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Extract from the Register of European Patents

EP About this file: EP1434793

EP1434793 - RECOMBINANT ALLERGEN WITH REDUCED IgE BINDING BUT UNDIMINISHED T-CELL ANTIGENICITY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  11.07.2014
Database last updated on 07.10.2024
Most recent event   Tooltip24.07.2015Lapse of the patent in a contracting state
New state(s): BG, LU		published on 26.08.2015  [2015/35]
Applicant(s)For all designated states
The University of Melbourne
Grattan Street
Parkville, Victoria 3052 / AU
[N/P]
Former [2013/36]For all designated states
The University of Melbourne
Grattan Street Parkville
Victoria 3052 / AU
Former [2004/28]For all designated states
THE UNIVERSITY OF MELBOURNE
Grattan Street
Parkville, Victoria 3052 / AU
Inventor(s)01 / DEWEERD, Nicole
122 Kananook Avenue
Seaford Victoria 3198 / AU
02 / SINGH, Mohan Bir
7 Lloyd Court
Templestowe, Victoria 3106 / AU
03 / BHALLA, Prem L.
7 Lloyd Court
Templestowe, Victoria 3106 / AU
04 / SWOBODA, Ines
F G Woldmullerstr 43
A-9020 Klagenfurt / AT
 [2013/20]
Former [2004/28]01 / DEWEERD Nicole
122 Kananook Avenue
Seaford Victoria 3198 / AU
02 / SINGH, Mohan, Bir
7 Lloyd Court
Templestowe, Victoria 3106 / AU
03 / BHALLA, Prem, L.
7 Lloyd Court
Templestowe, Victoria 3106 / AU
04 / SWOBODA, Ines
F G Woldmullerstr 43
A-9020 Klagenfurt / AT
Representative(s)Seemann, Joachim
Merck KGaA
Patents Healthcare
Frankfurter Strasse 250
64293 Darmstadt / DE
[N/P]
Former [2013/36]Seemann, Joachim
Merck Patent GmbH Frankfurter Strasse 250
64293 Darmstadt / DE
Former [2007/22]Seemann, Joachim
Merck Patent GmbH Frankfurter Str. 250
64293 Darmstadt / DE
Former [2004/28]Woods, Geoffrey Corlett
J.A. KEMP & CO. Gray's Inn 14 South Square
London WC1R 5JJ / GB
Application number, filing date02757980.413.09.2002
[2004/28]
WO2002AU01261
Priority number, dateAU2001PR0779220.09.2001         Original published format: AU PR779201
[2004/28]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO03025009
Date:27.03.2003
Language:EN
[2003/13]
Type: A1 Application with search report 
No.:EP1434793
Date:07.07.2004
Language:EN
The application published by WIPO in one of the EPO official languages on 27.03.2003 takes the place of the publication of the European patent application.
[2004/28]
Type: B1 Patent specification 
No.:EP1434793
Date:04.09.2013
Language:EN
[2013/36]
Search report(s)International search report - published on:AU27.03.2003
(Supplementary) European search report - dispatched on:EP28.07.2006
ClassificationIPC:A61K39/36, C07K14/415, C07K16/16
[2013/16]
CPC:
C07K16/16 (EP,KR,US); C07K14/415 (EP,KR,US); A61K39/36 (EP,US);
A61P27/14 (EP); A61P37/00 (EP); A61P37/08 (EP);
A61K2039/57 (EP,US); A61K2039/577 (EP,US) (-)
Former IPC [2013/15]A61K39/36, C07K14/415
Former IPC [2004/28]C07K14/415, C12N15/13, A61K39/36
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   SK,   TR [2004/28]
TitleGerman:REKOMBINANTES ALLERGEN MIT REDUZIERTER IgE-BINDUNG, JEDOCH UNVERMINDERTER T-ZELLEN-ANTIGENITÄT[2004/28]
English:RECOMBINANT ALLERGEN WITH REDUCED IgE BINDING BUT UNDIMINISHED T-CELL ANTIGENICITY[2004/28]
French:ALLERGEN RECOMBINANT PRESENTANT UNE FIXATION LIMITEE A IgE MAIS UNE ANTIGENICITE ILLIMITEE AUX LYMPHOCYTES T[2013/16]
