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Extract from the Register of European Patents

EP About this file: EP1305406

EP1305406 - MODULATION OF GAMMA-SECRETASE ACTIVITY [Right-click to bookmark this link]
Former [2003/18]MODULATION OF GAMMA-SECRETASE ACTIVITY
[2014/46]
StatusPatent maintained as amended
Status updated on  10.10.2014
Database last updated on 18.03.2026
Most recent event   Tooltip10.10.2014Patent maintained (B2 publication)published on 12.11.2014  [2014/46]
Applicant(s)For all designated states
SCIOS INC.
6500 Paseo Padre Parkway
Fremont, CA 94555 / US
[2005/36]
Former [2003/18]For all designated states
Scios Inc.
749 North Mary Avenue
Sunnyvale, CA 94086 / US
Inventor(s)01 / CORDELL, Barbara
4051 Ben Lomond Drive
Palo Alto, CA 94306 / US
02 / HIGAKI, Jeffrey, N.
2111 Windrose Place
Mountain View, CA 94043 / US
03 / MUTZ, Mitchell
2298 Oberlin Street
Palo Alto, CA 94306 / US
 [2003/18]
Representative(s)Goodfellow, Hugh Robin, et al
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2014/12]
Former [2009/51]Fisher, Adrian John, et al
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Former [2006/32]Fisher, Adrian John, et al
Carpmaels & Ransford, 43-45 Bloomsbury Square
London WC1A 2RA / GB
Former [2003/18]Duckworth, Timothy John
J.A. Kemp & Co., 14 South Square, Gray's Inn
London WC1R 5JJ / GB
Application number, filing date01935260.809.05.2001
[2014/46]
WO2001US15089
Priority number, dateUS20000203506P11.05.2000         Original published format: US 203506 P
[2003/18]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO0185924
Date:15.11.2001
Language:EN
[2001/46]
Type: A2 Application without search report 
No.:EP1305406
Date:02.05.2003
Language:EN
The application published by WIPO in one of the EPO official languages on 15.11.2001 takes the place of the publication of the European patent application.
[2003/18]
Type: B1 Patent specification 
No.:EP1305406
Date:13.09.2006
Language:EN
[2006/37]
Type: B2 New European patent specification 
No.:EP1305406
Date:12.11.2014
Language:EN
[2014/46]
Search report(s)International search report - published on:EP27.02.2003
ClassificationIPC:C12N9/64, C07K14/47, G01N33/68, A61K38/17, A61K38/43
[2003/18]
CPC:
C12N9/6421 (EP,US); A61P25/28 (EP); C07K14/4711 (EP,US);
A61K38/00 (EP,US)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2003/18]
TitleGerman:MODULATION VON GAMMA-SECRETASE AKTIVITÄT[2014/46]
English:MODULATION OF GAMMA-SECRETASE ACTIVITY[2014/46]
French:MODULATION DE L'ACTIVITE DES GAMMA-SECRETASES[2014/46]
Former [2003/18]MODULATION VON GAMMA-SECRETASE ACTIVITÄT
Former [2003/18]MODULATION OF GAMMA-SECRETASE ACTIVITY
Former [2003/18]MODULATION DE L'ACTIVIT DES GAMMA-SECRETASES
Entry into regional phase10.12.2002National basic fee paid 
10.12.2002Designation fee(s) paid 
10.12.2002Examination fee paid 
Examination procedure29.10.2001Request for preliminary examination filed
International Preliminary Examining Authority: EP
11.12.2002Examination requested  [2003/18]
24.11.2003Despatch of a communication from the examining division (Time limit: M06)
25.05.2004Reply to a communication from the examining division
26.07.2004Despatch of a communication from the examining division (Time limit: M06)
04.02.2005Reply to a communication from the examining division
20.03.2006Communication of intention to grant the patent
21.07.2006Fee for grant paid
21.07.2006Fee for publishing/printing paid
Opposition(s)Opponent(s)01  08.06.2007  13.08.2007  ADMISSIBLE
F. Hoffmann-La Roche Ltd
-
4070 Basel / CH
Opponent's representative
White, Martin Paul
Whites IP Ltd
24A Carnatic Road
Liverpool L18 8BZ / GB
 [N/P]
Former [2010/08]
Opponent(s)01  08.06.2007  13.08.2007  ADMISSIBLE
F. Hoffmann-La Roche Ltd
-
4070 Basel / CH
Opponent's representative
White, Martin Paul
Patents Designs & Brands Ltd 211 The Colonnades Albert Dock
Liverpool L3 4AB / GB
Former [2008/39]
Opponent(s)01  08.06.2007  13.08.2007  ADMISSIBLE
F. Hoffmann-La Roche Ltd
-
4070 Basel / CH
Opponent's representative
White, Martin Paul
Patents Designs & Brands Ltd. Suite 46, Oriel Chambers 14 Water Street Liverpool
L2 8TD / GB
Former [2007/33]
Opponent(s)01  08.06.2007   
F. Hoffmann-La Roche Ltd
-
4070 Basel / CH
Opponent's representative
White, Martin Paul
Patents Designs & Brands Ltd Suite 46 Oriel Chambers 14 Water Street
GB-Liverpool L2 8TD / GB
19.08.2008Invitation to proprietor to file observations on the notice of opposition
23.12.2008Reply of patent proprietor to notice(s) of opposition
13.10.2010Date of oral proceedings
22.10.2010Despatch of minutes of oral proceedings
07.12.2010Despatch of interlocutory decision in opposition
05.12.2013Legal effect of interlocutory decision in opposition
25.07.2014Despatch of communication that the patent will be maintained as amended
17.09.2014Fee for printing new specification paid
Appeal following opposition16.02.2011Appeal received No.  T0412/11
18.04.2011Statement of grounds filed
05.12.2013Result of appeal procedure: appeal of the proprietor withdrawn
05.12.2013Date of oral proceedings
11.12.2013Minutes of the oral proceedings despatched
Fees paidRenewal fee
12.06.2003Renewal fee patent year 03
13.05.2004Renewal fee patent year 04
12.05.2005Renewal fee patent year 05
10.05.2006Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
31.05.200303   M06   Fee paid on   12.06.2003
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT13.09.2006
CY13.09.2006
FI13.09.2006
IT13.09.2006
NL13.09.2006
TR13.09.2006
SE13.12.2006
GR14.12.2006
ES24.12.2006
PT26.02.2007
LU09.05.2007
MC31.05.2007
[2009/42]
Former [2009/37]AT13.09.2006
CY13.09.2006
FI13.09.2006
IT13.09.2006
NL13.09.2006
SE13.12.2006
GR14.12.2006
ES24.12.2006
PT26.02.2007
LU09.05.2007
MC31.05.2007
Former [2008/19]AT13.09.2006
FI13.09.2006
IT13.09.2006
NL13.09.2006
SE13.12.2006
GR14.12.2006
ES24.12.2006
PT26.02.2007
MC31.05.2007
Former [2008/09]AT13.09.2006
FI13.09.2006
IT13.09.2006
NL13.09.2006
SE13.12.2006
ES24.12.2006
PT26.02.2007
MC31.05.2007
Former [2007/36]AT13.09.2006
FI13.09.2006
IT13.09.2006
NL13.09.2006
SE13.12.2006
ES24.12.2006
PT26.02.2007
Former [2007/28]AT13.09.2006
FI13.09.2006
NL13.09.2006
SE13.12.2006
ES24.12.2006
PT26.02.2007
Former [2007/26]FI13.09.2006
NL13.09.2006
SE13.12.2006
ES24.12.2006
PT26.02.2007
Former [2007/21]FI13.09.2006
NL13.09.2006
SE13.12.2006
ES24.12.2006
Former [2007/19]FI13.09.2006
NL13.09.2006
SE13.12.2006
Former [2007/10]FI13.09.2006
SE13.12.2006
Cited inInternational search[DXY]   WOLFE MICHAEL S ET AL: "Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 398, no. 6727, 8 April 1999 (1999-04-08), pages 513 - 517, XP001010554, ISSN: 0028-0836 [DX] 1-18,22,23 * abstract * * page 515, column L, paragraph 3 - page 517, column L, paragraph 3 * [Y] 19,20

