Deutsch English Français

Contact

EP1283906

European procedure

Quick help

Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...

News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...

Extract from the Register of European Patents

EP About this file: EP1283906

EP1283906 - EPIGENETIC SEQUENCES FOR ESOPHAGEAL ADENOCARCINOMA [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 21.10.2011 Database last updated on 19.10.2024
Most recent event Tooltip	21.10.2011	Application deemed to be withdrawn	published on 23.11.2011 [2011/47]
Applicant(s)	For all designated states UNIVERSITY OF SOUTHERN CALIFORNIA 3716 Hope Street 200 Los Angeles, CA 90007-4344 / US
	[2003/08]
Inventor(s)	01 / LAIRD, Peter 649 Forrest Avenue South Pasadena, CA 91010 / US
	02 / EADS, Cindy 635 Prospect Street B15 South Pasadena, CA 91010 / US
	[2003/08]
Representative(s)	Raggers, René John, et al Exter Polak & Charlouis B.V. P.O. Box 3241 2280 GE Rijswijk / NL
	[2011/03]
Former [2003/08]	Wittop Koning, Tom Hugo, et al Exter Polak & Charlouis B.V., P.O. Box 3241 2280 GE Rijswijk / NL
Application number, filing date	01926558.6	02.04.2001
	[2003/08]
	WO2001US10658
Priority number, date	US20000193839P	31.03.2000 Original published format: US 193839 P
	[2003/08]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO0175172
	Date:	11.10.2001
	Language:	EN
	[2001/41]
	Type:	A1 Application with search report
	No.:	EP1283906
	Date:	19.02.2003
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 11.10.2001 takes the place of the publication of the European patent application.
	[2003/08]
Search report(s)	International search report - published on:	US	11.10.2001
	(Supplementary) European search report - dispatched on:	EP	11.03.2005
Classification	IPC:	C12Q1/68	[2003/08]
	CPC:	C12Q1/6809 (EP,US); C12Q1/6886 (EP,US); C12Q2600/112 (EP,US); C12Q2600/118 (EP,US); C12Q2600/154 (EP,US)
	C-Set:	C12Q1/6809, C12Q2523/125 (EP,US)
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, TR [2003/08]
Extension states	AL	Not yet paid
	LT	Not yet paid
	LV	Not yet paid
	MK	Not yet paid
	RO	Not yet paid
	SI	Not yet paid
Title	German:	EPIGENETISCHE SEQUENZEN FÜR SPEISERÖHRENADENOKARZINOME	[2003/08]
	English:	EPIGENETIC SEQUENCES FOR ESOPHAGEAL ADENOCARCINOMA	[2003/08]
	French:	SEQUENCES EPIGENETIQUES D'ADENOCARCINOMES OESOPHAGIENS	[2003/08]
Entry into regional phase	31.10.2002	National basic fee paid
	31.10.2002	Search fee paid
	31.10.2002	Designation fee(s) paid
	31.10.2002	Examination fee paid
Examination procedure	25.10.2001	Request for preliminary examination filed International Preliminary Examining Authority: US
	31.10.2002	Examination requested [2003/08]
	27.01.2003	Amendment by applicant (claims and/or description)
	06.07.2006	Despatch of a communication from the examining division (Time limit: M06)
	25.04.2007	Reply to a communication from the examining division
	20.10.2008	Despatch of a communication from the examining division (Time limit: M06)
	14.08.2009	Reply to a communication from the examining division
	16.11.2010	Despatch of a communication from the examining division (Time limit: M06)
	27.05.2011	Application deemed to be withdrawn, date of legal effect [2011/47]
	30.06.2011	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2011/47]
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 06.07.2006
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	14.08.2009	Request for further processing filed
	14.08.2009	Full payment received (date of receipt of payment)
	25.04.2007	Request for further processing filed
	25.04.2007	Full payment received (date of receipt of payment) Request granted
	15.05.2007	Decision despatched
Fees paid	Renewal fee
	22.04.2003	Renewal fee patent year 03
	26.04.2004	Renewal fee patent year 04
	20.04.2005	Renewal fee patent year 05
	26.04.2006	Renewal fee patent year 06
	27.04.2007	Renewal fee patent year 07
	25.04.2008	Renewal fee patent year 08
	29.04.2009	Renewal fee patent year 09
	29.03.2010	Renewal fee patent year 10
	25.04.2011	Renewal fee patent year 11
