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EP1363625

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EP About this file: EP1363625

EP1363625 - COMBINATIONS OF DRUGS (E.G., A BENZIMIDAZOLE AND PENTAMIDINE) FOR THE TREATMENT OF NEOPLASTIC DISORDERS [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 20.04.2007 Database last updated on 03.10.2024
Most recent event Tooltip	23.09.2011	Change - classification	published on 26.10.2011 [2011/43]
	23.09.2011	Change - classification	published on 26.10.2011 [2011/43]
Applicant(s)	For all designated states CombinatoRx, Incorporated 650 Albany Street Boston, MA 02118 / US
	[N/P]
Former [2003/48]	For all designated states Combinatorx, Incorporated 650 Albany Street Boston, MA 02118 / US
Inventor(s)	01 / BORISY, Alexis 31 Revere Street, Apartment 2 Boston, MA 02114 / US
	02 / KEITH, Curtis 42 Rutland Square, Apartment 2 Boston, MA 02118 / US
	03 / FOLEY, Michael, A. 93 Wolcott Road Chestnut Hill, MA 02467 / US
	04 / STOCKWELL, Brent, R. 59 West Cedar Street, Apartment 4 Boston, MA 02114 / US
	[2003/48]
Representative(s)	Gervasi, Gemma Notarbartolo & Gervasi GmbH Bavariaring 21 80336 München / DE
	[N/P]
Former [2003/48]	Gervasi, Gemma, Dr. Notarbartolo & Gervasi GmbH, Bavariaring 21 80336 München / DE
Application number, filing date	02709117.2	22.01.2002
	[2003/48]
	WO2002US01707
Priority number, date	US20010768870	24.01.2001 Original published format: US 768870
	[2003/48]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO02058697
	Date:	01.08.2002
	Language:	EN
	[2002/31]
	Type:	A1 Application with search report
	No.:	EP1363625
	Date:	26.11.2003
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 01.08.2002 takes the place of the publication of the European patent application.
	[2003/48]
Search report(s)	International search report - published on:	US	01.08.2002
	(Supplementary) European search report - dispatched on:	EP	01.06.2004
Classification	IPC:	A61K31/415, A61K31/155, A61K31/00, G01N33/574, A61P35/00	[2004/16]
	CPC:	A61K31/415 (EP,US); A61P35/00 (EP)
	C-Set:	A61K31/415, A61K2300/00 (US,EP); A61K31/415, A61K31/135 (EP,US)
	Former IPC [2003/48]	A61K31/415
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, TR [2003/48]
Extension states	AL	Not yet paid
	LT	Not yet paid
	LV	Not yet paid
	MK	Not yet paid
	RO	Not yet paid
	SI	Not yet paid
Title	German:	ARZNEIMITTELKOMBINATIONEN (Z.B. EIN BENZIMIDAZOL UND EIN PENTAMIDIN) ZUR BEHANDLUNG VON NEOPLASTISCHEN STÖRUNGEN	[2003/48]
	English:	COMBINATIONS OF DRUGS (E.G., A BENZIMIDAZOLE AND PENTAMIDINE) FOR THE TREATMENT OF NEOPLASTIC DISORDERS	[2003/48]
	French:	COMBINAISONS DE MEDICAMENTS (P. EX. UN BENZIMIDAZOLE ET PENTAMIDINE) DANS LE TRAITEMENT DE TROUBLES NEOPLASIQUES	[2003/48]
Entry into regional phase	21.08.2003	National basic fee paid
	21.08.2003	Search fee paid
	21.08.2003	Designation fee(s) paid
	21.08.2003	Examination fee paid
Examination procedure	24.07.2002	Request for preliminary examination filed International Preliminary Examining Authority: US
	21.08.2003	Amendment by applicant (claims and/or description)
	21.08.2003	Examination requested [2003/48]
	18.05.2006	Despatch of a communication from the examining division (Time limit: M06)
	29.11.2006	Application deemed to be withdrawn, date of legal effect [2007/21]
