blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP1516059

EP1516059 - METHOD FOR THE PRODUCTION OF SULPHUR-CONTAINING FINE CHEMICALS BY FERMENTATION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.02.2013
Database last updated on 24.08.2024
Most recent event   Tooltip18.07.2014Lapse of the patent in a contracting state
New state(s): HU
published on 20.08.2014  [2014/34]
Applicant(s)For all designated states
Evonik Degussa GmbH
Rellinghauser Straße 1-11
45128 Essen / DE
[N/P]
Former [2008/50]For all designated states
Evonik Degussa GmbH
Rellinghauser Straße 1- 11
45128 Essen / DE
Former [2008/10]For all designated states
BASF SE
67056 Ludwigshafen / DE
Former [2005/12]For all designated states
BASF AKTIENGESELLSCHAFT
67056 Ludwigshafen / DE
Inventor(s)01 / SCHRÖDER, Hartwig
Benzstr. 4
69226 Nussloch / DE
02 / KRÖGER, Burkhard
Im Waldhof 1
67117 Limburgerhof / DE
03 / ZELDER, Oskar
Franz-Stützel-Str. 8
67346 Speyer / DE
04 / KLOPPROGGE, Corinna
Diemersteinstrasse 3
67065 Ludwigshafen / DE
05 / HÄFNER, Stefan
Luitpoldstr. 11
67063 Ludwigshafen / DE
 [2005/12]
Representative(s)(deleted)
[2008/50]
Former [2005/12]Reitstötter - Kinzebach
Patentanwälte Postfach 86 06 49
81633 München / DE
Application number, filing date03732449.823.05.2003
[2005/12]
WO2003EP05423
Priority number, dateDE200212285823.05.2002         Original published format: DE 10222858
[2005/12]
Filing languageDE
Procedural languageDE
PublicationType: A2 Application without search report
No.:WO03100072
Date:04.12.2003
Language:DE
[2003/49]
Type: A2 Application without search report 
No.:EP1516059
Date:23.03.2005
Language:DE
The application published by WIPO in one of the EPO official languages on 04.12.2003 takes the place of the publication of the European patent application.
[2005/12]
Type: B1 Patent specification 
No.:EP1516059
Date:28.03.2012
Language:DE
[2012/13]
Search report(s)International search report - published on:EP27.01.2005
ClassificationIPC:C12P13/12, C12N9/10
[2011/31]
CPC:
C12N9/1085 (EP,US); C12P11/00 (KR); C12N1/205 (EP,US);
C12P13/12 (EP,KR,US); C12R2001/15 (EP,US)
Former IPC [2005/15]C12P13/12, C12N9/10, C12R1/15, // (C12P13/12, C12R1:15)
Former IPC [2005/12]C12P13/12, C12N9/10, C12R1/15, // C12P13:12, C12R1:15
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/12]
TitleGerman:VERFAHREN ZUR FERMENTATIVEN HERSTELLUNG SCHWEFELHALTIGER FEINCHEMIKALIEN[2005/12]
English:METHOD FOR THE PRODUCTION OF SULPHUR-CONTAINING FINE CHEMICALS BY FERMENTATION[2005/12]
French:PROCEDE POUR PRODUIRE PAR FERMENTATION DES PRODUITS DE CHIMIE FINE CONTENANT DU SOUFRE[2005/12]
Entry into regional phase23.12.2004National basic fee paid 
27.07.2005Designation fee(s) paid 
27.07.2005Examination fee paid 
Examination procedure22.12.2003Request for preliminary examination filed
International Preliminary Examining Authority: EP
27.07.2005Examination requested  [2005/38]
02.11.2007Despatch of a communication from the examining division (Time limit: M06)
13.05.2008Reply to a communication from the examining division
05.12.2008Despatch of a communication from the examining division (Time limit: M06)
04.06.2009Reply to a communication from the examining division
25.09.2009Despatch of a communication from the examining division (Time limit: M04)
14.01.2010Reply to a communication from the examining division
07.11.2011Communication of intention to grant the patent
15.02.2012Fee for grant paid
15.02.2012Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  02.11.2007
Opposition(s)03.01.2013No opposition filed within time limit [2013/10]
Fees paidRenewal fee
31.05.2005Renewal fee patent year 03
31.05.2006Renewal fee patent year 04
31.05.2007Renewal fee patent year 05
31.03.2008Renewal fee patent year 06
25.05.2009Renewal fee patent year 07
28.05.2010Renewal fee patent year 08
