EP1469717 - TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 21.05.2010 Database last updated on 24.08.2024 | Most recent event Tooltip | 21.05.2010 | Application deemed to be withdrawn | published on 23.06.2010 [2010/25] | Applicant(s) | For all designated states The Regents of the University of California 1111 Franklin Street, 12th Floor Oakland, CA 94607 / US | [N/P] |
Former [2004/44] | For all designated states The Regents of The University of California 5th floor, 1111 Franklin Street Oakland, CA 94607-5200 / US | Inventor(s) | 01 /
LAFERLA, Frank, M. 58 Harvey Court Irvine, CA 92612 / US | [2004/44] | Representative(s) | Müller, Wolfram Hubertus, et al Patentanwälte Maikowski & Ninnemann Postfach 15 09 20 10671 Berlin / DE | [N/P] |
Former [2004/44] | Müller, Wolfram Hubertus, Dipl.-Phys., et al Patentanwälte Maikowski & Ninnemann, Postfach 15 09 20 10671 Berlin / DE | Application number, filing date | 02794343.0 | 20.12.2002 | [2004/44] | WO2002US40929 | Priority number, date | US20010343383P | 20.12.2001 Original published format: US 343383 P | [2004/44] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO03053136 | Date: | 03.07.2003 | Language: | EN | [2003/27] | Type: | A2 Application without search report | No.: | EP1469717 | Date: | 27.10.2004 | Language: | EN | The application published by WIPO in one of the EPO official languages on 03.07.2003 takes the place of the publication of the European patent application. | [2004/44] | Search report(s) | International search report - published on: | US | 19.02.2004 | (Supplementary) European search report - dispatched on: | EP | 19.07.2007 | Classification | IPC: | G01N33/00, A01K67/033, A01K67/027, C12N15/00, A01N61/00, A61K31/00 | [2007/48] | CPC: |
C12N15/8509 (EP,US);
A01K67/0275 (EP,US);
A01K67/0278 (EP,US);
A61P25/28 (EP);
C07K14/4711 (EP,US);
A01K2207/15 (EP,US);
A01K2217/00 (EP,US);
A01K2217/05 (EP,US);
A01K2217/072 (EP,US);
|
Former IPC [2004/44] | A01K1/00 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, SI, SK, TR [2004/44] | Extension states | AL | Not yet paid | LT | Not yet paid | LV | Not yet paid | MK | Not yet paid | RO | Not yet paid | Title | German: | DREIFACH TRANSGENES MAUSMODELL FÜR MORBUS ALZHEIMER | [2004/44] | English: | TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE | [2004/44] | French: | MODELE DE SOURIS TRIPLEMENT TRANSGENIQUE DE LA MALADIE D'ALZHEIMER | [2004/44] | Entry into regional phase | 15.07.2004 | National basic fee paid | 15.07.2004 | Search fee paid | 15.07.2004 | Designation fee(s) paid | 15.07.2004 | Examination fee paid | Examination procedure | 15.07.2004 | Examination requested [2004/44] | 21.08.2009 | Despatch of a communication from the examining division (Time limit: M04) | 05.01.2010 | Application deemed to be withdrawn, date of legal effect [2010/25] | 04.02.2010 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2010/25] | Fees paid | Renewal fee | 23.12.2004 | Renewal fee patent year 03 | 27.12.2005 | Renewal fee patent year 04 | 27.12.2006 | Renewal fee patent year 05 | 24.12.2007 | Renewal fee patent year 06 | 24.12.2008 | Renewal fee patent year 07 | Penalty fee | Additional fee for renewal fee | 31.12.2009 | 08   M06   Not yet paid |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [X]WO9416557 (FOX CHASE CANCER CENTER [US]) [X] 29-33 * page 23, line 17 - line 21 *; | [A]WO9817782 (UNIV SOUTH FLORIDA [US], et al) [A] * claim - *; | [X]US5814318 (LONBERG NILS [US], et al) [X] 29-33 * column 79, line 35 - line 55 * * column 83, line 29 - line 36 *; | [X]WO9931969 (AMERICAN HOME PROD [US], et al) [X] 29-33 * page 9, line 15 - line 26 *; | [X]US6255555 (SAWADA SHINICHIRO [JP]) [X] 29-33 * column 2, line 43 - line 56 * * column 4, line 3 - line 6 * * column 4, line 17 - line 21 * * column 5, line 61 - line 67 * * column 6, line 16 - line 24 *; | [PX] - ODDO S ET AL, "A NOVEL TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE", SOCIETY FOR NEUROSCIENCE ABSTRACTS, SOCIETY FOR NEUROSCIENCE, US, (20021107), vol. 2002, ISSN 0190-5295, XP009086160 [PX] 1-39 * abstract * | [T] - ODDO SALVATORE ET AL, "Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.", NEUROBIOLOGY OF AGING, (200312), vol. 24, no. 8, ISSN 0197-4580, pages 1063 - 1070, XP002440916 [T] * the whole document * DOI: http://dx.doi.org/10.1016/j.neurobiolaging.2003.08.012 | [T] - ODDO SALVATORE ET AL, "Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction.", NEURON, (20030731), vol. 39, no. 3, ISSN 0896-6273, pages 409 - 421, XP002440917 [T] * the whole document * DOI: http://dx.doi.org/10.1016/S0896-6273(03)00434-3 | International search | [A] - LAUB RUDIGER ET AL., "Replacement of murine by human CD4 and introduction of HLA-DR17 in mice: A triple-transgenic animal model to study human MHCII-CD4 interaction in situ", JOURNAL OF EXPERIMENTAL ANIMAL SCIENCE, (1998), vol. 39, pages 122 - 135, XP002968029 | [A] - VAN DER HAUTE C. ET AL., "Coexpression of human cdk5 and its activator p35 with human protein Tau in neurons in brain transgenic mice", NEUROBIOLOGY OF DISEASE, (2001), vol. 8, pages 32 - 44, XP001019796 DOI: http://dx.doi.org/10.1006/nbdi.2000.0333 | [A] - SIMON A.K. ET AL., "The lack of NF-kappa B transactivation and PKC epsilon expression in CD4+CD8+ thymocytes correlates with negative selection", CELL DEATH AND DIFFERENTIATION, (2000), vol. 7, pages 1253 - 1262, XP002968030 DOI: http://dx.doi.org/10.1038/sj.cdd.4400760 | [A] - DEWACHTER I. ET AL., "Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin 1 on amyloid biochemistry and pathology in APP/London mice", EXPERIMENTAL GERONTOLOGY, (2000), vol. 35, pages 831 - 841, XP002968031 DOI: http://dx.doi.org/10.1016/S0531-5565(00)00149-2 | [A] - TAKEUCHI A. ET AL., "Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss", AMERICAN JOURNAL OF PATHOLOGY, (200007), vol. 157, no. 1, pages 331 - 339, XP002968032 | [A] - VAN DORPE J. ET AL., "Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons", AMERICAN JOURNAL OF PATHOLOGY, (200010), vol. 157, no. 4, pages 1283 - 1298, XP002968033 | [A] - WENGENACK T.M. ET AL., "Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain", NEUROSCIENCE, (2000), vol. 101, no. 4, pages 939 - 944, XP002968034 DOI: http://dx.doi.org/10.1016/S0306-4522(00)00388-2 | [A] - VAN LEUVEN F., "Single and multiple transgenic mice as models for Alzheimer's disease", PROGRESS IN NEUROBIOLOGY, (2000), vol. 61, pages 305 - 312, XP001023899 DOI: http://dx.doi.org/10.1016/S0301-0082(99)00055-6 | [A] - WONG T.P. ET AL., "Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic ice carrying mutanted presenilin-1 and amyloid precursor protein transgenes", JOURNAL OF NEUROSCIENCES, (19990401), vol. 19, no. 7, pages 2706 - 2716, XP000978979 | [A] - GOTZ J. ET AL., "In vivo analysis of wild-type and FTDP-17 Tau transgenic mice", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (MOLECULAR BASIS OF DEMENTIA), (2000), vol. 920, pages 126 - 133, XP002968035 | [A] - MALESTER B. ET AL., "Characterization of pathology in transgenic mice over-expressing human genomic and cDNA Tau transgenes", NEUROBIOLOGY OF DISEASE, (2000), vol. 7, pages 87 - 98, XP002968036 DOI: http://dx.doi.org/10.1006/nbdi.1999.0279 | [X] - SCHENK D. ET AL., "Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse", NATURE, (19990708), vol. 400, pages 173 - 177, XP002942852 DOI: http://dx.doi.org/10.1038/22124 |