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Extract from the Register of European Patents

EP About this file: EP1373491

EP1373491 - PURIFIED LACTASE [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  24.06.2022
Database last updated on 31.08.2024
FormerThe patent has been granted
Status updated on  10.09.2019
Most recent event   Tooltip29.07.2022Lapse of the patent in a contracting state
New state(s): GB, IE		published on 31.08.2022  [2022/35]
Applicant(s)For all designated states
DSM IP Assets B.V.
Het Overloon 1
6411 TE Heerlen / NL
[2016/01]
Former [2004/01]For all designated states
DSM IP Assets B.V.
Het Overloon 1
6411 TE Heerlen / NL
Inventor(s)01 / BECKHOVEN VAN, Rudolf Franciscus Wilhelmus C.
Hofwijkstraat 69
4834 EK Breda / NL
02 / PARIDON, VAN, Petrus, Andreas
G.J. van der Veenstraat 15
NL-2264 DS Leidschendam / NL
 [2004/01]
Representative(s)dsm-firmenich IP
P.O. Box 4
6100 AA Echt / NL
[N/P]
Former [2016/01]van Grieken-Plooster, Izabella Johanna, et al
DSM Intellectual Property
P.O. Box 4
6100 AA Echt / NL
Former [2011/11]Matulewicz, Emil Rudolf Antonius, et al
DSM Intellectual Property P.O. Box 130
6100 AC Echt / NL
Former [2004/01]Matulewicz, Emil Rudolf Antonius, Dr., et al
DSM N.V. Patents & Trademarks Department Office Delft 600-0240 P.O. Box 1
2600 MA Delft / NL
Application number, filing date02759791.303.04.2002
[2004/01]
WO2002EP03680
Priority number, dateEP2001000010204.04.2001         Original published format: EP 01000102
[2004/01]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO02081673
Date:17.10.2002
Language:EN
[2002/42]
Type: A1 Application with search report 
No.:EP1373491
Date:02.01.2004
Language:EN
The application published by WIPO in one of the EPO official languages on 17.10.2002 takes the place of the publication of the European patent application.
[2004/01]
Type: B1 Patent specification 
No.:EP1373491
Date:30.12.2015
Language:EN
[2015/53]
Search report(s)International search report - published on:EP17.10.2002
ClassificationIPC:A23C9/12, C12N9/38
[2015/09]
CPC:
A23C9/1206 (EP,US); C12N9/2402 (EP,US); C12N9/2471 (EP,US);
C12Y302/01023 (EP,US); A23C2210/208 (EP,US); C12Y302/01108 (EP,US)
Former IPC [2004/01]C12N9/38, A23J1/18, A23J3/20, A23C9/14
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2016/01]
Former [2004/01]AT,  BE,  CH,  CY,  DE,  DK,  ES,  FI,  FR,  GB,  GR,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  SE,  TR 
Extension statesAL11.09.2003
LT11.09.2003
LV11.09.2003
MK11.09.2003
TitleGerman:GEREINIGTE LACTASE[2004/01]
English:PURIFIED LACTASE[2004/01]
French:LACTASE PURIFIEE[2004/01]
Entry into regional phase11.09.2003National basic fee paid 
11.09.2003Designation fee(s) paid 
11.09.2003Examination fee paid 
Examination procedure01.10.2002Request for preliminary examination filed
International Preliminary Examining Authority: EP
11.09.2003Examination requested  [2004/01]
20.02.2007Despatch of a communication from the examining division (Time limit: M06)
13.08.2007Reply to a communication from the examining division
24.04.2008Despatch of a communication from the examining division (Time limit: M04)
26.05.2008Reply to a communication from the examining division
20.10.2008Despatch of a communication from the examining division (Time limit: M04)
16.02.2009Reply to a communication from the examining division
10.09.2009Despatch of a communication from the examining division (Time limit: M06)
04.03.2010Reply to a communication from the examining division
20.11.2010Observations by third parties
07.12.2010Despatch of a communication from the examining division (Time limit: M06)
16.06.2011Reply to a communication from the examining division
25.07.2011Observations by third parties
30.12.2011Despatch of a communication from the examining division (Time limit: M06)
09.07.2012Reply to a communication from the examining division
14.06.2013Despatch of a communication from the examining division (Time limit: M04)
16.10.2013Reply to a communication from the examining division
16.01.2015Cancellation of oral proceeding that was planned for 29.01.2015
29.01.2015Date of oral proceedings (cancelled)
24.07.2015Communication of intention to grant the patent
05.11.2015Fee for grant paid
05.11.2015Fee for publishing/printing paid
05.11.2015Receipt of the translation of the claim(s)
Divisional application(s)EP10176987.5  / EP2280065
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  20.02.2007
Opposition(s)Opponent(s)01  28.09.2016  06.10.2016  ADMISSIBLE
Novozymes A/S
Krogshøjvej 36
2880 Bagsværd / DK
Opponent's representative
Wichmann, Hendrik
Wuesthoff & Wuesthoff
Patentanwälte und Rechtsanwalt PartG mbB
Schweigerstraße 2
81541 München / DE
 02  30.09.2016  06.10.2016  ADMISSIBLE
DuPont Nutrition Biosciences ApS
Langebrogade 1
P.O. Box 17
1001 Copenhagen K / DK