24.05.2011Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU23.05.2003
CY28.03.2012
CZ28.03.2012
DK28.03.2012
EE28.03.2012
FI28.03.2012
IT28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
TR28.03.2012
AT23.05.2012
IE23.05.2012
LU23.05.2012
CH31.05.2012
LI31.05.2012
MC31.05.2012
BG28.06.2012
GB28.06.2012
GR29.06.2012
PT30.07.2012
[2014/34]
Former [2014/27]CY28.03.2012
CZ28.03.2012
DK28.03.2012
EE28.03.2012
FI28.03.2012
IT28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
TR28.03.2012
AT23.05.2012
IE23.05.2012
LU23.05.2012
CH31.05.2012
LI31.05.2012
MC31.05.2012
BG28.06.2012
GB28.06.2012
GR29.06.2012
PT30.07.2012
Former [2014/21]CY28.03.2012
CZ28.03.2012
DK28.03.2012
EE28.03.2012
FI28.03.2012
IT28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
TR28.03.2012
AT23.05.2012
IE23.05.2012
CH31.05.2012
LI31.05.2012
MC31.05.2012
BG28.06.2012
GB28.06.2012
GR29.06.2012
PT30.07.2012
Former [2013/36]CY28.03.2012
CZ28.03.2012
DK28.03.2012
EE28.03.2012
FI28.03.2012
IT28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
AT23.05.2012
IE23.05.2012
CH31.05.2012
LI31.05.2012
MC31.05.2012
BG28.06.2012
GB28.06.2012
GR29.06.2012
PT30.07.2012
Former [2013/33]CY28.03.2012
CZ28.03.2012
DK28.03.2012
EE28.03.2012
FI28.03.2012
IT28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
IE23.05.2012
CH31.05.2012
LI31.05.2012
MC31.05.2012
BG28.06.2012
GB28.06.2012
GR29.06.2012
PT30.07.2012
Former [2013/21]CY28.03.2012
CZ28.03.2012
DK28.03.2012
EE28.03.2012
FI28.03.2012
IT28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
IE23.05.2012
CH31.05.2012
LI31.05.2012
MC31.05.2012
GB28.06.2012
GR29.06.2012
PT30.07.2012
Former [2013/20]CY28.03.2012
CZ28.03.2012
DK28.03.2012
EE28.03.2012
FI28.03.2012
IT28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
IE23.05.2012
CH31.05.2012
LI31.05.2012
MC31.05.2012
GR29.06.2012
PT30.07.2012
Former [2013/11]CY28.03.2012
CZ28.03.2012
DK28.03.2012
EE28.03.2012
FI28.03.2012
IT28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
CH31.05.2012
LI31.05.2012
MC31.05.2012
GR29.06.2012
PT30.07.2012
Former [2013/08]CY28.03.2012
CZ28.03.2012
DK28.03.2012
EE28.03.2012
FI28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
CH31.05.2012
LI31.05.2012
MC31.05.2012
GR29.06.2012
PT30.07.2012
Former [2013/07]CY28.03.2012
CZ28.03.2012
EE28.03.2012
FI28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
CH31.05.2012
LI31.05.2012
MC31.05.2012
GR29.06.2012
PT30.07.2012
Former [2013/03]CY28.03.2012
CZ28.03.2012
EE28.03.2012
FI28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
MC31.05.2012
GR29.06.2012
PT30.07.2012
Former [2013/01]CY28.03.2012
CZ28.03.2012
EE28.03.2012
FI28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
GR29.06.2012
PT30.07.2012
Former [2012/50]CY28.03.2012
CZ28.03.2012
EE28.03.2012
FI28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
SK28.03.2012
GR29.06.2012
Former [2012/49]CY28.03.2012
CZ28.03.2012
EE28.03.2012
FI28.03.2012
RO28.03.2012
SE28.03.2012
SI28.03.2012
GR29.06.2012
Former [2012/48]CY28.03.2012
EE28.03.2012
FI28.03.2012
SE28.03.2012
GR29.06.2012
Former [2012/41]CY28.03.2012
FI28.03.2012
GR29.06.2012
Former [2012/37]FI28.03.2012
GR29.06.2012
Former [2012/36]GR29.06.2012
Cited inInternational search[Y]JP2000139471  ;
 [DA]JPH07227287  ;
 [A]WO0100843  (BASF AG [DE]) [A] 1-21 * the whole document * * page 59 * * SEQ ID NOs 241 and 242;; claims 1-38 *;
 [Y]WO0210209  (DEGUSSA [DE]) [Y] 1-21 * the whole document *;
 [PX]WO03023044  (DEGUSSA [DE], et al) [PX] 1-4,7-18,21 * the whole document * * page 3, lines 13-24 * * claims 1-11 *;
 [XY]  - RECZKOWSKI R S ET AL, "Structural and functional roles of cysteine 90 and cysteine 240 in S-adenosylmethionine synthetase.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (19950804), vol. 270, no. 31, ISSN 0021-9258, pages 18484 - 18490, XP002260183 [X] 16,17,21 * the whole document * [Y] 5-7,16-21

