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EP About this file: EP1448200

EP1448200 - (4-PHENYL)PIPERIDIN-3-YL-PHENYLCARBOXYLATE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 20.02.2009 Database last updated on 05.10.2024
Most recent event Tooltip	20.02.2009	Application deemed to be withdrawn	published on 25.03.2009 [2009/13]
Applicant(s)	For all designated states ELAN PHARMACEUTICALS, INC. 800 Gateway Boulevard South San Francisco, CA 94080 / US
	For all designated states Pharmacia & Upjohn Company LLC 7000 Portage Road Kalamazoo, MI 49001 / US
	[N/P]
Former [2007/04]	For all designated states Elan Pharmaceuticals, Inc. 800 Gateway Boulevard South San Francisco, CA 94080 / US
	For all designated states Pharmacia & Upjohn Company LLC 7000 Portage Road Kalamazoo, MI 49001 / US
Former [2005/22]	For all designated states Elan Pharmaceuticals, Inc. 800 Gateway Boulevard South San Francisco, CA 94080 / US
	For all designated states Pharmacia & Upjohn Company LLC 301 Henrietta Street Kalamazoo, MI 49001 / US
Former [2004/35]	For all designated states Elan Pharmaceuticals, Inc. 800 Gateway Boulevard South San Francisco, CA 94080 / US
	For all designated states Pharmacia & Upjohn Company 301 Henrietta Street Kalamazoo, MI 49007 / US
Inventor(s)	01 / JOHN, Varghese 1722 - 18th Avenue San Francisco, CA 94122 / US
	02 / MOON, Joseph, B. 2203 Sheffield Drive Kalamazoo, MI 49008 / US
	03 / PULLEY, Shon, R. 13850 Kellogg School Road Hickory Corners, MI 49060 / US
	04 / RICH, Daniel, H. 2978 Woods Edge Way Madison, WI 53711 / US
	05 / BROWN, David, L. 15504 Twingate Chesterfield, MO 63017 / US
	06 / JAGODZINSKA, Barbara 1485 Kentfield Avenue Redwood City, CA 94061 / US
	07 / JACOBS, Jon, S. 103 Merriweather Lane Kalamazoo, MI 49006 / US
	[2004/35]
Representative(s)	Nargolwalla, Cyra Cabinet Plasseraud ATTENTION : ADDRESS INACTIVE - USE ASS-NR - CDR Paris / FR
	[N/P]
Former [2008/35]	Nargolwalla, Cyra Cabinet Plasseraud 52 rue de la Victoire 75440 Paris Cedex 09 / FR
Former [2004/35]	Nargolwalla, Cyra Cabinet Plasseraud, 65/67 rue de la Victoire 75009 Paris Cedex 09 / FR
Application number, filing date	02795653.1	19.11.2002
	[2004/35]
	WO2002US37037
Priority number, date	US20010332708P	19.11.2001 Original published format: US 332708 P
	US20020383167P	24.05.2002 Original published format: US 383167 P
	[2004/35]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO03043987
	Date:	30.05.2003
	Language:	EN
	[2003/22]
	Type:	A2 Application without search report
	No.:	EP1448200
	Date:	25.08.2004
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 30.05.2003 takes the place of the publication of the European patent application.
	[2004/35]
Search report(s)	International search report - published on:	EP	10.07.2003
Classification	IPC:	A61K31/451, C07D211/42, C07D407/04, C07D413/04	[2004/35]
	CPC:	C07D401/04 (EP,US); C07D405/04 (EP,KR,US); A61K31/451 (KR); A61P25/14 (EP); A61P25/28 (EP); A61P43/00 (EP); (+) A61P9/10 (EP); C07D211/40 (EP,US); C07D211/42 (EP,US); C07D401/12 (EP,US); C07D409/12 (EP,US); C07D409/14 (EP,US); C07D413/04 (KR) (-)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, SK, TR [2004/35]
Extension states	AL	01.06.2004
	LT	01.06.2004
	LV	01.06.2004
	MK	01.06.2004
	RO	01.06.2004
	SI	01.06.2004
Title	German:	DERIVATE DES (4-PHENYL)PIPERIDIN-3-YL-PHENYLCARBOXYLATS UND VERWANDTE VERBINDUNGEN ALS BETA-SECRETASE INHIBITOREN ZUR BEHANDLUNG VON ALZHEIMER	[2004/35]
	English:	(4-PHENYL)PIPERIDIN-3-YL-PHENYLCARBOXYLATE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE	[2004/35]
	French:	PIPERIDINES ET PIPERAZINES 3,4-DISUBSTITUEES, 3,5-DISUBSTITUEES ET 3,4,5-SUBSTITUEES	[2004/35]
Entry into regional phase	01.06.2004	National basic fee paid