Opponent's representative
D Young & Co LLP, et al, et al
3 Noble Street
London EC2V 7BQ / GB
 03  30.09.2016  06.10.2016  ADMISSIBLE
Chr. Hansen A/S
Bøge Allé 10-12
2970 Hørsholm / DK
Opponent's representative
Uexküll & Stolberg, et al, et al
Partnerschaft von
Patent- und Rechtsanwälten mbB
Beselerstraße 4
22607 Hamburg / DE
 [N/P]
Former [2019/20]
Opponent(s)01  28.09.2016  06.10.2016  ADMISSIBLE
Novozymes A/S
Krogshøjvej 36
2880 Bagsværd / DK
Opponent's representative
Wichmann, Hendrik
Wuesthoff & Wuesthoff
Patentanwälte PartG mbB
Schweigerstraße 2
81541 München / DE
 02  30.09.2016  06.10.2016  ADMISSIBLE
DuPont Nutrition Biosciences ApS
Langebrogade 1
P.O. Box 17
1001 Copenhagen K / DK
Opponent's representative
D Young & Co LLP, et al, et al
120 Holborn
London EC1N 2DY / GB
 03  30.09.2016  06.10.2016  ADMISSIBLE
Chr. Hansen A/S
Bøge Allé 10-12
2970 Hørsholm / DK
Opponent's representative
Uexküll & Stolberg, et al, et al
Partnerschaft von
Patent- und Rechtsanwälten mbB
Beselerstraße 4
22607 Hamburg / DE
Former [2016/45]
Opponent(s)01  28.09.2016  06.10.2016  ADMISSIBLE
Novozymes A/S
Krogshøjvej 36
2880 Bagsværd / DK
Opponent's representative
Wichmann, Hendrik
Wuesthoff & Wuesthoff
Patentanwälte PartG mbB
Schweigerstraße 2
81541 München / DE
 02  30.09.2016  06.10.2016  ADMISSIBLE
DuPont Nutrition BioSciences ApS
Langebrogade 1
P.O. Box 17
1001 Copenhagen K / DK
Opponent's representative
D Young & Co LLP, et al, et al
120 Holborn
London EC1N 2DY / GB
 03  30.09.2016  06.10.2016  ADMISSIBLE
Chr. Hansen A/S
Bøge Allé 10-12
2970 Hørsholm / DK
Opponent's representative
Uexküll & Stolberg, et al, et al
Partnerschaft von
Patent- und Rechtsanwälten mbB
Beselerstraße 4
22607 Hamburg / DE
08.11.2016Invitation to proprietor to file observations on the notice of opposition
20.03.2017Reply of patent proprietor to notice(s) of opposition
06.06.2019Date of oral proceedings
11.09.2019Despatch of minutes of oral proceedings
11.09.2019Despatch of communication that the patent will be revoked
13.06.2022Legal effect of revocation of patent [2022/30]
Appeal following opposition11.11.2019Appeal received No.  T2991/19
19.12.2019Statement of grounds filed
13.06.2022Result of appeal procedure: appeal of the proprietor withdrawn
Fees paidRenewal fee
26.04.2004Renewal fee patent year 03
20.04.2005Renewal fee patent year 04
26.04.2006Renewal fee patent year 05
27.04.2007Renewal fee patent year 06
25.04.2008Renewal fee patent year 07
29.04.2009Renewal fee patent year 08
26.04.2010Renewal fee patent year 09
25.04.2011Renewal fee patent year 10
28.03.2012Renewal fee patent year 11
12.04.2013Renewal fee patent year 12
25.03.2014Renewal fee patent year 13
10.04.2015Renewal fee patent year 14
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY30.12.2015
MC30.12.2015
LU03.04.2016
GB02.04.2022
IE03.04.2022
ES04.04.2022
PT12.04.2022
[2022/35]
Former [2022/34]CY30.12.2015
MC30.12.2015
LU03.04.2016
ES04.04.2022
PT12.04.2022
Former [2018/29]CY30.12.2015
MC30.12.2015
LU03.04.2016
Former [2017/04]LU03.04.2016
Cited inInternational search[XY]WO0104276  (UNIV LIEGE [BE]) [X] 1-3,8,11-14,19 * Table I; page 12 * [Y] 4-7,9,10,15-18;
 [XY]US4237230  (IIDA TAKAO, et al) [X] 1-3,8,11-14,19 * column 4, lines 1-13; example 3 * [Y] 4-7,9,10,15-18;
 [X]US4007283  (CRISAN ELI V, et al) [X] 1-3,11,12 * column 4, lines 17-22 *;
 [X]GB1306751  (BAXTER LABORATORIES INC) [X] 1-3,11,12 * example 4 *;
 [YD]EP0145092  (GIST BROCADES NV [NL]) [YD] 4-7,9,10,15-18 * page 4, lines 33-39 *;
 [X]  - RAHIM AND LEE, "Production and characterization of beta galactosidase from psychrotrophic Bacillus subtilis KL88", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (1991), XP002174412 [X] 1-3,11,12 * abstract *
 [X]  - HUSSEIN L. ET AL., "Reduction of Lactose in Milk by purified Lactase produced by Kluyveromyces lactis", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (1989), XP002174413 [X] 1-3,10-12 * abstract *
 [X]  - PARK ET AL., "Production and characterization of beta galactosidase EC 3.2.1.23 from Aspergillus orizae", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (1979), XP002174414 [X] 1-3,12 * abstract *
other   - DICKSON R.C. ET AL, "Purification and properties on an inducible beta-galactosidase isolated from the yeast Kluyveromyces lactis", JOURNAL OF BACTERIOLOGY, (197901), vol. 137, no. 1, pages 51 - 61, XP003028171
    - OPTIM(TM) GLYCERINE, "Viscosity of Aqueous Glycerine Solutions", DOW CHEMICAL COMPANY WEBSITE, (2010), page 1, URL: http://www.dow.com/glycerine/resources/table18.htm, (20101011), XP003028172
    - BECERRA M. ET AL, "Micro-scale purification of beta-galactosidase from Kluyveromyces lactis reveals that dimeric and tetrameric forms are active", BIOTECHNOLOGY TECHNIQUES, (199803), vol. 12, no. 3, pages 253 - 256, XP002378514

