 /
OHTA, Toshiharu, Daiichi Pharmaceutical Co., Ltd. Tokyo R & D Center, 16-13, Kita-kasai 1-chome Edogawa-ku, Tokyo 134-8630 / JP | 07 /
NAKAYAMA, Kiyoshi, Daiichi Pharmaceutical Co., Ltd Tokyo R & D Center, 16-13, Kita-kasai 1-chome Edogawa-ku, Tokyo 134-8630 / JP | 08 /
ISHIDA, Yohhei, Daiichi Pharmaceutical Co., Ltd. Tokyo R & D Center, 16-13, Kita-kasai 1-chome Edogawa-ku, Tokyo 134-8630 / JP | 09 /
OHTSUKA, Masami, Daiichi Pharmaceutical Co., Ltd. Tokyo R & D Center, 16-13, Kita-kasai 1-chome Edogawa-ku, Tokyo 134-8630 / JP | 10 /
KAWATO, Haruko, Daiichi Pharmaceutical Co., Ltd. Tokyo R & D Center, 16-13, Kita-kasai 1-chome Edogawa-ku, Tokyo 134-8630 / JP | [2002/31] | Representative(s) | polypatent Patentanwälte An den Gärten 7 51491 Overath / DE | [N/P] |
Former [2002/31] | Sternagel, Fleischer, Godemeyer & Partner Patentanwälte An den Gärten 7 51491 Overath / DE | Application number, filing date | 00970155.8 | 27.10.2000 | [2002/31] | WO2000JP07565 | Priority number, date | US19990428466 | 28.10.1999 Original published format: US 428466 | JP20000326713 | 26.10.2000 Original published format: JP 2000326713 | [2002/31] | Filing language | JA | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO0130757 | Date: | 03.05.2001 | Language: | EN | [2001/18] | Type: | A1 Application with search report | No.: | EP1227084 | Date: | 31.07.2002 | Language: | EN | The application published by WIPO in one of the EPO official languages on 03.05.2001 takes the place of the publication of the European patent application. | [2002/31] | Type: | B1 Patent specification | No.: | EP1227084 | Date: | 14.12.2005 | Language: | EN | [2005/50] | Search report(s) | International search report - published on: | JP | 03.05.2001 | (Supplementary) European search report - dispatched on: | EP | 07.07.2003 | Classification | IPC: | C07D213/30, C07D277/26, C07D277/28, C07D277/32, C07D277/44, C07D215/14, C07D215/56, C07D307/52, C07D513/04, C07D263/56, A61K31/425, A61K31/44 | [2003/18] | CPC: |
G01N33/6803 (EP);
A61K31/4738 (EP,KR);
A61K31/341 (EP);
A61K31/41 (EP);
A61K31/421 (EP);
A61K31/423 (EP);
A61K31/425 (EP);
A61K31/426 (EP);
A61K31/427 (EP);
A61K31/433 (EP);
A61K31/437 (EP);
A61K31/4375 (EP);
A61K31/44 (EP);
A61K31/4439 (EP);
A61K31/47 (EP);
A61K31/4709 (EP);
A61K31/502 (EP);
A61K31/517 (EP);
A61K31/519 (EP);
A61K31/5383 (EP);
A61P31/04 (EP);
C07D213/30 (EP);
C07D215/14 (EP);
C07D215/56 (EP);
C07D263/56 (EP);
C07D277/24 (EP);
C07D277/28 (EP);
C07D285/08 (EP);
C07D307/52 (EP);
C07D409/12 (EP);
C07D417/04 (EP);
C07D417/06 (EP);
C07D417/10 (EP);
C07D417/12 (EP);
C07D417/14 (EP);
C07D471/04 (EP);
C07D513/04 (EP);
C12Q1/18 (EP);
C07K2299/00 (EP);
G01N2500/04 (EP)
(-)
|
