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Extract from the Register of European Patents

EP About this file: EP1267854

EP1267854 - HIGHLY SELECTIVE INHIBITORS OF THE UROKINASE PLASMINOGEN ACTIVATOR [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.09.2008
Database last updated on 06.11.2024
Most recent event   Tooltip25.02.2011Lapse of the patent in a contracting state
New state(s): IT		published on 30.03.2011  [2011/13]
Applicant(s)For all designated states
Wilex AG
Grillparzerstrasse 10B
81675 München / DE
For all designated states
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Hofgartenstrasse 8
80539 München / DE
[N/P]
Former [2007/47]For all designated states
Wilex AG
Grillparzerstrasse 10B
81675 München / DE
For all designated states
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Hofgartenstrasse 8
80539 München / DE
Former [2003/01]For all designated states
Wilex AG
Grillparzer Strasse 10B
81675 München / DE
For all designated states
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Hofgartenstrasse 2
80539 München / DE
Inventor(s)01 / MAGDOLEN, Viktor
Münchnerstrasse 33
85551 Kirchheim / DE
02 / SPERL, Stefan
Anton-Koeck-Strasse 5a
82049 Pullach / DE
03 / STÜRZEBECHER, Jörg
Hubertusstrasse 38
99094 Erfurt / DE
04 / WILHELM, Olaf
Säbenerstrasse 188
81545 München / DE
05 / ARROYO-DEPRADA, Nuria
Calle Valencia, 400 6 1
E-08013 Barcelona / ES
06 / MORODER, Luis
Alexander Flemingstrasse 10D
82152 Martinsried / DE
07 / HUBER, Robert
Schlesierstrasse 10
82110 Germering / DE
08 / JACOB, Uwe
Guldeinstrasse 42
80339 München / DE
09 / BODE, Wolfram
Tulpenstrasse 5
82131 Gauting / DE
 [2003/01]
Representative(s)Weiss, Wolfgang, et al
Weickmann & Weickmann
Patent- und Rechtsanwälte PartmbB
Postfach 860 820
81635 München / DE
[N/P]
Former [2003/01]Weiss, Wolfgang, Dipl.-Chem. Dr., et al
Weickmann & Weickmann Patentanwälte Postfach 86 08 20
81635 München / DE
Application number, filing date01938022.915.03.2001
[2003/01]
WO2001EP02989
Priority number, dateDE200011371520.03.2000         Original published format: DE 10013715
[2003/01]
Filing languageDE
Procedural languageDE
PublicationType: A2 Application without search report
No.:WO0170204
Date:27.09.2001
Language:DE
[2001/39]
Type: A2 Application without search report 
No.:EP1267854
Date:02.01.2003
Language:DE
The application published by WIPO in one of the EPO official languages on 27.09.2001 takes the place of the publication of the European patent application.
[2003/01]
Type: B1 Patent specification 
No.:EP1267854
Date:21.11.2007
Language:DE
[2007/47]
Search report(s)International search report - published on:EP01.08.2002
ClassificationIPC:A61K31/00
[2003/01]
CPC:
C07C279/18 (EP,US); A61K31/155 (EP,US); C07C2603/74 (EP,US)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2003/01]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
RONot yet paid
SINot yet paid
TitleGerman:HOCHSELEKTIVE INHIBITOREN DES UROKINASE-PLASMINOGENAKTIVATORS[2003/01]
English:HIGHLY SELECTIVE INHIBITORS OF THE UROKINASE PLASMINOGEN ACTIVATOR[2003/01]
French:INHIBITEURS A SELECTIVITE ELEVEE DE L'ACTIVATEUR DE TYPE UROKINASE DU PLASMINOGENE[2003/01]
Entry into regional phase03.09.2002National basic fee paid 
03.09.2002Designation fee(s) paid 
03.09.2002Examination fee paid 
Examination procedure04.10.2001Request for preliminary examination filed
International Preliminary Examining Authority: EP
03.09.2002Examination requested  [2003/01]
20.09.2005Despatch of a communication from the examining division (Time limit: M02)
18.10.2005Reply to a communication from the examining division
20.03.2007Communication of intention to grant the patent
06.07.2007Fee for grant paid
