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Extract from the Register of European Patents

EP About this file: EP1278848

EP1278848 - NEW RAS GUANINE-NUCLEOTIDE-EXCHANGE FACTOR 1 (NRG1) [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  16.02.2007
Database last updated on 19.10.2024
Most recent event   Tooltip16.02.2007Application deemed to be withdrawnpublished on 21.03.2007  [2007/12]
Applicant(s)For all designated states
Merck Patent GmbH
Frankfurter Strasse 250
64293 Darmstadt / DE
[N/P]
Former [2003/05]For all designated states
MERCK PATENT GmbH
Frankfurter Strasse 250
64293 Darmstadt / DE
Inventor(s)01 / SIRRENBERG, Christian
Taunusstrasse 10
64289 Darmstadt / DE
 [2003/14]
Former [2003/05]01 / SIRRENBERG, Christian
Heinrich-Delp-Strasse 221
64297 Darmstadt / DE
Application number, filing date01933917.503.05.2001
[2003/05]
WO2001EP04950
Priority number, dateEP2000010913305.05.2000         Original published format: EP 00109133
[2003/05]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO0185934
Date:15.11.2001
Language:EN
[2001/46]
Type: A1 Application with search report 
No.:EP1278848
Date:29.01.2003
Language:EN
The application published by WIPO in one of the EPO official languages on 15.11.2001 takes the place of the publication of the European patent application.
[2003/05]
Search report(s)International search report - published on:EP15.11.2001
ClassificationIPC:C12N15/12, C12N15/62, C07K14/47, C07K16/18, C12Q1/68, G01N33/68
[2003/05]
CPC:
C07K14/4702 (EP,US); C07K2319/00 (EP,US)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2003/05]
TitleGerman:NEUER RAS-GUANIN-NUKLEOTID-AUSTAUSCHFAKTOR-1 (NRG1)[2003/05]
English:NEW RAS GUANINE-NUCLEOTIDE-EXCHANGE FACTOR 1 (NRG1)[2003/05]
French:NOUVEAU FACTEUR 1 D'ECHANGE DE NUCLEOTIDES DE LA GUANINE POUR RAS (NRG1)[2003/05]
Entry into regional phase30.08.2002National basic fee paid 
30.08.2002Designation fee(s) paid 
30.08.2002Examination fee paid 
Examination procedure15.11.2001Request for preliminary examination filed
International Preliminary Examining Authority: EP
30.08.2002Examination requested  [2003/05]
26.05.2004Despatch of a communication from the examining division (Time limit: M06)
30.11.2004Reply to a communication from the examining division
17.03.2006Despatch of a communication from the examining division (Time limit: M06)
28.09.2006Application deemed to be withdrawn, date of legal effect  [2007/12]
03.11.2006Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2007/12]
Fees paidRenewal fee
13.05.2003Renewal fee patent year 03
13.05.2004Renewal fee patent year 04
12.05.2005Renewal fee patent year 05
23.03.2006Renewal fee patent year 06
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[A]US5656595  (SCHWEIGHOFFER FABIEN [FR], et al) [A] 1-11 * the whole document *;
 [PX]WO0031263  (INCYTE PHARMA INC [US], et al) [PX] 1,4,6-11 * Note: 100.0% nt seq identity of SEQ ID NO:40 with SEQ ID NO:1 in 744 nt overlap (1-744:679-1422), 100.0% aa seq identity of SEQ ID NO:11 with SEQ ID NO:2 in 199 aa overlap (1-199:275-473); page 5, line 16 - page 7, line 6 * * page 61, table 2: SEQ ID NO:11;; claims 1-20 *;
 [PX]EP1033401  (GENSET SA [FR]) [PX] 1,4,6-11 * the whole document *;
 [PX]WO0105970  (INCYTE GENOMICS INC [US], et al) [PX] 1,4,6-11 * Note: 73.7% nt seq identity of SEQ ID NO:132 with SEQ ID NO:1 in 840 nt overlap (568-1401:564-1400), 67.9% aa seq identity of SEQ ID NO:66 with SEQ ID NO:2 in 473 aa overlap (1-465:1-472); page 4, line 35 - page 9, line 27 * * page 93, table 2: SEQ ID NO:66;; claims 1-28 *;
 [X]  - NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP), "UI-H-BI3-ajy-d-11-0-UI.s1 NCI_CGAP_Sub5 Homo sapiens cDNA clone IMAGE:2733380 3', mRNA sequence", EM_EST, EMBL, (20000220), XP002178533 [X] 1-11 * the whole document *
 [X]  - BIRREN B ET AL., "Homo sapiens clone RP11-29L8, WORKING DRAFT SEQUENCE, 9 unordered pieces", EM_HTG, EMBL, (19991126), XP002178534 [X] 4 * Note: 100.0% nt seq identity with SEQ ID NO:1 in 177 nt overlap (107043-107219:177-1), 100.0% aa seq identity of translated sequence with SEQ ID NO:2 in 59 aa overlap; page 26 *
 [A]  - NATIONAL CANCER INSTITUTE / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE, BRAIN TUMOR GENOME ANATOMY PROJECT, "wl83e12.x1 NCI_CGAP_Brn25 Homo sapiens cDNA clone IMAGE:2431534 3' similar to TR:O61605 O61605 PUTATIVE GUANINE NUCLEOTIDE RELEASING FACTOR ;, mRNA sequence", EM_EST, EMBL, (19990728), XP002178535 [A] 1,4 * the whole document *
 [A]  - FAM N P ET AL., "Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras.", MOLECULAR AND CELLULAR BIOLOGY, (1997), vol. 17, no. 3, ISSN 0270-7306, pages 1396 - 1406, XP002178531 [A] 1,4 * abstract * * figure 1 *
 [A]  - REBHUN J F ET AL., "Identification and characterization of a new family of guanine nucleotide exchange factors for the Ras-related GTPase Ral.", JOURNAL OF BIOLOGICAL CHEMISTRY, (20000315), vol. 275, no. 18, ISSN 0021-9258, pages 13406 - 13410, XP002178532 [A] * abstract *