Former IPC [2002/31] | C07D213/30, C07D277/26, C07D277/28, C07D277/32, C07D277/44, C07D215/14, C07D215/56, C07D307/52, C07D513/04, C07D263/56, C07D417/04 | Designated contracting states | AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2002/31] | Extension states | AL | Not yet paid | LT | Not yet paid | LV | Not yet paid | MK | Not yet paid | RO | Not yet paid | SI | Not yet paid | Title | German: | PUMPENINHIBITOREN ZUR FREISETZUNG VON MEDIKAMENTEN | [2002/31] | English: | DRUG DISCHARGE PUMP INHIBITORS | [2002/31] | French: | INHIBITEURS DE LA POMPE PAR LIBERATION DE MEDICAMENTS | [2002/31] | Entry into regional phase | 19.04.2002 | Translation filed | 19.04.2002 | National basic fee paid | 19.04.2002 | Search fee paid | 19.04.2002 | Designation fee(s) paid | 19.04.2002 | Examination fee paid | Examination procedure | 27.10.2000 | Request for preliminary examination filed International Preliminary Examining Authority: JP | 19.04.2002 | Examination requested [2002/31] | 25.09.2003 | Despatch of a communication from the examining division (Time limit: M06) | 01.04.2004 | Reply to a communication from the examining division | 30.12.2004 | Despatch of a communication from the examining division (Time limit: M04) | 05.04.2005 | Reply to a communication from the examining division | 29.04.2005 | Communication of intention to grant the patent | 05.09.2005 | Fee for grant paid | 05.09.2005 | Fee for publishing/printing paid | Divisional application(s) | EP05019514.8 / EP1652839 | Opposition(s) | 15.09.2006 | No opposition filed within time limit [2006/47] | Fees paid | Renewal fee | 15.10.2002 | Renewal fee patent year 03 | 14.10.2003 | Renewal fee patent year 04 | 14.10.2004 | Renewal fee patent year 05 | 12.10.2005 | Renewal fee patent year 06 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | AT | 14.12.2005 | CY | 14.12.2005 | FI | 14.12.2005 | DK | 14.03.2006 | GR | 14.03.2006 | ES | 25.03.2006 | PT | 15.05.2006 | [2009/02] |
Former [2007/50] | AT | 14.12.2005 | |
FI | 14.12.2005 | ||
DK | 14.03.2006 | ||
GR | 14.03.2006 | ||
ES | 25.03.2006 | ||
PT | 15.05.2006 | ||
Former [2007/35] | AT | 14.12.2005 | |
FI | 14.12.2005 | ||
IT | 14.12.2005 | ||
DK | 14.03.2006 | ||
GR | 14.03.2006 | ||
ES | 25.03.2006 | ||
PT | 15.05.2006 | ||
Former [2006/51] | AT | 14.12.2005 | |
FI | 14.12.2005 | ||
DK | 14.03.2006 | ||
GR | 14.03.2006 | ||
ES | 25.03.2006 | ||
PT | 15.05.2006 | ||
Former [2006/48] | AT | 14.12.2005 | |
FI | 14.12.2005 | ||
GR | 14.03.2006 | ||
ES | 25.03.2006 | ||
PT | 15.05.2006 | ||
Former [2006/38] | AT | 14.12.2005 | |
FI | 14.12.2005 | ||
GR | 14.03.2006 | ||
ES | 25.03.2006 | ||
Former [2006/34] | AT | 14.12.2005 | |
FI | 14.12.2005 | ||
ES | 25.03.2006 | ||
Former [2006/23] | FI | 14.12.2005 | Documents cited: | Search | [X]JPH03207789 ; | [X]JPH02219892 ; | [X]JPH0543878 ; | [X]JPH09323971 ; | [X]JPH10310578 ; | [X]US3907808 (LESHER GEORGE Y, et al) [X] 1-10 * claim - *; | [X]US4013647 (SELLSTEDT JOHN H, et al) [X] 1-10 * example 4; claim 3 *; | [A]US4404207 (STERN RICHARD M [US]) [A] 1-10 * claim - *; | [X]DE3417840 (CIBA GEIGY AG [CH]) [X] 1-8 * example 20 *; | [X]US4665079 (CULBERTSON TOWNLEY P [US], et al) [X] 1-10 * column 11 - column 