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Extract from the Register of European Patents

EP About this file: EP1555267

EP1555267 - 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES [Right-click to bookmark this link]
Former [2005/29]2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES
[2012/33]
StatusNo opposition filed within time limit
Status updated on  22.11.2013
Database last updated on 09.04.2026
Most recent event   Tooltip20.02.2026Change - lapse in a contracting statepublished on 25.03.2026  [2026/13]
Applicant(s)For all designated states
OTSUKA PHARMACEUTICAL CO., LTD.
9, Kanda Tsukasa-cho, 2-chome
Chiyoda-ku
Tokyo 101-8535 / JP
[2013/08]
Former [2013/03]For all designated states
OTSUKA PHARMACEUTICAL CO., LTD.
9, Kandatsukasa-cho 2-chome Chiyoda-ku
Tokyo 101-8535 / JP
Former [2005/29]For all designated states
OTSUKA PHARMACEUTICAL CO., LTD.
9, Kandatsukasa-cho 2-chome
Chiyoda-ku Tokyo 101-8535 / JP
Inventor(s)01 / TSUBOUCHI, Hidetsugu
2-35, Jotocho 1-chome
Tokushima-shi, Tokushima 770-0862 / JP
02 / SASAKI, Hirofumi
33-15, Kitamura Aza Sanchochi, Kitajimacho
Itano-gun, Tokushima 771-0201 / JP
03 / KURODA, Hideaki
5-7, Kokufucho Ido Aza Maeno
Tokushima-shi, Tokushima 779-3118 / JP
04 / ITOTANI, Motohiro
89-4, Myodocho 3-chome
Tokushima-shi, Tokushima 770-0047 / JP
05 / HASEGAWA, Takeshi;@Daiichiaijitsuhaitsu 607
146-11, Tokumei Aza Moto
mura, Aizumicho;
Itano-gun, Tokushima 771-1211 / JP
06 / HARAGUCHI, Yoshikazu
20-17, Nakayoshinocho 4-chome
Tokushima-shi, Tokushima 7700804 / JP
07 / KURODA, Takeshi
24-13, Ejiri Aza Ebisunomoto, Kitajiamacho
Itano-gun, Tokushima 771-0205 / JP
08 / MATSUZAKI, Takayuki
89, Minamishimadacho 2-chome
Tokushima-shi, Tokushima 770-0053 / JP
09 / TAI, Kuninori
RaforeKAWAUCHI 107, 5-2, Kawauchicho Kanaoka
Tokushima-shi, Tokushima 771-0125 / JP
10 / KOMATSU, Makoto
91-5, Sasagino Aza Hachiyamakaitaku, Matsushigecho
Itano-gun, Tokushima 771-0219 / JP
11 / MATSUMOTO, Makoto
418, Takashima Aza Kita, Narutocho
Naruto-shi, Tokushima 772-0051 / JP
12 / HASHIZUME, Hiroyuki;@Daiaparesu 1401
527-1, Minamihama Aza Higashihama
Muyacho;
Naruto-shi, Tokushima 772-0003 / JP
13 / TOMISHIGE, Tatsuo
Gurankawauchitawa 310, 422-1, Kawauchicho Okishima
Tokushima-shi, Tokushima 771-0142 / JP
14 / SEIKE, Yuji
1-13, Tateiwa Aza Kuguhara, Muyacho
Naruto-shi, Tokushima 772-0017 / JP
15 / KAWASAKI, Masanori
685-1-101, Aza Ishii, Ishii
Ishiicho,Myouzai-gun
Tokushima 7793233 / JP
16 / SUMIDA, Takumi
20-704, Higashishinmachi 2-chome
Tokusihma-shi, Tokushima 770-0912 / JP
17 / MIYAMURA, Shin;@147-13, Mukaininokoshi
Hiroshima Aza Kitakawa
Ma
tsushigecho;
Itano-gun, Tokushima771-0220 / JP
 [2013/03]
Former [2006/18]01 / TSUBOUCHI, Hidetsugu
2-35, Jotocho 1-chome
Tokushima-shi, Tokushima 770-0862 / JP
02 / SASAKI, Hirofumi
33-15, Kitamura Aza Sanchochi, Kitajimacho
Itano-gun, Tokushima 771-0201 / JP
03 / KURODA, Hideaki
5-7, Kokufucho Ido Aza Maeno
Tokushima-shi, Tokushima 779-3118 / JP
04 / ITOTANI, Motohiro
89-4, Myodocho 3-chome
Tokushima-shi, Tokushima 770-0047 / JP
05 / HASEGAWA, Takeshi; Daiichiaijitsuhaitsu 607
146-11, Tokumei Aza Moto mura, Aizumicho;
Itano-gun, Tokushima 771-1211 / JP
06 / HARAGUCHI, Yoshikazu
20-17, Nakayoshinocho 4-chome
Tokushima-shi, Tokushima 7700804 / JP
07 / KURODA, Takeshi
24-13, Ejiri Aza Ebisunomoto, Kitajiamacho
Itano-gun, Tokushima 771-0205 / JP
08 / MATSUZAKI, Takayuki
89, Minamishimadacho 2-chome
Tokushima-shi, Tokushima 770-0053 / JP
09 / TAI, Kuninori