Former [2004/28]ALLERGENE DE RECOMBINAISON PRESENTANT UNE FIXATION LIMITEE A IgE MAIS UNE ANTIGENICITE ILLIMITEE AUX LYMPHOCYTES T
Entry into regional phase08.04.2004National basic fee paid 
08.04.2004Search fee paid 
08.04.2004Designation fee(s) paid 
08.04.2004Examination fee paid 
Examination procedure14.04.2003Request for preliminary examination filed
International Preliminary Examining Authority: AU
08.04.2004Amendment by applicant (claims and/or description)
08.04.2004Examination requested  [2004/28]
14.01.2008Despatch of a communication from the examining division (Time limit: M06)
15.07.2008Reply to a communication from the examining division
04.09.2009Despatch of a communication from the examining division (Time limit: M04)
14.01.2010Reply to a communication from the examining division
08.02.2010Despatch of a communication from the examining division (Time limit: M06)
05.08.2010Reply to a communication from the examining division
28.12.2010Despatch of a communication from the examining division (Time limit: M04)
15.04.2011Reply to a communication from the examining division
06.05.2011Despatch of a communication from the examining division (Time limit: M04)
05.09.2011Reply to a communication from the examining division
17.01.2012Despatch of a communication from the examining division (Time limit: M02)
15.03.2012Reply to a communication from the examining division
19.06.2012Despatch of a communication from the examining division (Time limit: M02)
14.08.2012Reply to a communication from the examining division
19.04.2013Communication of intention to grant the patent
25.07.2013Fee for grant paid
25.07.2013Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  14.01.2008
Opposition(s)05.06.2014No opposition filed within time limit [2014/33]
Fees paidRenewal fee
14.09.2004Renewal fee patent year 03
14.09.2005Renewal fee patent year 04
11.09.2006Renewal fee patent year 05
12.09.2007Renewal fee patent year 06
31.03.2008Renewal fee patent year 07
11.09.2009Renewal fee patent year 08
14.09.2010Renewal fee patent year 09
29.09.2011Renewal fee patent year 10
12.09.2012Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipBE04.09.2013
BG04.09.2013
CY04.09.2013
CZ04.09.2013
DK04.09.2013
EE04.09.2013
FI04.09.2013
MC04.09.2013
SK04.09.2013
IE13.09.2013
LU13.09.2013
[2015/34]
Former [2014/41]BE04.09.2013
CY04.09.2013
CZ04.09.2013
DK04.09.2013
EE04.09.2013
FI04.09.2013
MC04.09.2013
SK04.09.2013
IE13.09.2013
Former [2014/33]BE04.09.2013
CY04.09.2013
CZ04.09.2013
EE04.09.2013
FI04.09.2013
MC04.09.2013
SK04.09.2013
IE13.09.2013
Former [2014/29]BE04.09.2013
CY04.09.2013
CZ04.09.2013
EE04.09.2013
FI04.09.2013
MC04.09.2013
SK04.09.2013
Former [2014/23]BE04.09.2013
CY04.09.2013
CZ04.09.2013
EE04.09.2013
FI04.09.2013
SK04.09.2013
Former [2014/18]BE04.09.2013
CY04.09.2013
FI04.09.2013
Former [2014/11]CY03.07.2013
FI04.09.2013
Former [2014/10]CY03.07.2013
Documents cited:Search[A]WO9506728  (IMMULOGIC PHARMA CORP [US], et al) [A] * the whole document *;
 [XY]  - SWOBODA I ET AL, "HYPOALLERGENIC FORMS OF THE RYEGRASS POLLEN ALLERGEN LOL P 5 AS CANDIDATES FOR IMMUNOTHERAPY", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, (200101), vol. 124, no. 1-3, ISSN 1018-2438, pages 380 - 382, XP009011304 [X] 1-6,8-14 * the whole document * [Y] 7