16; example -; claims 1-4 *; | [X]EP0279239 (CIBA GEIGY AG [CH]) [X] 1-10 * page 2, line 1 - line 24; example 3.097; claim -; table 3 *; | [X]EP0513974 (MERCK & CO INC [US]) [X] 1-10 * page 128 - page 129; example E; claim 1 *; | [X]EP0513387 (OTSUKA PHARMA CO LTD [JP]) [X] 1-10 * example 1; claim -; tables 8-10 *; | [X]EP0594861 (KASHIMA OIL [JP]) [X] 1-8 * example 8 *; | [A]WO9633285 (MICROCIDE PHARMACEUTICALS INC [US], et al) [A] 1-10 * claims 52-79 *; | [X]WO9802430 (PFIZER PHARMA [JP], et al) [X] 1-10 * example 63; claim - *; | [A]WO9937667 (MICROCIDE PHARMACEUTICALS INC [US], et al) [A] 1-10* page 63 - page 84 * | [X] - PATENT ABSTRACTS OF JAPAN, (19911204), vol. 015, no. 478, Database accession no. (C - 0891), & JP03207789 A 19910911 (DAINIPPON INK & CHEM INC;OTHERS: 01) [X] 1-8 * abstract * * page 719 * | [X] - PATENT ABSTRACTS OF JAPAN, (19901119), vol. 014, no. 526, Database accession no. (C - 0779), & JP02219892 A 19900903 (DAINIPPON INK & CHEM INC;OTHERS: 01) [X] 1-8 * abstract * * page 847 - page 850 * | [X] - PATENT ABSTRACTS OF JAPAN, (19930630), vol. 017, no. 345, Database accession no. (C - 1077), & JP05043878 A 19930223 (DAINIPPON INK & CHEM INC) [X] 1-8 * abstract * * page 647 * | [X] - PATENT ABSTRACTS OF JAPAN, (19980331), vol. 1998, no. 04, & JP09323971 A 19971216 (SANKYO CO LTD) [X] 1-10 * abstract * * page 10, paragraph L - page 19 * | [X] - PATENT ABSTRACTS OF JAPAN, (19990226), vol. 1999, no. 02, & JP10310578 A 19981124 (YOSHITOMI PHARMACEUT IND LTD) [X] 1-10 * abstract * * example 13; claim - * | International search | [X]FR1458066 (BOEHRINGER & SOEHNE GMBH); | [X]JPS442219B ; | [X]JPS4413952B ; | [X]GB1305820 ; | [X]US3870712 (HOLMES RICHARD E); | [X]US4891428 (NORDHOFF ERHARD [DE], et al); | [X]WO9322312 (STANFORD RES INST INT [US]); | [X]WO9322315 (STANFORD RES INST INT [US]); | [X]WO9602507 (ABBOTT LAB [US]); | [X]WO9633285 (MICROCIDE PHARMACEUTICALS INC [US], et al); | [X]WO9703967 (RHONE POULENC RORER LTD [GB], et al); | [X]EP0786457 (YAMANOUCHI PHARMA CO LTD [JP]); | [X]WO9817625 (DAIICHI SEIYAKU CO [JP], et al); | [X]WO9857957 (NISSAN CHEMICAL IND LTD [JP], et al); | [X]WO9936442 (GRAIN PROCESSING CORP [US], et al); | [X]US5936977 (CHURCHILL JONATHAN F [GB], et al); | [X]WO9950304 (RHODIA ACETOW AKTIENGESELLSCHA [DE], et al); | [X] - NISHIGAKI S. ET AL., "Synthesis of 1-substituted 1,4-dihydro-7-(2-(5-nitro-2-furyl)vinyl)-4-oxo-1,8-naphthyridine derivatives. I.", CHEM. PHARM. BULL., (1969), vol. 17, no. 9, pages 1827 - 1831, XP002944105 | [Y] - LI X.