RaforeKAWAUCHI 107, 5-2, Kawauchicho Kanaoka
Tokushima-shi, Tokushima 771-0125 / JP
10 / KOMATSU, Makoto
91-5, Sasagino Aza Hachiyamakaitaku, Matsushigecho
Itano-gun, Tokushima 771-0219 / JP
11 / MATSUMOTO, Makoto
418, Takashima Aza Kita, Narutocho
Naruto-shi, Tokushima 772-0051 / JP
12 / HASHIZUME, Hiroyuki; Daiaparesu 1401
527-1, Minamihama Aza Higashihama , Muyacho;
Naruto-shi, Tokushima 772-0003 / JP
13 / TOMISHIGE, Tatsuo
Gurankawauchitawa 310, 422-1, Kawauchicho Okishima
Tokushima-shi, Tokushima 771-0142 / JP
14 / SEIKE, Yuji
1-13, Tateiwa Aza Kuguhara, Muyacho
Naruto-shi, Tokushima 772-0017 / JP
15 / KAWASAKI, Masanori
685-1-101, Aza Ishii, Ishii Ishiicho,Myouzai-gun
Tokushima 7793233 / JP
16 / SUMIDA, Takumi
20-704, Higashishinmachi 2-chome
Tokusihma-shi, Tokushima 770-0912 / JP
17 / MIYAMURA, Shin; 147-13, Mukaininokoshi
Hiroshima Aza Kitakawa, Ma tsushigecho;
Itano-gun, Tokushima771-0220 / JP
Former [2005/29]01 / TSUBOUCHI, Hidetsugu
2-35, Jotocho 1-chome
Tokushima-shi, Tokushima 770-0862 / JP
02 / SASAKI, Hirofumi
33-15, Kitamura Aza Sanchochi, Kitajimacho
Itano-gun, Tokushima 771-0201 / JP
03 / KURODA, Hideaki
5-7, Kokufucho Ido Aza Maeno
Tokushima-shi, Tokushima 779-3118 / JP
04 / ITOTANI, Motohiro
89-4, Myodocho 3-chome
Tokushima-shi, Tokushima 770-0047 / JP
05 / HASEGAWA, Takeshi; Daiichiaijitsuhaitsu 607
146-11, Tokumei Aza Moto mura, Aizumicho;
Itano-gun, Tokushima 771-1211 / JP
06 / HARAGUCHI, Yoshikazu
Imagireryo E-312, 463-30, Kawauchicho Kagasuno
Tokushima-shi, Tokushima 771-0130 / JP
07 / KURODA, Takeshi
24-13, Ejiri Aza Ebisunomoto, Kitajiamacho
Itano-gun, Tokushima 771-0205 / JP
08 / MATSUZAKI, Takayuki
89, Minamishimadacho 2-chome
Tokushima-shi, Tokushima 770-0053 / JP
09 / TAI, Kuninori
RaforeKAWAUCHI 107, 5-2, Kawauchicho Kanaoka
Tokushima-shi, Tokushima 771-0125 / JP
10 / KOMATSU, Makoto
91-5, Sasagino Aza Hachiyamakaitaku, Matsushigecho
Itano-gun, Tokushima 771-0219 / JP
11 / MATSUMOTO, Makoto
418, Takashima Aza Kita, Narutocho
Naruto-shi, Tokushima 772-0051 / JP
12 / HASHIZUME, Hiroyuki; Daiaparesu 1401
527-1, Minamihama Aza Higashihama , Muyacho;
Naruto-shi, Tokushima 772-0003 / JP
13 / TOMISHIGE, Tatsuo
Gurankawauchitawa 310, 422-1, Kawauchicho Okishima
Tokushima-shi, Tokushima 771-0142 / JP
14 / SEIKE, Yuji
1-13, Tateiwa Aza Kuguhara, Muyacho
Naruto-shi, Tokushima 772-0017 / JP
15 / KAWASAKI, Masanori
9-6-306, Kitatamiya 2-chome
Tokushima-shi, Tokushima 770-0003 / JP
16 / SUMIDA, Takumi
20-704, Higashishinmachi 2-chome
Tokusihma-shi, Tokushima 770-0912 / JP
17 / MIYAMURA, Shin; 147-13, Mukaininokoshi
Hiroshima Aza Kitakawa, Ma tsushigecho;
Itano-gun, Tokushima771-0220 / JP
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[N/P]
Former [2013/03]HOFFMANN EITLE
Patent- und Rechtsanwälte
Arabellastrasse 4
81925 München / DE
Former [2008/31]HOFFMANN EITLE
Patent- und Rechtsanwälte Arabellastrasse 4
81925 München / DE
Former [2005/29]HOFFMANN EITLE
Patent- und Rechtsanwälte Arabellastrasse 4
81925 München / DE
Application number, filing date03754085.310.10.2003
[2005/29]
WO2003JP13070
Priority number, dateJP2002029825911.10.2002         Original published format: JP 2002298259
[2005/29]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2004033463
Date:22.04.2004
Language:EN
[2004/17]
Type: A1 Application with search report 
No.:EP1555267
Date:20.07.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 22.04.2004 takes the place of the publication of the European patent application.