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[PXY]WO0070090 (UNIV SOUTHERN CALIFORNIA [US]) [PX] 17-20 * page 21, line 5 - page 22, line 24 * [PY] 3,5,8,10;
		[XY] - WONG DAVID J ET AL, "P16-INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, (19970701), vol. 57, no. 13, ISSN 0008-5472, pages 2619 - 2622, XP002210105 [X] 1,2,4,6,7,9,11-18 * the whole document * [Y] 3,5,8,10,19,20
		[XY] - KLUMP B ET AL, "Hypermethylation of the CDKN2/p16 promoter during neoplastic progression in Barrett's esophagus.", GASTROENTEROLOGY. DEC 1998, (199812), vol. 115, no. 6, ISSN 0016-5085, pages 1381 - 1386, XP002305013 [X] 1,2,4,6,7,9,11-18 * the whole document * [Y] 3,5,8,10,19,20 DOI: http://dx.doi.org/10.1016/S0016-5085(98)70016-2
		[XY] - KEMPSTER S ET AL, "Methylation of exon 2 of p16 is associated with late stage oesophageal cancer", CANCER LETTERS, (20000313), vol. 150, no. 1, ISSN 0304-3835, pages 57 - 62, XP002305014 [X] 1,2,4,6,7,9,11-18 * abstract * * page 58, column 1, paragraph 4 - column 2, paragraph 1 * * page 59, column 2, paragraph 1 - page 61, column 1, paragraph 4 * [Y] 3,5,8,10,19,20 DOI: http://dx.doi.org/10.1016/S0304-3835(99)00372-9
		[XY] - XING ERIC POE ET AL, "Aberrant methylation of p16INK4a and deletion of p15INK4b are frequent events in human esophageal cancer in Linxian, China", CARCINOGENESIS (OXFORD), (199901), vol. 20, no. 1, ISSN 0143-3334, pages 77 - 84, XP002305015 [X] 1,2,4,6,7,9,11-18 * abstract * * page 78, column 2, paragraph 4 - page 79, column 1, paragraph 1 * * page 80, column 2, paragraph 3 - page 81, column 1, paragraph 1 * [Y] 3,5,8,10,19,20 DOI: http://dx.doi.org/10.1093/carcin/20.1.77
		[X] - EADS CINDY A ET AL, "CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, (19990515), vol. 59, no. 10, ISSN 0008-5472, pages 2302 - 2306, XP002170143 [X] 1-20 * abstract * * page 2304, column 1, paragraph 2 - paragraph 3; figure 3 *
		[XY] - HILTUNEN M O ET AL, "Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER. 17 MAR 1997, (19970317), vol. 70, no. 6, ISSN 0020-7136, pages 644 - 648, XP002305016 [X] 1,2,4,6,7,9,11-18 * the whole document * [Y] 3,5,8,10,19,20 DOI: http://dx.doi.org/10.1002/(SICI)1097-0215(19970317)70:6<644::AID-IJC3>3.0.CO;2-V
		[XY] - TOYOTA M ET AL, "Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.", CANCER RESEARCH. 1 NOV 1999, (19991101), vol. 59, no. 21, ISSN 0008-5472, pages 5438 - 5442, XP002305017 [X] 1,2,4,6,7,9,11-18 * abstract * * page 5438, column 2, paragraph 2 - page 5439, column 1, paragraph 1 * * page 5440, column 2, paragraph 2 * [Y] 3,5,8,10,19,20
		[PX] - EADS C A ET AL, "FIELDS OF ABERRANT CPG ISLAND HYPERMETHYLATION IN BARRETT'S ESOPHAGUS AND ASSOCIATED ADENOCARCINOMA", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, (20000915), vol. 60, ISSN 0008-5472, pages 5021 - 5026, XP002944669 [PX] 1-20 * the whole document *
		[PX] - KAWAKAMI K ET AL, "HYPERMETHYLATED APC DNA IN PLASMA AND PROGNOSIS OF PATIENTS WITH ESOPHAGEAL ADENOCARCINOMA", JOURNAL OF THE NATIONAL CANCER INSTITUTE, US DEPT. OF HEALTH, EDICATIONAND WELFARE, PUBLIC HEALTH, US, (20001115), vol. 92, no. 22, ISSN 0027-8874, pages 1805 - 1811, XP002944668 [PX] 1-20 * the whole document * DOI: http://dx.doi.org/10.1093/jnci/92.22.1805
		[PXY] - ESTELLER M ET AL, "Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.", CANCER RESEARCH. 15 AUG 2000, (20000815), vol. 60, no. 16, ISSN 0008-5472, pages 4366 - 4371, XP002305018 [PX] 1,2,4,6,7,9,11-18 * the whole document * [PY] 3,5,8,10,19,20
		[PA] - TSUCHIYA T ET AL, "Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia.", ONCOGENE. 27 JUL 2000, (20000727), vol. 19, no. 32, ISSN 0950-9232, pages 3642 - 3646, XP002305019 [PA] 1-20 * abstract * * page 3643, column 2, paragraph 2 - page 3645, column 1, paragraph 2 * DOI: http://dx.doi.org/10.1038/sj.onc.1203704
		[T] - EADS C A ET AL, "Epigenetic patterns in the progression of esophageal adenocarcinoma", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, (20010415), vol. 61, no. 8, ISSN 0008-5472, pages 3410 - 3418, XP002982118 [T] * the whole document * * page 2304, column 1, paragraph 2 - paragraph 3; figure 3 *