-A., LIVERMORE D.M., NIKAIDO H., "Role of efflux pumps(s) in intrinsic resistance of pseudomonas aeruginosa: Resistance to tetracycline, chloramphenicol and norfloxacin", ANTIMICROB. CHEMTH., (1994), vol. 38, no. 8, pages 1732 - 1734, XP002944106 | [Y] - GREENE J. ET AL., "Chemical function queries for 3D database search", J. CHEM. INF. COMPUT. SCI., (1994), no. 34, pages 1297 - 1308, XP002944107 DOI: http://dx.doi.org/10.1021/ci00022a012 | [X] - CHUPP J.P., MOLYNEAUX J.M., "Derivation of fluorine-containing pyridinedicarboxylates. III. Regioselective anion chemistry at the 2- and 4-position", J. HETEROCYCL. CHEM., (1989), vol. 26, no. 6, pages 1771 - 1780, XP002944108 | [X] - DEJOHN D. ET AL., "Functionalization of substituted 2(1H)- and 4(1H)-pyridones. III. The preparation of substituted 6-vinyl-1,2-dihydro-2-oxo- and 1,4-dihydro-4-oxo-3-pyridinecarboxylic acids through the chemistry of pyridone dianions", J. HETEROCYCL. CHEM., (1983), vol. 20, no. 5, pages 1295 - 1302, XP002944109 DOI: http://dx.doi.org/10.1002/jhet.5570200529 | [X] - ROZENBLIT A. ET AL., "Computer-aided prediction and study of biological properties of nitrofurylvinyl(polyenyl)quinolines", CHEMICAL ABSTRACTS, (1991), vol. 115, Database accession no. 105447 | [ ] - KHIM.-FARM. ZH., (1991), vol. 25, no. 5, pages 55 - 58 [ ] * Registry Nos. 5774-31-2, 59666-11-4, 73263-92-0 * | [X] - SUKHOVA N.M. ET AL., "Search for new drugs in a series of furan derivatives", CHEMICAL ABSTRACTS, (1980), vol. 92, Database accession no. 157718 | [ ] - KONF. KHIM. TEKHNOL. FURANOVYKH SOEDIN., (TEZISY DOKL.), 3RD, (1978), pages 97 - 98 [ ] * Registry Nos. 5774-31-2, 26170-82-1, 73263-92-0 * | [X] - LIPKIN A.E., BESPALOVA ZH. P., "Synthesis based on 2-methyl-4-quinolinecarboxylic acid", CHEMICAL ABSTRACTS, (1970), vol. 72, Database accession no. 111193 | [ ] - KHIM.-FARM. ZH., (1970), vol. 4, no. 1, pages 24 - 26 [ ] * Registry Nos. 5774-31-2, 26170-82-1, 26170-84-3, 26280-17-1 * | [X] - FUJITA AKIO ET AL., "Nitrofuran derivatives. VI. Synthesis of 2-(2-(5-nitro-2-furyl)vinyl)pyridinemethanol and 2-(2-(5-nitro-2-furyl)vinyl)pyridinecarboxylic acid derivatives", CHEMICAL ABSTRACTS, (1967), vol. 66, Database accession no. 75885 | [ ] - YAKUGAKU ZASSHI, (1966), vol. 86, no. 11, pages 1014 - 1021 [ ] * Registry Nos. 1030-71-3, 1030-72-4 * | [X] - CHEMICAL ABSTRACTS, (1988), vol. 108, Database accession no. 142146 | [ ] - INORG. CHEM., (1988), vol. 27, no. 7, pages 1167 - 1173 | [X] - CHEMICAL ABSTRACTS, (1987), vol. 106, Database accession no. 196227 | [ ] - TAP CHI HOA HOC, (1985), vol. 23, no. 5, pages 9 - 11 | [X] - CHEMICAL ABSTRACTS, (1985), vol. 103, Database accession no. 87754 | [ ] - YIYAO GONGYE, (1985), vol. 16, no. 2, pages 66 - 68, 91 | [X] - CHEMICAL ABSTRACTS, (1984), vol. 100, Database accession no. 138915 | [ ] - KHIM. GETEROTSIKL. SOEDIN., (1983), no. 11, pages 1521 - 1523 | [X] - CHEMICAL ABSTRACTS, (1980), vol. 92, Database accession no. 128023 | [ ] - KHIM. GETEROTSIKL. SOEDIN., (1979), no. 9, pages 1194 - 1200 | [X] - CHEMICAL ABSTRACTS, (1978), vol. 89, Database accession no. 109013 | [ ] - TEZISY DOKL. - RESP. KONF. MOLODYKH UCH.-KHIM., 2ND, AKAD. NAUK EST. SSR, INST. KHIM.: TALLINN, USSR, (1977), vol. 1, pages 14 - 15 | [X] - CHEMICAL ABSTRACTS, (1973), vol. 78, Database accession no. 97460 | [ ] - J. HETEROCYCL. CHEM., (1972), vol. 9, no. 6, pages 1203 - 1207 |