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EP About this file: EP1469717

EP1469717 - TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 21.05.2010 Database last updated on 24.08.2024
Most recent event Tooltip	21.05.2010	Application deemed to be withdrawn	published on 23.06.2010 [2010/25]
Applicant(s)	For all designated states The Regents of the University of California 1111 Franklin Street, 12th Floor Oakland, CA 94607 / US
	[N/P]
Former [2004/44]	For all designated states The Regents of The University of California 5th floor, 1111 Franklin Street Oakland, CA 94607-5200 / US
Inventor(s)	01 / LAFERLA, Frank, M. 58 Harvey Court Irvine, CA 92612 / US
	[2004/44]
Representative(s)	Müller, Wolfram Hubertus, et al Patentanwälte Maikowski & Ninnemann Postfach 15 09 20 10671 Berlin / DE
	[N/P]
Former [2004/44]	Müller, Wolfram Hubertus, Dipl.-Phys., et al Patentanwälte Maikowski & Ninnemann, Postfach 15 09 20 10671 Berlin / DE
Application number, filing date	02794343.0	20.12.2002
	[2004/44]
	WO2002US40929
Priority number, date	US20010343383P	20.12.2001 Original published format: US 343383 P
	[2004/44]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO03053136
	Date:	03.07.2003
	Language:	EN
	[2003/27]
	Type:	A2 Application without search report
	No.:	EP1469717
	Date:	27.10.2004
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 03.07.2003 takes the place of the publication of the European patent application.
	[2004/44]
Search report(s)	International search report - published on:	US	19.02.2004
	(Supplementary) European search report - dispatched on:	EP	19.07.2007
Classification	IPC:	G01N33/00, A01K67/033, A01K67/027, C12N15/00, A01N61/00, A61K31/00	[2007/48]
	CPC:	C12N15/8509 (EP,US); A01K67/0275 (EP,US); A01K67/0278 (EP,US); A61P25/28 (EP); C07K14/4711 (EP,US); A01K2207/15 (EP,US); (+) A01K2217/00 (EP,US); A01K2217/05 (EP,US); A01K2217/072 (EP,US); A01K2227/105 (EP,US); A01K2267/0312 (EP,US) (-)
	Former IPC [2004/44]	A01K1/00
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, SI, SK, TR [2004/44]
Extension states	AL	Not yet paid
	LT	Not yet paid
	LV	Not yet paid
	MK	Not yet paid
	RO	Not yet paid
Title	German:	DREIFACH TRANSGENES MAUSMODELL FÜR MORBUS ALZHEIMER	[2004/44]
	English:	TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE	[2004/44]
	French:	MODELE DE SOURIS TRIPLEMENT TRANSGENIQUE DE LA MALADIE D'ALZHEIMER	[2004/44]
Entry into regional phase	15.07.2004	National basic fee paid
	15.07.2004	Search fee paid
	15.07.2004	Designation fee(s) paid
	15.07.2004	Examination fee paid
Examination procedure	15.07.2004	Examination requested [2004/44]
	21.08.2009	Despatch of a communication from the examining division (Time limit: M04)
	05.01.2010	Application deemed to be withdrawn, date of legal effect [2010/25]
	04.02.2010	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2010/25]
Fees paid	Renewal fee
	23.12.2004	Renewal fee patent year 03
	27.12.2005	Renewal fee patent year 04
	27.12.2006	Renewal fee patent year 05
	24.12.2007	Renewal fee patent year 06
	24.12.2008	Renewal fee patent year 07
	Penalty fee
	Additional fee for renewal fee
	31.12.2009	08 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X]WO9416557 (FOX CHASE CANCER CENTER [US]) [X] 29-33 * page 23, line 17 - line 21 *;
		[A]WO9817782 (UNIV SOUTH FLORIDA [US], et al) [A] * claim - *;
		[X]US5814318 (LONBERG NILS [US], et al) [X] 29-33 * column 79, line 35 - line 55 * * column 83, line 29 - line 36 *;
		[X]WO9931969 (AMERICAN HOME PROD [US], et al) [X] 29-33 * page 9, line 15 - line 26 *;
		[X]US6255555 (SAWADA SHINICHIRO [JP]) [X] 29-33 * column 2, line 43 - line 56 * * column 4, line 3 - line 6 * * column 4, line 17 - line 21 * * column 5, line 61 - line 67 * * column 6, line 16 - line 24 *;