06.07.2007Fee for publishing/printing paid
Opposition(s)22.08.2008No opposition filed within time limit [2008/44]
Fees paidRenewal fee
31.12.2002Renewal fee patent year 03
31.12.2003Renewal fee patent year 04
31.12.2004Renewal fee patent year 05
30.12.2005Renewal fee patent year 06
29.12.2006Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY21.11.2007
DK21.11.2007
FI21.11.2007
GB21.11.2007
IE21.11.2007
NL21.11.2007
TR21.11.2007
SE21.02.2008
GR22.02.2008
ES04.03.2008
AT15.03.2008
LU15.03.2008
BE31.03.2008
CH31.03.2008
IT31.03.2008
LI31.03.2008
MC31.03.2008
PT21.04.2008
[2011/13]
Former [2010/37]CY21.11.2007
DK21.11.2007
FI21.11.2007
GB21.11.2007
IE21.11.2007
NL21.11.2007
TR21.11.2007
SE21.02.2008
GR22.02.2008
ES04.03.2008
AT15.03.2008
LU15.03.2008
BE31.03.2008
CH31.03.2008
LI31.03.2008
MC31.03.2008
PT21.04.2008
Former [2010/32]CY21.11.2007
DK21.11.2007
FI21.11.2007
GB21.11.2007
IE21.11.2007
NL21.11.2007
SE21.02.2008
GR22.02.2008
ES04.03.2008
AT15.03.2008
LU15.03.2008
BE31.03.2008
CH31.03.2008
LI31.03.2008
MC31.03.2008
PT21.04.2008
Former [2009/40]CY21.11.2007
DK21.11.2007
FI21.11.2007
GB21.11.2007
IE21.11.2007
NL21.11.2007
SE21.02.2008
GR22.02.2008
ES04.03.2008
AT15.03.2008
BE31.03.2008
CH31.03.2008
LI31.03.2008
MC31.03.2008
PT21.04.2008
Former [2009/33]CY21.11.2007
DK21.11.2007
FI21.11.2007
GB21.11.2007
IE21.11.2007
NL21.11.2007
SE21.02.2008
GR22.02.2008
ES04.03.2008
BE31.03.2008
CH31.03.2008
LI31.03.2008
MC31.03.2008
PT21.04.2008
Former [2009/12]DK21.11.2007
FI21.11.2007
GB21.11.2007
IE21.11.2007
NL21.11.2007
SE21.02.2008
GR22.02.2008
ES04.03.2008
BE31.03.2008
CH31.03.2008
LI31.03.2008
MC31.03.2008
PT21.04.2008
Former [2009/03]DK21.11.2007
FI21.11.2007
GB21.11.2007
IE21.11.2007
NL21.11.2007
SE21.02.2008
ES04.03.2008
MC31.03.2008
PT21.04.2008
Former [2008/48]DK21.11.2007
FI21.11.2007
IE21.11.2007
NL21.11.2007
SE21.02.2008
ES04.03.2008
MC31.03.2008
PT21.04.2008
Former [2008/46]DK21.11.2007
FI21.11.2007
NL21.11.2007
SE21.02.2008
ES04.03.2008
MC31.03.2008
PT21.04.2008
Former [2008/42]DK21.11.2007
FI21.11.2007
NL21.11.2007
SE21.02.2008
ES04.03.2008
PT21.04.2008
Former [2008/35]DK21.11.2007
FI21.11.2007
NL21.11.2007
SE21.02.2008
ES04.03.2008
Former [2008/24]FI21.11.2007
NL21.11.2007
SE21.02.2008
ES04.03.2008
Former [2008/23]NL21.11.2007
SE21.02.2008
ES04.03.2008
Cited inInternational search[DPX]WO0114324  (WILEX BIOTECHNOLOGY GMBH [DE], et al) [DPX] 1-14 * claims 1-14 *;
 [X]WO0004954  (WILEX BIOTECHNOLOGY GMBH [DE], et al) [X] 1-14 * p.1-5; S.27, Tabelle; S.21; Ansprüche 1-18 *;
 [X]US5914319  (SCHACHT AARON L [US], et al) [X] 1-14 * Spalte 112, Z.66-Spalte 113, Z.8; Spalte 117, Z.11- Z.22; Ansprüche 1-51 *;
 [X]WO9920608  (PFIZER LTD [GB], et al) [X] 1-14 * claim - *;
 [PY]  - SPERL S ET AL, "(4-Aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, (20000509), vol. 97, no. 10, ISSN 0027-8424, pages 5113 - 5118, XP002169711 [PY] 1-14 * Tables 1-3; Abstract; p.5117-18, Discussion *

DOI:   http://dx.doi.org/10.1073/pnas.97.10.5113
 [Y]  - RAI R ET AL, "GUANIDINOPHENYL-SUBSTITUTED ENOL LACTONES AS SELECTIVE MECHANISM-BASED INHIBITORS OF TRYPSIN-LIKE SERINE PROTEASES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, (1992), vol. 35, no. 22, ISSN 0022-2623, pages 4150 - 4159, XP000978771 [Y] 1-14 * abstract; p.4156, Conclusion *

DOI:   http://dx.doi.org/10.1021/jm00100a021
 [Y]  - HEECHUNG YANG ET AL, "SELECTIVE INHIBITION OF UROKINASE BY SUBSTITUTED PHENYLGUANIDINES: QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, (1990), vol. 33, no. 11, ISSN 0022-2623, pages 2956 - 2961, XP002059264 [Y] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1021/jm00173a008
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.