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EP About this file: EP1365020

EP1365020 - Crystal structure and mutants of interleukin-1beta converting enzyme [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 24.05.2013 Database last updated on 06.07.2024
Most recent event Tooltip	24.05.2013	Application deemed to be withdrawn	published on 26.06.2013 [2013/26]
Applicant(s)	For all designated states VERTEX PHARMACEUTICALS INCORPORATED 130 Waverly Street Cambridge, MA 02139-4242 / US
	[2005/03]
Former [2003/48]	For all designated states VERTEX PHARMACEUTICALS INCORPORATED 40 Allston Street Cambridge, MA 02139-4211 / US
Inventor(s)	01 / Wilson, Keith P. 298 Beacon Street, apt.1 Boston, MA 02166 / US
	02 / Griffith, James P. 15 Wood Ridge Circle Weston, MA 02193 / US
	03 / Kim, Eunice E. 1500 Worcester Road Framingham, MA 01701 / US
	04 / Livingston, David J. 20 Madison Avenue Newtonville, MA 02160 / US
	[2004/01]
Former [2003/48]	01 / Wilson, Keith P. 6 Longwood Drive Hopkinton, MA 01748 / US
	02 / Griffith, James P. 15 Wood Ridge Circle Weston, MA 02193 / US
	03 / Kim, Eunice E. 1500 Worcester Road Framingham, MA 01701 / US
	04 / Livingston, David J. 20 Madison Avenue Newtonville, MA 02160 / US
Representative(s)	Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
	[N/P]
Former [2008/35]	Vossius & Partner Siebertstrasse 3 81675 München / DE
Former [2003/48]	VOSSIUS & PARTNER Siebertstrasse 4 81675 München / DE
Application number, filing date	03010692.6	16.06.1995
	[2003/48]
Priority number, date	US19940261582	17.06.1994 Original published format: US 261582
	[2003/48]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP1365020
	Date:	26.11.2003
	Language:	EN
	[2003/48]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	06.10.2003
Classification	IPC:	C12N9/64, C12Q1/37	[2003/48]
	CPC:	C12N9/6475 (EP,US); C12Q1/37 (EP,US); C07K2299/00 (EP,US); G01N2333/96466 (EP,US)
Designated contracting states	AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2003/48]
Title	German:	Kristallstruktur und Mutanten des Interleukin-1-beta konvertierenden Enzyms	[2003/48]
	English:	Crystal structure and mutants of interleukin-1beta converting enzyme	[2003/48]
	French:	Structure cristalline et mutants de l'enzyme de conversion de l'interleukine-1-beta	[2003/48]
Examination procedure	24.05.2004	Examination requested [2004/30]
	16.10.2009	Despatch of a communication from the examining division (Time limit: M06)
	23.04.2010	Reply to a communication from the examining division
	24.08.2012	Despatch of a communication from the examining division (Time limit: M04)
	04.01.2013	Application deemed to be withdrawn, date of legal effect [2013/26]
	07.02.2013	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2013/26]
Parent application(s) Tooltip	EP95922329.8 / EP0765388
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP19950922329) is 10.12.1999
Fees paid	Renewal fee
	13.05.2003	Renewal fee patent year 03
	13.05.2003	Renewal fee patent year 04
	13.05.2003	Renewal fee patent year 05
	13.05.2003	Renewal fee patent year 06
	13.05.2003	Renewal fee patent year 07
	13.05.2003	Renewal fee patent year 08
	27.11.2003	Renewal fee patent year 09
	30.06.2004	Renewal fee patent year 10
	30.06.2005	Renewal fee patent year 11
	28.06.2006	Renewal fee patent year 12
	27.06.2007	Renewal fee patent year 13
	25.06.2008	Renewal fee patent year 14
	26.06.2009	Renewal fee patent year 15
	25.06.2010	Renewal fee patent year 16
	27.06.2011	Renewal fee patent year 17
	26.06.2012	Renewal fee patent year 18
	Penalty fee
	Additional fee for renewal fee
	30.06.2003	09 M06 Fee paid on 27.11.2003
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[XY]WO9400154 (MERCK & CO INC [US], et al) [X] 1-9 * the whole document * [Y] 10-33;
		[XY] - J. THOMSON ET AL, "In vito folding and autoprocessing of active interleukin-1 beta converting enzyme from an inactive recombinant precursor", JOURNAL OF CELLULAR BIOCHEMISTRY, SUPPLEMENT, (19940305), vol. 18D, page 148, XP008022057 [X] 1-9 * see abstract S 229 * [Y] 10-33
		[DX] - N. THORNBERRY ET AL, "A novel heterodimeric cysteine protease is required for interleukin-1-beta processing in monocytes", NATURE, (19920430), vol. 356, pages 768 - 774, XP001160810 [DX] 22-25,28 * page 771, column R, line 2 - page 773 * DOI: http://dx.doi.org/10.1038/356768a0
		[AY] - P. BRYAN, "Protein engineering", BIOTECH. ADV, vol. 5, pages 221 - 234, XP002093071 [A] 1-9 * the whole document * * especially page 222, last two sentences * [Y] 10-33 DOI: http://dx.doi.org/10.1016/0734-9750(87)90319-3
		[AY] - KAJIHARA A, "PROTEIN MODELLING USING A CHIMERA REFERENCE PROTEIN DERIVED FROM EXONS", PROTEIN ENGINEERING, (19930801), vol. 6, no. 6, pages 615 - 620, XP000385582 [A] 1-9 * see introduction * [Y] 12-33
		[AY] - A. RUSSELL, "Rational modification of enzyme catalysis by engineering surface charge", NATURE, (19870806), vol. 328, pages 496 - 500, XP000887130 [A] 1-9 * the whole document * [Y] 12-33
		[A] - C. SCHUBERT WRIGHT ET AL, "Structure of Subtilisin BPN' at 2.5A resolution", NATURE, vol. 221, pages 235 - 242, XP001160811 [A] 10-33 * the whole document * DOI: http://dx.doi.org/10.1038/221235a0
		[A] - D. MUSIL ET AL, "The refined 2.15A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity", THE EMBO JOURNAL, vol. 10, no. 9, pages 2321 - 2330, XP000749834 [A] 12-33 * the whole document *
		[A] - A. SIELECKI ET AL, "Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5A resolution", SCIENCE, vol. 243, pages 1346 - 1351, XP001160820 [A] 12-33 * the whole document * DOI: http://dx.doi.org/10.1126/science.2493678
		[PX] - WILSON, KEITH P. ET AL, "Structure and mechanism of interleukin -1.beta. converting enzyme", NATURE (LONDON) (1994), 370(6487), 270-5 CODEN: NATUAS;ISSN: 0028-0836, XP002054972 [PX] 1-33 * the whole document * DOI: http://dx.doi.org/10.1038/370270a0
		[PX] - WALKER, N. P. C. ET AL, "Crystal structure of the cysteine protease interleukin -1.beta.- converting enzyme: a (p20/p10)2 homodimer", CELL (CAMBRIDGE, MASS.) (1994), 78(2), 343-52 CODEN: CELLB5;ISSN: 0092-8674, XP002050334 [PX] 1-33 * the whole document * DOI: http://dx.doi.org/10.1016/0092-8674(94)90303-4

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