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EP1511519

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Extract from the Register of European Patents

EP About this file: EP1511519

EP1511519 - MODIFIED BYRODIN 1 WITH REDUCED IMMUNOGENICITY [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 01.09.2006 Database last updated on 18.11.2024
Most recent event Tooltip	01.09.2006	Application deemed to be withdrawn	published on 04.10.2006 [2006/40]
Applicant(s)	For all designated states Merck Patent GmbH Frankfurter Strasse 250 64293 Darmstadt / DE
	[2005/10]
Inventor(s)	01 / Baker, Matthew 8 Saffron Close, Littleport, Ely Cambridge CB6 1AR / GB
	02 / Carr, Francis J. Birchlea, The Holdings, Balmedie Aberdeenshire AB23 8XU / GB
	[2005/10]
Application number, filing date	03757049.6	10.06.2003
	[2005/10]
	WO2003EP06055
Priority number, date	EP20020012911	11.06.2002 Original published format: EP 02012911
	[2005/10]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO03103715
	Date:	18.12.2003
	Language:	EN
	[2003/51]
	Type:	A1 Application with search report
	No.:	EP1511519
	Date:	09.03.2005
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 18.12.2003 takes the place of the publication of the European patent application.
	[2005/10]
Search report(s)	International search report - published on:	EP	18.12.2003
Classification	IPC:	A61K47/48	[2005/10]
	CPC:	C07K14/415 (EP,US); A61K47/50 (KR); A61K38/00 (EP,KR,US); A61K48/00 (KR); A61P35/00 (EP); A61P43/00 (EP)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LI, LU, MC, NL, PT, RO, SE, SI, SK, TR [2005/10]
Extension states	AL	Not yet paid
	LT	Not yet paid
	LV	Not yet paid
	MK	Not yet paid
Title	German:	MODIFIZIERTES BRYODIN 1 MIT VERRINGERTER IMMUNOGENITÄT	[2005/10]
	English:	MODIFIED BYRODIN 1 WITH REDUCED IMMUNOGENICITY	[2005/10]
	French:	BRYODINE 1 MODIFIEE A IMMUNOGENICITE REDUITE	[2005/10]
Entry into regional phase	13.10.2004	National basic fee paid
	13.10.2004	Designation fee(s) paid
	13.10.2004	Examination fee paid
Examination procedure	16.12.2003	Request for preliminary examination filed International Preliminary Examining Authority: EP
	13.10.2004	Examination requested [2005/10]
	10.11.2005	Despatch of a communication from the examining division (Time limit: M04)
	21.03.2006	Application deemed to be withdrawn, date of legal effect [2006/40]
	24.04.2006	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2006/40]
Fees paid	Renewal fee
	14.06.2005	Renewal fee patent year 03
	Penalty fee
	Additional fee for renewal fee
	30.06.2006	04 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[AD]US5541110 (SIEGALL CLAY B [US]);
		[A]WO9852976 (BIOVATION LTD [GB], et al);
		[DX]WO0034317 (BIOVATION LTD [GB], et al) [DX] 1-16 * the whole document * * See especially Example 4 and Figure 10 *;
		[T]WO02069232 (MERCK PATENT GMBH [DE], et al);
		[A] - ALTUVIA Y ET AL, "RANKING POTENTIAL BINDING PEPTIDES TO MHC MOLECULES BY A COMPUTATIONAL THREADING APPROACH", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, (1995), vol. 249, no. 1, ISSN 0022-2836, pages 244 - 250, XP000925520 DOI: http://dx.doi.org/10.1006/jmbi.1995.0293