DOI:   http://dx.doi.org/10.1074/jbc.C000085200
 [DA]  - BOGUSKI M S ET AL., "Proteins regulating Ras and its relatives", NATURE, (19931216), vol. 366, ISSN 0028-0836, pages 643 - 654, XP002039500 [DA] * abstract * * page 645, column L, line 4 - page 647, column L, line 44 * * table 1 *

DOI:   http://dx.doi.org/10.1038/366643a0
 [PX]  - DIAS N E ET AL., "MR2-CN0037-210200-101-b02 CN0037 Homo sapiens cDNA, mRNA sequence.", EM_EST, EMBL, (20000523), XP002178536 [PX] 1,4 * the whole document *
 [A]  - PROCEEDINGS OF THE NATIONAL ACADEMY OF THE UNITED STATES, (20000328), vol. 97, no. 7, pages 3491 - 3496, XP000996193 [A] * abstract * * page 3495, column R, lines 18-20 *

DOI:   http://dx.doi.org/10.1073/pnas.97.7.3491
 [PX]  - NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP), "hz87b03.x1 NCI_CGAP_Lu24 Homo sapiens cDNA clone IMAGE:3214925 3', mRNA sequence", EM_EST, EMBL, (20000807), XP002178537 [PX] 1,4 * the whole document *
 [T]  - SPRANG S, "GEFs: master regulators of G-protein activation", TIBS TRENDS IN BIOCHEMICAL SCIENCES, (20010401), vol. 26, no. 4, ISSN 0968-0004, pages 266 - 267, XP004241856 [T] * the whole document *

DOI:   http://dx.doi.org/10.1016/S0968-0004(01)01818-7
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.