[2005/29]
Type: B1 Patent specification 
No.:EP1555267
Date:16.01.2013
Language:EN
[2013/03]
Search report(s)International search report - published on:JP22.04.2004
(Supplementary) European search report - dispatched on:EP21.07.2010
ClassificationIPC:C07D498/04, C07D498/20, C07D519/00, A61K31/424, A61P31/06, C07F7/08
[2012/33]
CPC:
C07D498/04 (EP,KR,US); A61P11/00 (EP); A61P31/00 (EP);
A61P31/04 (EP); A61P31/06 (EP); C07D498/20 (EP,US);
C07F7/0812 (EP,US) (-)
Former IPC [2005/29]C07D498/04, C07D498/20, C07D519/00, A61K31/424
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/29]
TitleGerman:2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLE[2012/33]
English:2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES[2012/33]
French:2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES[2012/33]
Former [2005/29]2,3-DIHYDRO-6-NITROIMIDAZOç2,1-b!OXAZOLE
Former [2005/29]2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES
Former [2005/29]2,3-DIHYDRO-6-NITROIMIDAZO 2,1-B]OXAZOLES
Entry into regional phase16.03.2005Translation filed 
16.03.2005National basic fee paid 
16.03.2005Search fee paid 
16.03.2005Designation fee(s) paid 
16.03.2005Examination fee paid 
Examination procedure28.04.2004Request for preliminary examination filed
International Preliminary Examining Authority: JP
16.03.2005Examination requested  [2005/29]
18.10.2010Amendment by applicant (claims and/or description)
24.08.2011Despatch of a communication from the examining division (Time limit: M04)
27.12.2011Reply to a communication from the examining division
22.03.2012Despatch of a communication from the examining division (Time limit: M02)
22.05.2012Reply to a communication from the examining division
10.08.2012Communication of intention to grant the patent
27.11.2012Fee for grant paid
27.11.2012Fee for publishing/printing paid
Divisional application(s)EP12193820.3  / EP2570418
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  24.08.2011
Opposition(s)17.10.2013No opposition filed within time limit [2013/52]
Fees paidRenewal fee
24.10.2005Renewal fee patent year 03
25.10.2006Renewal fee patent year 04
25.10.2007Renewal fee patent year 05
27.03.2008Renewal fee patent year 06
30.10.2009Renewal fee patent year 07
22.10.2010Renewal fee patent year 08
25.10.2011Renewal fee patent year 09
18.10.2012Renewal fee patent year 10
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Former [2016/35]CY16.01.2013
Former [2013/35]CY16.01.2013
Documents cited:Search  No further relevant documents disclosed
International search[A] WO9701562  (PATHOGENESIS CORP et al.) [A]
 [X]   SEHGAL, RAJ K ET AL: "Potential radiosensitizing agents. 2. Synthesis and biological activity of derivatives of dinitroimidazole with oxiranes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 24, no. 5, 1981, pages 601 - 604, XP002974846 [X]

DOI:   http://dx.doi.org/10.1021/jm00137a021
 [A]   ASHTEKAR, DILIP R. ET AL: "In vitro and in vivo activities of the nitroimidazole CGI 17341 against mycobacterium tuberculosis", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 1.37, no. 2, February 1993 (1993-02-01), pages 183 - 186, XP002974847 [A]
 [A]   NAGARAJAN, K. ET AL: "Nitroimidazoles. XXI. 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles with antitubercular activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 24, no. 6, 1989, pages 631 - 633, XP002071373 [A]

DOI:   http://dx.doi.org/10.1016/0223-5234(89)90034-2
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.