DOI:   http://dx.doi.org/10.1074/jbc.270.31.18484
 [Y]  - DATABASE WPI, 1, Derwent World Patents Index, vol. 2001, no. 03, Database accession no. 2001-018703, XP002260186 & JP2000139471 A 20000523 (AJINOMOTO KK) [Y] 1-21 * abstract *
 [Y]  - NAKAMORI S ET AL, "Mechanism of L-methionine overproduction by Escherichia coli: The replacement of Ser-54 by Asn in the MetJ protein causes the derepression of L-methionine biosynthetic enzymes", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, (199908), vol. 52, no. 2, ISSN 0175-7598, pages 179 - 185, XP002242975 [Y] 1-21 * page 179, column R, lines 30-37 * * figure 1 * * page 185, column L, lines 20-27 *

DOI:   http://dx.doi.org/10.1007/s002530051506
 [Y]  - SHEN BO ET AL, "High free-methionine and decreased lignin content result from a mutation in the Arabidopsis S-adenosyl-L-methionine synthetase 3 gene.", THE PLANT JOURNAL: FOR CELL AND MOLECULAR BIOLOGY, (200202), vol. 29, no. 3, ISSN 0960-7412, pages 371 - 380, XP002260184 [Y] 1-21 * abstract * * page 374, column L, line 1 - column R, line 6 * * table 1 * * figure 3 *

DOI:   http://dx.doi.org/10.1046/j.1365-313X.2002.01221.x
 [Y]  - GOTO D B ET AL, "A single-nucleotide mutation in a gene encoding S-adenosylmethionine synthetase is associated with methionine over-accumulation phenotype in Arabidopsis thaliana", GENES AND GENETIC SYSTEMS, (200204), vol. 77, no. 2, ISSN 1341-7568, pages 89 - 95, XP002242977 [Y] 1-21 * abstract * * page 92, column L, lines 5-22 * * page 93, column R, line 3 - page 94, column L, line 6 *

DOI:   http://dx.doi.org/10.1266/ggs.77.89
 [A]  - GROSSMANN K ET AL, "Rapid cloning of metK encoding methionine adenosyltransferase from Corynebacterium glutamicum by screening a genomic library on a high density colony-array", FEMS MICROBIOLOGY LETTERS, (20001201), vol. 193, no. 1, ISSN 0378-1097, pages 99 - 103, XP000984551 [A] 1,7,15-18,21 * abstract *

DOI:   http://dx.doi.org/10.1016/S0378-1097(00)00466-3
 [DA]  - PATENT ABSTRACTS OF JAPAN, (19951226), vol. 1995, no. 11, & JP07227287 A 19950829 (MITSUBISHI CHEM CORP) [DA] 1,7,15-18,21 * abstract *
 [A]  - SEKOWSKA A ET AL, "Sulfur metabolism in Escherichia coli and related bacteria: Facts and fiction", JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, (200004), vol. 2, no. 2, ISSN 1464-1801, pages 145 - 177, XP002242976 [A] * page 156, column L, line 58 - column R, line 13 *
 [DA]  - WEI YUHONG ET AL, "Studies on the role of the metK gene product of Escherichia coli K-12.", MOLECULAR MICROBIOLOGY, (200203), vol. 43, no. 6, ISSN 0950-382X, pages 1651 - 1656, XP002260185 [DA] * abstract *