DOI:   http://dx.doi.org/10.1023/A:1008885827560
OppositionEP0145092
 US5357852
 FR2500269
 US4612169
 EP0037667
 EP0026672
 US5821350
 US6146902
 GB1477087
 US4007283
 WO02081673
 US4237230
 US3919049
 US5283189
 EP0020781
 EP0919132
 US3753725
    - Declaration of Morten Krog Larsen
    - CAVAILLE, D. et al., "characterization of galactosidase fro kluyveromyces lactis", Biotechnol. Appl. Biochem., (19950000), vol. 22, pages 55 - 64, XP055312198
    - WIDMER, F. et al., "galactosidase from aspergillus niger", Eur. J. Biochem., (19790000), vol. 100, pages 559 - 567, XP055312203
    - DAHLQVIST, A et al., "hydrolysis of lactose in milk and whey with minute amounts of lactase", J. Dairy Res., (19770000), vol. 44, pages 541 - 548, XP009157855

DOI:   http://dx.doi.org/10.1017/S0022029900020495
    - MBUYI-KALALA, A et al., "separation and characterization of four enzyme forms of galactosidase from saccharomyces lactis", Eur. J. Biochem., (19880000), vol. 178, pages 437 - 443, XP055022811

DOI:   http://dx.doi.org/10.1111/j.1432-1033.1988.tb14467.x
    - DA SILVA, M. et al., "purification of microbial galactosidase from kluyveromyces fragilis by bioaffinity partitioning", T. Revista de Micobiologia, (19990000), vol. 30, pages 324 - 331, XP055312209
    - BECERRA, M. et al., "micro scale purification of galactosidase from kluyveromyces", Biotechnol. Techniques, (19980000), vol. 12, pages 253 - 256, XP002378514