		[XY] - ISSA J-P J ET AL, "METHYLATION OF THE OESTROGEN RECEPTOR CPG ISLAND LINKS AGEING AND NEOPLASIA IN HUMAN COLON", NATURE GENETICS, NEW YORK, NY, US, (199408), vol. 7, no. 4, ISSN 1061-4036, pages 536 - 540, XP008011825 [X] 1,2,4,6,7,9,11-18 * the whole document * [Y] 3,5,8,10,19,20 DOI: http://dx.doi.org/10.1038/ng0894-536
		[X] - BACHMAN KURTIS E ET AL, "Methylation-associated silencing of the tissue inhibitor of Metalloproteinase-3 gene suggests a suppressor role in kidney, brain, and other human cancers", CANCER RESEARCH, (19990215), vol. 59, no. 4, ISSN 0008-5472, pages 798 - 802, XP002318525 [X] 1,2,4,6,7,9,11-18 * abstract *
	International search	[YP] - KAWAKAMI K. ET AL., "Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma", JOURNAL OF THE NATIONAL CANCER INSTITUTE, (20001115), vol. 92, no. 22, pages 1805 - 1811, XP002944668 DOI: http://dx.doi.org/10.1093/jnci/92.22.1805
		[YP] - EADS C.A. ET AL., "Fields of aberrant CpG Island hypermethylation in Barrett's esophagus and associated adenocarcinoma", CANCER RESEARCH, (20000915), vol. 50, pages 5021 - 5026, XP002944669
		[Y] - SUZUKI H. ET AL., "Intragenic mutations of CDKN2B and CDKN2A iHn primary human esophageal cancers", HUMAN MOLECULAR GENETICS, (1995), vol. 4, no. 10, pages 1883 - 1887, XP002944670 DOI: http://dx.doi.org/10.1093/hmg/4.10.1883
		[Y] - CODY D.T., II ET AL., "Differential DNA methylation of the p16 INK4A/CDKN2A promoter in human opral cancer cells and normal human oral karatinocytes", ORAL ONCOLOGY, (1999), vol. 35, pages 516 - 522, XP002944671 DOI: http://dx.doi.org/10.1016/S1368-8375(99)00026-3
		[Y] - GRAFF J.R. ET AL., "Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurtle's cell and poorly differentiated thyroid carcinoma", CANCER RESEARCH, (19980515), vol. 58, pages 2063 - 2066, XP002944681
		[Y] - IWASE H. ET AL., "DNA methylation analysis at distal and proximal promoter regions of the oestrogen receptor gene in breast cancers", BRITISH JOURNAL OF CANCER, (1999), vol. 80, no. 12, pages 1982 - 1986, XP002944672 DOI: http://dx.doi.org/10.1038/sj.bjc.6690631
		[Y] - MILLAR D.S. ET AL., "Detailed methylation analysis of the glutathione S-transferase(GSTP!) gene in prostate cancer", ONCOGENE, (1999), vol. 18, pages 1313 - 1324, XP002944673 DOI: http://dx.doi.org/10.1038/sj.onc.1202415
		[Y] - JHAVERI M.S. ET AL., "Methylation-mediated regulation of the glutathione S-transferase pi gene in human breast cancer cells", GENE, (1998), vol. 210, pages 1 - 7, XP002944674 DOI: http://dx.doi.org/10.1016/S0378-1119(98)00021-3
		[Y] - BARRETT M.T. ET AL., "Evoluation of neoplastic cell lineages in Barrett oseophagus", NATURE GENETICS, (199905), vol. 22, pages 106 - 109, XP002944675 DOI: http://dx.doi.org/10.1038/8816
		[Y] - HERMAN J.G. ET AL., "Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma", PROC. NATL. ACAD. SCI. USA, (199806), vol. 95, pages 6870 - 6875, XP002944676 DOI: http://dx.doi.org/10.1073/pnas.95.12.6870
		[Y] - ESTELLER M. ET AL., "Inactivation of the DNA repair gene 06-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia", CANCER RESEARCH, (19990215), vol. 59, pages 793 - 797, XP002944677
		[Y] - LACOPETTA B.J. ET AL., "Hypermethylation of the Myf-3 gene in human colorectal cancer", ANTICANCER RESEARCH, (1997), vol. 17, pages 429 - 432, XP002944678
		[Y] - ESTELLER M. ET AL., "Hypermethylation-associated inactivation of p14ARF is independent of p16INK4A methylation and p53 mutatinal status", CANCER RESEARCH, (20000101), vol. 60, pages 129 - 133, XP002944682
		[YP] - NAKAMURA M. ET AL., "Promoter hypermethylation of the RB1 gene in glioblastomas", LABORATORY INVESTIGATIONS, (200101), vol. 81, no. 1, pages 77 - 82, XP002944679
		[Y] - MEKI J.R. ET AL., "Cancer-specific region of hypermethylation identified within the HIC1 putative tumour suppressor gene in acute myeloid leukaemia", LEUKEMIA, (1999), vol. 13, pages 877 - 883, XP002944680 DOI: http://dx.doi.org/10.1038/sj/leu/2401401

The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.

Legal notice
Terms of use
24.2.25; 34p