Extract from the Register of European Patents

EP About this file: EP1291429

EP1291429 - GLUTAMINE FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE SPLICE VARIANT AND ITS EXPRESSION PRODUCT [Right-click to bookmark this link]
Former [2003/11]NOVEL ENZYME GENE AND ITS EXPRESSION PRODUCT
[2008/02]
StatusNo opposition filed within time limit
Status updated on  10.07.2009
Database last updated on 21.03.2026
Most recent event   Tooltip30.09.2011Lapse of the patent in a contracting statepublished on 02.11.2011  [2011/44]
Applicant(s)For all designated states
OTSUKA PHARMACEUTICAL CO., LTD.
9, Kandatsukasa-cho 2-chome Chiyoda-ku
Tokyo 101-8535 / JP
[2008/36]
Former [2003/11]For all designated states
OTSUKA PHARMACEUTICAL CO., LTD.
9, Kandatsukasa-cho 2-chome
Chiyoda-ku Tokyo 101-8535 / JP
Inventor(s)01 / FUJIWARA, Tsutomu
436, Aza Nakajima, Takashima, Narutocho
Naruto-shi, Tokushima 772-0051 / JP
02 / OKAMOTO, Takashi
227-102, Hojomiyanomachi
Himeji-shi, Hyogo 670-0947 / JP
03 / NIIMI, Masashi
5-1-107, Kanaoka, Kawauchicho
Tokushima-shi, Tokushima 771-0125 / JP
04 / KYUSHIKI, Hiroyuki
377-1-1301, Tsurushima, Kawauchicho
Tokushima-shi, Tokushima 771-0117 / JP
05 / YAMAMOTO, Yasuchika
9806 Mahogany Drive
Gaithersburg, MD 2878 / US
06 / UEYAMA, Atsunori
2-44-1, Shomachi
Tokushima-shi, Tokushima 770-0044 / JP
 [2008/16]
Former [2003/16]01 / FUJIWARA, Tsutomu
436, Aza Nakajima, Takashima, Narutocho
Naruto-shi, Tokushima 772-0051 / JP
02 / OKAMOTO, Takashi
227-102, Hojomiyanomachi
Himeji-shi, Hyogo 670-094 / JP
03 / NIIMI, Masashi
5-1-107, Kanaoka, Kawauchicho
Tokushima-shi, Tokushima 771-0125 / JP
04 / KYUSHIKI, Hiroyuki
377-1-1301, Tsurushima, Kawauchicho
Tokushima-shi, Tokushima 771-0117 / JP
05 / YAMAMOTO, Yasuchika
9806 Mahogany Drive
Gaithersburg, MD 2878 / US
06 / UEYAMA, Atsunori
2-44-1, Shomachi
Tokushima-shi, Tokushima 770-0044 / JP
Former [2003/11]01 / FUJIWARA, Tsutomu
436, Aza Nakajima, Takashima, Narutocho
Naruto-shi, Tokushima 772-0051 / JP
02 / OKAMOTO, Takashi
227-102, Hojomiyanomachi
Himeji-shi, Hyogo 670-094 / JP
03 / NIIMI, Masashi
5-1-107, Kanaoka, Kawauchicho
Tokushima-shi, Tokushima 771-0125 / JP
04 / KYUSHIKI, Hiroyuki
377-1-1301, Tsurushima, Kawauchicho
Tokushima-shi, Tokushima 771-0117 / JP
05 / YAMAMOTO, Yasuchika
34-1, Aza Nishinosu, Tainohama, Kitajimacho
Itano-gun, Tokushima 771-0204 / JP
06 / UEYAMA, Atsunori
2-44-1, Shomachi
Tokushima-shi, Tokushima 770-0044 / JP
Representative(s)Hartz, Nikolai, et al
Wächtershäuser & Hartz
Patentanwaltspartnerschaft mbB
Weinstrasse 8
80333 München / DE
[N/P]
Former [2003/11]Hartz, Nikolai F., Dr., et al
Wächtershäuser & Hartz, Patentanwälte, Tal 29
80331 München / DE
Application number, filing date01938602.812.06.2001
[2003/11]
WO2001JP04941
Priority number, dateJP2000017663113.06.2000         Original published format: JP 2000176631
JP2000029067925.09.2000         Original published format: JP 2000290679
[2003/11]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO0196574
Date:20.12.2001
Language:EN
[2001/51]
Type: A1 Application with search report 
No.:EP1291429
Date:12.03.2003
Language:EN
The application published by WIPO in one of the EPO official languages on 20.12.2001 takes the place of the publication of the European patent application.
[2003/11]
Type: B1 Patent specification 
No.:EP1291429
Date:03.09.2008
Language:EN
[2008/36]
Search report(s)International search report - published on:JP20.12.2001
(Supplementary) European search report - dispatched on:EP16.04.2004
ClassificationIPC:C12N15/53, C12N9/10, C12N9/12, C12Q1/48
[2004/21]
CPC:
C12N9/1096 (EP,US); C12N15/52 (KR); A61P3/08 (EP);
A61P3/10 (EP); A61K48/00 (EP,US)
Former IPC [2003/11]C12N15/53, C12N9/10, C12N1/21, C12N1/19, C12N5/10, C12P21/08, C07K16/40, C12Q1/48, G01N33/53, G01N33/573, G01N33/543, G01N33/50, A61K38/45, A61K48/00, A61P3/08, A61P3/10
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2003/11]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
RONot yet paid
SINot yet paid
TitleGerman:SPLEISSVARIANTE DER GLUTAMINE FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE UND DESSEN EXPRESSIONSPRODUKT[2008/02]
English:GLUTAMINE FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE SPLICE VARIANT AND ITS EXPRESSION PRODUCT[2008/16]
French:VARIANT D'EPISSAGE DE GLUTAMINE FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE ET SON PRODUIT D'EXPRESSION[2008/02]
Former [2003/11]ENZYM-GEN UND DESSEN EXPRESSIONSPRODUKT
Former [2003/11]NOVEL ENZYME GENE AND ITS EXPRESSION PRODUCT
Former [2003/11]NOUVEAU GENE ENZYMATIQUE ET SON PRODUIT D'EXPRESSION
Entry into regional phase03.12.2002Translation filed 
03.12.2002National basic fee paid 
03.12.2002Search fee paid 
03.12.2002Designation fee(s) paid 
03.12.2002Examination fee paid 
Examination procedure04.12.2001Request for preliminary examination filed
International Preliminary Examining Authority: JP
03.12.2002Examination requested  [2003/11]
13.09.2004Despatch of a communication from the examining division (Time limit: M06)
21.03.2005Reply to a communication from the examining division
09.05.2006Despatch of a communication from the examining division (Time limit: M06)
08.11.2006Reply to a communication from the examining division
26.07.2007Despatch of a communication from the examining division (Time limit: M04)
05.10.2007Reply to a communication from the examining division
22.10.2007Despatch of a communication from the examining division (Time limit: M01)
16.11.2007Reply to a communication from the examining division
25.03.2008Communication of intention to grant the patent
16.07.2008Fee for grant paid
16.07.2008Fee for publishing/printing paid
Opposition(s)04.06.2009No opposition filed within time limit [2009/33]
Fees paidRenewal fee
18.06.2003Renewal fee patent year 03
15.06.2004Renewal fee patent year 04
28.06.2005Renewal fee patent year 05
27.06.2006Renewal fee patent year 06
13.06.2007Renewal fee patent year 07
30.06.2008Renewal fee patent year 08
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Lapses during opposition  TooltipCY03.09.2008
[2011/44]
Documents cited:Search[X]   DATABASE UNIPROT [online] 1 June 1994 (1994-06-01), XP002275456, Database accession no. Q06210; Q9BXF8 [X] 1-13 * the whole document *
 [X]   DATABASE UNIPROT [online] 1 February 1996 (1996-02-01), XP002275457, Database accession no. P47856; Q91XG9; Q99LP7; Q99MJ4 [X] 1-13 * the whole document *
 [X]   DATABASE EMBL [online] 9 May 1992 (1992-05-09), XP002275458, Database accession no. M90516 [X] 1-13 * the whole document *
 [X]   DATABASE EMBL [online] 20 May 1994 (1994-05-20), XP002275459, Database accession no. AAQ51188 [X] 1-13 * the whole document *
 [XP]   DEHAVEN J E AND BUSE M G: "A Novel Variant of Glutamine:Fructose-6-Phosphate Amidotransferase-1 (GFAT1) is Selectively Expressed in Skeletal Muscle", DIABETES, vol. 50, no. 2, 2001, pages A284 - 285, XP009028613 [XP] 1-13 * the whole document *
 [XP]   DATABASE EMBL [online] 19 September 2000 (2000-09-19), XP002275460, Database accession no. AAA30882 [XP] 1-13 * the whole document *
 [XP]   DATABASE EMBL [online] 11 August 2000 (2000-08-11), XP002275461, Database accession no. BE551543 [XP] 1-13 * the whole document *
 [XP]   DATABASE EMBL [online] 24 April 2001 (2001-04-24), XP002275462, Database accession no. BG614693 [XP] 1-3 * the whole document *
 [XP]   DATABASE EMBL [online] 16 May 2001 (2001-05-16), XP002275463, Database accession no. BG777268 [XP] 1-3 * the whole document *
 [A]   YKI-JAERVINEN H ET AL: "INCREASED GLUTAMINE: FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE ACTIVITYIN SKELETAL MUSCLE OF PATIENTS WITH NIDDM", DIABETES, NEW YORK, NY, US, vol. 45, no. 3, 1996, pages 302 - 307, XP000908709, ISSN: 0012-1797 [A]

