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Extract from the Register of European Patents

EP About this file: EP1404368

EP1404368 - MUTANT FORMS OF CHOLERA HOLOTOXIN AS AN ADJUVANT [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  15.10.2010
Database last updated on 20.07.2024
Most recent event   Tooltip19.10.2012Lapse of the patent in a contracting state
New state(s): TR		published on 21.11.2012  [2012/47]
Applicant(s)For all designated states
Wyeth Holdings Corporation
Five Giralda Farms
Madison, NJ 07940 / US
For all designated states
The Regents of the University of Colorado
1800 Grant Street, 8th Floor
Denver, CO 80203 / US
[N/P]
Former [2009/35]For all designated states
Wyeth Holdings Corporation
Five Giralda Farms
Madison, NJ 07940 / US
For all designated states
The Regents of the University of Colorado
A body corporate 1800 Grant Street 8th Floor
Denver, Colorado 80203 / US
Former [2004/20]For all designated states
Wyeth Holdings Corporation
Five Giralda Farms
Madison, NJ 07940 / US
For all designated states
The Regents of the University of Colorado
4001 Discovery Drive, Suite 390, Campus Box 588
Boulder, CO 80309 / US
Former [2004/15]For all designated states
Wyeth Holdings Corporation
Five Giralda Farms
Madison, NJ 07940 / US
For all designated states
University of Colorado
Health Science Center, Technology Transfer Office, 13001 East 17 Place, Bldg. 500, Room C 1009
Aurora, CO 80010 / US
Inventor(s)01 / GREEN, Bruce, A.
49 Northfield Gate
Pittsford, NY 14534 / US
02 / HOLMES, Randall, K.
23371 Morning Rose Drive
Golden, CO 80401 / US
03 / JOBLING, Michael, G.
12743 East Wyoming Place
Aurora, CO 80012 / US
04 / ZHU, Duzhang
50 Brittany Circle
Rochester, NY 14618 / US
 [2004/15]
Representative(s)Silveston, Judith, et al
ABEL & IMRAY
20 Red Lion Street
London, WC1R 4PQ / GB
[N/P]
Former [2004/15]Silveston, Judith, et al
ABEL & IMRAY 20 Red Lion Street
London, WC1R 4PQ / GB
Application number, filing date02752145.905.06.2002
[2004/15]
WO2002US20978
Priority number, dateUS20010296537P07.06.2001         Original published format: US 296537 P
[2004/15]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO02098368
Date:12.12.2002
Language:EN
[2002/50]
Type: A2 Application without search report 
No.:EP1404368
Date:07.04.2004
Language:EN
The application published by WIPO in one of the EPO official languages on 12.12.2002 takes the place of the publication of the European patent application.
[2004/15]
Type: B1 Patent specification 
No.:EP1404368
Date:09.12.2009
Language:EN
[2009/50]
Search report(s)International search report - published on:US08.05.2003
(Supplementary) European search report - dispatched on:EP31.03.2006
ClassificationIPC:C07K14/28, A61K39/39
[2008/29]
CPC:
C07K14/28 (EP,US); A61K39/42 (KR); A61K39/39 (EP,KR,US);
A61P31/00 (EP); A61P31/04 (EP); A61P31/10 (EP);
A61P31/12 (EP); A61P33/02 (EP); A61P35/00 (EP);
A61K2039/106 (KR); A61K2039/55544 (EP,US); A61K39/00 (EP,KR,US);
Y02A50/30 (EP,US) (-)
Former IPC [2004/15]A61K39/42
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2004/15]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
RONot yet paid
SINot yet paid
TitleGerman:MUTANTENFORMEN VON CHOLERA HOLOTOXIN ALS ADJUVANS[2004/15]
English:MUTANT FORMS OF CHOLERA HOLOTOXIN AS AN ADJUVANT[2004/15]
French:FORMES MUTANTES DE L'HOLOTOXINE DU CHOLERA EN TANT QU'ADJUVANT[2004/15]
Entry into regional phase05.01.2004National basic fee paid 
05.01.2004Search fee paid 
05.01.2004Designation fee(s) paid 
05.01.2004Examination fee paid 
Examination procedure02.01.2003Request for preliminary examination filed
International Preliminary Examining Authority: US
07.01.2004Amendment by applicant (claims and/or description)
07.01.2004Examination requested  [2004/15]
09.05.2007Despatch of a communication from the examining division (Time limit: M04)
19.09.2007Reply to a communication from the examining division