		[A] - SPENCER D I R ET AL, "A STRATEGY FOR MAPPING AND NEUTRALIZING CONFORMATIONAL IMMUNOGENIC SITES ON PROTEIN THERAPEUTICS", PROTEOMICS, XX, XX, (200203), vol. 2, no. 3, pages 271 - 279, XP009009265 DOI: http://dx.doi.org/10.1002/1615-9861(200203)2:3<271::AID-PROT271>3.0.CO;2-W
		[A] - MEISTER G E ET AL, "Two novel T cell epitope prediction algorithms based on MHC-binding motifs;comparison of predicted and published epitopes from Mycobacterium tuberculosis and HIV protein sequences", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, (19950401), vol. 13, no. 6, ISSN 0264-410X, pages 581 - 591, XP004057605 DOI: http://dx.doi.org/10.1016/0264-410X(94)00014-E
		[A] - WEBER J R ET AL, "IMMUNODOMINANT STRUCTURESOF HUMAN GROWTH HORMONE IDENTIFIED BY HOMOLOG-SCANNING MUTAGENESIS", MOLECULAR IMMUNOLOGY, ELMSFORD, NY, US, (1992), vol. 29, no. 9, ISSN 0161-5890, pages 1081 - 1088, XP009004807 DOI: http://dx.doi.org/10.1016/0161-5890(92)90040-5
		[A] - MOOLA Z B ET AL, "ERWINIA CHRYSANTHEMI L-ASPARAGINASE: EPITOPE MAPPING AND PRODUCTIONOF ANTIGENICALLY MODIFIED ENZYMES", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, (1994), vol. 302, no. PART 3, ISSN 0264-6021, pages 921 - 927, XP000918634
		[A] - CUNNINGHAM B C ET AL, "HIGH-RESOLUTION EPITOPE MAPPING OF HGH-RECEPTOR INTERACTIONS BY ALANINE-SCANNING MUTAGENESIS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, (19890602), vol. 244, no. 4908, ISSN 0036-8075, pages 1081 - 1085, XP000025308 DOI: http://dx.doi.org/10.1126/science.2471267
		[A] - SALI A ET AL, "COMPARATIVE PROTEIN MODELLING BY SATISFACTION OF SPATIAL RESTRAINTS", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, (1993), vol. 234, ISSN 0022-2836, pages 779 - 815, XP002948615 DOI: http://dx.doi.org/10.1006/jmbi.1993.1626
		[A] - KWOK W W ET AL, "Rapid epitope identification from complex class-II-restricted T-cell antigens", TRENDS IN IMMUNOLOGY, ELSEVIER, CAMBRIDGE, GB, (20011101), vol. 22, no. 11, ISSN 1471-4906, pages 583 - 588, XP004319746 DOI: http://dx.doi.org/10.1016/S1471-4906(01)02038-5
		[AD] - GAWLAK SUSAN L ET AL, "Molecular, biological, and preliminary structural analysis of recombinant bryodin 1, a ribosome-inactivating protein from the plant Bryonia dioica.", BIOCHEMISTRY, vol. 36, no. 11, ISSN 0006-2960, (1997), Database accession no. AAL34334, pages 3095 - 3103, URL: EMBL, XP002256641 DOI: http://dx.doi.org/10.1021/bi962474+
		[ ] - GAWLAK, S L. ET AL., "Ribosome-inactivating protein [Bryonia dioica]", EMBL, (20011121), Database accession no. AAL34334, URL: EMBL, XP002256642 [ ] * the whole document *
		[A] - STIRPE F ET AL, "BRYODIN A RIBOSOME-INACTIVATING PROTEIN FROM THE ROOTS OF BRYONIA-DIOICA L. WHITE BRYONY", BIOCHEMICAL JOURNAL, (1986), vol. 240, no. 3, ISSN 0264-6021, pages 659 - 666, XP009018531
		[A] - BATTELLI M G ET AL, "TOXICITY OF AND HISTOLOGICAL LESIONS CAUSED BY RIBOSOME-INACTIVATING PROTEINS THEIR IGG-CONJUGATES AND THEIR HOMOPOLYMERS", APMIS, (1990), vol. 98, no. 7, ISSN 0903-4641, pages 585 - 593, XP009018529 DOI: http://dx.doi.org/10.1111/j.1699-0463.1990.tb04975.x
		[A] - FRYXELL DANIEL K ET AL, "Identification of a specific tyrosine residue in Bryodin 1 distinct from the active site but required for full catalytic and cytotoxic activity", PROTEIN SCIENCE, (199802), vol. 7, no. 2, ISSN 0961-8368, pages 318 - 324, XP009018559

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