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Extract from the Register of European Patents

EP About this file: EP1328653

EP1328653 - HIGHLY EXPRESSIBLE GENES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.06.2013
Database last updated on 14.03.2026
Most recent event   Tooltip30.05.2014Lapse of the patent in a contracting state
New state(s): LU		published on 02.07.2014  [2014/27]
Applicant(s)For all designated states
The Trustees of The University of Pennsylvania
3160 Chestnut Street
Suite 200
Philadelphia PA 19104-6283 / US
[N/P]
Former [2012/31]For all designated states
The Trustees of The University of Pennsylvania
3160 Chestnut Street Suite 200
Philadelphia PA 19104-6283 / US
Former [2008/28]For all designated states
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
3160 Chestnut Street Suite 200
Philadelphia PA 19104-6283 / US
Former [2003/30]For all designated states
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Center for Technology Transfer, 3700 Market Street, Suite 300
Philadelphia, Pennsylvania 19104-3147 / US
Inventor(s)01 / WEINER, David, B.
717 Beacon Lane
Merion, PA 19066 / US
02 / YANG, Joo-Sung
102 South 42nd Street, Apartment 1
Philadelphia, PA 19104 / US
 [2003/30]
Representative(s)Perry, Robert Edward
Gill Jennings & Every LLP The Broadgate Tower
20 Primrose Street
London
EC2A 2ES / GB
[N/P]
Former [2012/31]Perry, Robert Edward
Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London
EC2A 2ES / GB
Former [2003/30]Perry, Robert Edward
GILL JENNINGS & EVERY Broadgate House 7 Eldon Street
London EC2M 7LH / GB
Application number, filing date01979579.804.10.2001
[2003/30]
WO2001US31451
Priority number, dateUS20000237885P04.10.2000         Original published format: US 237885 P
[2003/30]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO0229088
Date:11.04.2002
Language:EN
[2002/15]
Type: A2 Application without search report 
No.:EP1328653
Date:23.07.2003
Language:EN
The application published by WIPO in one of the EPO official languages on 11.04.2002 takes the place of the publication of the European patent application.
[2003/30]
Type: B1 Patent specification 
No.:EP1328653
Date:01.08.2012
Language:EN
[2012/31]
Search report(s)International search report - published on:US18.07.2002
(Supplementary) European search report - dispatched on:EP06.06.2005
ClassificationIPC:C12P21/00, C12P21/02, A01N43/04, C12N15/00, C12N15/09, C12N15/11, C12N15/63, C12N15/87, A61K38/16, C07K14/16, C07K14/18, G01N33/569, A61K39/00, C07K19/00
[2012/07]
CPC:
A61K38/162 (EP,US); A61P1/04 (EP); A61P17/00 (EP);
A61P17/06 (EP); A61P19/02 (EP); A61P21/00 (EP);
A61P25/00 (EP); A61P3/10 (EP); A61P35/00 (EP);
A61P37/02 (EP); A61P43/00 (EP); A61P5/14 (EP);
A61P9/00 (EP); C07K14/005 (EP,US); G01N33/56983 (EP,US);
A61K2039/53 (EP,US); A61K48/00 (EP,US); C07K2319/02 (EP,US);
C12N2740/16222 (EP,US); C12N2770/24122 (EP,US); C12N2770/24322 (EP,US);
G01N2469/20 (EP,US); Y02A50/30 (EP,US) (-)
Former IPC [2005/29]C12P21/00, C12P21/02, A01N43/04, C12N15/00, C12N15/09, C12N15/11, C12N15/63, C12N15/87, A61K38/16, C07K14/16, C07K14/18, G01N33/569
Former IPC [2003/30]C12P21/00, C12P21/02, A01N43/04, C12N15/00, C12N15/09, C12N15/11, C12N15/63
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2003/30]
TitleGerman:HOCHEXPRIMIERBARE GENE[2003/30]
English:HIGHLY EXPRESSIBLE GENES[2003/30]
French:GENES HAUTEMENT EXPRIMABLES[2003/30]
Entry into regional phase17.04.2003National basic fee paid 
17.04.2003Search fee paid 
17.04.2003Designation fee(s) paid 
17.04.2003Examination fee paid 
Examination procedure03.05.2002Request for preliminary examination filed
International Preliminary Examining Authority: US
09.04.2003Amendment by applicant (claims and/or description)
17.04.2003Examination requested  [2003/30]