29.10.2007Despatch of a communication from the examining division (Time limit: M02)
08.01.2008Reply to a communication from the examining division
22.09.2008Despatch of a communication from the examining division (Time limit: M02)
18.11.2008Reply to a communication from the examining division
02.04.2009Communication of intention to grant the patent
12.08.2009Fee for grant paid
12.08.2009Fee for publishing/printing paid
07.10.2009Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
Opposition(s)10.09.2010No opposition filed within time limit [2010/46]
Request for further processing for:The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent
05.10.2009Request for further processing filed
05.10.2009Full payment received (date of receipt of payment)
Request granted
02.11.2009Decision despatched
Fees paidRenewal fee
23.06.2004Renewal fee patent year 03
21.06.2005Renewal fee patent year 04
27.03.2006Renewal fee patent year 05
27.06.2007Renewal fee patent year 06
25.06.2008Renewal fee patent year 07
26.06.2009Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT09.12.2009
BE09.12.2009
CY09.12.2009
DK09.12.2009
FI09.12.2009
IT09.12.2009
NL09.12.2009
SE09.12.2009
TR09.12.2009
GR10.03.2010
ES20.03.2010
PT09.04.2010
GB05.06.2010
IE05.06.2010
LU05.06.2010
CH30.06.2010
FR30.06.2010
LI30.06.2010
MC30.06.2010
[2012/47]
Former [2012/43]AT09.12.2009
BE09.12.2009
CY09.12.2009
DK09.12.2009
FI09.12.2009
IT09.12.2009
NL09.12.2009
SE09.12.2009
GR10.03.2010
ES20.03.2010
PT09.04.2010
GB05.06.2010
IE05.06.2010
LU05.06.2010
CH30.06.2010
FR30.06.2010
LI30.06.2010
MC30.06.2010
Former [2011/35]AT09.12.2009
BE09.12.2009
CY09.12.2009
DK09.12.2009
FI09.12.2009
IT09.12.2009
NL09.12.2009
SE09.12.2009
GR10.03.2010
ES20.03.2010
PT09.04.2010
GB05.06.2010
IE05.06.2010
CH30.06.2010
FR30.06.2010
LI30.06.2010
MC30.06.2010
Former [2011/31]AT09.12.2009
BE09.12.2009
CY09.12.2009
DK09.12.2009
FI09.12.2009
IT09.12.2009
NL09.12.2009
SE09.12.2009
GR10.03.2010
ES20.03.2010
PT09.04.2010
IE05.06.2010
CH30.06.2010
FR30.06.2010
LI30.06.2010
MC30.06.2010
Former [2011/20]AT09.12.2009
BE09.12.2009
CY09.12.2009
DK09.12.2009
FI09.12.2009
IT09.12.2009
NL09.12.2009
SE09.12.2009
GR10.03.2010
ES20.03.2010
PT09.04.2010
IE05.06.2010
CH30.06.2010
LI30.06.2010
MC30.06.2010
Former [2011/19]AT09.12.2009
BE09.12.2009
CY09.12.2009
DK09.12.2009
FI09.12.2009
IT09.12.2009
NL09.12.2009
SE09.12.2009
GR10.03.2010
ES20.03.2010
PT09.04.2010
IE05.06.2010
MC30.06.2010
Former [2011/14]AT09.12.2009
BE09.12.2009
CY09.12.2009
DK09.12.2009
FI09.12.2009
IT09.12.2009
NL09.12.2009
SE09.12.2009
GR10.03.2010
ES20.03.2010
PT09.04.2010
MC30.06.2010
Former [2011/07]AT09.12.2009
BE09.12.2009
CY09.12.2009
DK09.12.2009
FI09.12.2009
NL09.12.2009
SE09.12.2009
GR10.03.2010
ES20.03.2010
PT09.04.2010
MC30.06.2010
Former [2010/48]AT09.12.2009
BE09.12.2009
CY09.12.2009
FI09.12.2009
NL09.12.2009
SE09.12.2009
GR10.03.2010
ES20.03.2010
PT09.04.2010
Former [2010/37]AT09.12.2009
BE09.12.2009
FI09.12.2009
NL09.12.2009
SE09.12.2009
ES20.03.2010
PT09.04.2010
Former [2010/35]AT09.12.2009
FI09.12.2009
NL09.12.2009
SE09.12.2009
ES20.03.2010
PT09.04.2010
Former [2010/32]AT09.12.2009
FI09.12.2009
SE09.12.2009
ES20.03.2010
Former [2010/30]AT09.12.2009
FI09.12.2009
SE09.12.2009
Former [2010/22]FI09.12.2009
SE09.12.2009
Documents cited:Search[X]WO9842375  (CHIRON CORP [US]) [X] 1,5-22 * page 38 - page 41 *;
 [A]WO9845324  (UAB RESEARCH FOUNDATION [US], et al) [A] 1-22 * the whole document *;
 [E]WO02098369  (AMERICAN CYANAMID CO [US], et al) [E] 1,5-22* the whole document *
International search[Y]WO9313202  (SCLAVO BIOCINE SPA [IT]);
 [X]  - JOBLING MICHAEL G. ET AL., "Identification of motifs in cholera toxin A1 polypeptide that are required for its interaction with human ADP-ribosylation factor 6 in a bacterial two-hybrid system", PROC. NATL. ACAD. SCI. USA, (20001219), vol. 97, no. 26, pages 14662 - 14667, XP002959142