		[PX] - ODDO S ET AL, "A NOVEL TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE", SOCIETY FOR NEUROSCIENCE ABSTRACTS, SOCIETY FOR NEUROSCIENCE, US, (20021107), vol. 2002, ISSN 0190-5295, XP009086160 [PX] 1-39 * abstract *
		[T] - ODDO SALVATORE ET AL, "Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.", NEUROBIOLOGY OF AGING, (200312), vol. 24, no. 8, ISSN 0197-4580, pages 1063 - 1070, XP002440916 [T] * the whole document * DOI: http://dx.doi.org/10.1016/j.neurobiolaging.2003.08.012
		[T] - ODDO SALVATORE ET AL, "Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction.", NEURON, (20030731), vol. 39, no. 3, ISSN 0896-6273, pages 409 - 421, XP002440917 [T] * the whole document * DOI: http://dx.doi.org/10.1016/S0896-6273(03)00434-3
	International search	[A] - LAUB RUDIGER ET AL., "Replacement of murine by human CD4 and introduction of HLA-DR17 in mice: A triple-transgenic animal model to study human MHCII-CD4 interaction in situ", JOURNAL OF EXPERIMENTAL ANIMAL SCIENCE, (1998), vol. 39, pages 122 - 135, XP002968029
		[A] - VAN DER HAUTE C. ET AL., "Coexpression of human cdk5 and its activator p35 with human protein Tau in neurons in brain transgenic mice", NEUROBIOLOGY OF DISEASE, (2001), vol. 8, pages 32 - 44, XP001019796 DOI: http://dx.doi.org/10.1006/nbdi.2000.0333
		[A] - SIMON A.K. ET AL., "The lack of NF-kappa B transactivation and PKC epsilon expression in CD4+CD8+ thymocytes correlates with negative selection", CELL DEATH AND DIFFERENTIATION, (2000), vol. 7, pages 1253 - 1262, XP002968030 DOI: http://dx.doi.org/10.1038/sj.cdd.4400760
		[A] - DEWACHTER I. ET AL., "Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin 1 on amyloid biochemistry and pathology in APP/London mice", EXPERIMENTAL GERONTOLOGY, (2000), vol. 35, pages 831 - 841, XP002968031 DOI: http://dx.doi.org/10.1016/S0531-5565(00)00149-2
		[A] - TAKEUCHI A. ET AL., "Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss", AMERICAN JOURNAL OF PATHOLOGY, (200007), vol. 157, no. 1, pages 331 - 339, XP002968032
		[A] - VAN DORPE J. ET AL., "Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons", AMERICAN JOURNAL OF PATHOLOGY, (200010), vol. 157, no. 4, pages 1283 - 1298, XP002968033
		[A] - WENGENACK T.M. ET AL., "Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain", NEUROSCIENCE, (2000), vol. 101, no. 4, pages 939 - 944, XP002968034 DOI: http://dx.doi.org/10.1016/S0306-4522(00)00388-2
		[A] - VAN LEUVEN F., "Single and multiple transgenic mice as models for Alzheimer's disease", PROGRESS IN NEUROBIOLOGY, (2000), vol. 61, pages 305 - 312, XP001023899 DOI: http://dx.doi.org/10.1016/S0301-0082(99)00055-6
		[A] - WONG T.P. ET AL., "Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic ice carrying mutanted presenilin-1 and amyloid precursor protein transgenes", JOURNAL OF NEUROSCIENCES, (19990401), vol. 19, no. 7, pages 2706 - 2716, XP000978979
		[A] - GOTZ J. ET AL., "In vivo analysis of wild-type and FTDP-17 Tau transgenic mice", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (MOLECULAR BASIS OF DEMENTIA), (2000), vol. 920, pages 126 - 133, XP002968035
		[A] - MALESTER B. ET AL., "Characterization of pathology in transgenic mice over-expressing human genomic and cDNA Tau transgenes", NEUROBIOLOGY OF DISEASE, (2000), vol. 7, pages 87 - 98, XP002968036 DOI: http://dx.doi.org/10.1006/nbdi.1999.0279
		[X] - SCHENK D. ET AL., "Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse", NATURE, (19990708), vol. 400, pages 173 - 177, XP002942852 DOI: http://dx.doi.org/10.1038/22124

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