04.09.2006Despatch of a communication from the examining division (Time limit: M06)
29.06.2007Reply to a communication from the examining division
26.03.2008Despatch of a communication from the examining division (Time limit: M06)
06.10.2008Reply to a communication from the examining division
11.03.2010Despatch of a communication from the examining division (Time limit: M06)
28.10.2010Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
24.12.2010Reply to a communication from the examining division
09.03.2012Communication of intention to grant the patent
13.06.2012Fee for grant paid
13.06.2012Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.09.2006
Opposition(s)03.05.2013No opposition filed within time limit [2013/28]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
24.12.2010Request for further processing filed
24.12.2010Full payment received (date of receipt of payment)
Request granted
12.01.2011Decision despatched
29.06.2007Request for further processing filed
29.06.2007Full payment received (date of receipt of payment)
Request granted
17.07.2007Decision despatched
Fees paidRenewal fee
14.10.2003Renewal fee patent year 03
14.10.2004Renewal fee patent year 04
12.10.2005Renewal fee patent year 05
12.10.2006Renewal fee patent year 06
12.10.2007Renewal fee patent year 07
27.10.2008Renewal fee patent year 08
26.10.2009Renewal fee patent year 09
25.10.2010Renewal fee patent year 10
25.10.2011Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT01.08.2012
BE01.08.2012
CY01.08.2012
DK01.08.2012
FI01.08.2012
IT01.08.2012
NL01.08.2012
SE01.08.2012
TR01.08.2012
LU04.10.2012
CH31.10.2012
LI31.10.2012
MC31.10.2012
GR02.11.2012
ES12.11.2012
PT03.12.2012
[2014/27]
Former [2014/21]AT01.08.2012
BE01.08.2012
CY01.08.2012
DK01.08.2012
FI01.08.2012
IT01.08.2012
NL01.08.2012
SE01.08.2012
TR01.08.2012
CH31.10.2012
LI31.10.2012
MC31.10.2012
GR02.11.2012
ES12.11.2012
PT03.12.2012
Former [2013/33]AT01.08.2012
BE01.08.2012
CY01.08.2012
DK01.08.2012
FI01.08.2012
IT01.08.2012
NL01.08.2012
SE01.08.2012
CH31.10.2012
LI31.10.2012
MC31.10.2012
GR02.11.2012
ES12.11.2012
PT03.12.2012
Former [2013/24]AT01.08.2012
BE01.08.2012
CY01.08.2012
DK01.08.2012
FI01.08.2012
IT01.08.2012
NL01.08.2012
SE01.08.2012
MC31.10.2012
GR02.11.2012
ES12.11.2012
PT03.12.2012
Former [2013/23]AT01.08.2012
BE01.08.2012
CY01.08.2012
DK01.08.2012
FI01.08.2012
IT01.08.2012
NL01.08.2012
SE01.08.2012
GR02.11.2012
ES12.11.2012
PT03.12.2012
Former [2013/22]AT01.08.2012
BE01.08.2012
CY01.08.2012
DK01.08.2012
FI01.08.2012
NL01.08.2012
SE01.08.2012
GR02.11.2012
ES12.11.2012
PT03.12.2012
Former [2013/21]AT01.08.2012
BE01.08.2012
CY01.08.2012
DK01.08.2012
FI01.08.2012
NL01.08.2012
SE01.08.2012
GR02.11.2012
PT03.12.2012
Former [2013/15]AT01.08.2012
BE01.08.2012
CY01.08.2012
FI01.08.2012
NL01.08.2012
SE01.08.2012
GR02.11.2012
PT03.12.2012
Former [2013/13]AT01.08.2012
BE01.08.2012
CY01.08.2012
FI01.08.2012
SE01.08.2012
GR02.11.2012
PT03.12.2012
Former [2013/12]AT01.08.2012
BE01.08.2012
CY01.08.2012
FI01.08.2012
SE01.08.2012
GR02.11.2012
Former [2013/11]AT01.08.2012
CY01.08.2012
FI01.08.2012
GR02.11.2012
Former [2013/10]AT01.08.2012
CY01.08.2012
FI01.08.2012
Former [2013/09]AT01.08.2012
FI01.08.2012
Former [2013/07]AT01.08.2012
Documents cited:Search[A] WO9731115  (MERCK & CO INC et al.) [A] 1-32 * examples 11,19 * * page 27, lines 15-21 *
 [XDY]   KIM C H ET AL: "Codon optimization for high-level expression of human erythropoietin (EPO) in mammalian cells", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 199, no. 1-2, 15 October 1997 (1997-10-15), pages 293 - 301, XP004126394, ISSN: 0378-1119 [XD] 9-15,23,24 * figures 2,6 * * page 298, column R * * page 299, paragraph L * * page 294, column L, paragraph 2 - column R, paragraph 1 * [Y] 5-8,16-22,29-32