DOI:   http://dx.doi.org/10.1073/pnas.011442598
 [Y]  - PIZZA M. ET AL., "Mucosal vaccines: non-toxic derivatives of LT and CT as mucosal adjuvants", VACCINE, (20010321), pages 2534 - 2541, XP004231077

DOI:   http://dx.doi.org/10.1016/S0264-410X(00)00553-3
 [Y]  - GIULIANI MARZIA M. ET AL., "Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of escherichia coli heat labile enterotoxin with partial knockout of ADP-ribosyltransferase activity", JOURNAL OF EXPERIMENTAL MEDICINE, (19980406), vol. 187, no. 7, pages 1123 - 1132, XP002118943

DOI:   http://dx.doi.org/10.1084/jem.187.7.1123
 [XP]  - JOBLING M.G. ET AL., "Biological and biochemical characterization of variant A subunits of cholera toxin constructed by site-directed mutagenesis", JOURNAL OF BACTERIOLOGY, (200107), vol. 183, no. 13, pages 4024 - 4032, XP002959143

DOI:   http://dx.doi.org/10.1128/JB.183.13.4024-4032.2001
Examination   - TEBBEY P.W. ET AL, "Effective mucosal immunization against respiratory syncytial virus using purified F protein and a genetically detoxified cholera holotoxin, CT-E29H", VACCINE, (2000), vol. 18, pages 2723 - 2734, XP004196905

DOI:   http://dx.doi.org/10.1016/S0264-410X(00)00058-X
by applicant   - J. F. COLLINS ET AL., COMPUT. APPL. BIOSCI., (1988), vol. 4, pages 67 - 72
    - "Practical Approach Series: Nucleic Acid and Protein Sequence Analysis XVIII", J. F. COLLINS ET AL., Molecular Sequence Comparison and Alignment, IRL PRESS, (1987), page 417
    - E. G. SHPAER ET AL., GENOMICS, (1996), vol. 38, pages 179 - 191
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.