DOI:   http://dx.doi.org/10.1038/19077
 [X]   MUNDY D I: "Identification of the multicatalytic enzyme as a possible gamma-secretase for the amyloid precursor protein", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 204, no. 1, 14 October 1994 (1994-10-14), pages 333 - 341, XP000602247, ISSN: 0006-291X [X] 1-18,22,23 * abstract *

DOI:   http://dx.doi.org/10.1006/bbrc.1994.2464
 [YA]   SHPUNGIN S ET AL: "Activation of the superoxide forming NADPH oxidase in a cell-free system by sodium dodecyl sulfate. Absolute lipid dependence of the solubilized enzyme.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 5 JUN 1989, vol. 264, no. 16, 5 June 1989 (1989-06-05), pages 9195 - 9203, XP002217634, ISSN: 0021-9258 [Y] 19,20 * abstract *[A] 4
 [A]   SHOJI M ET AL: "PRODUCTION OF THE ALZHEIMER AMYLOID BETA PROTEIN BY NORMAL PROTEOLYTIC PROCESSING", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 258, 2 October 1992 (1992-10-02), pages 126 - 129, XP000616170, ISSN: 0036-8075 [A] 1-23 * abstract *

DOI:   http://dx.doi.org/10.1126/science.1439760
 [XP]   LI YUE-MING ET AL: "Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 11, 23 May 2000 (2000-05-23), pages 6138 - 6143, XP002159974, ISSN: 0027-8424 [XP] 1-4,8-18,22,23 * abstract * * page 3, line 16 - page 8, line 11; figures 1-8 * * page 6139, column L, paragraph 1 - column R, paragraph 2; figures 1-3 *

DOI:   http://dx.doi.org/10.1073/pnas.110126897
 [PX]   PINNIX I ET AL: "A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 5 JAN 2001, vol. 276, no. 1, 5 January 2001 (2001-01-05), pages 481 - 487, XP002217635, ISSN: 0021-9258 [PX] 1-4,8-18,22,23 * abstract * * page 482, column R, paragraph 4 - paragraph 6 *

DOI:   http://dx.doi.org/10.1074/jbc.M005968200
 [PX]   MCLENDON C ET AL: "Cell-free assays for gamma-secretase activity.", THE FASEB JOURNAL: OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY. UNITED STATES DEC 2000, vol. 14, no. 15, December 2000 (2000-12-01), pages 2383 - 2386, XP002217636, ISSN: 0892-6638 [PX] 1-4,8-18,22,23 * abstract * * page 2385, column R, paragraph 2; figure 2 * * page 2383, column R, paragraph 2 - page 2384, column R, paragraph 1 *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.