DOI:   http://dx.doi.org/10.2337/diabetes.45.3.302
 [A]   NIIMI M ET AL: "Identification of GFAT1-L, a novel splice variant of human glutamine: fructose-6-phosphate amidotransferase (GFAT1) that is expressed abundantly in skeletal muscle", JOURNAL OF HUMAN GENETICS, XX, XX, vol. 46, no. 10, 2001, pages 566 - 571, XP002959859 [A]

DOI:   http://dx.doi.org/10.1007/s100380170022
 [A]   DEHAVEN J E ET AL: "A novel variant of glutamine: fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle", DIABETES, NEW YORK, NY, US, vol. 50, no. 11, November 2001 (2001-11-01), pages 2419 - 2424, XP002959858, ISSN: 0012-1797 [A]

DOI:   http://dx.doi.org/10.2337/diabetes.50.11.2419
International search[X]   MCKNIGHT G.L. ET AL: "Molecular cloning, cDNA sequence and bacterial expression of human glutamine: fructose-6-phosphate amidotransferase", J. BIOL. CHEM., vol. 267, no. 35, 1992, pages 25208 - 25212, XP002945069 [X]
 [X]   OKI T. ET AL.: "cDNA cloning and mapping of a novel subtype of glutamine: fructose-6-phosphate amidotransferase (GFAT2) in human and mouse", GENOMICS, vol. 57, no. 2, 1999, pages 227 - 234, XP002945070 [X]

DOI:   http://dx.doi.org/10.1006/geno.1999.5785
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