DOI:   http://dx.doi.org/10.1023/A:1008885827560
    - BECERRA, M et al., "dealing with different methods for kluyveromyces", Biological Procedures, (19980000), vol. 1, pages 48 - 58, XP002378487

DOI:   http://dx.doi.org/10.1251/bpo4
    - STEERS, E. et al., "the purification of galactosidase from escheridia coli", J. Biol. Chem., (19710000), vol. 246, pages 196 - 200, XP055312215
    - MAHONEY et al., "Beta-D-Galactosidase", Encyclopedia of Dairy Sciences, (20020000), pages 907 - 914
    - DICKSON et al., Journal of Bacteriology, (19790000), vol. 137, no. 1, pages 51 - 61
    - WIDMER et al., "beta-Galactosidase from Aspergillus niger", Eur. J. Biochem, (19790000), vol. 100, pages 559 - 567
    - FCC, (19960701), pages 801 - 802
    - Voedingsmiddelentechnologie, (19800000), vol. 13, no. 23
    - Anonymous, "Melk met gereduceerd lactose gehalte", Voedingsmiddelentechnologie, (19800306), vol. 13, no. 5, page 23, XP055313331
    - RICHMOND et al., "Beta-Galactosidase: Review of Recent Research related to technological application, nutritional concerns, and immobilization", J. Dairy Sci, (19810900), vol. 64, no. 9, pages 1759 - 1771, XP001314507
    - MAHONEY et al., "Purification and physicochemical properties of Ã?- galactosidase from Kluyveromyces fragilis", J. Food Sci, (19780000), vol. 43, pages 584 - 591, XP055313346
    - STEERS et al., "The purification of Beta-galactosidase from Escherichia coli by affinity chromatography", JBC, (19710000), vol. 246, pages 196 - 200, XP055313346
    - BECERRA M et al., "Dealing with different methods for Kluyveromyces lactis beta-galactosidase purification", Biological Procedures online, (19980514), vol. 1, no. 1, pages 48 - 58, XP002378487

DOI:   http://dx.doi.org/10.1251/bpo4
    - BECERRA M et al., "Micro-scale purification of beta-galactosidase from Kluyveromyces lactis reveals that dimeric and tetrameric forms are active", Biotechnol. Techniques, (19980300), vol. 12, no. 3, pages 253 - 256, XP002378514

DOI:   http://dx.doi.org/10.1023/A:1008885827560
    - DA SILVA M E et al., "Purification of microbial Beta-galactosidase from Kluyveromyces fragilis by bioaffinity partitioning", Revista de Microbiologia, vol. 30, (19990000), pages 324 - 331, URL: http://www.scielo.br/pdf/rm/v30n4/06_99-45.pdf, XP055312209
    - MITTAL et al., "The effect of protease contamination in lactase on the flavour of lactose-hydrolyzed milks", Austr. J Dairy Technol., (19910500), vol. 46, no. 1, pages 46 - 48, XP000214450
    - WEIQUN et al., "Purification and characterization of beta- galactosidase from Kluyveromyces lactis", Chin. J Biotechnol., (19930000), vol. 9, no. 4, pages 348 - 354, XP003031057
    - JIEYAN et al., "Lactose hydrolysis of milks by Klyveromyces lactis lactase", Food & Fermentation Industries, (19910000), pages 354 - 360, XP055316113
    - COENEN et al., "Safety evaluation of a lactase enzyme prepara- tion derived from Kluyveromyces lactis", Food Chem. Toxicol., (20000800), vol. 38, pages 671 - 677, XP055316549

DOI:   http://dx.doi.org/10.1016/S0278-6915(00)00053-3
    - HUSSEIN et al., "Reduction of lactose in milk by purification lactase produced by Kluyveromyces lactis", J Food Protection, (19880100), vol. 52, no. 1, pages 30 - 34, XP003028138
    - DE VRESE et al., "Probiotics-compensation for lactase insufficiency", Am J Clin Nutr, (20010000), vol. 73, pages 421S - 429S, XP000984968
    - Anonymous, "List of compounds", Sigma Biochemikalien organische verbindungen und diagnostika, (19960000), pages 492 - 493, XP055316554
    - PORTNOY et al., "Separation of Alternaria into protein and carbohydrate fractions with phenyl Sepharose", J. Allergy Clin Immunol., vol. 87, no. 4, (19910400), pages 789 - 793, URL: 10.1016/0091-6749(91)90124-7, XP055316563

DOI:   http://dx.doi.org/10.1016/0091-6749(91)90124-7
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.