DOI:   http://dx.doi.org/10.1046/j.1365-2958.2002.02856.x
Examination   - KASE H ET AL, "Isolation and characterization of S-adenosylmethionine-requiring mutants and role of S-adenosylmethionine in the regulation of methionine biosynthesis in Corynebacterium glutamicum", AGR. BIOL. CHEM., (1975), vol. 39, no. 1, pages 161 - 168, XP009012949
by applicantUS4601893
 EP0472869
 JPH0620809
 WO9615246
 JPH10229891
 US5811238
 WO0100843
 EP1108790
 DE19953854
    - SAHM H.; EGGELING L.; DE GRAAF A., A. BIOLOGICAL CHEMISTRY, (2000), vol. 381, no. 9-10, pages 899 - 910
    - EIKMANNS BJ.; EGGELING L.; SAHM H. ANTONIE, VAN LEEUWENHOEK, (1993), vol. 64, pages 145 - 63
    - BIOCHEM., vol. 53, page 323
    - LTAKURA ET AL., SCIENCE, (1984), vol. 198, page 1056
    - IKE ET AL., NUCLEIC ACIDS RES., (1983), vol. 11, page 477
    - WM ET AL., "DNA shuffling method for generating highly recombined genes and evolved enzymes", NATURE BIOTECHNOL., (2001), vol. 19, doi:doi:10.1038/86744, pages 354 - 359, XP002185585

DOI:   http://dx.doi.org/10.1038/86744
    - LEUNG DW ET AL., "A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction", TECHNIQUE, (1989), vol. 1, pages 11 - 15
    - STEMMER WPC, "DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution", PROC. NATL. ACAD. SCI USA, (1994), vol. 91, doi:doi:10.1073/pnas.91.22.10747, pages 10747 - 10751, XP002912215

