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Extract from the Register of European Patents

EP About this file: EP1436298

EP1436298 - HIMBACINE ANALOGUES AS THROMBIN RECEPTOR ANTAGONISTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.07.2012
Database last updated on 03.10.2024
Most recent event   Tooltip27.09.2013Lapse of the patent in a contracting state
New state(s): TR		published on 30.10.2013  [2013/44]
Applicant(s)For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
[N/P]
Former [2012/33]For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway NJ 07065-0907 / US
Former [2004/29]For all designated states
SCHERING CORPORATION
2000 Galloping Hill Road
Kenilworth, New Jersey 07033-0530 / US
Inventor(s)01 / CHACKALAMANNIL, Samuel
17 Windy Heights Road
Califon, New Jersey 07830 / US
02 / CHELLIAH, Mariappan, V.
42K Reading Road
Edison, NJ 08817 / US
03 / CLASBY, Martin, C.
79 Elsie Drive
Plainsboro, NJ 08536 / US
04 / XIA, Yan
137 Christie Street
Edison, NJ 08820 / US
 [2004/29]
Representative(s)Jaap, David Robert, et al
Merck Sharp & Dohme Corp.
120 Moorgate
London, EC2M 6UR / GB
[N/P]
Former [2011/38]Jaap, David Robert, et al
Merck & Co., Inc. Hertford Road
Hoddesdon, Herts EN11 9BU / GB
Former [2011/24]Jaap, David Robert, et al
Merck & Co., Inc. Hertford Road
Hoddesdon, Herts EN11 9BU / GB
Former [2004/29]Wiedemann, Peter
Hoffmann - Eitle Patent- und Rechtsanwälte Arabellastrasse 4
81925 München / DE
Application number, filing date02801732.516.10.2002
[2004/29]
WO2002US32936
Priority number, dateUS20010330359P18.10.2001         Original published format: US 330359 P
[2004/29]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO03033501
Date:24.04.2003
Language:EN
[2003/17]
Type: A1 Application with search report 
No.:EP1436298
Date:14.07.2004
Language:EN
The application published by WIPO in one of the EPO official languages on 24.04.2003 takes the place of the publication of the European patent application.
[2004/29]
Type: B1 Patent specification 
No.:EP1436298
Date:21.09.2011
Language:EN
[2011/38]
Search report(s)International search report - published on:EP24.04.2003
ClassificationIPC:C07D491/04, A61K31/445, A61K31/34, A61P29/00, A61P19/02, A61P9/00
[2004/29]
CPC:
C07D491/04 (EP,US); C07D491/048 (KR); A61P11/00 (EP);
A61P13/12 (EP); A61P19/00 (EP); A61P19/02 (EP);
A61P29/00 (EP); A61P35/00 (EP); A61P43/00 (EP);
A61P7/02 (EP); A61P9/00 (EP); A61P9/04 (EP);
A61P9/06 (EP); A61P9/10 (EP); A61P9/12 (EP);
C07D493/04 (EP,US); C07D495/04 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   SK,   TR [2004/29]
Extension statesAL06.04.2004
LT06.04.2004
LV06.04.2004
MK06.04.2004
RO06.04.2004
SI06.04.2004
TitleGerman:HIMBACINANALOGA ALS THROMBINREZEPTORANTAGONISTEN[2004/29]
English:HIMBACINE ANALOGUES AS THROMBIN RECEPTOR ANTAGONISTS[2004/29]
French:ANALOGUES D'HIMBACINE EN TANT QU'ANTAGONISTES DES RECEPTEURS DE LA THROMBINE[2011/15]
Former [2004/29]ANALOGUES D'HIMBACINE TELS QUE DES ANTAGONISTES RECEPTEURS DE LATHROMBINE
Entry into regional phase06.04.2004National basic fee paid 
06.04.2004Designation fee(s) paid 
06.04.2004Examination fee paid 
Examination procedure25.04.2003Request for preliminary examination filed
International Preliminary Examining Authority: EP
06.04.2004Examination requested  [2004/29]
18.03.2008Despatch of a communication from the examining division (Time limit: M04)
17.07.2008Reply to a communication from the examining division
27.01.2009Despatch of a communication from the examining division (Time limit: M04)
27.05.2009Reply to a communication from the examining division
02.12.2009Despatch of a communication from the examining division (Time limit: M04)
12.04.2010Reply to a communication from the examining division
22.10.2010Despatch of a communication from the examining division (Time limit: M04)