DOI:   http://dx.doi.org/10.1016/S0378-1119(97)00384-3
 [XY]   VERVOORT E B ET AL: "OPTIMIZING HETERLOGOUS EXPRESSION IN DICTYOSTELIUM: IMPORTANCE OF 5' CODON ADAPTATION", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 28, no. 10, 15 May 2000 (2000-05-15), pages 2069 - 2074, XP000999469, ISSN: 0305-1048 [X] 9-15,23-28 * page 2073, column L, paragraph 3 - column R, paragraph L * * figures 1,2 * [Y] 5-8,16-22,29-32

DOI:   http://dx.doi.org/10.1093/nar/28.10.2069
 [A]   HAAS J ET AL: "CODON USAGE LIMITATION IN THE EXPRESSION OF HIV-1 ENVELOPE GLYCOPROTEIN", CURRENT BIOLOGY, CURRENT SCIENCE,, GB, vol. 6, no. 3, 1 March 1996 (1996-03-01), pages 315 - 324, XP000619599, ISSN: 0960-9822 [A] 1-32 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0960-9822(02)00482-7
International search[X]   DE SMIT ET AL.: "Control of translation by mRNA secondary structure in escherichia coli", JOURNAL OF MOLECULAR BIOLOGY, vol. 244, 1994, pages 144 - 150, XP002909546 [X]

DOI:   http://dx.doi.org/10.1006/jmbi.1994.1714
 [X]   MUKUND ET AL.: "Effect of mRNA secondary structure in the regulation of gene expression: unfolding of stable loop causes the expression of Taq polymerase in E. coli", CURRENT SCIENCE, vol. 76, no. 11, 10 June 1999 (1999-06-10), pages 1486 - 1490, XP002909547 [X]
 [X]   SUO ET AL.: "RNA secondary structure switching during DNA synthesis catalyzed by HIV-1 reverse transcriptase", BIOCHEMISTRY, vol. 36, 1997, pages 14778 - 14785, XP002909548 [X]

DOI:   http://dx.doi.org/10.1021/bi971963m
Examination  SVANHOLM C. ET AL: "Enhancement of antibody responses by DNA immunization using expression vectors mediating efficient antigen secretion", J. IMMUNOL. METHODS, vol. 228, 31 August 1999 (1999-08-31), pages 121 - 130 [XD] 9-15,23,24 * figures 2,6 * * page 298, column R * * page 299, paragraph L * * page 294, column L, paragraph 2 - column R, paragraph 1 *[Y] 5-8,16-22,29-32
by applicantUS2933693
   KIM ET AL., GENE, vol. 199, 1997, pages 293 - 301
   DE SMIT ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 244, pages 144 - 150
   KIM C ET AL., GENE, vol. 1999, no. 1-2
   VERVOORT B ET AL., NUCLEIC ACIDS RESEARCH, vol. 28, no. 10
   SVANHOLM ET AL., J.IMMUNO METHODS, vol. 228
   SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
   AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 2001, JOHN WILEY & SONS
   "DNA Cloning 3: A Practical Approach", vol. I, III, 1995, IRL PRESS
   "Methods in Enzymology", ACADEMIC PRESS
   WEIR ET AL.: "Handbook of Experimental Immunology", 1997, BLACKWELL SCIENTIFIC PUBLICATIONS, LTD.
   "Fields Virology", vol. I, 1996, LIPPINCOTT WILLIAMS & WILKINS PUBS.
   "Principles of Virology: Molecular Biology, Pathogenesis, and Control", 1999, ASM PRESS
   "Current Protocols in Immunology", 2001, JOHN WILEY & SONS
   "Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.