	01.06.2004	Designation fee(s) paid
	01.06.2004	Examination fee paid
Examination procedure	17.06.2003	Request for preliminary examination filed International Preliminary Examining Authority: US
	01.06.2004	Examination requested [2004/35]
	08.07.2004	Amendment by applicant (claims and/or description)
	24.04.2007	Despatch of a communication from the examining division (Time limit: M06)
	16.10.2007	Reply to a communication from the examining division
	16.05.2008	Despatch of a communication from the examining division (Time limit: M04)
	27.09.2008	Application deemed to be withdrawn, date of legal effect [2009/13]
	04.11.2008	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2009/13]
Fees paid	Renewal fee
	22.11.2004	Renewal fee patent year 03
	29.11.2005	Renewal fee patent year 04
	27.11.2006	Renewal fee patent year 05
	27.11.2007	Renewal fee patent year 06
	Penalty fee
	Additional fee for renewal fee
	30.11.2008	07 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[X]US4745122 (LASSEN JOERGEN B [DK]) [X] 1-33,35-58 * column 1, line 7 - line 9 *;
		[X]EP0296721 (LUNDBECK & CO AS H [DK]) [X] 1-58 * page 3, line 37; example -; claim - *;
		[X]EP0316718 (FERROSAN AS [DK]) [X] 1-58 * page 3, paragraph 1 * * compounds of formulae (I) and (II) *;
		[X]WO9709311 (HOFFMANN LA ROCHE [CH]) [X] 1-33,35-58 * example -; claim - *;
		[X]WO9912532 (HOFFMANN LA ROCHE [CH], et al) [X] 1-33,35-58 * example -; claim - *;
		[X]EP0979819 (HOFFMANN LA ROCHE [CH]) [X] 1-33,35-58 * example 7 *;
		[X]WO0020390 (UNIV GEORGETOWN [US]) [X] 1-58 * page 6, line 1 * * example -; claim - *;
		[PX]WO02066469 (AVENTIS PHARMA INC [US], et al) [PX] 1-58* page 26, line 35; examples 2,3 *;
		[PX]WO02076440 (ELAN PHARM INC [US], et al) [PX] 1-58 * page 1, paragraph 2; example -; claim - *;
		[PX]WO02088101 (VERTEX PHARMA [US], et al) [PX] 1-58 * page 1, paragraph 1; example -; claim - *;
		[X] - BURSAVICH, MATTHEW G. ET AL, "Solid-Phase Synthesis of Aspartic Peptidase Inhibitors: 3-Alkoxy-4-Aryl Piperidines", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 135:226867, URL: STN, XP002237590 [X] 1-33,36-58 * abstract *
		[ ] - ORGANIC LETTERS (2001), 3(17), 2625-2628
		[X] - VIEIRA, ERIC ET AL, "Substituted piperidines - highly potent renin inhibitors due to induced fit adaptation of the active site", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 131:102177, URL: STN, XP002237591 [X] 1-33,38-58 * abstract *
		[ ] - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (1999), 9(10), 1397-1402
		[X] - BURSAVICH, MATTHEW G. ET AL, "From Peptides to Non-Peptide Peptidomimetics: Design and Synthesis of New Piperidine Inhibitors of Aspartic Peptidases", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 135:210920, URL: STN, XP002237592 [X] 1-33,35-58 * abstract *
		[ ] - ORGANIC LETTERS (2001), 3(15), 2317-2320
		[X] - OEFNER, C. ET AL, "Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases?", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 131:2120, URL: STN, XP002237593 [X] 1-33,35-58 * abstract *
		[ ] - CHEMISTRY & BIOLOGY (1999), 6(3), 127-131
		[X] - MCERLANE K M J ET AL, "STEREOCHEMISTRY OF 3-METHYL-4-PHENYLPIPERIDINES DERIVED FROM CORRESPONDING 4-PHENYL-4-PIPERIDINOLS", CANADIAN JOURNAL OF CHEMISTRY, NATIONAL RESEARCH COUNCIL. OTTAWA, CA, (1972), vol. 50, no. 13, ISSN 0008-4042, pages 2149 - 2151, XP000995803 [X] 1-33,35-58 * example 2C * DOI: http://dx.doi.org/10.1139/v72-345
		[X] - ROGERS G A ET AL, "THE MOST INTERESTING MEMBERS OF THE AH5183 FAMILY OF DRUGS", CELLULAR AND MOLECULAR BASIS OF COLINERGIC FUNCTION, XX, XX, (1987), pages 333 - 337, XP001056296 [X] 1-33,35-58 * example 13 *

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