DOI:   http://dx.doi.org/10.1073/pnas.91.22.10747
    - AUSUBEL ET AL., Current Protocols in Molecular Biology, JOHN WILEY & SONS, (1989), pages 6.3.1 - 6.3.6
    - VON KOHARA ET AL., CELL, (1987), vol. 50, pages 495 - 508
    - WAHL ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, (1987), vol. 84, pages 2160 - 2164
    - BOLIVAR, LIFE SCIENCES, (1979), vol. 25, pages 807 - 818
    - VIEIRA ET AL., GENE, (1982), vol. 19, pages 259 - 268
    - DER VON GRANT ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, (1990), vol. 87, pages 4645 - 4649
    - SANGER ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1977), vol. 74, pages 5463 - 5467
    - VON STADEN, NUCLEIC ACIDS RESEARCH, (1986), vol. 14, pages 217 - 232
    - VON MARCK, NUCLEIC ACIDS RESEARCH, (1988), vol. 16, pages 1829 - 1836
    - VON BUTLER, METHODS OF BIOCHEMICAL ANALYSIS, (1998), vol. 39, pages 74 - 97
    - LIEBL ET AL., INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, (1991), vol. 41, pages 255 - 260
    - BEN-BASSAT ET AL., JOURNAL OF BACTERIOLOGY, (1987), vol. 169, pages 751 - 757
    - O'REGAN ET AL., GENE, (1989), vol. 77, pages 237 - 251
    - SAHIN-TOTH ET AL., PROTEIN SCIENCES, (1994), vol. 3, pages 240 - 247
    - HOCHULI ET AL., BIOTECHNOLOGY, (1988), vol. 6, pages 1321 - 1325
    - MOTOYAMA H.; YANO H.; TERASAKI Y.; ANAZAWA H., APPLIED--&--ENVIRONMENTAL MICROBIOLOGY, (2001), vol. 67, pages 3064 - 70
    - EIKMANNS BJ; EGGELING L.; SAHM H. ANTONIE, VAN LEEUWENHOEK, (1993), vol. 64, pages 145 - 63
    - EIKMANNS, JOURNAL OF BACTERIOLOGY, (1992), vol. 174, pages 6076 - 6086
    - EIKMANNS, JOUMAL OF BACTERIOLOGY, (1992), vol. 174, pages 6076 - 6086
    - MARTIN ET AL., BIOTECHNOLOGY, (1987), vol. 5, pages 137 - 146
    - GUERRERO ET AL., GENE, (1994), vol. 138, pages 35 - 41
    - TSUCHIYA; MORINAGA, BIOLTECHNOLOGY, (1988), vol. 6, pages 428 - 430
    - EIKMANNS ET AL., GENE, (1991), vol. 102, pages 93 - 98
    - SCHWARZER; PÜHLER, BIOTECHNOLOGY, (1991), vol. 9, pages 84 - 87
    - REMSCHEID ET AL., APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (1994), vol. 60, pages 126 - 132
    - LABARRE ET AL., JOUMAL OF BACTERIOLOGY, (1993), vol. 175, pages 1001 - 1007
    - MALUMBRES ET AL., GENE, (1993), vol. 134, pages 15 - 24
    - JENSEN; HAMMER, BIOTECHNOLOGY AND BIOENGINEERING, (1998), vol. 58, pages 191 - 195
    - MAKRIDES, MICROBIOLOGICAL REVIEWS, (1996), vol. 60, pages 512 - 538
    - PATEK M.; EIKMANNS BJ.; PATEK J.; SAHM H., MICROBIOLOGY, (1996), vol. 142, pages 1297 - 309
    - PCR Cloning Protocols, Methods in Molecular Biology Ser., HUMANA PRESS, (2002), vol. 192
    - VON REMSCHEID ET AL., APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (1994), vol. 60, pages 126 - 132
    - SIMON ET AL., BIO/TECHNOLOGY, (1983), vol. 1, pages 784 - 791
    - SCHÄFER ET AL., GENE, (1994), vol. 145, pages 69 - 73
    - BERNARD ET AL., JOURNAL OFMOLECULAR BIOLOGY, (1993), vol. 234, pages 534 - 541
    - SCHRUMPF ET AL., JOURNAL OF BACTERIOLOGY, (1991), vol. 173, pages 4510 - 4516
    - SPRATT ET AL., GENE, (1986), vol. 41, pages 337 - 342
    - THIERBACH ET AL., APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, (1988), vol. 29, pages 356 - 362
    - DUNICAN; SHIVNAN, BIOTECHNOLOGY, (1989), vol. 7, pages 1067 - 1070
    - TAUCH ET AL., FEMS MICROBIOLOGICAL LETTERS, (1994), vol. 123, pages 343 - 347
    - Applied Microbiol. Physiology, A Practical Approach, IRL PRESS, (1997), pages 53 - 73
    - PATEK ET AL., APPL. ENVIRON. MICROBIOL., (1994), vol. 60, pages 133 - 140
    - MALAKHOVA ET AL., BIOTEKHNOLOGIYA, (1996), vol. 11, pages 27 - 32
    - SCHMIDT ET AL., BIOPROCESS ENGINEER., (1998), vol. 19, pages 67 - 70
    - Ulmann's Encyclopedia of Industrial Chemistry, VCH, (1996), vol. A27, pages 89 - 90,521-5
    - FALLON, A. GROSSMANN K ET AL., "Rapid cloning of metK encoding methionine adenosyltransferase from Corynebacterium glutamicum by screening a genomic library on a high density colonyarray", FEMS MICROBIOLOGY LETTERS, (2000), vol. 193, no. 1, pages 99 - 103
    - RECZKOWSKI R S ET AL., "Structural and functional roles of cysteine 90 and cysteine 240 in S-adenosylmethionine synthetase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 31, doi:doi:10.1074/jbc.270.31.18484, pages 18484 - 18490, XP002260183

DOI:   http://dx.doi.org/10.1074/jbc.270.31.18484
    - KASE H ET AL., "Isolation and characterization of S-adenosylmethionine-requiring mutants and role of S-adenosylmethionine in the regulation of methionine biosynthesis in Corynebacterium glutamicum", AGR. BIOL. CHEM., vol. 39, no. 1, pages 161 - 168, XP009012949
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.