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Extract from the Register of European Patents

EP About this file: EP1352956

EP1352956 - Inhibition of DNA methyltransferase [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  28.08.2009
Database last updated on 13.11.2024
Most recent event   Tooltip28.08.2009Application deemed to be withdrawnpublished on 30.09.2009  [2009/40]
Applicant(s)For all designated states
McGill University
845 Sherbrooke Street West Montréal
Québec H3A 1B1 / CA
[N/P]
Former [2003/42]For all designated states
McGILL UNIVERSITY
845 Sherbrooke Street West
Montreal, Québec H3A 1B1 / CA
Inventor(s)01 / Szyf, Moshe
5770 Melling, Cote St. Luc
Montreal, Quebec H4W 2C7 / CA
 [2003/42]
Representative(s)Schnappauf, Georg, et al
ZSP Patentanwälte PartG mbB
Hansastraße 32
80686 München / DE
[N/P]
Former [2006/10]Schnappauf, Georg, et al
Dr. Volker Vossius Patent- und Rechtsanwaltskanzlei Geibelstrasse 6
81679 München / DE
Former [2003/42]Grund, Martin, Dr., et al
Dr. Volker Vossius, Patentanwaltskanzlei, Geibelstrasse 6
81679 München / DE
Application number, filing date03012172.730.11.1994
[2003/42]
Priority number, dateCA1993211021330.11.1993         Original published format: CA 2110213
GB1994001368007.07.1994         Original published format: GB 9413680
[2003/42]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP1352956
Date:15.10.2003
Language:EN
[2003/42]
Search report(s)(Supplementary) European search report - dispatched on:EP25.08.2003
ClassificationIPC:C12N9/10, C07K16/40, A61K31/713, C12N15/11
[2003/42]
CPC:
C12N15/1137 (EP,US); A61K31/706 (EP,US); A61P35/00 (EP);
A61P7/06 (EP); C07K16/40 (EP,US); C12N9/00 (EP,US);
C12N9/1007 (EP,US); A61K2039/505 (EP,US); C12N2310/111 (EP,US) (-)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2003/42]
TitleGerman:Inhibition der DNA Methyltransferase[2003/42]
English:Inhibition of DNA methyltransferase[2003/42]
French:Inhbition d' une méthyltransferase d' ADN[2003/42]
Examination procedure30.03.2004Examination requested  [2004/22]
25.09.2008Despatch of a communication from the examining division (Time limit: M06)
06.04.2009Application deemed to be withdrawn, date of legal effect  [2009/40]
13.05.2009Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2009/40]
Parent application(s)   TooltipEP95901306.1  / EP0734436
EP98112207.0  / EP0889122
Fees paidRenewal fee
03.06.2003Renewal fee patent year 03
03.06.2003Renewal fee patent year 04
03.06.2003Renewal fee patent year 05
03.06.2003Renewal fee patent year 06
03.06.2003Renewal fee patent year 07
03.06.2003Renewal fee patent year 08
03.06.2003Renewal fee patent year 09
21.11.2003Renewal fee patent year 10
22.11.2004Renewal fee patent year 11
25.11.2005Renewal fee patent year 12
27.11.2006Renewal fee patent year 13
27.11.2007Renewal fee patent year 14
25.11.2008Renewal fee patent year 15
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]WO9206985  (HOPE CITY [US]) [Y] 1,4 * the whole document *;
 [PX]  - SZYF M., "DNA methylation properties: consequences for pharmacology", TRENDS IN PHARMACEUTICAL SCIENCES, (199407), vol. 15, pages 233 - 238, XP002087766 [PX] 1,4 * the whole document *

DOI:   http://dx.doi.org/10.1016/0165-6147(94)90317-4
 [PX]  - BALLAL, S. K. ET AL, "Inhibition of O6-methylguanine-DNA methyltransferase in HeLa S3 cells by antisense oligodeoxynucleotides", SAAS BULLETIN BIOCHEMISTRY AND BIOTECHNOLOGY ( 1994 ), 7, 40-3, (1994), XP009015336 [PX] 1,3,4 * the whole document *
 [X]  - BABISS L. E. ET AL., "Reversibility of progression of the transformed phenotype in Ad5-transformed rat embryo cells", SCIENCE, LANCASTER, PA US, (1985), vol. 228, pages 1099 - 1101, XP002250418 [X] 1,4 * the whole document *