25.02.2011Reply to a communication from the examining division
24.03.2011Communication of intention to grant the patent
19.07.2011Fee for grant paid
19.07.2011Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  18.03.2008
Opposition(s)22.06.2012No opposition filed within time limit [2012/35]
Fees paidRenewal fee
06.10.2004Renewal fee patent year 03
07.10.2005Renewal fee patent year 04
05.10.2006Renewal fee patent year 05
15.10.2007Renewal fee patent year 06
27.03.2008Renewal fee patent year 07
07.10.2009Renewal fee patent year 08
23.09.2010Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT21.09.2011
BE21.09.2011
CY21.09.2011
CZ21.09.2011
DK21.09.2011
EE21.09.2011
FI21.09.2011
IT21.09.2011
SE21.09.2011
SK21.09.2011
TR21.09.2011
IE16.10.2011
LU16.10.2011
MC31.10.2011
BG21.12.2011
GR22.12.2011
ES01.01.2012
PT23.01.2012
[2013/44]
Former [2013/29]AT21.09.2011
BE21.09.2011
CY21.09.2011
CZ21.09.2011
DK21.09.2011
EE21.09.2011
FI21.09.2011
IT21.09.2011
SE21.09.2011
SK21.09.2011
IE16.10.2011
LU16.10.2011
MC31.10.2011
BG21.12.2011
GR22.12.2011
ES01.01.2012
PT23.01.2012
Former [2013/25]AT21.09.2011
BE21.09.2011
CY21.09.2011
CZ21.09.2011
DK21.09.2011
EE21.09.2011
FI21.09.2011
IT21.09.2011
SE21.09.2011
SK21.09.2011
IE16.10.2011
LU16.10.2011
MC31.10.2011
GR22.12.2011
ES01.01.2012
PT23.01.2012
Former [2013/22]AT21.09.2011
BE21.09.2011
CY21.09.2011
CZ21.09.2011
DK21.09.2011
EE21.09.2011
FI21.09.2011
IT21.09.2011
SE21.09.2011
SK21.09.2011
IE16.10.2011
MC31.10.2011
GR22.12.2011
ES01.01.2012
PT23.01.2012
Former [2012/47]AT21.09.2011
BE21.09.2011
CY21.09.2011
CZ21.09.2011
DK21.09.2011
EE21.09.2011
FI21.09.2011
IT21.09.2011
SE21.09.2011
SK21.09.2011
IE16.10.2011
MC31.10.2011
GR22.12.2011
PT23.01.2012
Former [2012/35]AT21.09.2011
BE21.09.2011
CY21.09.2011
CZ21.09.2011
DK21.09.2011
EE21.09.2011
FI21.09.2011
IT21.09.2011
SE21.09.2011
SK21.09.2011
MC31.10.2011
GR22.12.2011
PT23.01.2012
Former [2012/25]AT21.09.2011
BE21.09.2011
CY21.09.2011
CZ21.09.2011
EE21.09.2011
FI21.09.2011
IT21.09.2011
SE21.09.2011
SK21.09.2011
MC31.10.2011
GR22.12.2011
PT23.01.2012
Former [2012/23]AT21.09.2011
BE21.09.2011
CY21.09.2011
CZ21.09.2011
EE21.09.2011
FI21.09.2011
IT21.09.2011
SE21.09.2011
SK21.09.2011
GR22.12.2011
PT23.01.2012
Former [2012/21]AT21.09.2011
BE21.09.2011
CY21.09.2011
CZ21.09.2011
FI21.09.2011
SE21.09.2011
GR22.12.2011
Former [2012/18]AT21.09.2011
BE21.09.2011
CY21.09.2011
FI21.09.2011
SE21.09.2011
GR22.12.2011
Former [2012/12]AT21.09.2011
CY21.09.2011
FI21.09.2011
SE21.09.2011
GR22.12.2011
Former [2012/11]AT21.09.2011
FI21.09.2011
SE21.09.2011
GR22.12.2011
Former [2012/10]FI21.09.2011
SE21.09.2011
GR22.12.2011
Former [2012/09]FI21.09.2011
Cited inInternational search[Y]US5716952  (WOLDEMUSSIE ELIZABETH [US], et al) [Y] 1-7 * column 9, line 57 - column 10, line 20; claim 3 *;
 [Y]EP1138679  (SAGAMI CHEM RES [JP], et al) [Y] 1-7 * claim 1- *;
 [Y]  - M. J. MALASKA ET AL., "Chemical modification of ring C of himbacine: discovery of a pharmacophoric element for M2-selectivity", BIOORG. MED. CHEM. LETT., (1995), vol. 5, no. 1, pages 61 - 66, XP002222738 [Y] 1-7 * table 1 *

DOI:   http://dx.doi.org/10.1016/0960-894X(94)00459-S
 [Y]  - M. TAKADOI ET AL., "A novel total synthesis of (+)-himbacine, a potent antagonist of the muscarinic receptor of M2 subtype", TETRAHEDRON LETT., (1999), vol. 40, no. 17, pages 3399 - 3402, XP004162293 [Y] 1-7 * entire document *

DOI:   http://dx.doi.org/10.1016/S0040-4039(99)00473-6
 [Y]  - D. DOLLER ET AL., "Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists", BIOORG. MED. CHEM. LETT., (1999), vol. 9, no. 6, pages 901 - 906, XP004160496 [Y] 1-7 * table 1 *

DOI:   http://dx.doi.org/10.1016/S0960-894X(99)00101-8
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.