DOI:   http://dx.doi.org/10.1159/000053763
 [Y]  - SUPHIOGLU CENK ET AL, "Molecular basis of IgE-recognition of Lol p 5, a major allergen of rye-grass pollen", MOLECULAR IMMUNOLOGY, (199804), vol. 35, no. 5, ISSN 0161-5890, pages 293 - 305, XP002377122 [Y] 7 * abstract *

DOI:   http://dx.doi.org/10.1016/S0161-5890(98)00050-9
 [DA]  - ONG ENG KOK ET AL, "Cloning of a cDNA encoding a group-V (group-IX) allergen isoform from rye-grass pollen that demonstrates specific antigenic immunoreactivity", GENE (AMSTERDAM), (1993), vol. 134, no. 2, ISSN 0378-1119, pages 235 - 240, XP002377123 [DA] 7 * the whole document *

DOI:   http://dx.doi.org/10.1016/0378-1119(93)90099-O
 [A]  - BLAHER B ET AL, "IDENTIFICATION OF T-CELL EPITOPES OF LOL P 9, A MAJOR ALLERGEN OF RYEGRASS (LOLIUM PERENNC) POLLEN", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY - YEARLY BOOK, INC, US, (199607), vol. 98, no. 1, ISSN 0091-6749, pages 124 - 132, XP009038240 [A] 7 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0091-6749(96)70234-8
 [A]  - BURTON M D ET AL, "T-cell receptor contact and MHC binding residues of a major rye grass pollen allgergen T-cell epitope", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY - YEARLY BOOK, INC, US, (1999), vol. 103, no. 2, PART 1, ISSN 0091-6749, pages 255 - 261, XP002994069 [A] 7 * abstract *

DOI:   http://dx.doi.org/10.1016/S0091-6749(99)70499-9
 [A]  - LALLA DE C ET AL, "Cutting edge: identification of novel T cell epitopes in Lol p5a by computational prediction", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, (19990815), vol. 163, no. 4, ISSN 0022-1767, pages 1725 - 1729, XP002300994 [A] 7 * the whole document *
 [A]  - ONG E K ET AL, "Mapping of the antigenic and allergenic epitopes of Lol p VB using gene fragmentation", MOLECULAR IMMUNOLOGY, (1995), vol. 32, no. 4, ISSN 0161-5890, pages 295 - 302, XP002377124 [A] 7 * the whole document *

DOI:   http://dx.doi.org/10.1016/0161-5890(94)00127-M
 [PX]  - SWOBODA INES ET AL, "Mutants of the major ryegrass pollen allergen, Lol p 5, with reduced IgE-binding capacity: Candidates for grass pollen-specific immunotherapy", EUROPEAN JOURNAL OF IMMUNOLOGY, (200201), vol. 32, no. 1, ISSN 0014-2980, pages 270 - 280, XP002377125 [PX] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1002/1521-4141(200201)32:1<270::AID-IMMU270>3.0.CO;2-X
International search[X]  - SCHRAMM G. ET AL., "Allergen engineering: Variants of the timothy grass pollen allergen Ph1 p 5B with reduced IgE-binding capacity but not conserved T cell reactivity", THE JOURNAL OF IMMUNOLOGY, (1999), vol. 162, pages 2406 - 2414, XP002216586
 [X]  - MULLER W.D. ET AL., "T-zell epitope von allegnenen", ALLERGOLOGIE, (199908), vol. 22, no. 8, pages 455 - 459, XP008052524
 [X]  - WIEDERMANN U. ET AL., "Mucosal tolerance induction with hypoallergenic molecules in a murine model of allergic asthma", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, (2001), vol. 124, pages 391 - 394, XP002990423

DOI:   http://dx.doi.org/10.1159/000053767
 [X]  - BANNON G.A. ET AL., "Engineering, characterization and in vitro efficacy of the major peanut allergens for use in immunotherapy", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, (2001), vol. 124, pages 70 - 72, XP002990422

