Extract from the Register of European Patents

EP About this file: EP1400171

EP1400171 - Transgenic production of antibodies in milk [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  12.12.2008
Database last updated on 11.04.2026
Most recent event   Tooltip02.10.2009Change - representativepublished on 04.11.2009  [2009/45]
Applicant(s)For all designated states
GTC Biotherapeutics, Inc.
175 Crossing Boulevard
Framingham, MA 01702 / US
[2004/13]
Inventor(s)01 / Meade, Harry
62 Grasmere Street
Newton, MA 02158 / US
02 / Ditullio, Paul
42 Juniper Brook Road
Northborough, MA 01532 / US
03 / Pollock, Daniel
4 Redgate Drive
Medway, MA 02053 / US
 [2004/13]
Representative(s)Gillard, Richard Edward, et al
Elkington and Fife LLP
Thavies Inn House
3-4 Holborn Circus
London EC1N 2HA / GB
[N/P]
Former [2009/45]Gillard, Richard Edward, et al
Elkington and Fife LLP Thavies Inn House 3-4 Holborn Circus
London EC1N 2HA / GB
Former [2006/43]Gillard, Richard Edward, et al
Elkington and Fife LLP, Prospect House 8 Pembroke Road Sevenoaks
Kent TN13 1XR / GB
Former [2004/13]Froud, Clive, et al
Elkington and Fife Prospect House 8 Pembroke Road
Sevenoaks, Kent TN13 1XR / GB
Application number, filing date03077751.020.12.1994
[2004/13]
Priority number, dateUS1993017057920.12.1993         Original published format: US 170579
[2004/13]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP1400171
Date:24.03.2004
Language:EN
[2004/13]
Search report(s)(Supplementary) European search report - dispatched on:EP12.12.2003
ClassificationIPC:A01K67/027, C07K16/04, C07H21/00
[2004/13]
CPC:
A01K67/0278 (EP,US); C07K16/04 (EP,US); C07K16/3046 (EP,US);
C12N15/8509 (EP,US); A01K2207/15 (EP,US); A01K2217/00 (EP,US);
A01K2217/05 (EP,US); A01K2227/105 (EP,US); A01K2267/01 (EP,US);
C07K2317/21 (EP,US); Y10S530/867 (EP,US) (-)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2004/13]
TitleGerman:Transgene Antikörperherstellung in Milch[2004/13]
English:Transgenic production of antibodies in milk[2004/13]
French:Production transgénique d'anticorps dans le lait[2004/13]
Examination procedure17.09.2003Examination requested  [2004/13]
07.08.2006Despatch of a communication from the examining division (Time limit: M06)
01.06.2007Reply to a communication from the examining division
15.01.2008Despatch of a communication from the examining division (Time limit: M06)
26.07.2008Application deemed to be withdrawn, date of legal effect  [2009/03]
29.08.2008Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2009/03]
Parent application(s)   TooltipEP95906691.1  / EP0741515
Request for further processing for:01.06.2007Request for further processing filed
01.06.2007Full payment received (date of receipt of payment)
Request granted
22.06.2007Decision despatched
Fees paidRenewal fee
17.09.2003Renewal fee patent year 03
17.09.2003Renewal fee patent year 04
17.09.2003Renewal fee patent year 05
17.09.2003Renewal fee patent year 06
17.09.2003Renewal fee patent year 07
17.09.2003Renewal fee patent year 08
17.09.2003Renewal fee patent year 09
17.09.2003Renewal fee patent year 10
23.12.2004Renewal fee patent year 11
27.12.2005Renewal fee patent year 12
27.12.2006Renewal fee patent year 13
24.12.2007Renewal fee patent year 14
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Documents cited:Search[A] EP0279582  (BAYLOR COLLEGE MEDICINE et al.) [A] * page 5, column 7, line 38; claim 2 *
 [A] WO8810118  (BIOGEN NV et al.) [A] * the whole document *
 [YD]   ROBERTS B ET AL: "CLONING OF THE GOAT BETA-CASEIN-ENCODING GENE AND EXPRESSION IN TRANSGENIC MICE", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 121, no. 2, 1992, pages 255 - 262, XP001121108, ISSN: 0378-1119 [YD] 1-3 * the whole document *

DOI:   http://dx.doi.org/10.1016/0378-1119(92)90129-D
 [Y]   BREMEL R D ET AL: "ALTERATION OF MILK COMPOSITION USING MOLECULAR GENETICS", JOURNAL OF DAIRY SCIENCE, vol. 72, no. 10, 1 October 1989 (1989-10-01), pages 2826 - 2833, XP000328883 [Y] 1-3 * page 2826, column R, paragraph 4 * * page 2830, column L, paragraph 3; table 2 * * page 2830, column R, paragraph 3 *

DOI:   http://dx.doi.org/10.3168/jds.S0022-0302(89)79428-5
 [A]   YOM H -C ET AL: "GENETIC ENGINEERING OF MILK COMPOSITION: MODIFICATION OF MILK COMPONENTS IN LACTATING TRANSGENIC ANIMALS 1-3", AMERICAN JOURNAL OF CLINICAL NUTRITION, vol. 58, no. 2, 1 August 1993 (1993-08-01), pages 299S - 306S, XP000579070 [A] * page 302S, column R, paragraph 2 *
 [AD]   DITULLO, P. ET AL.: "Production of cystic fibrosis transmembrane conductance regulator in the milk of transgenic mice.", BIO/TECHNOLOGY, vol. 10, no. 1, January 1992 (1992-01-01), pages 74 - 77, XP002059092 [AD] * abstract *

DOI:   http://dx.doi.org/10.1038/nbt0192-74
ExaminationWO9108216
   GREENBERG N.M. ET AL: "Expression of biologically active heterodimeric bovine follicle-stimulating hormone in milk of transgenic mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 88, October 1991 (1991-10-01), NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, pages 8327 - 8331, XP002142421 [YD] 1-3 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.88.19.8327
   PINKERT C.A. ET AL: "Elevated PC Responsive B Cells adn Anti-PC Antibody Production in Transgenic Mice Harboring Anti-PC Immunolgobulin Genes", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 23, 1989, pages 321 - 332
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