DOI:   http://dx.doi.org/10.1126/science.2581317
 [X]  - WALKER C. ET AL., "5-Azacytidine-induced uncoupling of differentiation and tumorigenicity in a murine cell line", JOURNAL OF THE NATIONAL CANCER INSTITUTE, (1984), vol. 73, no. 4, pages 877 - 882, XP002250419 [X] 1,4 * the whole document *
 [X]  - JONES P. A., "Altering gene expression with 5-Azacytidine", CELL, CAMBRIDGE, NA US, (1985), vol. 40, pages 485 - 486, XP002250420 [X] 1,4 * the whole document *

DOI:   http://dx.doi.org/10.1016/0092-8674(85)90192-8
 [X]  - SOULTANAS P. ET AL., "Modulation of human DNA methyltransferase activity and mRNA levels in the monoblast cell line U937 induced to differentiate with dibutyryl cyclic AMP and phorbol ester", JOURNAL OF MOLECULAR ENDOCRINOLOGY, (199310), vol. 11, pages 191 - 200, XP002250421 [X] 1,4 * the whole document *

DOI:   http://dx.doi.org/10.1677/jme.0.0110191
 [Y]  - EL-DEIRY W S ET AL, "HIGH EXPRESSION OF THE DNA AND METHYLTRANSFERASE GENE CHARACTERIZES HUMAN NEOPLASTIC CELLS AND PROGRESSION STAGES OF COLON CANCER", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, 1991, (1991), vol. 88, no. 8, ISSN 0027-8424, pages 3470 - 3474, XP002250422 [Y] 1-4 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.88.8.3470
 [Y]  - KAUL S. ET AL., "Preparation of monoclonal antibodies against DNA-cytosine-5-methyltransferase from human placenta", EUROPEAN JOURNAL OF CELL BIOLOGY, (1984), vol. 34, pages 330 - 335, XP002250423 [Y] 1,2,4 * the whole document *
 [Y]  - SZYF M. ET AL., "Induction of myogenic differentiation by an expression vector encoding the DNA methyltransferase cDNA sequence in the antisense orientation", JOURNAL OF BIOLOGICAL CHEMISTRY, BALTIMORE, MD US, (199206), vol. 267, no. 18, pages 12831 - 12836, XP000310546 [Y] 1,3,4 * the whole document *
 [Y]  - NEUBAUER A. ET AL., "A flow cytometric assay for the determination of cell proliferation with a monoclonal antibody directed against DNA-methyltransferase", BRITISH JOURNAL OF HAEMATOLOGY, (1989), vol. 72, pages 492 - 496, XP002250424 [Y] 1,2,4 * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1365-2141.1989.tb04311.x
 [Y]  - KAUTIAINEN T. L. ET AL., "DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture", JOURNAL OF BIOLOGICAL CHEMISTRY. (MICROFILMS), BALTIMORE, MD US, (1986), vol. 261, no. 4, pages 1594 - 1598, XP002250425 [Y] 1,4 * the whole document *
 [A]  - RAZIN A. ET AL., "Replacement of 5-methylcytosine by cytosine: A possible mechanism for transient DNA demethylation during differentiation", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, WASHINGTON US, (198605), vol. 83, pages 2827 - 2831, XP002087764

DOI:   http://dx.doi.org/10.1073/pnas.83.9.2827
 [A]  - FEINBERG A P ET AL, "Hypomethylation distinguishes genes of some human cancers from their normal counterparts.", NATURE. ENGLAND 6 JAN 1983, (19830106), vol. 301, no. 5895, ISSN 0028-0836, pages 89 - 92, XP001154390

DOI:   http://dx.doi.org/10.1038/301089a0
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.