DOI:   http://dx.doi.org/10.1159/000053672
 [X]  - AKDIS C.A. ET AL., "Regulation of specific immune responses by chemical and structural modifications of allergens", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, (2000), vol. 121, pages 261 - 269, XP001016273

DOI:   http://dx.doi.org/10.1159/000024352
 [X]  - SON D.Y. ET AL., "Pollen-related food allergy: cloning and immunological analysis of isoforms and mutants of Mal d 1, the major apple allergen and Bet v 1, the major birch pollen allergen", EUROPEAN JOURNAL OF NUTRITION, (1999), vol. 38, pages 201 - 215, XP002988494

DOI:   http://dx.doi.org/10.1007/s003940050063
 [X]  - KRAFT D. ET AL., "The importance of recombinant allergens for diagnosis and therapy of IgE-mediated allergies", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, (1999), vol. 118, pages 171 - 176, XP002269826

DOI:   http://dx.doi.org/10.1159/000024058
 [X]  - LARCHE M. ET AL., "Allergen, IgE and mast-cell-directed therapies: an overview", PROGRESS IN RESPIRATORY RESEARCH, (2001), vol. 31, pages 182 - 185, XP008052550
 [X]  - TAKAI T. ET AL., "Non-anaphylactic combination of partially deleted fragments of the major house dust mite allergen Der f for allergen-specific immunotherapy", MOLECULAR IMMUNOLOGY, (1999), vol. 36, pages 1055 - 1065, XP001024190

DOI:   http://dx.doi.org/10.1016/S0161-5890(99)00098-X
by applicantWO9506728
    - BOND ET AL., J. ALLERGY CLIN. IMMUNOL., (1993), vol. 91, page 339
    - SINGH ET AL., PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 1384 - 1388
    - ONG ET AL., GENE, (1993), vol. 134, pages 235 - 240
    - SWOBODA I. ET AL., INT. ARCH. ALLERG. IMMUNOL., (2001), vol. 134, pages 1018 - 2438
    - SUPHIOGLU C. ET AL., MOL. IMMUNOL., (1998), vol. 35, pages 293 - 305
    - BLAHER B. ET AL., J. ALLERGY CLIN. IMMUNOL., (1996), vol. 98, pages 124 - 132
    - BURTON M. D. ET AL., J. ALLERGY CLIN IMMUNOL., (1999), vol. 103, pages 255 - 61
    - LALLA DE C. ET AL., J. IMMUNOL., (1999), vol. 163, pages 1725 - 1729
    - ONG E. K. ET AL., MOL. IMMUNOL., (1995), vol. 32, pages 295 - 302
    - SWOBODA I. ET AL., EUROP. J. IMMUNOL., (2002), vol. 32, pages 270 - 280
    - SCHRAMM G. ET AL., J. IMMUNOL., (1999), vol. 162, pages 2406 - 2414
    - MULLER W. D. ET AL., ALLERGOLOGIE, (1999), vol. 22, pages 455 - 459
    - WIEDERMANN U. ET AL., INT. ARCH. ALLERG. IMMUNOL., (2001), vol. 124, pages 391 - 394
    - BANNON G. A. ET AL., INT. ARCH. ALLERG. IMMUNOL., (2001), vol. 124, pages 70 - 72
    - AKDIS C. A. ET AL., INT. ARCH. ALLERG. IMMUNOL, (2000), vol. 121, pages 261 - 269
    - SON D. Y. ET AL., EUROP. J. NUTRIT, (1999), vol. 38, pages 201 - 215
    - KRAFT D. ET AL., INT. ARCH. ALLERG. IMMUNOL., (1999), vol. 118, pages 171 - 176
    - LARCHE M. ET AL., PROGR. RESPIRAT. RES., (2001), vol. 31, pages 182 - 185
    - TAKAI T. ET AL., MOL. IMMUNOL., (1999), vol. 36, pages 1055 - 1065
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.