	05.01.2007	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2007/21]
Fees paid	Renewal fee
	26.01.2004	Renewal fee patent year 03
	20.01.2005	Renewal fee patent year 04
	27.01.2006	Renewal fee patent year 05
	Penalty fee
	Additional fee for renewal fee
	31.01.2007	06 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X] - MAKULU D R ET AL, "EFFECTS OF PENTAMIDINE UPON MURINE LEUKEMIA AND THE WALKER 256 CARCINOMA (W256)", PHARMACOLOGIST, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTIC, US, (1974), vol. 16, no. 2, ISSN 0031-7004, page 105, XP001095144 [X] 1-25 * abstract *
		[X] - POURGHOLAMI MOHAMMAD HOSSEIN ET AL, "In vitro inhibition of human liver cancer cells by albendazole", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, & 91ST ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH.; SAN FRANCISCO, CALIFORNIA, USA; APRIL 01-05, 2000, (200003), no. 41, ISSN 0197-016X, page 656, XP001179562 [X] 1-25 * abstract *
		[X] - RAM S ET AL, "SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN ALKYL 5-(ALKOXYCARBONYL)-1H-BENZIMIDAZOLE-2-CARBAMATES AND RELATED DERIVATIVES: A NEW CLASS OF POTENTIAL ANTINEOPLASTIC AND ANTIFILARIAL AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, (1992), vol. 35, ISSN 0022-2623, pages 539 - 547, XP002056332 [X] 1-25 * abstract; Tables I-V; p.543-44, left hand col., Antitumor Results and Discussion * DOI: http://dx.doi.org/10.1021/jm00081a016
		[X] - "ACTIVITY OF BENZIMIDAZOLE CARBAMATES AGAINST L1210 MOUSE LEUKAEMIA CELLS: CORRELATION WITH IN VITRO TUBULIN POLYMERIZATION ASSAY", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, (1985), vol. 34, no. 19, ISSN 0006-2952, pages 3603 - 3605, XP001088887 [X] 1-25 * Abstract; Table 1; Results and Discussion * DOI: http://dx.doi.org/10.1016/0006-2952(85)90742-7
	International search	[A] - CHARLES ET AL., "Echinococcal infection of the spine with neural involvement", EMBASE, Database accession no. 88127571, XP002950843
		[ ] - SPINE, (1988), vol. 31, no. 1, pages 47 - 49
		[A] - AYUB ET AL., "Inhibition of testicular 17.alpha.-hydroxylase and 17,20-lyase but not 3.beta.-hydroxysteroid dehydrogenase-isomerase or 17.beta.-hydroxysteroid oxidoreductase by ketoconazole and other imidazole drugs", CAPLUS, Database accession no. 1988:15796, XP002950844
		[ ] - J. STEROID BIOCHEM., (1987), vol. 28, no. 5, pages 521 - 531
		[A] - WILSON ET AL., "Alveolar hydatid disease. A review of clinical features of 33 indigenous cases of echinococcus multilocularis infection in Alaskan Eskimos", EMBASE, Database accession no. 81053181, XP002950845
		[ ] - AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, (1980), vol. 29, no. 6, pages 1340 - 1355
	Examination	WO9632107
		WO9851304
		US5900429
		- DELATOUR P AND RICHARD Y, "Propriétés embryotoxiques et antimitotiques en série benzimidazole", THÉRAPIE, (1976), vol. 31, pages 505 - 515, XP001071185
		- ANEES M. AND STEVEN F.S., "Inhibition of a tumour protease with 3,4-dichloroisocoumarin, pentamidine isethionate and guandidino derivatives", JOURNAL OF ENZYME INHIBITION, (1994), vol. 8, pages 213 - 221, XP008007332
		- PRAVEEN REDDY B.S. ET AL, "Synthetic DNA minor grove-binding drugs", PHARMACOLOGY AND THERAPEUTICS, (1999), vol. 84, pages 1 - 111, XP000984832 DOI: http://dx.doi.org/10.1016/S0163-7258(99)00021-2

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